Richard L Bowen

Richard L Bowen

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Richard L Bowen

Richard L Bowen

Publications by authors named "Richard L Bowen"

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Putative Gonadotropin-Releasing Hormone Agonist Therapy and Dementia: An Application of Medicare Hospitalization Claims Data.

J Alzheimers Dis 2018 ;63(4):1269-1277

Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-170847DOI Listing
June 2019

Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species.

Geroscience 2017 02 7;39(1):103-116. Epub 2017 Mar 7.

Department of Psychiatry, Medical University of South Carolina, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1007/s11357-016-9955-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352586PMC
February 2017

A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis.

J Alzheimers Dis 2015 ;47(1):33-47

Patiently, LLC, Charleston, SC, USA.

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http://dx.doi.org/10.3233/JAD-143210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807856PMC
June 2016

A clinical study of lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks.

J Alzheimers Dis 2015 ;44(2):549-60

Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI, USA School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

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http://dx.doi.org/10.3233/JAD-141626DOI Listing
September 2015

The reproductive-cell cycle theory of aging: an update.

Exp Gerontol 2011 Feb-Mar;46(2-3):100-7. Epub 2010 Sep 17.

Geriatric Research, Education and Clinical Center, Veterans Administration Hospital and Department of Medicine, University of Wisconsin, Madison, WI 53705, USA.

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http://dx.doi.org/10.1016/j.exger.2010.09.007DOI Listing
April 2011

The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes.

Stem Cell Res Ther 2010 Sep 13;1(4):28. Epub 2010 Sep 13.

Geriatric Research, Education and Clinical Center, Veterans Administration Hospital and Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 2500 Highland Avenue, Madison, WI 53705, USA.

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http://dx.doi.org/10.1186/scrt28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983441PMC
September 2010

Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells.

J Biol Chem 2009 Aug 19;284(35):23806-17. Epub 2009 Jun 19.

Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Affairs Hospital, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1074/jbc.M109.026328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749153PMC
August 2009

Activin receptor signaling regulates prostatic epithelial cell adhesion and viability.

Neoplasia 2009 Apr;11(4):365-76

Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Veterans Administration Hospital, Madison, WI 53705, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657882PMC
http://dx.doi.org/10.1593/neo.81544DOI Listing
April 2009

Reproductive hormones regulate the selective permeability of the blood-brain barrier.

Biochim Biophys Acta 2008 Jun 14;1782(6):401-7. Epub 2008 Mar 14.

Department of Medicine, University of Wisconsin-Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705 USA.

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http://linkinghub.elsevier.com/retrieve/pii/S092544390800060
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http://dx.doi.org/10.1016/j.bbadis.2008.02.011DOI Listing
June 2008

Menopause, estrogen, and gonadotropins in Alzheimer's disease.

Adv Clin Chem 2008 ;45:139-53

Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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June 2008

A multi-hit endocrine model of intrinsic adult-onset asthma.

Ageing Res Rev 2008 Apr 31;7(2):114-25. Epub 2007 Dec 31.

Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA.

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http://dx.doi.org/10.1016/j.arr.2007.12.002DOI Listing
April 2008

A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele.

BMC Med Genet 2008 Apr 25;9:37. Epub 2008 Apr 25.

Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

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http://dx.doi.org/10.1186/1471-2350-9-37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396156PMC
April 2008

Evidence for the role of luteinizing hormone in Alzheimer disease.

Endocr Metab Immune Disord Drug Targets 2007 Dec;7(4):300-3

Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA.

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December 2007

Leuprolide acetate: a drug of diverse clinical applications.

Expert Opin Investig Drugs 2007 Nov;16(11):1851-63

University of Wisconsin-Madison, Department of Medicine, and Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA.

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http://dx.doi.org/10.1517/13543784.16.11.1851DOI Listing
November 2007

Metabolic clues regarding the enhanced performance of elite endurance athletes from orchiectomy-induced hormonal changes.

Med Hypotheses 2007 13;68(4):735-49. Epub 2006 Nov 13.

Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA.

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http://dx.doi.org/10.1016/j.mehy.2006.08.037DOI Listing
July 2007

Increases in luteinizing hormone are associated with declines in cognitive performance.

Mol Cell Endocrinol 2007 Apr 6;269(1-2):107-11. Epub 2007 Feb 6.

Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, United States.

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http://dx.doi.org/10.1016/j.mce.2006.06.013DOI Listing
April 2007

Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression.

J Neurochem 2007 Mar 11;100(5):1329-39. Epub 2007 Jan 11.

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04307.xDOI Listing
March 2007

Gonadotropins: a cohesive gender-based etiology of Alzheimer disease.

Mol Cell Endocrinol 2007 Jan 18;260-262:271-5. Epub 2006 Oct 18.

Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.mce.2006.01.018DOI Listing
January 2007

Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression.

J Endocrinol 2006 Dec;191(3):651-63

Department of Pathology and Laboratory Medicine, Veterans Administration Hospital, University of Wisconsin, 2500 Overlook Terrace, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1677/joe.1.07047DOI Listing
December 2006

Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice.

Biochim Biophys Acta 2006 Apr 13;1762(4):447-52. Epub 2006 Feb 13.

Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.bbadis.2006.01.008DOI Listing
April 2006

Antigonadotropins: a novel strategy to halt Alzheimer's disease progression.

Curr Pharm Des 2006 ;12(6):685-90

Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA.

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http://dx.doi.org/10.2174/138161206775474288DOI Listing
March 2006

The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target.

Curr Pharm Des 2006 ;12(6):691-7

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106. USA.

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http://dx.doi.org/10.2174/138161206775474305DOI Listing
March 2006

What is aging? What is its role in Alzheimer's disease? What can we do about it?

J Alzheimers Dis 2005 Jun;7(3):247-53; discussion 255-62

Stanford/VA Alzheimer Center, Palo Alto, CA 94304-1207, USA.

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June 2005

Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis.

Ann N Y Acad Sci 2005 Jun;1052:201-9

Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd., Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1196/annals.1347.020DOI Listing
June 2005

Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones.

Gerontology 2004 Sep-Oct;50(5):265-90

Voyager Pharmaceutical Corporation, Raleigh, N.C., USA.

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http://dx.doi.org/10.1159/000079125DOI Listing
April 2005

The gonadotropin connection in Alzheimer's disease.

Endocrine 2005 Apr;26(3):317-26

Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Veterans Administration Hospital, Madison, 53705, USA.

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http://dx.doi.org/10.1385/ENDO:26:3:317DOI Listing
April 2005

Dementia and testosterone levels in men.

JAMA 2005 Feb;293(5):551; author reply 552

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http://dx.doi.org/10.1001/jama.293.5.551-bDOI Listing
February 2005

Feedback on a feedback loop: the hypothalamic-pituitary-gonadal axis.

J Alzheimers Dis 2005 Feb;7(1):1-2

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February 2005

Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence.

J Neuropathol Exp Neurol 2005 Feb;64(2):93-103

Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, 53705, USA.

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http://dx.doi.org/10.1093/jnen/64.2.93DOI Listing
February 2005

Is the Abeta vaccine the answer?

Authors:
Richard L Bowen

Neurobiol Aging 2004 May-Jun;25(5):617-8

Voyager Pharmaceutical Corporation, 8540 Colonnade Center Drive, Suite 409, Raleigh, NC 27615, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.02.006DOI Listing
August 2004

Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease.

Curr Drug Targets CNS Neurol Disord 2004 Aug;3(4):281-5

Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

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August 2004

Sex hormones and ApoE4: beyond steroids.

J Alzheimers Dis 2004 Jun;6(3):229-30

Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA.

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June 2004

Pennington scientific symposium on mechanisms and retardation of aging.

Exp Gerontol 2003 Oct;38(10):1217-26

Section of Geriatrics and Gerontology, University of Wisconsin Medical School, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.exger.2003.08.005DOI Listing
October 2003

Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply.

Brain Res Brain Res Rev 2003 Sep;43(1):164-78

School of Medicine, University of Wisconsin and William S. Middleton Memorial Veterans Administration, GRECC 11G, 2500 Overlook Terrace, Madison, WI 53705, USA.

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September 2003

Estrogen replacement and risk of Alzheimer disease.

JAMA 2003 Mar;289(9):1100; author reply 1101-2

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http://dx.doi.org/10.1001/jama.289.9.1100-aDOI Listing
March 2003