Richard Letrero

Richard Letrero

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Richard Letrero

Richard Letrero

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NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib.

Authors:
Vishwas Parekh Joseph Sobanko Christopher J Miller Giorgos Karakousis Wei Xu Richard Letrero Rosalie Elenitsas Xiaowei Xu David E Elder Ravi Amaravadi Lynn M Schuchter Katherine L Nathanson Melissa A Wilson Emily Y Chu

J Cutan Pathol 2019 Mar 27;46(3):190-194. Epub 2018 Dec 27.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13401
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http://dx.doi.org/10.1111/cup.13401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367041PMC
March 2019

Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib.

Authors:
Melissa A Wilson Fengmin Zhao Richard Letrero Kurt D'Andrea David L Rimm John M Kirkwood Harriet M Kluger Sandra J Lee Lynn M Schuchter Keith T Flaherty Katherine L Nathanson

Clin Cancer Res 2014 Jun 8;20(12):3328-37. Epub 2014 Apr 8.

Authors' Affiliations: Hematology/Oncology, Department of Medicine, University of Pennsylvania; Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania; Abramson Cancer Center of the University of Pennsylvania, Philadelphia; University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; Dana Farber Cancer Institute; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Pathology, Yale University School of Medicine; and Section of Medical Oncology, Yale Cancer Center, New Haven, ConnecticutAuthors' Affiliations: Hematology/Oncology, Department of Medicine, University of Pennsylvania; Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania; Abramson Cancer Center of the University of Pennsylvania, Philadelphia; University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; Dana Farber Cancer Institute; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Pathology, Yale University School of Medicine; and Section of Medical Oncology, Yale Cancer Center, New Haven, Connecticut

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058354PMC
June 2014

The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.

Authors:
Eric K Lee Zhaorui Lian Kurt D'Andrea Richard Letrero WeiQi Sheng Shujing Liu J Nathaniel Diehl Dariusz Pytel Olena Barbash Lynn Schuchter Ravi Amaravaradi Xiaowei Xu Meenhard Herlyn Katherine L Nathanson J Alan Diehl

Mol Cell Biol 2013 Nov 9;33(22):4422-33. Epub 2013 Sep 9.

The Leonard and Madlyn Abramson Family Cancer Research Institute.

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http://dx.doi.org/10.1128/MCB.00706-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838190PMC
November 2013

Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436).

Authors:
Katherine L Nathanson Anne-Marie Martin Bradley Wubbenhorst Joel Greshock Richard Letrero Kurt D'Andrea Steven O'Day Jeffrey R Infante Gerald S Falchook Hendrik-Tobias Arkenau Michael Millward Michael P Brown Anna Pavlick Michael A Davies Bo Ma Robert Gagnon Martin Curtis Peter F Lebowitz Richard Kefford Georgina V Long

Clin Cancer Res 2013 Sep 5;19(17):4868-78. Epub 2013 Jul 5.

Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924894PMC
September 2013

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

Authors:
Christopher A Maxwell Javier Benítez Laia Gómez-Baldó Ana Osorio Núria Bonifaci Ricardo Fernández-Ramires Sylvain V Costes Elisabet Guinó Helen Chen Gareth J R Evans Pooja Mohan Isabel Català Anna Petit Helena Aguilar Alberto Villanueva Alvaro Aytes Jordi Serra-Musach Gad Rennert Flavio Lejbkowicz Paolo Peterlongo Siranoush Manoukian Bernard Peissel Carla B Ripamonti Bernardo Bonanni Alessandra Viel Anna Allavena Loris Bernard Paolo Radice Eitan Friedman Bella Kaufman Yael Laitman Maya Dubrovsky Roni Milgrom Anna Jakubowska Cezary Cybulski Bohdan Gorski Katarzyna Jaworska Katarzyna Durda Grzegorz Sukiennicki Jan Lubiński Yin Yao Shugart Susan M Domchek Richard Letrero Barbara L Weber Frans B L Hogervorst Matti A Rookus J Margriet Collee Peter Devilee Marjolijn J Ligtenberg Rob B van der Luijt Cora M Aalfs Quinten Waisfisz Juul Wijnen Cornelis E P van Roozendaal Douglas F Easton Susan Peock Margaret Cook Clare Oliver Debra Frost Patricia Harrington D Gareth Evans Fiona Lalloo Rosalind Eeles Louise Izatt Carol Chu Diana Eccles Fiona Douglas Carole Brewer Heli Nevanlinna Tuomas Heikkinen Fergus J Couch Noralane M Lindor Xianshu Wang Andrew K Godwin Maria A Caligo Grazia Lombardi Niklas Loman Per Karlsson Hans Ehrencrona Anna von Wachenfeldt Rosa Bjork Barkardottir Ute Hamann Muhammad U Rashid Adriana Lasa Trinidad Caldés Raquel Andrés Michael Schmitt Volker Assmann Kristen Stevens Kenneth Offit João Curado Hagen Tilgner Roderic Guigó Gemma Aiza Joan Brunet Joan Castellsagué Griselda Martrat Ander Urruticoechea Ignacio Blanco Laima Tihomirova David E Goldgar Saundra Buys Esther M John Alexander Miron Melissa Southey Mary B Daly Rita K Schmutzler Barbara Wappenschmidt Alfons Meindl Norbert Arnold Helmut Deissler Raymonda Varon-Mateeva Christian Sutter Dieter Niederacher Evgeny Imyamitov Olga M Sinilnikova Dominique Stoppa-Lyonne Sylvie Mazoyer Carole Verny-Pierre Laurent Castera Antoine de Pauw Yves-Jean Bignon Nancy Uhrhammer Jean-Philippe Peyrat Philippe Vennin Sandra Fert Ferrer Marie-Agnès Collonge-Rame Isabelle Mortemousque Amanda B Spurdle Jonathan Beesley Xiaoqing Chen Sue Healey Mary Helen Barcellos-Hoff Marc Vidal Stephen B Gruber Conxi Lázaro Gabriel Capellá Lesley McGuffog Katherine L Nathanson Antonis C Antoniou Georgia Chenevix-Trench Markus C Fleisch Víctor Moreno Miguel Angel Pujana

PLoS Biol 2011 Nov 15;9(11):e1001199. Epub 2011 Nov 15.

Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet, Catalonia, Spain.

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http://dx.doi.org/10.1371/journal.pbio.1001199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217025PMC
November 2011

A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.

Authors:
Peter A Kanetsky Nandita Mitra Saran Vardhanabhuti David J Vaughn Mingyao Li Stephanie L Ciosek Richard Letrero Kurt D'Andrea Madhavi Vaddi David R Doody Joellen Weaver Chu Chen Jacqueline R Starr Håkon Håkonarson Daniel J Rader Andrew K Godwin Muredach P Reilly Stephen M Schwartz Katherine L Nathanson

Hum Mol Genet 2011 Aug 6;20(15):3109-17. Epub 2011 May 6.

Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/hmg/ddr207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131044PMC
August 2011

Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.

Authors:
Jessie Villanueva Adina Vultur John T Lee Rajasekharan Somasundaram Mizuho Fukunaga-Kalabis Angela K Cipolla Bradley Wubbenhorst Xiaowei Xu Phyllis A Gimotty Damien Kee Ademi E Santiago-Walker Richard Letrero Kurt D'Andrea Anitha Pushparajan James E Hayden Kimberly Dahlman Brown Sylvie Laquerre Grant A McArthur Jeffrey A Sosman Katherine L Nathanson Meenhard Herlyn

Cancer Cell 2010 Dec;18(6):683-95

The Wistar Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026446PMC
December 2010

Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases.

Authors:
Ravi K Amaravadi Lynn M Schuchter David F McDermott Amy Kramer Lydia Giles Kristi Gramlich Mary Carberry Andrea B Troxel Richard Letrero Katherine L Nathanson Michael B Atkins Peter J O'Dwyer Keith T Flaherty

Clin Cancer Res 2009 Dec;15(24):7711-7718

Authors' Affiliations: Abramson Cancer Center at the University of Pennsylvania and Department of Medicine, Division of Medical Genetics, University of Pennsylvania, Philadelphia, Pennsylvania; and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795076PMC
December 2009

Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.

Authors:
Peter A Kanetsky Nandita Mitra Saran Vardhanabhuti Mingyao Li David J Vaughn Richard Letrero Stephanie L Ciosek David R Doody Lauren M Smith Joellen Weaver Anthony Albano Chu Chen Jacqueline R Starr Daniel J Rader Andrew K Godwin Muredach P Reilly Hakon Hakonarson Stephen M Schwartz Katherine L Nathanson

Nat Genet 2009 Jul 31;41(7):811-5. Epub 2009 May 31.

Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://www.nature.com/doifinder/10.1038/ng.393
Publisher Site
http://dx.doi.org/10.1038/ng.393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865677PMC
July 2009

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma.

Authors:
John D Gordan Priti Lal Vijay R Dondeti Richard Letrero Krishna N Parekh C Elisa Oquendo Roger A Greenberg Keith T Flaherty W Kimryn Rathmell Brian Keith M Celeste Simon Katherine L Nathanson

Cancer Cell 2008 Dec;14(6):435-46

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621440PMC
December 2008

Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma.

Authors:
Cynthia Spittle M Renee Ward Katherine L Nathanson Phyllis A Gimotty Eric Rappaport Marcia S Brose Angelica Medina Richard Letrero Meenhard Herlyn Robin H Edwards

J Mol Diagn 2007 Sep 9;9(4):464-71. Epub 2007 Aug 9.

Clinical Translational Medicine, Oncology, Wyeth Research, 500 Arcola Rd., Collegeville, PA 19426, USA.

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http://dx.doi.org/10.2353/jmoldx.2007.060191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1975103PMC
September 2007

The Y deletion gr/gr and susceptibility to testicular germ cell tumor.

Authors:
Katherine L Nathanson Peter A Kanetsky Rachel Hawes David J Vaughn Richard Letrero Kathy Tucker Michael Friedlander Kelly-Anne Phillips David Hogg Michael A S Jewett Radka Lohynska Gedske Daugaard Stéphane Richard Agnés Chompret Catherine Bonaïti-Pellié Axel Heidenreich Edith Olah Lajos Geczi Istvan Bodrogi Wilma J Ormiston Peter A Daly J Wolter Oosterhuis Ad J M Gillis Leendert H J Looijenga Parry Guilford Sophie D Fosså Ketil Heimdal Sergei A Tjulandin Ludmila Liubchenko Hans Stoll Walter Weber Matthew Rudd Robert Huddart Gillian P Crockford David Forman D Timothy Oliver Lawrence Einhorn Barbara L Weber Joan Kramer Mary McMaster Mark H Greene Malcolm Pike Victoria Cortessis Chu Chen Stephen M Schwartz D Timothy Bishop Douglas F Easton Michael R Stratton Elizabeth A Rapley

Am J Hum Genet 2005 Dec 24;77(6):1034-43. Epub 2005 Oct 24.

Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1086/498455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1285161PMC
December 2005

Resolving ATM haplotypes in whites.

Authors:
Richard Letrero Barbara L Weber Katherine L Nathanson

Am J Hum Genet 2003 Apr;72(4):1071-3

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http://dx.doi.org/10.1086/373879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180340PMC
April 2003