Richard Kaplan

Richard Kaplan

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Richard Kaplan

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High EMSY expression defines a BRCA-like subgroup of high-grade serous ovarian carcinoma with prolonged survival and hypersensitivity to platinum.

Cancer 2019 Aug 2;125(16):2772-2781. Epub 2019 Jun 2.

Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/cncr.32079DOI Listing
August 2019

Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

Nat Commun 2019 05 14;10(1):2154. Epub 2019 May 14.

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://www.nature.com/articles/s41467-019-09775-w
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http://dx.doi.org/10.1038/s41467-019-09775-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517433PMC
May 2019

Mind the gap? The platform trial as a working environment.

Trials 2019 May 29;20(1):297. Epub 2019 May 29.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s13063-019-3377-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540560PMC
May 2019

Pain Control after Intravitreal Injection Using Topical Nepafenac 0.3% or Pressure Patching: A Randomized, Placebo-Controlled Trial.

Ophthalmol Retina 2019 Apr 26. Epub 2019 Apr 26.

Retina Service, Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, New York; Department of Ophthalmology, NYU Winthrop Hospital, Mineola, New York. Electronic address:

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http://dx.doi.org/10.1016/j.oret.2019.04.022DOI Listing
April 2019

HIV prevalence and determinants of loss-to-follow-up in adolescents and young adults with tuberculosis in Cape Town.

PLoS One 2019 5;14(2):e0210937. Epub 2019 Feb 5.

The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210937PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363173PMC
February 2019

Impact of automated OCT in a high-volume eye urgent care setting.

BMJ Open Ophthalmol 2019 20;4(1):e000187. Epub 2019 Jan 20.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mt. Sinai, New York City, New York, USA.

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http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
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http://dx.doi.org/10.1136/bmjophth-2018-000187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340595PMC
January 2019

Family Caregiving and the Intergenerational Transmission of Poverty.

Authors:
Richard L Kaplan

J Law Med Ethics 2018 Sep;46(3):629-635

Richard L. Kaplan, J.D., is the Guy Raymond Jones Chair in Law at the University of Illinois.

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http://dx.doi.org/10.1177/1073110518804216DOI Listing
September 2018

MACULAR VORTEX VEIN IN A HIGHLY MYOPIC EYE IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Retin Cases Brief Rep 2018 Aug 6. Epub 2018 Aug 6.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.

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http://dx.doi.org/10.1097/ICB.0000000000000808DOI Listing
August 2018

HIV and TB co-infection in the ART era: CD4 count distributions and TB case fatality in Cape Town.

BMC Infect Dis 2018 07 31;18(1):356. Epub 2018 Jul 31.

The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.

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http://dx.doi.org/10.1186/s12879-018-3256-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069570PMC
July 2018

Resistance to first-line ART and a role for dolutegravir.

Lancet HIV 2018 03 22;5(3):e112-e113. Epub 2017 Nov 22.

Desmond Tutu HIV Centre, University of Cape Town, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1016/S2352-3018(17)30207-2DOI Listing
March 2018

Intravitreal triamcinolone acetate for radiation maculopathy recalcitrant to high-dose intravitreal bevacizumab.

Br J Ophthalmol 2017 12 17;101(12):1694-1698. Epub 2017 Apr 17.

The New York Eye Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1136/bjophthalmol-2017-310315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754875PMC
December 2017

Uterine Body Stuffing Confirmed by Computed Tomography.

Clin Pract Cases Emerg Med 2017 Nov 18;1(4):365-369. Epub 2017 Oct 18.

Allegheny General Hospital, Department of Emergency Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.5811/cpcem.2017.5.33495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965216PMC
November 2017

Anesthetic Management of Two Pediatric Patients With Concurrent Diagnoses of Mitochondrial Disease and Malignant Hyperthermia Susceptibility: A Case Report.

