Richard M Caprioli

Richard M Caprioli

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Richard M Caprioli

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Two Specific Sulfatide Species Are Dysregulated during Renal Development in a Mouse Model of Alport Syndrome.

Lipids 2019 06 13;54(6-7):411-418. Epub 2019 Jun 13.

Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1002/lipd.12171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655412PMC
June 2019

Zinc intoxication induces ferroptosis in A549 human lung cells.

Metallomics 2019 May;11(5):982-993

Vanderbilt Institute for Infection, Immunology and Inflammation and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://xlink.rsc.org/?DOI=C8MT00360B
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http://dx.doi.org/10.1039/c8mt00360bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531343PMC
May 2019

Combining MALDI-2 and transmission geometry laser optics to achieve high sensitivity for ultra-high spatial resolution surface analysis.

J Mass Spectrom 2019 Apr;54(4):366-370

Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA.

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http://doi.wiley.com/10.1002/jms.4335
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http://dx.doi.org/10.1002/jms.4335DOI Listing
April 2019

Imaging Mass Spectrometry: A Perspective.

J Biomol Tech 2019 Apr;30(1):7-11

Biochemistry Department, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8576, USA.

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http://dx.doi.org/10.7171/jbt.19-3001-002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430189PMC
April 2019

Multiple TOF/TOF Events in a Single Laser Shot for Multiplexed Lipid Identifications in MALDI Imaging Mass Spectrometry.

Int J Mass Spectrom 2019 Mar 28;437:30-37. Epub 2018 Jun 28.

Department of Biochemistry, Vanderbilt University, Nashville, TN 37232.

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http://dx.doi.org/10.1016/j.ijms.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424509PMC
March 2019

Protein identification strategies in MALDI imaging mass spectrometry: a brief review.

Curr Opin Chem Biol 2019 02 23;48:64-72. Epub 2018 Nov 23.

Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN 37235, USA; Mass Spectrometry Research Center, Vanderbilt University, 465 21st Ave S #9160, Nashville, TN 37235, USA; Department of Biochemistry, Vanderbilt University, 607 Light Hall, Nashville, TN 37205, USA; Department of Pharmacology, Vanderbilt University, 442 Robinson Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA; Department of Medicine, Vanderbilt University, 465 21st Ave S #9160, Nashville, TN 37235, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382520PMC
February 2019

Discerning the Primary Carcinoma in Malignant Peritoneal and Pleural Effusions Using Imaging Mass Spectrometry-A Feasibility Study.

Proteomics Clin Appl 2019 01 29;13(1):e1800064. Epub 2018 Oct 29.

Mass Spectrometry Research Center and Departments of Biochemistry, Pharmacology, Medicine and Chemistry, Vanderbilt University, Nashville, TN, USA.

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http://doi.wiley.com/10.1002/prca.201800064
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http://dx.doi.org/10.1002/prca.201800064DOI Listing
January 2019

Beyond the H&E: Advanced Technologies for in situ Tissue Biomarker Imaging.

ILAR J 2018 12;59(1):51-65

Lauren E. Himmel, DVM, PhD, is an assistant professor and veterinary pathologist in the Division of Comparative Medicine at Vanderbilt University Medical Center in Nashville, Tennessee. Troy A. Hackett, PhD, is a professor in the Department of Hearing and Speech Sciences at Vanderbilt University Medical Center in Nashville, Tennessee. Jessica L. Moore, PhD, is a postdoctoral research fellow in the Mass Spectrometry Research Center at the Vanderbilt University School of Medicine in Nashville, Tennessee. Wilson R. Adams, BS, is graduate student in the Biophotonics Center and Department of Biomedical Engineering at Vanderbilt University in Nashville, Tennessee. Giju Thomas, PhD, is a post-doctoral researcher in the Biophotonics Center and Department of Biomedical Engineering at Vanderbilt University in Nashville, Tennessee. Tatiana Novitskaya, MD, PhD, is a staff scientist in the Department of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center. Richard M. Caprioli, PhD, is a professor in the Department of Chemistry at the Vanderbilt University School of Medicine in Nashville, Tennessee. Andries Zijlstra, PhD, is an associate professor in the Department of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center in Nashville, Tennessee. Anita Mahadevan-Jansen, PhD, is a professor in the Department of Biomedical Engineering at the Vanderbilt University School of Engineering and Department of Neurosurgery at Vanderbilt University Medical Center in Nashville, Tennessee. Kelli L. Boyd, DVM, PhD, is a professor and veterinary pathologist in the Division of Comparative Medicine at Vanderbilt University Medical Center in Nashville, Tennessee.

