Richard Koche

Richard Koche

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Richard Koche

Richard Koche

Publications by authors named "Richard Koche"

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Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development.

iScience 2020 Mar 27;23(3):100941. Epub 2020 Feb 27.

Department of Pediatric Oncology, Dana Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, 450 Brookline Avenue, Boston, MA 02215-5450, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066224PMC
March 2020

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.

Cell Stem Cell 2019 Nov 5;25(5):682-696.e8. Epub 2019 Sep 5.

Human Oncology and Pathogenesis Program and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193033
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http://dx.doi.org/10.1016/j.stem.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842438PMC
November 2019

2-hydroxyglutarate inhibits MyoD-mediated differentiation by preventing H3K9 demethylation.

Proc Natl Acad Sci U S A 2019 06 10;116(26):12851-12856. Epub 2019 Jun 10.

Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1817662116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600935PMC
June 2019

PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression.

Cell Rep 2019 04;27(1):294-306.e5

Human Oncology and Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Research & Development Oncology, AstraZeneca Pharmaceuticals, Gaithersburg, MD 20878, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193029
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http://dx.doi.org/10.1016/j.celrep.2019.02.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503687PMC
April 2019

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

Cancer Cell 2018 10 27;34(4):643-658.e5. Epub 2018 Sep 27.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179449PMC
October 2018

DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells.

Stem Cell Reports 2018 09 23;11(3):616-625. Epub 2018 Aug 23.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135725PMC
September 2018

Arid1a restrains Kras-dependent changes in acinar cell identity.

Elife 2018 07 17;7. Epub 2018 Jul 17.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.

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http://dx.doi.org/10.7554/eLife.35216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050044PMC
July 2018

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

Cell 2018 02;172(5):1007-1021.e17

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02210, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052445PMC
February 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer Cell 2018 01 14;33(1):29-43.e7. Epub 2017 Dec 14.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760343PMC
January 2018

Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance.

Cancer Cell 2017 Dec 16;32(6):792-806.e7. Epub 2017 Nov 16.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728174PMC
December 2017

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

Cancer Cell 2016 Dec 23;30(6):863-878. Epub 2016 Nov 23.

Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501282PMC
December 2016

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

Cancer Discov 2016 10 17;6(10):1166-1181. Epub 2016 Aug 17.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584808PMC
October 2016

Forward genetic screen of human transposase genomic rearrangements.

BMC Genomics 2016 Aug 4;17:548. Epub 2016 Aug 4.

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1186/s12864-016-2877-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973553PMC
August 2016

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

Clin Cancer Res 2016 05 2;22(10):2470-81. Epub 2015 Dec 2.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany. Neuroblastoma Genomics, B087, German Cancer Research Center (DKFZ), Heidelberg, Germany. Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1449DOI Listing
May 2016

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

Cell Stem Cell 2015 Nov 24;17(5):611-23. Epub 2015 Sep 24.

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Cancer Science Institute, National University of Singapore, Singapore, 117599. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636971PMC
November 2015

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition.

Haematologica 2015 May 16;100(5):e190-3. Epub 2015 Jan 16.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2014.115337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420229PMC
May 2015

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

Cancer Cell 2014 Dec 20;26(6):896-908. Epub 2014 Nov 20.

Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA; Department of Pediatrics and the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291116PMC
December 2014

Genomic dark matter sheds light on EVI1-driven leukemia.

Cancer Cell 2014 Apr;25(4):407-8

Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046890PMC
April 2014

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.

J Exp Med 2013 Nov 11;210(12):2641-59. Epub 2013 Nov 11.

Human Oncology and Pathogenesis Program, 2 Leukemia Service, 3 Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, and 4 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://dx.doi.org/10.1084/jem.20131141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832937PMC
November 2013

GC-rich sequence elements recruit PRC2 in mammalian ES cells.

PLoS Genet 2010 Dec 9;6(12):e1001244. Epub 2010 Dec 9.

Howard Hughes Medical Institute and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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https://dash.harvard.edu/bitstream/handle/1/4874826/3000368.
Web Search
http://dx.plos.org/10.1371/journal.pgen.1001244
Publisher Site
http://dx.doi.org/10.1371/journal.pgen.1001244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000368PMC
December 2010

The MicrobesOnline Web site for comparative genomics.

Genome Res 2005 Jul;15(7):1015-22

Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1101/gr.3844805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172046PMC
July 2005