Richard Longnecker

Richard Longnecker

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Richard Longnecker

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Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells.

Adv Virus Res 2019 17;104:313-343. Epub 2019 Jul 17.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

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http://dx.doi.org/10.1016/bs.aivir.2019.05.006DOI Listing
December 2019

Epithelial cell infection by Epstein-Barr virus.

FEMS Microbiol Rev 2019 Nov;43(6):674-683

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1093/femsre/fuz023DOI Listing
November 2019

Two Pathways of p27 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A.

mBio 2019 04 16;10(2). Epub 2019 Apr 16.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/mBio.00548-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469971PMC
April 2019

Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice.

mSphere 2019 03 27;4(2). Epub 2019 Mar 27.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/mSphere.00073-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437272PMC
March 2019

Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor.

mBio 2019 02 19;10(1). Epub 2019 Feb 19.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/mBio.02892-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381284PMC
February 2019

Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant.

mBio 2018 10 16;9(5). Epub 2018 Oct 16.

Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01948-18
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http://dx.doi.org/10.1128/mBio.01948-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191544PMC
October 2018

Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

Nat Microbiol 2018 02 1;3(2):172-180. Epub 2018 Jan 1.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41564-017-0081-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972547PMC
February 2018

Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site.

J Virol 2017 12 14;91(23). Epub 2017 Nov 14.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01255-17
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http://dx.doi.org/10.1128/JVI.01255-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686762PMC
December 2017

EBV latent membrane protein 2A orchestrates p27 degradation via Cks1 to accelerate MYC-driven lymphoma in mice.

Blood 2017 12 26;130(23):2516-2526. Epub 2017 Oct 26.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-07
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http://dx.doi.org/10.1182/blood-2017-07-796821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721284PMC
December 2017

Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.

Proc Natl Acad Sci U S A 2017 10 22;114(41):E8703-E8710. Epub 2017 Sep 22.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1704661114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642686PMC
October 2017

Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye.

J Virol 2017 07 9;91(13). Epub 2017 Jun 9.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/JVI.00115-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469272PMC
July 2017

The COMPLEXity in herpesvirus entry.

Curr Opin Virol 2017 06 21;24:97-104. Epub 2017 May 21.

Department of Structural Biology, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18796257173000
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http://dx.doi.org/10.1016/j.coviro.2017.04.006DOI Listing
June 2017

The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection.

DNA Cell Biol 2017 May 9;36(5):329-334. Epub 2017 Mar 9.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.

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http://dx.doi.org/10.1089/dna.2017.3668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421632PMC
May 2017

EBV germinates lymphoma from the germinal center in a battle with T and NK cells.

Proc Natl Acad Sci U S A 2017 05 25;114(18):4571-4573. Epub 2017 Apr 25.

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1704102114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422813PMC
May 2017

Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype.

mBio 2017 05 16;8(3). Epub 2017 May 16.

Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/mBio.00614-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433099PMC
May 2017

Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage.

Sci Rep 2017 03 3;7:43712. Epub 2017 Mar 3.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://www.nature.com/articles/srep43712
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http://dx.doi.org/10.1038/srep43712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334651PMC
March 2017

Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy.

Invest Ophthalmol Vis Sci 2017 01;58(1):282-291

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.

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http://dx.doi.org/10.1167/iovs.16-20668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256684PMC
January 2017

Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.

Nat Commun 2016 12 8;7:13557. Epub 2016 Dec 8.

Department of Structural Biology, Stanford University School of Medicine, 1201 Welch Road, Stanford, California 94305.

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http://dx.doi.org/10.1038/ncomms13557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155155PMC
December 2016

The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment.

mBio 2016 11 15;7(6). Epub 2016 Nov 15.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/mBio.01871-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111410PMC
November 2016

The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis.

mBio 2016 Apr 12;7(2):e00437-16. Epub 2016 Apr 12.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/mBio.00437-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959527PMC
April 2016

Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus.

Mol Cells 2016 Apr 6;39(4):286-91. Epub 2016 Apr 6.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.14348/molcells.2016.0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844934PMC
April 2016

The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions.

PLoS Pathog 2016 Mar 10;12(3):e1005449. Epub 2016 Mar 10.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786305PMC
March 2016

Latent Membrane Protein 2 (LMP2).

Curr Top Microbiol Immunol 2015 ;391:151-80

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1007/978-3-319-22834-1_5DOI Listing
December 2015

HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):E6937-44. Epub 2015 Nov 30.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1513045112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687582PMC
December 2015

Herpesvirus entry mediator on radiation-resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry-independent manner.

mBio 2015 Oct 20;6(5):e01532-15. Epub 2015 Oct 20.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/mBio.01532-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620471PMC
October 2015

Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha.

Org Lett 2015 Aug 17;17(15):3834-7. Epub 2015 Jul 17.

†Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.

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http://dx.doi.org/10.1021/acs.orglett.5b01806DOI Listing
August 2015

A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras.

J Virol 2015 Jul 29;89(14):7159-69. Epub 2015 Apr 29.

Department of Health Sciences, Department of Biological Sciences, DePaul University, Chicago, Illinois, USA.

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00740-15
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http://dx.doi.org/10.1128/JVI.00740-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473573PMC
July 2015

Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers.

mBio 2015 Jan 6;6(1). Epub 2015 Jan 6.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/mBio.02285-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313908PMC
January 2015

Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults.

PLoS Pathog 2015 Jan 8;11(1):e1004580. Epub 2015 Jan 8.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287605PMC
January 2015

The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells.

J Virol 2014 Dec 17;88(23):13570-9. Epub 2014 Sep 17.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/JVI.02272-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248955PMC
December 2014

The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion.

J Virol 2014 Oct 6;88(20):11686-95. Epub 2014 Aug 6.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/JVI.01349-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178708PMC
October 2014

Assembly and architecture of the EBV B cell entry triggering complex.

PLoS Pathog 2014 Aug 21;10(8):e1004309. Epub 2014 Aug 21.

Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140853PMC
August 2014

Substitution of herpes simplex virus 1 entry glycoproteins with those of saimiriine herpesvirus 1 reveals a gD-gH/gL functional interaction and a region within the gD profusion domain that is critical for fusion.

J Virol 2014 Jun 26;88(11):6470-82. Epub 2014 Mar 26.

Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/JVI.00465-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093879PMC
June 2014

Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.

Blood 2014 Jan 30;123(4):530-40. Epub 2013 Oct 30.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1182/blood-2013-07-517649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901066PMC
January 2014

The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion.

J Virol 2013 Apr 16;87(7):3620-7. Epub 2013 Jan 16.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/JVI.03245-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624213PMC
April 2013

Drosophila Schneider 2 (S2) cells: a novel tool for studying HSV-induced membrane fusion.

Virology 2013 Mar 9;437(2):100-9. Epub 2013 Feb 9.

Northwestern University, Department of Microbiology-Immunology, Ward 6-241, 303 East Chicago Avenue, Chicago, IL 60611, United States.

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http://dx.doi.org/10.1016/j.virol.2013.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578051PMC
March 2013

Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function.

Sci Rep 2012 3;2:353. Epub 2012 Apr 3.

Department of Microbiology - Immunology, The Feinberg School of Medicine, Northwestern University , Chicago IL 60611, USA.

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http://www.nature.com/articles/srep00353
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http://dx.doi.org/10.1038/srep00353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354779PMC
February 2013

A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion.

Virology 2013 Feb 29;436(1):118-26. Epub 2012 Nov 29.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States.

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http://dx.doi.org/10.1016/j.virol.2012.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545092PMC
February 2013

Modulation of Epstein-Barr virus glycoprotein B (gB) fusion activity by the gB cytoplasmic tail domain.

mBio 2013 Jan 22;4(1):e00571-12. Epub 2013 Jan 22.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/mBio.00571-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551549PMC
January 2013

Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes.

Proc Natl Acad Sci U S A 2012 Dec 26;109(50):20649-54. Epub 2012 Nov 26.

Department of Microbiology-Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.1216967109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528501PMC
December 2012

Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice.

PLoS Pathog 2012 19;8(4):e1002662. Epub 2012 Apr 19.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334893PMC
August 2012

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.

Proc Natl Acad Sci U S A 2012 Aug 23;109(32):12962-7. Epub 2012 Jul 23.

Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1205309109
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http://dx.doi.org/10.1073/pnas.1205309109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420185PMC
August 2012

Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A.

Antiviral Res 2012 Jul 16;95(1):49-56. Epub 2012 May 16.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Ward 6-245, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.antiviral.2012.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377840PMC
July 2012

Is nectin-1 the "master" receptor for deadly herpes B virus infection?

Virulence 2012 Jul 22;3(4):405. Epub 2012 Jun 22.

Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.4161/viru.20587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478243PMC
July 2012

Residues within the C-terminal arm of the herpes simplex virus 1 glycoprotein B ectodomain contribute to its refolding during the fusion step of virus entry.

J Virol 2012 Jun 4;86(12):6386-93. Epub 2012 Apr 4.

The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/JVI.00104-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393567PMC
June 2012

Off-targeting oft-targeted CD20 in cHL.

Blood 2012 May;119(18):4095-6

Robert H. Lurie Comprehensive Cancer Center.

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http://dx.doi.org/10.1182/blood-2012-03-413146DOI Listing
May 2012

The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells.

mBio 2012 3;3(1). Epub 2012 Jan 3.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/mBio.00290-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251506PMC
April 2012

Herpes B virus utilizes human nectin-1 but not HVEM or PILRα for cell-cell fusion and virus entry.