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http://dx.doi.org/10.1093/ilar/ily004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645175PMC
December 2018

Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection.

PLoS Pathog 2018 12 21;14(12):e1007486. Epub 2018 Dec 21.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303022PMC
December 2018

Advanced Registration and Analysis of MALDI Imaging Mass Spectrometry Measurements through Autofluorescence Microscopy.

Anal Chem 2018 11 16;90(21):12395-12403. Epub 2018 Oct 16.

Delft Center for Systems and Control (DCSC) , Delft University of Technology , 2628 CD Delft , The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b02884
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http://dx.doi.org/10.1021/acs.analchem.8b02884DOI Listing
November 2018

Next Generation Histology-Directed Imaging Mass Spectrometry Driven by Autofluorescence Microscopy.

Anal Chem 2018 11 16;90(21):12404-12413. Epub 2018 Oct 16.

Delft Center for Systems and Control (DCSC) , Delft University of Technology , 2628 CD , Delft , The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b02885
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http://dx.doi.org/10.1021/acs.analchem.8b02885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309458PMC
November 2018

Imaging mass spectrometry reveals direct albumin fragmentation within the diabetic kidney.

Kidney Int 2018 08 18;94(2):292-302. Epub 2018 May 18.

Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Mass Spectrometry Research Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054886PMC
August 2018

Micro-Data-Independent Acquisition for High-Throughput Proteomics and Sensitive Peptide Mass Spectrum Identification.

Anal Chem 2018 08 23;90(15):8905-8911. Epub 2018 Jul 23.

Mass Spectrometry Research Center, Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37240 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b01026DOI Listing
August 2018

Regional differences in brain glucose metabolism determined by imaging mass spectrometry.

Mol Metab 2018 06 6;12:113-121. Epub 2018 Apr 6.

Department of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001904PMC
June 2018

Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation.

J Am Soc Mass Spectrom 2018 05 13;29(5):1012-1020. Epub 2018 Mar 13.

Mass Spectrometry Research Center, Vanderbilt University, 465 21st Avenue South, Nashville, TN, 37240, USA.

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http://dx.doi.org/10.1007/s13361-018-1899-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943162PMC
May 2018

Enhanced Ion Transmission Efficiency up to m/ z 24 000 for MALDI Protein Imaging Mass Spectrometry.

Anal Chem 2018 04 2;90(8):5090-5099. Epub 2018 Apr 2.

Delft Center for Systems and Control , Delft University of Technology , Delft 2628 CD , The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.7b05105DOI Listing
April 2018

Protein identification in imaging mass spectrometry through spatially targeted liquid micro-extractions.

Rapid Commun Mass Spectrom 2018 Mar;32(5):442-450

Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN, 37235, USA.

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http://dx.doi.org/10.1002/rcm.8042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812809PMC
March 2018

Imaging MS of Rodent Ocular Tissues and the Optic Nerve.

Methods Mol Biol 2017 ;1618:15-27

Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University School of Medicine, 9126D MRB III, 465 21st Ave., South, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/978-1-4939-7051-3_3DOI Listing
February 2018

Pyruvate induces torpor in obese mice.

Proc Natl Acad Sci U S A 2018 01 8;115(4):810-815. Epub 2018 Jan 8.

Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1717507115
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http://dx.doi.org/10.1073/pnas.1717507115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789941PMC
January 2018

Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry.

Invest Ophthalmol Vis Sci 2018 01;59(1):212-222

Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.