A A Case Rep 2017 Oct;9(7):204-206

From the Division of Anesthesiology and Pain Medicine, Children's National Health System/The George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.1213/XAA.0000000000000565DOI Listing
October 2017

The impact of the roll-out of rapid molecular diagnostic testing for tuberculosis on empirical treatment in Cape Town, South Africa.

Bull World Health Organ 2017 Aug 28;95(8):554-563. Epub 2017 Apr 28.

The Desmond Tutu HIV Centre, Institute for Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Anzio Road, Observatory, Cape Town, 7925, South Africa.

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http://dx.doi.org/10.2471/BLT.16.185314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537747PMC
August 2017

Diagnostic accuracy of the PROMIS study - Authors' reply.

Lancet 2017 07;390(10092):362

Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK; Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(17)31595-7DOI Listing
July 2017

and Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer.

Clin Cancer Res 2017 Jun 4;23(11):2742-2749. Epub 2016 Nov 4.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1541DOI Listing
June 2017

Derived neutrophil to lymphocyte ratio as a prognostic factor in patients with advanced colorectal cancer according to RAS and BRAF status: a post-hoc analysis of the MRC COIN study.

Anticancer Drugs 2017 06;28(5):546-550

aDepartment of Oncology, University College London Hospital bCancer Research UK & UCL Cancer Trials Centre cMRC Clinical Trials Unit at UCL dUCL Cancer Institute, London, UK eInstitute of Cancer & Genetics, Cardiff University School of Medicine, Velindre Hospital, Cardiff fCRUK/MRC Oxford Institute for Radiation, Oxford, UK gOncology Institute, Shaare Zedek Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1097/CAD.0000000000000488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390854PMC
June 2017

Factor Eight Inhibitor Bypassing Agent (FEIBA) for Reversal of Target-Specific Oral Anticoagulants in Life-Threatening Intracranial Bleeding.

J Emerg Med 2017 May 19;52(5):731-737. Epub 2016 Dec 19.

Department of Emergency Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1016/j.jemermed.2016.11.011DOI Listing
May 2017

Metformin and cancer in type 2 diabetes: a systematic review and comprehensive bias evaluation.

Int J Epidemiol 2017 04;46(2):728-744

Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1093/ije/dyw275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837266PMC
April 2017

Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection.

AIDS 2017 04;31(7):953-963

aUniversity of Minnesota, Minneapolis, Minnesota bDenver Public Health, Denver, Colorado, USA cDesmond Tutu HIV Foundation, Cape Town, South Africa dKirby Institute, University of New South Wales, Sydney, Australia eRoyal Berkshire Hospital, Reading, Berkshire, UK fCentre Universitaire de Recherche Clinique, Bamako, Mali gInstitute of Tropical Medicine, Antwerp, Belgium hHospital Universitario de la Princessa, Madrid, Spain.

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http://dx.doi.org/10.1097/QAD.0000000000001417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373969PMC
April 2017

Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study.

Lancet 2017 02 20;389(10071):815-822. Epub 2017 Jan 20.

Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK; Department of Urology, UCLH NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(16)32401-1DOI Listing
February 2017

The impact of HIV status and antiretroviral treatment on TB treatment outcomes of new tuberculosis patients attending co-located TB and ART services in South Africa: a retrospective cohort study.

BMC Infect Dis 2015 Nov 19;15:536. Epub 2015 Nov 19.

The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s12879-015-1275-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653912PMC
November 2015

Evaluation of an automated single-channel sleep staging algorithm.

Nat Sci Sleep 2015 18;7:101-11. Epub 2015 Sep 18.

General Sleep Corporation, Euclid, OH, USA.

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http://dx.doi.org/10.2147/NSS.S77888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583116PMC
October 2015

Discordance between the results and conclusions of ICON7 - Authors' reply.

Lancet Oncol 2015 Oct;16(13):e478-9

St James Institute of Oncology, St James University Hospital, Leeds, UK.

