Publications by authors named "Richard M Ransohoff"

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Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.
Nat Neurosci 2018 Mar 20;21(3):329-340. Epub 2018 Feb 20.
Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.




Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.
Cell Rep 2017 Oct;21(2):366-380
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:


Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.
Sci Rep 2017 Jul 10;7(1):4942. Epub 2017 Jul 10.
Departments of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.


Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro.
Neurol Neuroimmunol Neuroinflamm 2017 Jan 19;4(1):e311. Epub 2016 Dec 19.
Neuroinflammation Research Center (Y.T., B.O., A.C.C., S.F.S., F.S., E.Y., R.M.R.), Lerner Research Institute, Cleveland Clinic, OH; Department of Neurology and Clinical Neuroscience (Y.S., T.K.), Yamaguchi University Graduate School of Medicine, Japan; and Department of Laboratory Medicine and Pathology (T.J.K., V.A.L.), Mayo Clinic, Rochester, MN. Y.T. and F.S. are currently affiliated with the Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan. B.O., A.C.C., and R.M.R. are currently affiliated with Neuroimmunology Research, Biogen, Cambridge, MA. S.F.S. is currently affiliated with the Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Italy.




Spatiotemporal ablation of CXCR2 on oligodendrocyte lineage cells: Role in myelin repair.
Neurol Neuroimmunol Neuroinflamm 2015 Dec 19;2(6):e174. Epub 2015 Nov 19.
Neuroinflammation Research Center (L.L., L.C.S., B.H., S.S., A.L., C.Z., M.Y., A.C.C., R.M.R.), Lerner Research Institute, Cleveland Clinic; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (B.P.); and Case Western Reserve University School of Medicine (B.B.), Cleveland, OH.


A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury.
J Exp Med 2015 Apr 23;212(4):447-56. Epub 2015 Mar 23.
Immunology Research Group, Snyder Institute for Chronic Diseases; Department of Microbiology, Immunology, and Infectious Diseases; and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada Immunology Research Group, Snyder Institute for Chronic Diseases; Department of Microbiology, Immunology, and Infectious Diseases; and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
J Exp Med 2015 Mar 2;212(3):287-95. Epub 2015 Mar 2.
The Lerner Research Institute and Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH 44195 The Lerner Research Institute and Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH 44195 Case Western Reserve University, Cleveland, OH 44106

Meet the new team!
Neurol Neuroimmunol Neuroinflamm 2014 Dec 18;1(4):e44. Epub 2014 Dec 18.
Neuroinflammation Research Center, Mellen Center for MS Treatment and Research; and Cleveland Clinic Lerner College of Medicine, Cleveland, OH.

Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.
J Neurosci 2014 Sep;34(37):12538-46
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, Department of Genetics and Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, and

Differential roles of microglia and monocytes in the inflamed central nervous system.
J Exp Med 2014 Jul 7;211(8):1533-49. Epub 2014 Jul 7.
Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute; Department of Quantitative Health Sciences; and Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH 44106Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute; Department of Quantitative Health Sciences; and Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH 44106 Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106

Gathering thunder.
Neurol Neuroimmunol Neuroinflamm 2014 Jun 31;1(1):e15. Epub 2014 May 31.
Neuroinflammation Research Center, Mellen Center for MS Treatment and Research, and Cleveland Clinic Lerner College of Medicine, Cleveland, OH.

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases.
J Exp Med 2014 May 21;211(5):887-907. Epub 2014 Apr 21.
Department of Immunology, 2 Department of Cellular and Molecular Medicine, 3 Department of Pathobiology, 4 Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195.

High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury.
Exp Neurol 2014 Apr 24;254:109-20. Epub 2014 Jan 24.
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events.
Neurobiol Dis 2014 Feb 17;62:273-85. Epub 2013 Oct 17.
Department of Neurosciences, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

Clinical outcomes following surgical management of coexistent cervical stenosis and multiple sclerosis: a cohort-controlled analysis.
Spine J 2014 Feb 12;14(2):331-7. Epub 2013 Nov 12.
Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Cleveland, OH 44195, USA; Cleveland Clinic Center for Spine Health, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Department of Neurological Surgery, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA. Electronic address:

Identification of a unique TGF-β-dependent molecular and functional signature in microglia.
Nat Neurosci 2014 Jan 8;17(1):131-43. Epub 2013 Dec 8.
Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

CCR7 signaling in pediatric opsoclonus-myoclonus: upregulated serum CCL21 expression is steroid-responsive.
Cytokine 2013 Oct 10;64(1):331-6. Epub 2013 Jun 10.
National Pediatric Myoclonus Center and Neuroimmunology Research Laboratory, P.O. Box 19643, Springfield, IL 62794-9643, USA; Department of Neurology, SouthernIllinois University School of Medicine, P.O. Box 19643, Springfield, IL 62794-9643, USA. Electronic address:

Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells.
Nat Neurosci 2013 Oct 1;16(10):1401-8. Epub 2013 Sep 1.
1] Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2] Department of Immunology, Cleveland Clinic, Cleveland, Ohio, USA.

CCR4 agonists CCL22 and CCL17 are elevated in pediatric OMS sera: rapid and selective down-regulation of CCL22 by ACTH or corticosteroids.
J Clin Immunol 2013 May 23;33(4):817-25. Epub 2013 Jan 23.
Neuroimmunology Research Laboratory, National Pediatric Myoclonus Center, Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62794-9643, USA.

Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation.
J Neuroimmunol 2013 Jan 2;254(1-2):165-9. Epub 2012 Sep 2.
Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Center for Molecular Medicine, Berlin, Germany.

BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
J Neuroinflammation 2013 Jan 16;10:10. Epub 2013 Jan 16.
Department of Neurology, National Pediatric Myoclonus Center and Neuroimmunology Laboratory, and Southern Illinois University School of Medicine, PO Box 19643, Springfield, IL 62794-9643, USA.

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.
Proc Natl Acad Sci U S A 2012 Oct 15;109(44):18150-5. Epub 2012 Oct 15.
German Center for Neurodegenerative Diseases, DZNE, and Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.

Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
PLoS One 2015 21;10(7):e0133392. Epub 2015 Jul 21.
Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.





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