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http://dx.doi.org/10.1167/iovs.17-22509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770179PMC
January 2018

Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Cell Host Microbe 2017 Oct 21;22(4):531-542.e8. Epub 2017 Sep 21.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21(st) Avenue South, MCN A-5102, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638708PMC
October 2017

Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma.

Am J Dermatopathol 2017 Sep;39(9):689-695

*Department of Dermatology, Yale University School of Medicine, New Haven, CT; †Smilow Cancer Center, New Haven, CT; ‡Department of Plastic Surgery, Plastic Surgery Hospital, Peking Union Medical College and the Chinese Academy of Medical Science, Beijing, China; §Department of Dermatology, School of Medicine, University of Balamand, Beirut, Lebanon; ¶Department of Genetics, Yale School of Medicine, New Haven, CT; ‖Protea Biosciences, Inc, Morgantown, WV; and **Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN.

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http://Insights.ovid.com/crossref?an=00000372-201709000-0000
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http://dx.doi.org/10.1097/DAD.0000000000000849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647999PMC
September 2017

Label-free molecular imaging of the kidney.

Kidney Int 2017 09 24;92(3):580-598. Epub 2017 Jul 24.

Biophotonic Laboratory, UMR CNRS 7369 URCA, Reims, France; Nephropathology, Department of Biopathology Laboratory, CHU de Reims, Reims, France; Nephrology and Renal Transplantation department, CHU de Reims, Reims, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.03.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193761PMC
September 2017

Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis.

Biochim Biophys Acta Proteins Proteom 2017 Jul 27;1865(7):967-977. Epub 2017 Feb 27.

Delft Center for Systems and Control (DCSC), Delft University of Technology, Mekelweg 2, 2628 CD Delft, the Netherlands; Mass Spectrometry Research Center (MSRC), Vanderbilt University, 465 21st Ave. South, 9160 Medical Research Building III, Nashville, TN 37240, USA; Department of Biochemistry, Vanderbilt University, 607 Light Hall, Nashville, TN 37205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2017.02.016DOI Listing
July 2017

Enhanced Spatially Resolved Proteomics Using On-Tissue Hydrogel-Mediated Protein Digestion.

Anal Chem 2017 03 17;89(5):2948-2955. Epub 2017 Feb 17.

Department of Chemistry, ‡Department of Biochemistry, §Mass Spectrometry Research Center, and ∥Departments of Pharmacology and Medicine, Vanderbilt University , Nashville, Tennessee 37232, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b04395DOI Listing
March 2017

Absolute Quantification of Rifampicin by MALDI Imaging Mass Spectrometry Using Multiple TOF/TOF Events in a Single Laser Shot.

J Am Soc Mass Spectrom 2017 01 21;28(1):136-144. Epub 2016 Sep 21.

Department of Biochemistry, Vanderbilt University, 9160 MRB III, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/s13361-016-1501-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177505PMC
January 2017

Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging.

Exp Eye Res 2017 01 9;154:70-78. Epub 2016 Nov 9.

School of Medical Sciences, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2016.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359059PMC
January 2017

Multiple Time-of-Flight/Time-of-Flight Events in a Single Laser Shot for Improved Matrix-Assisted Laser Desorption/Ionization Tandem Mass Spectrometry Quantification.

Anal Chem 2016 10 14;88(19):9780-9788. Epub 2016 Sep 14.

Department of Biochemistry, ‡Department of Chemistry, §Departments of Pharmacology and Medicine, and ∥Mass Spectrometry Research Center, Vanderbilt University , Nashville, Tennessee 37232, United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.6b02821
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http://dx.doi.org/10.1021/acs.analchem.6b02821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672909PMC
October 2016

3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.

J Proteomics 2016 10 13;149:77-84. Epub 2016 Feb 13.

Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983271PMC
October 2016

Imaging mass spectrometry for accessing molecular changes during burn wound healing.

Wound Repair Regen 2016 Sep 26;24(5):775-785. Epub 2016 Jul 26.

Department of Plastic Surgery, Vanderbilt School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1111/wrr.12450DOI Listing
September 2016

Life history linked to immune investment in developing amphibians.

Conserv Physiol 2016 26;4(1):cow025. Epub 2016 Aug 26.

Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232-2363, USA; Department of Biological Science, Vanderbilt University, Nashville, TN 37235-1634, USA; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2363, USA.

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http://dx.doi.org/10.1093/conphys/cow025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001151PMC
August 2016

Potential of MALDI imaging for the toxicological evaluation of environmental pollutants.

J Proteomics 2016 07 10;144:133-9. Epub 2016 May 10.

Protim, Inserm U1085, IRSET, Campus de Beaulieu, Rennes Cedex F-35042, France; Université de Rennes I, Campus de Beaulieu, Rennes Cedex F-35042, France. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197801PMC
July 2016

Standard Reticle Slide To Objectively Evaluate Spatial Resolution and Instrument Performance in Imaging Mass Spectrometry.

Anal Chem 2016 07 27;88(14):7302-11. Epub 2016 Jun 27.

National Research Resource for Imaging Mass Spectrometry, ‡Department of Chemical and Biomolecular Engineering, §Department of Biochemistry, and ∥Departments of Chemistry and Medicine, Vanderbilt University , Nashville, Tennessee, United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.6b01655
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http://dx.doi.org/10.1021/acs.analchem.6b01655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672908PMC
July 2016

Imaging mass spectrometry: Molecular microscopy for the new age of biology and medicine.

Proteomics 2016 06 27;16(11-12):1607-12. Epub 2016 May 27.

Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.1002/pmic.201600133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197803PMC
June 2016

Pathology interface for the molecular analysis of tissue by mass spectrometry.

J Pathol Inform 2016 11;7:13. Epub 2016 Apr 11.

Department of Biochemistry, National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37240, USA.

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http://www.jpathinformatics.org/text.asp?2016/7/1/13/179903
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http://dx.doi.org/10.4103/2153-3539.179903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837791PMC
May 2016

The Need for Speed in Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry.

Postdoc J 2016 Mar;4(3):3-13

Department of Biochemistry Vanderbilt University, Nashville, TN 37232; Department of Chemistry Vanderbilt University, Nashville, TN 37232; Department of Pharmacology and Medicine Vanderbilt University, Nashville, TN 37232; Department of Mass Spectrometry Research Center Vanderbilt University, Nashville, TN 37232.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996283PMC
March 2016

MALDI Imaging Mass Spectrometry as a Lipidomic Approach to Heart Valve Research.

J Heart Valve Dis 2016 03;25(2):240-252

Mass Spectrometry Research Center and Department of Biochemistry, Medicine, Pharmacology and Chemistry, Vanderbilt University Medical Center, Nashville, TN, USA.

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March 2016

Histology-guided protein digestion/extraction from formalin-fixed and paraffin-embedded pressure ulcer biopsies.

Exp Dermatol 2016 Feb 23;25(2):143-6. Epub 2015 Nov 23.

Mass Spectrometry Research Center, Vanderbilt School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1111/exd.12870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724279PMC
February 2016

Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues.

Anal Chem 2016 Feb 5;88(4):2392-8. Epub 2016 Feb 5.

Department of Chemistry, Vanderbilt University , Nashville, Tennessee 37235, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080977PMC
http://dx.doi.org/10.1021/acs.analchem.5b04409DOI Listing
February 2016

High spatial resolution proteomic comparison of the brain in humans and chimpanzees.

J Comp Neurol 2015 Oct 14;523(14):2043-61. Epub 2015 Jul 14.

Department of Anthropology, The George Washington University, Washington, DC, 20052.

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http://dx.doi.org/10.1002/cne.23777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801118PMC
October 2015

Imaging mass spectrometry: enabling a new age of discovery in biology and medicine through molecular microscopy.

J Am Soc Mass Spectrom 2015 Jun 24;26(6):850-2. Epub 2015 Mar 24.

Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA,

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http://link.springer.com/10.1007/s13361-015-1108-z
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http://dx.doi.org/10.1007/s13361-015-1108-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425622PMC
June 2015

Peptide spectra in Wilms tumor that associate with adverse outcomes.

J Surg Res 2015 Jun 18;196(2):332-8. Epub 2015 Mar 18.

