Richard L M Faull

Richard L M Faull

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Richard L M Faull

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Altered microglia and neurovasculature in the Alzheimer's disease cerebellum.

Neurobiol Dis 2019 Aug 24;132:104589. Epub 2019 Aug 24.

Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104589DOI Listing
August 2019

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease.

Metabolites 2019 Jun 11;9(6). Epub 2019 Jun 11.

Centre for Advanced Discovery and Experimental Therapeutics, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester M19 9NT, UK.

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http://dx.doi.org/10.3390/metabo9060113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630497PMC
June 2019

Chemical neuroanatomy of the substantia nigra in the ovine brain.

J Chem Neuroanat 2019 Apr 18;97:43-56. Epub 2019 Jan 18.

Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.jchemneu.2019.01.007DOI Listing
April 2019

Stereological Methods to Quantify Cell Loss in the Huntington's Disease Human Brain.

Methods Mol Biol 2018 ;1780:1-16

Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1007/978-1-4939-7825-0_1DOI Listing
February 2019

Regional protein expression in human Alzheimer's brain correlates with disease severity.

Commun Biol 2019 4;2:43. Epub 2019 Feb 4.

1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.

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http://dx.doi.org/10.1038/s42003-018-0254-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361956PMC
February 2019

The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.

Adv Neurobiol 2017 ;15:129-161

Centre for Brain Research, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

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http://dx.doi.org/10.1007/978-3-319-57193-5_5DOI Listing
November 2018

Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone.

Dev Neurosci 2018 20;40(2):145-161. Epub 2018 Apr 20.

Department of Anatomy and Medical Imaging, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1159/000487633DOI Listing
November 2018

Markers for human brain pericytes and smooth muscle cells.

J Chem Neuroanat 2018 10 7;92:48-60. Epub 2018 Jun 7.

Department of Pharmacology and Clinical Pharmacology, Auckland, New Zealand; Centre for Brain Research, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.jchemneu.2018.06.001DOI Listing
October 2018

The GABAergic system as a therapeutic target for Alzheimer's disease.

J Neurochem 2018 09 1;146(6):649-669. Epub 2018 Aug 1.

Centre for Brain Research, Faculty of Medical and Health Sciences, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/jnc.14345DOI Listing
September 2018

Subventricular zone lipidomic architecture loss in Huntington's disease.

J Neurochem 2018 09 8;146(5):613-630. Epub 2018 Aug 8.

Centre for Brain Research, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/jnc.14468DOI Listing
September 2018

Unique and shared inflammatory profiles of human brain endothelia and pericytes.

J Neuroinflammation 2018 May 11;15(1):138. Epub 2018 May 11.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

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http://dx.doi.org/10.1186/s12974-018-1167-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948925PMC
May 2018

Layer-specific lipid signatures in the human subventricular zone demonstrated by imaging mass spectrometry.

Sci Rep 2018 02 7;8(1):2551. Epub 2018 Feb 7.

Centre for Brain Research, University of Auckland, Auckland, 1023, New Zealand.

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http://dx.doi.org/10.1038/s41598-018-20793-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803191PMC
February 2018

Neurochemical Characterization of PSA-NCAM Cells in the Human Brain and Phenotypic Quantification in Alzheimer's Disease Entorhinal Cortex.

Neuroscience 2018 02;372:289-303

Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.12.019DOI Listing
February 2018

Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction.

BMC Neurosci 2018 02 22;19(1). Epub 2018 Feb 22.

Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.

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http://dx.doi.org/10.1186/s12868-018-0405-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824614PMC
February 2018

Alzheimer's disease markers in the aged sheep (Ovis aries).

Neurobiol Aging 2017 10 24;58:112-119. Epub 2017 Jun 24.

The Neurogenetics Group, School of Biological Sciences, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.020DOI Listing
October 2017

A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction.

Brain 2017 Oct;140(10):2722-2736

Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1093/brain/awx208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841151PMC
October 2017

Metal concentrations and distributions in the human olfactory bulb in Parkinson's disease.

Sci Rep 2017 09 5;7(1):10454. Epub 2017 Sep 5.