J Virol 2012 Apr 15;86(8):4468-76. Epub 2012 Feb 15.

Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/JVI.00041-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318624PMC
April 2012

A shared gene expression signature in mouse models of EBV-associated and non-EBV-associated Burkitt lymphoma.

Blood 2011 Dec 28;118(26):6849-59. Epub 2011 Oct 28.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1182/blood-2011-02-338434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245207PMC
December 2011

Herpesvirus entry mediator and nectin-1 mediate herpes simplex virus 1 infection of the murine cornea.

J Virol 2011 Oct 27;85(19):10041-7. Epub 2011 Jul 27.

The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.05445-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196397PMC
October 2011

Investigation of the function of the putative self-association site of Epstein-Barr virus (EBV) glycoprotein 42 (gp42).

Virology 2011 Jul 8;415(2):122-31. Epub 2011 May 8.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.virol.2011.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107886PMC
July 2011

Fusing structure and function: a structural view of the herpesvirus entry machinery.

Nat Rev Microbiol 2011 May 11;9(5):369-81. Epub 2011 Apr 11.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/nrmicro2548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242325PMC
May 2011

Rapamycin reverses splenomegaly and inhibits tumor development in a transgenic model of Epstein-Barr virus-related Burkitt's lymphoma.

Mol Cancer Ther 2011 Apr 31;10(4):679-86. Epub 2011 Jan 31.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Ward 6-241, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073035PMC
April 2011

Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL.

Virology 2011 Apr 3;413(1):26-38. Epub 2011 Mar 3.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004268221000750
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http://dx.doi.org/10.1016/j.virol.2010.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075949PMC
April 2011

Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex.

Proc Natl Acad Sci U S A 2010 Dec 13;107(52):22641-6. Epub 2010 Dec 13.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1011806108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012493PMC
December 2010

Reevaluating herpes simplex virus hemifusion.

J Virol 2010 Nov 15;84(22):11814-21. Epub 2010 Sep 15.

Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.01615-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977880PMC
November 2010

Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays.

J Virol 2010 Oct 28;84(19):10375-85. Epub 2010 Jul 28.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1128/JVI.00381-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937788PMC
October 2010

Epstein-Barr virus LMP2A imposes sensitivity to apoptosis.

J Gen Virol 2010 Sep 19;91(Pt 9):2197-202. Epub 2010 May 19.

Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60516, USA.

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http://dx.doi.org/10.1099/vir.0.021444-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066549PMC
September 2010

The Ig-like v-type domain of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion.

J Virol 2010 Sep 23;84(17):8664-72. Epub 2010 Jun 23.

Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1128/JVI.01039-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919009PMC
September 2010

Characteristics of Epstein-Barr virus envelope protein gp42.

Virus Genes 2010 Jun 17;40(3):307-19. Epub 2010 Feb 17.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/s11262-010-0455-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854865PMC
June 2010

Epstein-Barr virus in Burkitt's lymphoma: a role for latent membrane protein 2A.

Cell Cycle 2010 Mar 3;9(5):901-8. Epub 2010 Mar 3.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855765PMC
http://dx.doi.org/10.4161/cc.9.5.10840DOI Listing
March 2010

Insertion mutations in herpes simplex virus 1 glycoprotein H reduce cell surface expression, slow the rate of cell fusion, or abrogate functions in cell fusion and viral entry.

J Virol 2010 Feb 9;84(4):2038-46. Epub 2009 Dec 9.

Department of Microbiology and Immunology, the Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 6-231, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.02215-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812360PMC
February 2010

Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis.

Proc Natl Acad Sci U S A 2009 Oct 7;106(42):17945-50. Epub 2009 Oct 7.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.0907994106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764894PMC
October 2009

Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion.

J Virol 2009 Aug 20;83(15):7678-89. Epub 2009 May 20.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.00457-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708620PMC
August 2009

Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes.

J Virol 2009 Jul 15;83(13):6664-72. Epub 2009 Apr 15.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1128/JVI.00195-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698568PMC
July 2009

EBV LMP-2A employs a novel mechanism to transactivate the HERV-K18 superantigen through its ITAM.

Virology 2009 Mar 12;385(1):261-6. Epub 2008 Dec 12.

Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.virol.2008.11.025DOI Listing
March 2009

The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling.

Virology 2009 Mar 10;385(1):183-91. Epub 2008 Dec 10.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1016/j.virol.2008.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768052PMC
March 2009

Cleavage of Epstein-Barr virus glycoprotein B is required for full function in cell-cell fusion with both epithelial and B cells.

J Gen Virol 2009 Mar;90(Pt 3):591-595

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1099/vir.0.007237-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768059PMC
March 2009

Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B.