Department of Pediatric Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.

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https://linkinghub.elsevier.com/retrieve/pii/S00224804150028
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http://dx.doi.org/10.1016/j.jss.2015.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599776PMC
June 2015

MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data.

J Am Soc Mass Spectrom 2015 Jun 23;26(6):974-85. Epub 2015 Apr 23.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37205, USA,

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http://dx.doi.org/10.1007/s13361-015-1147-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442642PMC
June 2015

Histology-directed and imaging mass spectrometry: An emerging technology in ectopic calcification.

Bone 2015 May 13;74:83-94. Epub 2015 Jan 13.

Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.

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http://dx.doi.org/10.1016/j.bone.2015.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355241PMC
May 2015

Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping.

Nat Methods 2015 Apr 23;12(4):366-72. Epub 2015 Feb 23.

1] Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA. [2] Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA. [3] Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA. [4] Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA. [5] Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/nmeth.3296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382398PMC
April 2015

High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling.

J Mass Spectrom 2015 Apr;50(4):703-10

Department of Biochemistry, Vanderbilt University, Nashville, TN, 37232.

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http://doi.wiley.com/10.1002/jms.3579
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http://dx.doi.org/10.1002/jms.3579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498415PMC
April 2015

Tissue protein imaging at 1 μm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS.

Anal Bioanal Chem 2015 Mar 12;407(8):2337-42. Epub 2015 Feb 12.

The Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University, Nashville, TN, 37235, USA.

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http://link.springer.com/10.1007/s00216-015-8532-6
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http://dx.doi.org/10.1007/s00216-015-8532-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359058PMC
March 2015

Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili.

PLoS Pathog 2015 Mar 4;11(3):e1004697. Epub 2015 Mar 4.

Department of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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https://dx.doi.org/10.1371/journal.ppat.1004697
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http://dx.doi.org/10.1371/journal.ppat.1004697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349694PMC
March 2015

Imaging mass spectrometry for assessing cutaneous wound healing: analysis of pressure ulcers.

J Proteome Res 2015 Feb 19;14(2):986-96. Epub 2014 Dec 19.

Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria , Via P. Bucci, cubo 12/D, Arcavacata di Rende, CS, 87036, Italy.

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http://dx.doi.org/10.1021/pr5010218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324443PMC
February 2015

Histology-directed microwave assisted enzymatic protein digestion for MALDI MS analysis of mammalian tissue.

Anal Chem 2015 Jan 9;87(1):670-6. Epub 2014 Dec 9.

Department of Chemistry and Technological Chemistry, University of Calabria , Arcavacata di Rende, Cosenza 87036, Italy.

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http://dx.doi.org/10.1021/ac503479aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287167PMC
January 2015

Automated anatomical interpretation of ion distributions in tissue: linking imaging mass spectrometry to curated atlases.

Anal Chem 2014 Sep 25;86(18):8974-82. Epub 2014 Aug 25.

Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven , Kasteelpark Arenberg 10, Box 2446, 3001 Leuven, Belgium.

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http://dx.doi.org/10.1021/ac502838tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165455PMC
September 2014

Towards automated discrimination of lipids versus peptides from full scan mass spectra.

EuPA Open Proteom 2014 Sep;4:87-100

Applied Bio & molecular Systems, VITO, Mol, Belgium ; Center for Proteomics, Antwerp, Belgium ; Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium.

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http://dx.doi.org/10.1016/j.euprot.2014.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234154PMC
September 2014

High resolution MALDI imaging mass spectrometry of retinal tissue lipids.

J Am Soc Mass Spectrom 2014 Aug 13;25(8):1394-403. Epub 2014 May 13.

Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

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http://link.springer.com/10.1007/s13361-014-0883-2
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http://dx.doi.org/10.1007/s13361-014-0883-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180438PMC
August 2014

MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery.

J Proteomics 2014 Jul 29;107:71-82. Epub 2014 Mar 29.

National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States; Department of Biochemistry, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104210PMC
July 2014

Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.

Cancer Prev Res (Phila) 2014 Jul 12;7(7):748-57. Epub 2014 May 12.