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http://dx.doi.org/10.1016/S1470-2045(15)00311-3DOI Listing
October 2015

The FOCUS4 design for biomarker stratified trials.

Authors:
Richard Kaplan

Chin Clin Oncol 2015 Sep;4(3):35

Medical Research Council Clinical Trials Unit, University College London, 125 Kingsway, London WC2B 6NH, UK.

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http://dx.doi.org/10.3978/j.issn.2304-3865.2015.02.03DOI Listing
September 2015

The University College London/Medical Research Council/National Institute of Health Research-Health Technology Assessment PROMIS Trial: An Update.

Eur Urol Focus 2015 Sep;1(2):212-214

Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, UCLH NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.euf.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694096PMC
September 2015

Limited use for dual treatment with boosted protease inhibitors plus lamivudine in first-line antiretroviral therapy.

Lancet Infect Dis 2015 Jul 7;15(7):748-9. Epub 2015 Jun 7.

Desmond Tutu HIV Foundation, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1016/S1473-3099(15)00098-5DOI Listing
July 2015

Comparative Cost-effectiveness of the Baerveldt Implant, Trabeculectomy With Mitomycin, and Medical Treatment.

JAMA Ophthalmol 2015 May;133(5):560-7

Department of Ophthalmology, Edward Harkness Eye Institute, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaophthalmol.2015.44DOI Listing
May 2015

Renal impairment in HIV-infected patients initiating tenofovir-containing antiretroviral therapy regimens in a Primary Healthcare Setting in South Africa.

Trop Med Int Health 2015 Apr 12;20(4):518-26. Epub 2014 Dec 12.

Division of Epidemiology & Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/tmi.12446DOI Listing
April 2015

We can predict when driving is no longer safe for people who have HD using standard neuropsychological measures.

J Huntingtons Dis 2014 ;3(4):351-3

Department of Psychiatry, UCONN HEALTH, Farmington, CT, USA.

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http://dx.doi.org/10.3233/JHD-140125DOI Listing
April 2015

Outcomes of a nurse-managed service for stable HIV-positive patients in a large South African public sector antiretroviral therapy programme.

Trop Med Int Health 2014 Sep 8;19(9):1029-39. Epub 2014 Jul 8.

Division of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/tmi.12346DOI Listing
September 2014

Processing speed in normal aging: effects of white matter hyperintensities and hippocampal volume loss.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2014 29;21(2):197-213. Epub 2013 Jul 29.

a Department of Psychiatry , University of Connecticut Health Center , Farmington , CT , USA.

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http://dx.doi.org/10.1080/13825585.2013.795513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974573PMC
August 2014

Impact of ART on TB case fatality stratified by CD4 count for HIV-positive TB patients in Cape Town, South Africa (2009-2011).

J Acquir Immune Defic Syndr 2014 Aug;66(5):487-94

*The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, Cape Town, South Africa; †City Health Directorate, City of Cape Town, South Africa; and ‡Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1097/QAI.0000000000000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161924PMC
August 2014

Normovolemic hemodilution using hydroxyethyl starch 130/0.4 (Voluven) in a Jehovah's Witness child requiring cardiopulmonary bypass for ventricular septal defect repair.

J Clin Anesth 2014 Aug 11;26(5):402-6. Epub 2014 Aug 11.

Division of Anesthesiology and Pain Medicine, Children's National Health System, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.jclinane.2014.03.001DOI Listing
August 2014

Rates of switching antiretroviral drugs in a primary care service in South Africa before and after introduction of tenofovir.

PLoS One 2013 22;8(5):e63596. Epub 2013 May 22.

Desmond Tutu HIV Centre, Institute for Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063596PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661537PMC
April 2014

Response.

J Natl Cancer Inst 2014 Apr 26;106(5). Epub 2014 Apr 26.