Centre for Brain Research and Department of Anatomy with Medical Imaging, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1038/s41598-017-10659-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585381PMC
September 2017

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

Metallomics 2017 08;9(8):1106-1119

School of Biological Sciences, Faculty of Science, and the Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. and Centre for Advanced Discovery and Experimental Therapeutics, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester M13 9WL, UK and Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand and Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, and Manchester Academic Health Science Centre, Manchester M13 9NT, UK.

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http://dx.doi.org/10.1039/c7mt00074jDOI Listing
August 2017

Insulin promotes cell migration by regulating PSA-NCAM.

Exp Cell Res 2017 06 21;355(1):26-39. Epub 2017 Mar 21.

Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand; Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144827173015
Publisher Site
http://dx.doi.org/10.1016/j.yexcr.2017.03.029DOI Listing
June 2017

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.

Sci Rep 2017 05 2;7(1):1307. Epub 2017 May 2.

UCL Huntington's Disease Centre, Sobell Department of Motor Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-01510-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431000PMC
May 2017

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients.

Sci Rep 2017 02 23;7:42984. Epub 2017 Feb 23.

Department of Anatomy and Medical Imaging, Faculty of Medical and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand.

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http://dx.doi.org/10.1038/srep42984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322400PMC
February 2017

C9ORF72 and UBQLN2 mutations are causes of amyotrophic lateral sclerosis in New Zealand: a genetic and pathologic study using banked human brain tissue.

Neurobiol Aging 2017 01 5;49:214.e1-214.e5. Epub 2016 Jul 5.

Centre for Brain Research, University of Auckland, Auckland, New Zealand; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.06.019DOI Listing
January 2017

Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex.

Neurobiol Dis 2016 Dec 25;96:67-74. Epub 2016 Aug 25.

Centre for Brain Research, University of Auckland, Auckland, New Zealand; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.08.015DOI Listing
December 2016

The role of the human globus pallidus in Huntington's disease.

Brain Pathol 2016 11;26(6):741-751

Centre for Brain Research, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/bpa.12429DOI Listing
November 2016

Comparison of Huntington's disease CAG Repeat Length Stability in Human Motor Cortex and Cingulate Gyrus.

J Huntingtons Dis 2016 10;5(3):297-301

School of Biological Sciences, Centre for Brain Research, Faculty of Science, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.3233/JHD-160203DOI Listing
October 2016

Hippocampal lipid differences in Alzheimer's disease: a human brain study using matrix-assisted laser desorption/ionization-imaging mass spectrometry.

Brain Behav 2016 10 14;6(10):e00517. Epub 2016 Jul 14.

Centre for Brain Research Faculty of Medical and Health Science University of Auckland Auckland New Zealand; Department of Anatomy and Medical Imaging Faculty of Medical and Health Science University of Auckland Auckland New Zealand.

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http://dx.doi.org/10.1002/brb3.517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064331PMC
October 2016

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.

Biochim Biophys Acta 2016 09 4;1862(9):1650-62. Epub 2016 Jun 4.

School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand; Centre for Brain Research and Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK; Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.06.002DOI Listing
September 2016

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes.

J Neuroinflammation 2016 Sep 21;13(1):249. Epub 2016 Sep 21.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, 1023, Auckland, New Zealand.

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http://dx.doi.org/10.1186/s12974-016-0722-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031293PMC
September 2016

Globus pallidus degeneration and clinicopathological features of Huntington disease.

Ann Neurol 2016 08 24;80(2):185-201. Epub 2016 Jun 24.

Centre for Brain Research, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/ana.24694DOI Listing
August 2016

Distribution of PSA-NCAM in normal, Alzheimer's and Parkinson's disease human brain.

Neuroscience 2016 08 7;330:359-75. Epub 2016 Jun 7.

Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.06.003DOI Listing
August 2016

Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease.

Hum Mol Genet 2016 08 4;25(16):3454-3466. Epub 2016 Jul 4.

Department of Microbiology, Immunology, & Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA

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http://dx.doi.org/10.1093/hmg/ddw187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179942PMC
August 2016

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels.

Aging (Albany NY) 2016 07;8(7):1485-512

Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.18632/aging.101005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993344PMC
July 2016

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder.

Biochim Biophys Acta 2016 06 5;1862(6):1084-92. Epub 2016 Mar 5.

