Richard Kolesnick

Richard Kolesnick

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Richard Kolesnick

Richard Kolesnick

Publications by authors named "Richard Kolesnick"

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Phenotype-Oriented Ablation of Oligometastatic Cancer with Single Dose Radiation Therapy.

Int J Radiat Oncol Biol Phys 2019 07 21;104(3):593-603. Epub 2019 Feb 21.

The Champalimaud Centre for the Unknown, Lisbon, Portugal; Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.033DOI Listing
July 2019

Logarithmic expansion of LGR5 cells in human colorectal cancer.

Cell Signal 2018 Jan 25;42:97-105. Epub 2017 Sep 25.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766032PMC
January 2018

Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?

Cell Signal 2017 10 4;38:134-145. Epub 2017 Jul 4.

Laboratory of Signal Transduction, Sloan Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, United States.

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http://dx.doi.org/10.1016/j.cellsig.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726251PMC
October 2017

Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation.

Cell Signal 2017 06 24;34:86-91. Epub 2017 Feb 24.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565230PMC
June 2017

Establishing estrogen-responsive mouse mammary organoids from single Lgr5 cells.

Cell Signal 2017 01 7;29:41-51. Epub 2016 Aug 7.

Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138122PMC
January 2017

Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart.

J Mol Cell Cardiol 2016 04 28;93:69-72. Epub 2016 Feb 28.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026316PMC
April 2016

Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis.

Biochim Biophys Acta 2015 Nov 4;1851(11):1482-9. Epub 2015 Aug 4.

Department of Medicine, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026326PMC
November 2015

The life and work of Dr. Robert Bittman (1942-2014).

Biol Chem 2015 Jun;396(6-7):827-30

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http://dx.doi.org/10.1515/hsz-2014-0275DOI Listing
June 2015

Caenorhabditis elegans as a model to study sphingolipid signaling.

Biol Chem 2015 Jun;396(6-7):767-73

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http://dx.doi.org/10.1515/hsz-2014-0298DOI Listing
June 2015

C16:0-ceramide signals insulin resistance.

Cell Metab 2014 Nov 4;20(5):703-705. Epub 2014 Nov 4.

Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393079PMC
November 2014

Axitinib sensitization of high Single Dose Radiotherapy.

Radiother Oncol 2014 Apr 29;111(1):88-93. Epub 2014 Apr 29.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1016/j.radonc.2014.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278650PMC
April 2014

It takes a CAD to kill a tumor cell with a LMP.

Cancer Cell 2013 Sep;24(3):279-81

Department of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.

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http://ac.els-cdn.com/S1535610813003711/1-s2.0-S153561081300
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http://linkinghub.elsevier.com/retrieve/pii/S153561081300371
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http://dx.doi.org/10.1016/j.ccr.2013.08.025DOI Listing
September 2013

Using ASMase knockout mice to model human diseases.

Handb Exp Pharmacol 2013 (216):29-54

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/978-3-7091-1511-4_2DOI Listing
July 2013

Acid sphingomyelinase.

Handb Exp Pharmacol 2013 (215):77-88

Department of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.

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http://dx.doi.org/10.1007/978-3-7091-1368-4_4DOI Listing
July 2013

Crypt base columnar stem cells in small intestines of mice are radioresistant.

Gastroenterology 2012 Nov 27;143(5):1266-1276. Epub 2012 Jul 27.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.07.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480544PMC
November 2012

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.

J Clin Invest 2012 May 2;122(5):1786-90. Epub 2012 Apr 2.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, New York, USA.

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http://dx.doi.org/10.1172/JCI59920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336980PMC
May 2012

Accelerated hematopoietic toxicity by high energy (56)Fe radiation.

Int J Radiat Biol 2012 Mar 12;88(3):213-22. Epub 2011 Dec 12.

Department of Biochemistry and Molecular & Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057-1468, USA.

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http://dx.doi.org/10.3109/09553002.2012.639434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580183PMC
March 2012

Alpha particles induce apoptosis through the sphingomyelin pathway.

Radiat Res 2011 Oct 1;176(4):434-46. Epub 2011 Jun 1.

a  Memorial Sloan-Kettering Cancer Center, Department of Chemistry and Molecular Pharmacology, New York, New York 10065.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185310PMC
http://dx.doi.org/10.1667/rr2472.1DOI Listing
October 2011

Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.

