Richard K Benninger

Richard K P Benninger

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Richard K Benninger

Richard K P Benninger

Publications by authors named "Richard K P Benninger"

37Publications

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1PubMed Central Citations

Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species.

J Mol Evol 2019 Jul 4;87(4-6):147-151. Epub 2019 Jul 4.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 8415 MRB IV, 2213 Garland Ave, Nashville, TN, 37232-0615, USA.

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http://dx.doi.org/10.1007/s00239-019-09898-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699160PMC
July 2019

Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets.

J Physiol 2019 Jan 29;597(2):431-447. Epub 2018 Nov 29.

Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

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http://doi.wiley.com/10.1113/JP276106
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http://dx.doi.org/10.1113/JP276106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332825PMC
January 2019

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis.

Curr Diab Rep 2018 09 24;18(11):112. Epub 2018 Sep 24.

Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s11892-018-1085-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153573PMC
September 2018

Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models.

Nat Commun 2018 05 1;9(1):1742. Epub 2018 May 1.

Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, 80045, CO, USA.

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http://dx.doi.org/10.1038/s41467-018-03953-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931596PMC
May 2018

New Understanding of β-Cell Heterogeneity and In Situ Islet Function.

Diabetes 2018 04;67(4):537-547

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, U.K.

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http://dx.doi.org/10.2337/dbi17-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860861PMC
April 2018

Spatially Organized β-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans.

Biophys J 2017 Sep;113(5):1093-1108

Department of Bioengineering, University of Colorado, Aurora, Colorado; Barbara Davis Center for Diabetes, University of Colorado, Aurora, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658715PMC
September 2017

Zinc Transport Gets Its Zing Back: Double-Knockout of ZnT7 and ZnT8 Reveals the Importance of Zinc Transporters to Insulin Secretion.

Endocrinology 2016 12;157(12):4542-4544

Diabetes Institute and Department of Biomedical Sciences (C.S.N.), Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701; and Barbara Davis Center for Diabetes and Department of Bioengineering (R.K.P.B.), University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.

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http://dx.doi.org/10.1210/en.2016-1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133344PMC
December 2016

Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise.

PLoS Comput Biol 2016 Sep 28;12(9):e1005116. Epub 2016 Sep 28.

Department of Bioengineering, University of Colorado, Anschutz Medical campus, Aurora, Colorado, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040430PMC
September 2016

Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ.

J Biol Chem 2016 Feb 14;291(7):3184-96. Epub 2015 Dec 14.

From the Barbara Davis Center for Childhood Diabetes, Department of Bioengineering, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045

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http://dx.doi.org/10.1074/jbc.M115.679506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751367PMC
February 2016

Fluorescence linear dichroism imaging for quantifying membrane order.

Methods Mol Biol 2015 ;1232:161-79

Department of Bioengineering, University of Colorado, 1775 Aurora Court, Aurora, CO, 80045, USA,

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http://dx.doi.org/10.1007/978-1-4939-1752-5_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560120PMC
July 2015

Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2014 Dec 17;307(11):L868-76. Epub 2014 Oct 17.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and.

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http://dx.doi.org/10.1152/ajplung.00096.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254965PMC
December 2014

Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²⁺ wave dynamics.

Biophys J 2014 Dec 2;107(11):2723-33. Epub 2014 Dec 2.

Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.10.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255172PMC
December 2014

A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution.

Circ Cardiovasc Genet 2014 Oct 1;7(5):659-66. Epub 2014 Aug 1.

From the Department of Medicine, National Jewish Health, Denver, CO (J.M.H., D.A.G., R.E.O.-D., M.R.W., K.F.L., F.G., B.K., R.P.B.); Integrated Department of Immunology, University of Colorado, Denver (J.M.H.); Departments of Pediatrics (T.S., R.K.P.B., R.J., E.N.-G.) and Bioengineering (R.K.P.B.), University of Colorado School of Medicine, Aurora; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark (Z.V.-H., C.S., J.J.E.); and Institut de Biologie du Developpement de Marseille Luminy, Aix-Marseille University, Marseille, France (A.K.Z.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270938PMC
October 2014

Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans.

J Physiol 2014 Oct 28;592(20):4431-46. Epub 2014 Aug 28.

Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA Department of Bioengineering, University of Colorado, Aurora, CO, USA

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http://dx.doi.org/10.1113/jphysiol.2014.276733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287745PMC
October 2014

Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability.

PLoS Comput Biol 2014 Sep 4;10(9):e1003819. Epub 2014 Sep 4.

Department of Bioengineering, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States of America; Barbara Davis Center for Childhood Diabetes, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154652PMC
September 2014

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.

Trends Endocrinol Metab 2014 Aug 26;25(8):399-406. Epub 2014 Mar 26.

Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112137PMC
August 2014

The MafA transcription factor becomes essential to islet β-cells soon after birth.

Diabetes 2014 Jun 11;63(6):1994-2005. Epub 2014 Feb 11.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN

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http://dx.doi.org/10.2337/db13-1001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030115PMC
June 2014

New insights into the role of connexins in pancreatic islet function and diabetes.

FEBS Lett 2014 Apr 28;588(8):1278-87. Epub 2014 Feb 28.

Barbara Davis center for childhood diabetes, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, United States; Department of Bioengineering, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, United States. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004767PMC
April 2014

Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 β-cell clusters.

Biophys J 2014 Jan;106(1):299-309

Department of Bioengineering, University of Colorado, Anschutz Medical campus, Aurora, CO; Barbara Davis Center for Childhood Diabetes, University of Colorado, Anschutz Medical Campus, Aurora, CO. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495130126
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http://dx.doi.org/10.1016/j.bpj.2013.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907241PMC
January 2014

Two-photon excitation microscopy for the study of living cells and tissues.

Curr Protoc Cell Biol 2013 Jun;Chapter 4:Unit 4.11.1-24

University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1002/0471143030.cb0411s59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004770PMC
June 2013

Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse.

Diabetes 2012 Jul 17;61(7):1700-7. Epub 2012 Apr 17.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.2337/db11-1312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379660PMC
July 2012

Rapid and inexpensive fabrication of polymeric microfluidic devices via toner transfer masking.

Lab Chip 2009 Apr 19;9(8):1119-27. Epub 2009 Jan 19.

Department of Molecular Physiology, Vanderbilt University Medical Center, Vanderbilt University, 747D Light Hall, 21st Avenue South, Nashville, TN 37232-0615, USA.

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http://dx.doi.org/10.1039/b816575kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752280PMC
April 2009

Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes.

Am J Physiol Endocrinol Metab 2009 Feb 9;296(2):E323-32. Epub 2008 Dec 9.

Dept. of Molecular Physiology and Biophysics, Vanderbilt Univ. School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1152/ajpendo.90544.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645017PMC
February 2009

Gap junction coupling and calcium waves in the pancreatic islet.

Biophys J 2008 Dec 19;95(11):5048-61. Epub 2008 Sep 19.

Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1529/biophysj.108.140863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586567PMC
December 2008

Single-photon-counting detector for increased sensitivity in two-photon laser scanning microscopy.

Opt Lett 2008 Dec;33(24):2895-7

Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749309PMC
http://dx.doi.org/10.1364/ol.33.002895DOI Listing
December 2008

Optical lock-in detection of FRET using synthetic and genetically encoded optical switches.

Biophys J 2008 Jun 15;94(11):4515-24. Epub 2008 Feb 15.

Department of Physiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1529/biophysj.107.124859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480664PMC
June 2008

Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems.

Angew Chem Int Ed Engl 2007 ;46(13):2228-31

Department of Physics, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1002/anie.200604112DOI Listing
June 2007

Rapid hyperspectral fluorescence lifetime imaging.

Microsc Res Tech 2007 May;70(5):481-4

Department of Physics, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1002/jemt.20434DOI Listing
May 2007

Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.

J Immunol 2006 Dec;177(12):8476-83

Division of Cell and Molecular Biology, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK.

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http://dx.doi.org/10.4049/jimmunol.177.12.8476DOI Listing
December 2006

Quantitative 3D mapping of fluidic temperatures within microchannel networks using fluorescence lifetime imaging.

Anal Chem 2006 Apr;78(7):2272-8

Department of Physics and Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac051990fDOI Listing
April 2006