School of Biological Sciences, Faculty of Science and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand; Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK; Department of Pharmacology, Medical Sciences Division, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856736PMC
June 2016

Mapping the calcitonin receptor in human brain stem.

Am J Physiol Regul Integr Comp Physiol 2016 05 24;310(9):R788-93. Epub 2016 Feb 24.

School of Biological Sciences, University of Auckland, Auckland, New Zealand; Centre for Brain Research, University of Auckland, Auckland, New Zealand;

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http://dx.doi.org/10.1152/ajpregu.00539.2015DOI Listing
May 2016

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

Biochem Biophys Res Commun 2015 Dec 4-11;468(1-2):161-6. Epub 2015 Oct 30.

School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand; Centre for Brain Research and Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK; Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.140DOI Listing
March 2016

New Perspectives on the Neuropathology in Huntington's Disease in the Human Brain and its Relation to Symptom Variation.

J Huntingtons Dis 2012 ;1(2):143-53

Faculty of Medical and Health Sciences, Department of Anatomy and Radiology, University of Auckland, Auckland, New Zealand Centre for Brain Research, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.3233/JHD-2012-120018DOI Listing
February 2016

Epigenetic Regulation of Tissue-Type Plasminogen Activator in Human Brain Tissue and Brain-Derived Cells.

Gene Regul Syst Bio 2016 24;10:9-13. Epub 2016 Jan 24.

Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.4137/GRSB.S30241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727487PMC
January 2016

Erratum to: A role for human brain pericytes in neuroinflammation.

J Neuroinflammation 2015 Nov 19;12:213. Epub 2015 Nov 19.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, 85 Park Road, Auckland, 1023, New Zealand.

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http://dx.doi.org/10.1186/s12974-015-0430-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653926PMC
November 2015

The Neuropathology of Huntington's Disease.

Curr Top Behav Neurosci 2015 ;22:33-80

Centre for Brain Research, Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand,

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http://dx.doi.org/10.1007/7854_2014_354DOI Listing
September 2015

The RAGE receptor and its ligands are highly expressed in astrocytes in a grade-dependant manner in the striatum and subependymal layer in Huntington's disease.

J Neurochem 2015 Sep 1;134(5):927-42. Epub 2015 Jul 1.

Department of Anatomy with Radiology, Faculty of Medical and Health Science (FMHS), University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/jnc.13178DOI Listing
September 2015

Disrupted vasculature and blood-brain barrier in Huntington disease.

Ann Neurol 2015 Aug 1;78(2):158-9. Epub 2015 Jul 1.

Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://doi.wiley.com/10.1002/ana.24445
Publisher Site
http://dx.doi.org/10.1002/ana.24445DOI Listing
August 2015

An anti-inflammatory role for C/EBPδ in human brain pericytes.

Sci Rep 2015 Jul 13;5:12132. Epub 2015 Jul 13.

1] Department of Pharmacology and Clinical Pharmacology [2] Gravida National Centre for Growth and Development [3] Centre for Brain Research.

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http://dx.doi.org/10.1038/srep12132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499812PMC
July 2015

Stroke awareness and knowledge in an urban New Zealand population.

J Stroke Cerebrovasc Dis 2015 Jun 3;24(6):1153-62. Epub 2015 Apr 3.

Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.01.003DOI Listing
June 2015

Assessing fibrinogen extravasation into Alzheimer's disease brain using high-content screening of brain tissue microarrays.

J Neurosci Methods 2015 May 23;247:41-9. Epub 2015 Mar 23.

Gravida, National Centre for Growth and Development, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand; Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2015.03.017DOI Listing
May 2015

Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity.

J Comp Neurol 2015 Apr 12;523(5):699-725. Epub 2014 Sep 12.

Centre for Brain Research and Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand.

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http://dx.doi.org/10.1002/cne.23667DOI Listing
April 2015

Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFβ1 or M-CSF.

PLoS One 2013 5;8(12):e80463. Epub 2013 Dec 5.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand ; Gravida - National Research Centre for Growth and Development, Auckland, New Zealand ; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080463PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855168PMC
March 2015

Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington's disease.

J Huntingtons Dis 2014 ;3(1):45-64

Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand Centre for Brain Research, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.3233/JHD-140092DOI Listing
October 2014

Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.