Cancer Res 2010 Oct 5;70(20):8179-86. Epub 2010 Oct 5.

Laboratory of Signal Transduction and Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center; Department of Pathology, Columbia University, New York, NY 10065, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976483PMC
October 2010

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.

Cell Signal 2010 Sep 18;22(9):1300-7. Epub 2010 Apr 18.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.cellsig.2010.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348005PMC
September 2010

Ceramide-rich platforms in transmembrane signaling.

FEBS Lett 2010 May 20;584(9):1728-40. Epub 2010 Feb 20.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.febslet.2010.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440589PMC
May 2010

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.

Cancer Res 2010 Feb 19;70(3):957-67. Epub 2010 Jan 19.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440583PMC
February 2010

Kinase suppressor of Ras transphosphorylates c-Raf-1.

Biochem Biophys Res Commun 2009 Dec 17;390(3):434-40. Epub 2009 Sep 17.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800940PMC
December 2009

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation.

Cell Physiol Biochem 2009 3;24(3-4):219-30. Epub 2009 Aug 3.

Laboratory of Signal Transduction, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1159/000233248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978518PMC
November 2009

RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance.

Expert Rev Mol Med 2009 May 21;11:e15. Epub 2009 May 21.

Translational Cancer Therapeutics Laboratory, Cancer Research UK, London Research Institute, London, UK.

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http://dx.doi.org/10.1017/S1462399409001070DOI Listing
May 2009

Timing of lethality from gastrointestinal syndrome in mice revisited.

Int J Radiat Oncol Biol Phys 2009 Jan;73(1):6-8

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http://dx.doi.org/10.1016/j.ijrobp.2008.09.009DOI Listing
January 2009

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.

Science 2008 Oct;322(5898):110-5

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1158111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585063PMC
October 2008

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake.

Cancer Biol Ther 2008 Sep 15;7(9):1490-5. Epub 2008 Sep 15.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576298PMC
http://dx.doi.org/10.4161/cbt.7.9.6472DOI Listing
September 2008

Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo.

Proc Natl Acad Sci U S A 2008 Jun 27;105(22):7670-5. Epub 2008 May 27.

Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.0712260105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409385PMC
June 2008

Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa.

Int J Radiat Oncol Biol Phys 2008 Mar 11;70(3):804-15. Epub 2008 Jan 11.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2007.11.043DOI Listing
March 2008

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

FEBS Lett 2007 Nov 23;581(27):5289-94. Epub 2007 Oct 23.

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1016/j.febslet.2007.10.018DOI Listing
November 2007

A CERTain role for ceramide in taxane-induced cell death.

Cancer Cell 2007 Jun;11(6):473-5

Program of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080700147
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http://dx.doi.org/10.1016/j.ccr.2007.05.003DOI Listing
June 2007

Sphingolipids and cell death.

Apoptosis 2007 May;12(5):923-39

Liver Unit and Centro de Investigaciones Biomédicas Esther Koplowitz, IMDiM, Hospital, Clínic i Provincial, Instituto Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.

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http://link.springer.com/10.1007/s10495-007-0721-0
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http://dx.doi.org/10.1007/s10495-007-0721-0DOI Listing
May 2007

Engaging the vascular component of the tumor response.

Cancer Cell 2005 Aug;8(2):89-91

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080500235
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http://dx.doi.org/10.1016/j.ccr.2005.07.014DOI Listing
August 2005

Caspase-dependent and -independent activation of acid sphingomyelinase signaling.

J Biol Chem 2005 Jul 22;280(28):26425-34. Epub 2005 Apr 22.

Laboratory of Signal Transduction and Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.M414569200DOI Listing
July 2005

Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis.

J Biol Chem 2005 Jun 18;280(24):23262-72. Epub 2005 Apr 18.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.M503701200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855286PMC
June 2005

A central role for ceramide in the age-related acceleration of apoptosis in the female germline.

FASEB J 2005 May 23;19(7):860-2. Epub 2005 Feb 23.

Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.04-2903fjeDOI Listing
May 2005

ATM regulates target switching to escalating doses of radiation in the intestines.

Nat Med 2005 May 1;11(5):484-90. Epub 2005 May 1.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nm1237DOI Listing
May 2005

Inflammatory bowel disease reveals the kinase activity of KSR1.

J Clin Invest 2004 Nov;114(9):1233-7

Laboratory of Signal Transduction, The Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1172/JCI23441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524240PMC
November 2004

Host acid sphingomyelinase regulates microvascular function not tumor immunity.