Division of Allergy, Pulmonary and Critical Care Medicine, Departments of Veterans Affairs Medical Center, Nashville, Tennessee; and

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090029PMC
July 2014

Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles.

J Lipid Res 2014 07 26;55(7):1375-85. Epub 2014 May 26.

Departments of Chemistry, Vanderbilt University Medical Center, Nashville, TN 37232 Mass Spectrometry Research Center, Vanderbilt University Medical Center, Nashville, TN 37232 Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M049189
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http://dx.doi.org/10.1194/jlr.M049189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076088PMC
July 2014

Advanced mass spectrometry technologies for the study of microbial pathogenesis.

Curr Opin Microbiol 2014 Jun 3;19:45-51. Epub 2014 Jul 3.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2014.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125470PMC
June 2014

Matrix pre-coated targets for high throughput MALDI imaging of proteins.

J Mass Spectrom 2014 May;49(5):417-22

Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.

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http://doi.wiley.com/10.1002/jms.3354
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http://dx.doi.org/10.1002/jms.3354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028164PMC
May 2014

Co-registration of multi-modality imaging allows for comprehensive analysis of tumor-induced bone disease.

Bone 2014 Apr 30;61:208-16. Epub 2014 Jan 30.

Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Vanderbilt University, Nashville, TN, USA; Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN, USA; Department of Medicine, Vanderbilt University, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005328PMC
April 2014

Imaging mass spectrometry: a new tool for pathology in a molecular age.

Proteomics Clin Appl 2013 Dec;7(11-12):733-8

Department of Biochemistry, National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN.

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http://dx.doi.org/10.1002/prca.201300055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919023PMC
December 2013

Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry.

Neuroimage Clin 2013 30;2:620-9. Epub 2013 Apr 30.

Institute of Imaging Science, Vanderbilt University, 1161, 21st Avenue South, Nashville, TN 37232, USA ; Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, USA ; Vanderbilt Brain Institute, USA.

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http://dx.doi.org/10.1016/j.nicl.2013.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778261PMC
November 2013

An LC-MS assay for the screening of cardiovascular medications in human samples.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Oct 16;937:44-53. Epub 2013 Aug 16.

Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.jchromb.2013.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800555PMC
October 2013

Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis.

PLoS One 2013 25;8(2):e57165. Epub 2013 Feb 25.

Columbia University, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057165PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581520PMC
September 2013

Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis.

Proteomics Clin Appl 2013 Aug 8;7(7-8):541-9. Epub 2013 May 8.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1002/prca.201200107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737405PMC
August 2013

MALDI imaging and in situ identification of integral membrane proteins from rat brain tissue sections.

Anal Chem 2013 Aug 19;85(15):7191-6. Epub 2013 Jul 19.

Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

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http://dx.doi.org/10.1021/ac400902hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782084PMC
August 2013

Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research.

Chem Rev 2013 Apr 11;113(4):2309-42. Epub 2013 Feb 11.

National Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8575, USA.

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http://pubs.acs.org/doi/10.1021/cr3004295
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624074PMC
April 2013

Targeted multiplex imaging mass spectrometry in transmission geometry for subcellular spatial resolution.

J Am Soc Mass Spectrom 2013 Apr 9;24(4):609-14. Epub 2013 Feb 9.

Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1007/s13361-012-0563-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624063PMC
April 2013

Localized in situ hydrogel-mediated protein digestion and extraction technique for on-tissue analysis.

Anal Chem 2013 Mar 12;85(5):2717-23. Epub 2013 Feb 12.

Department of Biochemistry and the Mass Spectrometry Research Center, Vanderbilt University, 9160 MRB3, 465 21st Avenue South, Nashville, Tennessee 37235, United States.

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http://dx.doi.org/10.1021/ac3031493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595595PMC
March 2013

Matrix precoated targets for direct lipid analysis and imaging of tissue.

Anal Chem 2013 Mar 18;85(5):2907-12. Epub 2013 Feb 18.

Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, United States.

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http://pubs.acs.org/doi/10.1021/ac303554e
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http://dx.doi.org/10.1021/ac303554eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632340PMC
March 2013