Richard Killick

Richard Killick

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Richard Killick

Richard Killick

Publications by authors named "Richard Killick"

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A role for APP in Wnt signalling links synapse loss with β-amyloid production.

Transl Psychiatry 2018 09 20;8(1):179. Epub 2018 Sep 20.

Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London, SE5 9RT, UK.

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http://dx.doi.org/10.1038/s41398-018-0231-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145937PMC
September 2018

Knockdown of the schizophrenia susceptibility gene alters gene expression and proliferation of progenitor cells from the developing human neocortex.

J Psychiatry Neurosci 2017 05;42(3):181-188

From the Department of Basic and Clinical Neuroscience, King's College London, London, UK (Hill, Killick, Maruszak, McLaughlin, Williams, Bray); the MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Navarrete); Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK (Hill); and the MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK (Bray).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403663PMC
http://dx.doi.org/10.1503/jpn.160073DOI Listing
May 2017

Clusterin expression is upregulated following acute head injury and localizes to astrocytes in old head injury.

Neuropathology 2017 Feb 1;37(1):12-24. Epub 2016 Jul 1.

Basic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1111/neup.12320DOI Listing
February 2017

How Does p73 Cause Neuronal Defects?

Mol Neurobiol 2016 09 13;53(7):4509-20. Epub 2015 Aug 13.

Toxicology Unit, Medical Research Council, Leicester, LE1 9HN, UK.

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http://dx.doi.org/10.1007/s12035-015-9381-1DOI Listing
September 2016

Reducing β-amyloid by inhibition of BACE1: how low should you go?

Biol Psychiatry 2015 Apr;77(8):683-4

Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2015.03.001DOI Listing
April 2015

The Notch intracellular domain represses CRE-dependent transcription.

Cell Signal 2015 Mar 3;27(3):621-9. Epub 2014 Dec 3.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, Denmark Hill, London SE5 8AF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.11.034DOI Listing
March 2015

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology.

Alzheimers Dement 2014 Nov 25;10(6):724-34. Epub 2014 Apr 25.

King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2013.09.016DOI Listing
November 2014

Wnt3a induces exosome secretion from primary cultured rat microglia.

BMC Neurosci 2012 Nov 23;13:144. Epub 2012 Nov 23.

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://link.springer.com/content/pdf/10.1186%2F1471-2202-13-
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http://www.biomedcentral.com/1471-2202/13/144
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http://dx.doi.org/10.1186/1471-2202-13-144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541220PMC
November 2012

Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons.

Neurochem Int 2012 Aug 9;61(3):321-33. Epub 2012 May 9.

KHP Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.neuint.2012.05.006DOI Listing
August 2012

Plasma transthyretin as a candidate marker for Alzheimer's disease.

J Alzheimers Dis 2012 ;28(2):369-75

Department of Old Age Psychiatry, NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.3233/JAD-2011-110611DOI Listing
May 2012

Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones.

J Neurochem 2011 Aug 1;118(4):512-20. Epub 2011 Jul 1.

MRC Centre for Neurodegenerative Research, Institute of Psychiatry, King's College London, London, UK.

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http://doi.wiley.com/10.1111/j.1471-4159.2011.07349.x
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http://dx.doi.org/10.1111/j.1471-4159.2011.07349.xDOI Listing
August 2011

β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration.

Neurosci Lett 2010 Nov 6;485(3):162-6. Epub 2010 Sep 6.

Department of Old Age Psychiatry, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.neulet.2010.08.088DOI Listing
November 2010

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

PLoS Genet 2010 Sep 2;6(9):e1001087. Epub 2010 Sep 2.

Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1001087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932684PMC
September 2010

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system.

Eur J Neurosci 2008 Apr;27(8):2103-14

Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2008.06152.xDOI Listing
April 2008

The GSK3 hypothesis of Alzheimer's disease.

J Neurochem 2008 Mar 18;104(6):1433-9. Epub 2007 Dec 18.

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05194.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073119PMC
March 2008

Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4.

Biol Psychiatry 2008 Jan 5;63(1):13-6. Epub 2007 Jun 5.

Department of Psychological Medicine, Institute of Psychiatry, King's College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2007.03.014DOI Listing
January 2008

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells.

Neurosci Lett 2007 May 15;418(1):34-7. Epub 2007 Mar 15.

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.neulet.2007.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885960PMC
May 2007

Schizophrenia as a GSK-3 dysregulation disorder.

Trends Neurosci 2007 Apr 26;30(4):142-9. Epub 2007 Feb 26.

Departments of Psychological Medicine and Neuroscience Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.tins.2007.02.002DOI Listing
April 2007

The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons.

Neurosci Lett 2007 Mar 27;415(2):135-9. Epub 2007 Jan 27.

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.neulet.2007.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885995PMC
March 2007

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

Eur J Neurosci 2007 Jan;25(1):81-6

MRC Centre for Neurodegeneration Research, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2006.05245.xDOI Listing
January 2007

GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

Eur J Neurosci 2006 Dec;24(12):3387-92

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2006.05243.xDOI Listing
December 2006

TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.

J Neurochem 2006 Nov;99(3):989-99

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, London, UK.

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http://doi.wiley.com/10.1111/j.1471-4159.2006.04142.x
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http://dx.doi.org/10.1111/j.1471-4159.2006.04142.xDOI Listing
November 2006

TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism.

Neurosci Lett 2006 Jun 31;401(1-2):30-4. Epub 2006 Mar 31.

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.neulet.2006.02.082DOI Listing
June 2006

E1A activates transcription of p73 and Noxa to induce apoptosis.

J Biol Chem 2005 Feb 29;280(7):5945-59. Epub 2004 Nov 29.

Head and Neck Oncology Group, Guy's King's & St. Thomas's School of Dentistry, King's College London, SE5 9NU, UK.

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http://dx.doi.org/10.1074/jbc.M406661200DOI Listing
February 2005

Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.

Hum Mol Genet 2003 Apr;12(8):869-77

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1093/hmg/ddg098DOI Listing
April 2003

Toward an understanding of cochlear homeostasis: the impact of location and the role of OCP1 and OCP2.

Acta Otolaryngol 2003 Jan;123(2):203-8

Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1080/0036554021000028100DOI Listing
January 2003