Affiliations of authors: Institute of Cancer and Genetics (CGS, HW, RH, SI, JPC) and Institute of Psychological Medicine and Clinical Neurosciences (VM), School of Medicine, Cardiff University, Cardiff, UK; Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK (TSM); MRC Clinical Trials Unit, London, UK (RK); Wellcome Trust Brenner Building, St James' University Hospital, University of Leeds, Leeds, UK (SR, PQ, MS); Institute of Human Genetics, University Hospital Bonn, Bonn, Germany (VS, PP); Leiden University Medical Center, Department of Clinical Genetics, Leiden, The Netherlands (FJH, JW).

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http://dx.doi.org/10.1093/jnci/dju087DOI Listing
April 2014

Increasing transfers-out from an antiretroviral treatment service in South Africa: patient characteristics and rates of virological non-suppression.

PLoS One 2013 5;8(3):e57907. Epub 2013 Mar 5.

The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057907PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589459PMC
December 2013

Evaluating many treatments and biomarkers in oncology: a new design.

J Clin Oncol 2013 Dec 18;31(36):4562-8. Epub 2013 Nov 18.

Richard Kaplan, Angela Crook, David Fisher, Louise Brown, and Mahesh Parmar, Medical Research Council Clinical Trials Unit, London; Timothy Maughan, University of Oxford, Oxford; and Richard Wilson, Queen's University Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2013.50.7905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394353PMC
December 2013

Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons.

J Gerontol A Biol Sci Med Sci 2013 Nov 13;68(11):1387-94. Epub 2013 Jun 13.

Professor and Chair, Department of Neurology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030.

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http://dx.doi.org/10.1093/gerona/glt072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805298PMC
November 2013

Low prevalence of renal dysfunction in HIV-infected pregnant women: implications for guidelines for the prevention of mother-to-child transmission of HIV.

Trop Med Int Health 2013 Nov 16;18(11):1400-5. Epub 2013 Sep 16.

School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa; Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/tmi.12194DOI Listing
November 2013

Prevalent and incident tuberculosis are independent risk factors for mortality among patients accessing antiretroviral therapy in South Africa.

PLoS One 2013 13;8(2):e55824. Epub 2013 Feb 13.

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055824PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572168PMC
August 2013

Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer.

Hum Mutat 2013 Jul 20;34(7):1026-34. Epub 2013 May 20.

Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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http://dx.doi.org/10.1002/humu.22333DOI Listing
July 2013

Late-life onset bipolar disorder presenting as a case of pseudo-dementia: a case discussion and review of literature.

Yale J Biol Med 2013 Jun 13;86(2):235-44. Epub 2013 Jun 13.

Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670442PMC
June 2013

Tuberculosis incidence rates during 8 years of follow-up of an antiretroviral treatment cohort in South Africa: comparison with rates in the community.

PLoS One 2012 30;7(3):e34156. Epub 2012 Mar 30.

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034156PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316623PMC
November 2012

An electronic medical record-based model to predict 30-day risk of readmission and death among HIV-infected inpatients.

J Acquir Immune Defic Syndr 2012 Nov;61(3):349-58

Department of Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Center for Clinical Innovation, Parkland Health and Hospital System, Dallas, TX 75235, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/QAI.0b013e31826ebc83DOI Listing
November 2012

Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis.

Cancer Treat Rev 2012 Oct 26;38(6):618-25. Epub 2011 Nov 26.

Medical Research Council Clinical Trials Unit, Aviation House, 125 Kingsway, London WC2B 6NH, UK.

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http://dx.doi.org/10.1016/j.ctrv.2011.11.002DOI Listing
October 2012

Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa.

BMC Infect Dis 2012 Jan 25;12:21. Epub 2012 Jan 25.

The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa.

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http://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-
Publisher Site
http://dx.doi.org/10.1186/1471-2334-12-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295677PMC
January 2012

Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people.

Circulation 2011 Nov;124(21):2312-9

Division of Hypertension and Clinical Pharmacology, Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Ave., Farmington, CT 06030-3940, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.037036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235794PMC
November 2011