J Huntingtons Dis 2013 ;2(4):491-500

RNA Therapeutics Institute and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.3233/JHD-130079DOI Listing
September 2014

Proteomic analysis of the human brain in Huntington's Disease indicates pathogenesis by molecular processes linked to other neurodegenerative diseases and to type-2 diabetes.

J Huntingtons Dis 2013 ;2(1):89-99

School of Biological Sciences, University of Auckland, Auckland, New Zealand Faculty of Science, Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand Centre for Brain Research, Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand Faculty of Medical and Human Sciences, Institute of Human Development, The University of Manchester, and Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, UK.

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http://dx.doi.org/10.3233/JHD-120044DOI Listing
September 2014

Altered arginine metabolism in Alzheimer's disease brains.

Neurobiol Aging 2014 Sep 20;35(9):1992-2003. Epub 2014 Mar 20.

Brain Health Research Centre, University of Otago, Dunedin, New Zealand; School of Pharmacy, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.013DOI Listing
September 2014

Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain.

J Chem Neuroanat 2014 Sep 27;59-60:62-71. Epub 2014 Jun 27.

Department of Pharmacology and Clinical Pharmacology, Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.jchemneu.2014.06.004DOI Listing
September 2014

Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment.

Hum Mol Genet 2014 Jul 31;23(13):3375-83. Epub 2014 Jan 31.

South Australian Research and Development Institute, Roseworthy, SA, Australia.

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http://dx.doi.org/10.1093/hmg/ddu047DOI Listing
July 2014

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.

Neurobiol Aging 2014 Jun 4;35(6):1334-44. Epub 2013 Dec 4.

Departments of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand; Gravida National Centre for Growth and Development, The University of Auckland, Auckland, New Zealand; Centre for Brain Research, The University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.11.031DOI Listing
June 2014

A role for human brain pericytes in neuroinflammation.

J Neuroinflammation 2014 Jun 11;11:104. Epub 2014 Jun 11.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, 85 Park Road, Auckland 1023, New Zealand.

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http://dx.doi.org/10.1186/1742-2094-11-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105169PMC
June 2014

Cortical interneuron loss and symptom heterogeneity in Huntington disease.

Ann Neurol 2014 May 13;75(5):717-27. Epub 2014 May 13.

Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand; Centre for Brain Research, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/ana.24162DOI Listing
May 2014

Identifying neural progenitor cells in the adult human brain.

Methods Mol Biol 2013 ;1059:195-225

Department of Pharmacology, Faculty of Medical and Health Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1007/978-1-62703-574-3_17DOI Listing
February 2014

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia.

Mov Disord 2013 Oct 3;28(12):1691-9. Epub 2013 Sep 3.

Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/mds.25624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812318PMC
October 2013

GABA(A) receptor characterization and subunit localization in the human sub-ventricular zone.

J Chem Neuroanat 2013 Sep 11;52:58-68. Epub 2013 Jun 11.

Department of Anatomy with Radiology and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand.

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http://dx.doi.org/10.1016/j.jchemneu.2013.06.001DOI Listing
September 2013

Insulin and IGF1 modulate turnover of polysialylated neural cell adhesion molecule (PSA-NCAM) in a process involving specific extracellular matrix components.

J Neurochem 2013 Sep 5;126(6):758-70. Epub 2013 Aug 5.

Faculty of Medical and Health Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/jnc.12363DOI Listing
September 2013

Dissociated expression of mitochondrial and cytosolic creatine kinases in the human brain: a new perspective on the role of creatine in brain energy metabolism.

J Cereb Blood Flow Metab 2013 Aug 29;33(8):1295-306. Epub 2013 May 29.

Centre for Brain Research and Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1038/jcbfm.2013.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734782PMC
August 2013

M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia.

J Neuroinflammation 2013 Jul 17;10:85. Epub 2013 Jul 17.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1186/1742-2094-10-85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729740PMC
July 2013

Selective neurodegeneration, neuropathology and symptom profiles in Huntington's disease.

Adv Exp Med Biol 2012 ;769:141-52

Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1007/978-1-4614-5434-2_9DOI Listing
June 2013

The transcription factor PU.1 is critical for viability and function of human brain microglia.

