Richard J Kulmacz

Richard J Kulmacz

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Richard J Kulmacz

Richard J Kulmacz

Publications by authors named "Richard J Kulmacz"

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Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia.

Int J Mol Epidemiol Genet 2013 12;4(3):140-9. Epub 2013 Sep 12.

National Center for Tumor Diseases/German Cancer Research Center Im Neuenheimer Feld 460, 69120 Heidelberg,Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773565PMC
September 2013

Functional analysis of human thromboxane synthase polymorphic variants.

Pharmacogenet Genomics 2012 Sep;22(9):653-8

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283562d82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434599PMC
September 2012

Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1.

Pharmacogenet Genomics 2012 Jul;22(7):525-37

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32835366f6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376194PMC
July 2012

High-yield production, purification and characterization of functional human duodenal cytochrome b in an Escherichia coli system.

Protein Expr Purif 2011 Sep 8;79(1):115-21. Epub 2011 Apr 8.

Department of Internal Medicine, University of Texas Health Science Center, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.pep.2011.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133858PMC
September 2011

Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561.

Biochemistry 2011 Apr 25;50(15):3149-60. Epub 2011 Mar 25.

Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, United States.

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http://dx.doi.org/10.1021/bi101796mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099539PMC
April 2011

Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects.

J Inorg Biochem 2011 Mar;105(3):382-90

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jinorgbio.2010.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049311PMC
March 2011

Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2.

J Inorg Biochem 2011 Mar 27;105(3):366-74. Epub 2010 Nov 27.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jinorgbio.2010.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073652PMC
March 2011

Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.

Cancer Epidemiol Biomarkers Prev 2010 Feb 19;19(2):547-57. Epub 2010 Jan 19.

Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849740PMC
February 2010

Prostaglandin H synthase: resolved and unresolved mechanistic issues.

Arch Biochem Biophys 2010 Jan 1;493(1):103-24. Epub 2009 Sep 1.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.abb.2009.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812681PMC
January 2010

Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2.

Biochemistry 2009 Dec;48(50):11902-11

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/bi901600fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805951PMC
December 2009

Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1.

J Inorg Biochem 2009 Jun 17;103(6):912-22. Epub 2009 Apr 17.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jinorgbio.2009.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697118PMC
June 2009

His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561).

Biochim Biophys Acta 2008 Sep 1;1777(9):1218-28. Epub 2008 May 1.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.1016/j.bbabio.2008.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578830PMC
September 2008

Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics.

Prostaglandins Other Lipid Mediat 2008 Mar 8;85(3-4):134-43. Epub 2007 Dec 8.

Department of Integrative Biology & Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.prostaglandins.2007.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278380PMC
March 2008

Development of a bacterial system for high yield expression of fully functional adrenal cytochrome b561.

Protein Expr Purif 2007 Dec 25;56(2):145-52. Epub 2007 Apr 25.

Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.pep.2007.04.010DOI Listing
December 2007

Axial ligation and stoichiometry of heme centers in adrenal cytochrome b561.

Biochemistry 2007 Jul 30;46(29):8647-58. Epub 2007 Jun 30.

Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77251, USA.

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http://dx.doi.org/10.1021/bi700054gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551744PMC
July 2007

Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps.

Carcinogenesis 2007 Jun 2;28(6):1259-63. Epub 2007 Feb 2.

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1093/carcin/bgm026DOI Listing
June 2007

Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation.

Biochemistry 2007 Jan;46(2):534-42

Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/bi061859hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851183PMC
January 2007

Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases.

FASEB J 2006 Jun;20(8):1097-108

Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, Texas 77030, USA.

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http://dx.doi.org/10.1096/fj.05-5273comDOI Listing
June 2006

Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2.

Biochemistry 2006 Jan;45(2):523-32

Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/bi051235wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851202PMC
January 2006

Regulation of cyclooxygenase catalysis by hydroperoxides.

Biochem Biophys Res Commun 2005 Dec 15;338(1):25-33. Epub 2005 Aug 15.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.030DOI Listing
December 2005

Purification and characterization of bovine adrenal cytochrome b561 expressed in insect and yeast cell systems.

Protein Expr Purif 2005 Apr;40(2):429-39

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.pep.2004.12.027DOI Listing
April 2005

Characterization of the heme environment in Arabidopsis thaliana fatty acid alpha-dioxygenase-1.

J Biol Chem 2004 Jul 20;279(28):29805-15. Epub 2004 Apr 20.

Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M401779200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862001PMC
July 2004

Role of Asn-382 and Thr-383 in activation and inactivation of human prostaglandin H synthase cyclooxygenase catalysis.

J Biol Chem 2004 Feb 18;279(6):4084-92. Epub 2003 Nov 18.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M304762200DOI Listing
February 2004

Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.

Biochemistry 2004 Feb;43(6):1560-8

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/bi035717oDOI Listing
February 2004

Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide.

Biochemistry 2003 Nov;42(46):13772-7

Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/bi035415mDOI Listing
November 2003

Comparison of the properties of prostaglandin H synthase-1 and -2.

Prog Lipid Res 2003 Sep;42(5):377-404

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s0163-7827(03)00023-7DOI Listing
September 2003

The cyclooxygenase reaction mechanism.

Biochemistry 2002 Dec;41(52):15451-8

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1021/bi026938hDOI Listing
December 2002

Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.

J Biol Chem 2002 Oct 6;277(41):38311-21. Epub 2002 Aug 6.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M206961200DOI Listing
October 2002

Composition of the heme centers in chromaffin granule cytochrome b(561).

Ann N Y Acad Sci 2002 Oct;971:450-3

Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2002.tb04507.xDOI Listing
October 2002

Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase.

J Am Chem Soc 2002 Sep;124(36):10785-96

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1021/ja026880uDOI Listing
September 2002

Thromboxane synthase: structure and function of protein and gene.

Prostaglandins Other Lipid Mediat 2002 Aug;68-69:409-22

Department of Internal Medicine, University of Texas Health Science Center at Houston, 77030, USA.

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http://dx.doi.org/10.1016/s0090-6980(02)00045-xDOI Listing
August 2002