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2880-5. Epub 2009 Feb 5.

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208.

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http://dx.doi.org/10.1073/pnas.0810530106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650359PMC
February 2009

Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry.

Structure 2009 Feb;17(2):223-33

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1016/j.str.2008.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085316PMC
February 2009

Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo.

Blood 2009 Jan 24;113(1):108-16. Epub 2008 Sep 24.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1182/blood-2008-06-160937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614628PMC
January 2009

Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn.

J Virol 2008 Sep 25;82(17):8520-8. Epub 2008 Jun 25.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1128/JVI.00843-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519656PMC
September 2008

EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.

J Gen Virol 2008 Jul;89(Pt 7):1563-1568

Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1099/vir.0.2008/001461-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841786PMC
July 2008

An auto-regulatory loop for EBV LMP2A involves activation of Notch.

Virology 2008 Feb 5;371(2):257-66. Epub 2007 Nov 5.

Department of Microbiology and Immunology, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1016/j.virol.2007.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288488PMC
February 2008

Latent membrane protein 2B regulates susceptibility to induction of lytic Epstein-Barr virus infection.

J Virol 2008 Feb 5;82(4):1739-47. Epub 2007 Dec 5.

Experimental Infectious Diseases and Cancer Research, Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1128/JVI.01723-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258708PMC
February 2008

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins.

Virology 2007 Nov 25;368(1):102-13. Epub 2007 Jul 25.

Department of Biochemistry, Molecular Biology, Cell Biology, Northwestern University, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1016/j.virol.2007.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131761PMC
November 2007

Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor.

J Immunol 2007 Oct;179(7):4435-43

Section of Rheumatology, Department of Medicine, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.4049/jimmunol.179.7.4435DOI Listing
October 2007

Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity.

J Virol 2007 Sep 6;81(17):9596-600. Epub 2007 Jun 6.

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.

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http://dx.doi.org/10.1128/JVI.00758-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951416PMC
September 2007

Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion.

J Virol 2007 Sep 20;81(17):9216-29. Epub 2007 Jun 20.

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1128/JVI.00575-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951443PMC
September 2007

Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway.

J Virol 2007 Sep 20;81(17):9299-306. Epub 2007 Jun 20.

Department of Microbiology-Immunology, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.00537-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951437PMC
September 2007

Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion.

Virology 2007 Aug 2;365(1):157-65. Epub 2007 May 2.

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Ward 6-231, 303 E. Chicago Ave., Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.virol.2007.03.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771917PMC
August 2007

Epstein-Barr virus latent membrane protein 2A and autoimmunity.

Trends Immunol 2007 May 29;28(5):213-8. Epub 2007 Mar 29.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.it.2007.03.002DOI Listing
May 2007

Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability.

Virology 2007 Apr 5;360(2):461-8. Epub 2006 Dec 5.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.virol.2006.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868700PMC
April 2007

Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity.

J Virol 2007 Jan 11;81(1):84-94. Epub 2006 Oct 11.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Ward 6-231, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.01302-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797235PMC
January 2007

Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion.

J Virol 2006 Oct;80(19):9444-54

Northwestern University, Department of Biochemistry, Molecular Biology, Cell Biology, 2205 Tech Drive, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1128/JVI.00572-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617263PMC
October 2006

Epstein-Barr virus LMP2A enhances B-cell responses in vivo and in vitro.

J Virol 2006 Jul;80(14):6764-70

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Ward 6-231, 303 E. Chicago Ave., Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.00433-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489056PMC
July 2006

Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells.

J Biol Chem 2006 Mar 23;281(13):8806-14. Epub 2006 Jan 23.

Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 10063, Taiwan.

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http://dx.doi.org/10.1074/jbc.M507305200DOI Listing
March 2006

The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells.

J Virol 2005 Oct;79(19):12408-15

Department of Microbiology and Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.79.19.12408-12415.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1211543PMC
October 2005

Epstein-Barr virus (EBV) latent membrane protein 2A regulates B-cell receptor-induced apoptosis and EBV reactivation through tyrosine phosphorylation.

J Virol 2005 Jul;79(13):8655-60

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1128/JVI.79.13.8655-8660.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143726PMC
July 2005

Epstein-Barr virus LMP2A alters in vivo and in vitro models of B-cell anergy, but not deletion, in response to autoantigen.

J Virol 2005 Jun;79(12):7355-62

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Ward 6-231, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/JVI.79.12.7355-7362.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143642PMC
June 2005

A nonimprinted Prader-Willi Syndrome (PWS)-region gene regulates a different chromosomal domain in trans but the imprinted pws loci do not alter genome-wide mRNA levels.

Genomics 2005 May;85(5):630-40

Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104-6140, USA.

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http://dx.doi.org/10.1016/j.ygeno.2005.02.004DOI Listing
May 2005