Glia 2013 Jun 9;61(6):929-42. Epub 2013 Mar 9.

Department of Pharmacology and Clinical Pharmacology, the University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/glia.22486DOI Listing
June 2013

Neurogenesis and progenitor cells in the adult human brain: a comparison between hippocampal and subventricular progenitor proliferation.

Dev Neurobiol 2012 Jul;72(7):990-1005

Department of Anatomy with Radiology and Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/dneu.22028DOI Listing
July 2012

A method for generating high-yield enriched neuronal cultures from P19 embryonal carcinoma cells.

J Neurosci Methods 2012 Feb 11;204(1):87-103. Epub 2011 Nov 11.

Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand; Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2011.11.008DOI Listing
February 2012

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain.

Nat Methods 2011 Oct 9;8(11):945-7. Epub 2011 Oct 9.

Laboratory of Functional Neurogenomics, Ecole Polytechnique Fédérale de Lausanne, Switzerland.

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http://dx.doi.org/10.1038/nmeth.1710DOI Listing
October 2011

Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review.

Front Mol Neurosci 2009 4;2:25. Epub 2009 Nov 4.

Molecular Neuroscience, Institute of Life Science, School of Medicine, Swansea University Swansea, UK.

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http://journal.frontiersin.org/article/10.3389/neuro.02.025.
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http://dx.doi.org/10.3389/neuro.02.025.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776491PMC
July 2011

Neurogenesis in humans.

Eur J Neurosci 2011 Mar;33(6):1170-4

Centre for Brain Research, Auckland University, Auckland, New Zealand.

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http://dx.doi.org/10.1111/j.1460-9568.2011.07616.xDOI Listing
March 2011

Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures.

Neurobiol Dis 2011 Jan 9;41(1):96-103. Epub 2010 Sep 9.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1016/j.nbd.2010.08.024DOI Listing
January 2011

Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography.

Brain Res 2011 Jan 11;1370:204-14. Epub 2010 Nov 11.

Preclinical Neuroscience Research, F Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.brainres.2010.11.020DOI Listing
January 2011

Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice.

Brain Res 2010 Dec 25;1363:180-90. Epub 2010 Sep 25.

Preclinical Neuroscience Research, F Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.brainres.2010.09.072DOI Listing
December 2010

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

J Neurosci 2010 Nov;30(45):15019-29

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics , Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1523/JNEUROSCI.2071-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074336PMC
November 2010

ABC efflux transporters in brain vasculature of Alzheimer's subjects.

Brain Res 2010 Oct 19;1358:228-38. Epub 2010 Aug 19.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.

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http://dx.doi.org/10.1016/j.brainres.2010.08.034DOI Listing
October 2010

An ovine transgenic Huntington's disease model.

Hum Mol Genet 2010 May 13;19(10):1873-82. Epub 2010 Feb 13.

Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1093/hmg/ddq063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860888PMC
May 2010

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease.

Brain 2010 Apr;133(Pt 4):1094-110

Department of Anatomy with Radiology, University of Auckland, and Department of Forensic Pathology, Auckland City Hospital, Private Bag 92019, Auckland, New Zealand.

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http://dx.doi.org/10.1093/brain/awq047DOI Listing
April 2010

The rostral migratory stream and olfactory system: smell, disease and slippery cells.

Prog Brain Res 2009 ;175:33-42

Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1016/S0079-6123(09)17503-9DOI Listing
October 2009

Distinct neuroinflammatory profile in post-mortem human Huntington's disease.

Neuroreport 2009 Aug;20(12):1098-103

Department of Neurology bCenter for Neurogenetics and Neurotherapeutics, School of Medicine, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1097/WNR.0b013e32832e34eeDOI Listing
August 2009

The cellular composition and morphological organization of the rostral migratory stream in the adult human brain.

J Chem Neuroanat 2009 May 30;37(3):196-205. Epub 2008 Dec 30.

Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

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http://dx.doi.org/10.1016/j.jchemneu.2008.12.009DOI Listing
May 2009

Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.

Neurobiol Dis 2009 Mar 11;33(3):331-41. Epub 2008 Dec 11.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.

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http://dx.doi.org/10.1016/j.nbd.2008.11.015DOI Listing
March 2009