Cancer Res 2004 Nov;64(22):8285-91

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2715DOI Listing
November 2004

CD95 rapidly clusters in cells of diverse origins.

Cancer Biol Ther 2003 Jul-Aug;2(4):392-5

The first six authors contributed equally to this work. Department of Medicine, Columbia University; New York, New York USA.

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http://dx.doi.org/10.4161/cbt.2.4.442DOI Listing
June 2004

The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.

J Biol Chem 2004 Jun 13;279(25):26210-4. Epub 2004 Apr 13.

Laboratory of Signal Transduction, the Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.M401323200DOI Listing
June 2004

Ceramide synthesis and metabolism as a target for cancer therapy.

Cancer Lett 2004 Apr;206(2):169-80

Division of Hematology-Oncology MS 57, Children's Hospital of Los Angeles, The University of Southern California Keck School of Medicine, 4650 Sunset Blvd., Los Angeles, CA 90054-0700, USA.

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http://dx.doi.org/10.1016/j.canlet.2003.08.034DOI Listing
April 2004

Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer.

Nat Med 2003 Oct 7;9(10):1266-8. Epub 2003 Sep 7.

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nm927DOI Listing
October 2003

Raft ceramide in molecular medicine.

Oncogene 2003 Oct;22(45):7070-7

Department of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45122, Germany.

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http://dx.doi.org/10.1038/sj.onc.1207146DOI Listing
October 2003

Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes.

J Biol Chem 2003 Sep 10;278(39):37169-74. Epub 2003 Jul 10.

Unidad de Biofísica (Centro Mixto CSIC-UPV/EHU), Universidad del País Vasco, 48080 Bilbao, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M303206200
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http://dx.doi.org/10.1074/jbc.M303206200DOI Listing
September 2003

Radiation and ceramide-induced apoptosis.

Oncogene 2003 Sep;22(37):5897-906

Laboratory of Signal Transduction, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/sj.onc.1206702DOI Listing
September 2003

Microvascular function regulates intestinal crypt response to radiation.

Cancer Res 2003 Aug;63(15):4338-41

Laboratory of Signal Transduction, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

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August 2003

Ceramide-mediated clustering is required for CD95-DISC formation.

Oncogene 2003 Aug;22(35):5457-70

Department of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.

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http://dx.doi.org/10.1038/sj.onc.1206540DOI Listing
August 2003

Ceramide and sphingosine 1-phosphate in anti-cancer therapies.

Cancer Treat Res 2003 ;115:345-54

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1007/0-306-48158-8_14DOI Listing
July 2003

Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.

Cancer Res 2003 Jul;63(14):4232-8

Laboratory of Signal Transduction, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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July 2003

Sphingolipids as therapeutics.

Pharmacol Res 2003 May;47(5):365-71

Department of Pharmacology, Penn State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1016/s1043-6618(03)00048-3DOI Listing
May 2003

Tumor response to radiotherapy regulated by endothelial cell apoptosis.

Science 2003 May;300(5622):1155-9

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1082504DOI Listing
May 2003

Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.

Endocrinology 2003 Jan;144(1):69-74

Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2002-220814DOI Listing
January 2003

Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility.

Biochim Biophys Acta 2002 Dec;1585(2-3):135-8

Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, VBK137E-GYN, Boston, MA 02114-2696, USA.

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http://dx.doi.org/10.1016/s1388-1981(02)00333-5DOI Listing
December 2002

Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?

FEBS Lett 2002 Oct;531(1):47-53

Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 430 East 67th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0014-5793(02)03489-0DOI Listing
October 2002

Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins.

J Biol Chem 2002 Jul 10;277(30):26796-803. Epub 2002 May 10.

Department of Biology, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1074/jbc.M200754200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246046PMC
July 2002

Acid sphingomyelinase-derived ceramide signaling in apoptosis.

Subcell Biochem 2002 ;36:229-44

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/0-306-47931-1_12DOI Listing
July 2002

The therapeutic potential of modulating the ceramide/sphingomyelin pathway.

J Clin Invest 2002 Jul;110(1):3-8

Laboratory of Signal Transduction, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1172/JCI16127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151041PMC
July 2002

Involvement of membrane signaling in the bystander effect in irradiated cells.

Cancer Res 2002 May;62(9):2531-4

Laboratory of Radiobiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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May 2002