Richard J Epstein

Richard J Epstein

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Richard J Epstein

Publications by authors named "Richard J Epstein"

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Effective conservative management of locally advanced conjunctival melanoma using initial systemic therapy.

Clin Exp Ophthalmol 2019 Nov 26. Epub 2019 Nov 26.

The Kinghorn Cancer Centre, St Vincent's Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ceo.13691DOI Listing
November 2019

Beyond BCG: the approaching era of personalised bladder-sparing therapies for non-muscle-invasive urothelial cancers.

Future Oncol 2019 Feb 10;15(4):409-420. Epub 2018 Oct 10.

University of New South Wales Clinical School, St Vincent's Hospital, 390 Victoria St, Darlinghurst 2010, Sydney, Australia.

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https://www.futuremedicine.com/doi/10.2217/fon-2018-0565
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http://dx.doi.org/10.2217/fon-2018-0565DOI Listing
February 2019

Cancer Care Treatment Outcome Ontology: A Novel Computable Ontology for Profiling Treatment Outcomes in Patients With Solid Tumors.

JCO Clin Cancer Inform 2018 12;2:1-14

Frank P. Lin and Richard J. Epstein, St Vincent's Hospital and The Kinghorn Cancer Centre; Frank P. Lin, Tudor Groza, Simon Kocbek, and Richard J. Epstein, Garvan Institute of Medical Research, Sydney, Australia; Frank P. Lin, Waikato Hospital, Hamilton, New Zealand; and Erick Antezana, Norwegian University of Science and Technology, Trondheim, Norway.

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http://ascopubs.org/doi/10.1200/CCI.18.00026
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http://dx.doi.org/10.1200/CCI.18.00026DOI Listing
December 2018

Cancer and the omics revolution.

Aust Fam Physician 2017 ;46(4):189-193

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September 2017

TEPAPA: a novel in silico feature learning pipeline for mining prognostic and associative factors from text-based electronic medical records.

Sci Rep 2017 07 31;7(1):6918. Epub 2017 Jul 31.

Department of Oncology, St Vincent's Hospital & The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1038/s41598-017-07111-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537364PMC
July 2017

Damage-inducible intragenic demethylation of the human TP53 tumor suppressor gene is associated with transcription from an alternative intronic promoter.

Mol Carcinog 2016 12 16;55(12):1940-1951. Epub 2015 Dec 16.

Laboratory of Genome Evolution, The Kinghorn Cancer Centre, Garvan Institute for Medical Research, Sydney, Australia.

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http://dx.doi.org/10.1002/mc.22441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111752PMC
December 2016

Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach.

BMC Cancer 2016 12 1;16(1):929. Epub 2016 Dec 1.

Department of Oncology, St Vincent's Hospital, The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, Sydney, Australia.

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http://dx.doi.org/10.1186/s12885-016-2972-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131452PMC
December 2016

Be careful what you wish for.

Med J Aust 2016 Dec;205(11):521-522

St Vincent's Hospital, Sydney, NSW

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http://dx.doi.org/10.5694/mja16.00836DOI Listing
December 2016

A periodic table for cancer.

Future Oncol 2015 ;11(5):785-800

*Clinical Informatics & Research Centre, The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst 2010, Sydney, Australia.

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http://dx.doi.org/10.2217/fon.14.315DOI Listing
November 2015

"By the way doctor, I've booked an African safari after my next chemo".

BMJ 2015 Jan 6;350:g7822. Epub 2015 Jan 6.

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http://dx.doi.org/10.1136/bmj.g7822DOI Listing
January 2015

Papillomavirus-associated squamous skin cancers following transplant immunosuppression: one Notch closer to control.

Cancer Treat Rev 2014 Mar 22;40(2):205-14. Epub 2013 Aug 22.

Department of Oncology, St. Vincent's Hospital, The Kinghorn Cancer Centre, UNSW Clinical School, Sydney, Australia.

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http://dx.doi.org/10.1016/j.ctrv.2013.08.005DOI Listing
March 2014

Efficacy and tolerability of adjuvant oral capecitabine plus intravenous oxaliplatin (XELOX) in Asian patients with colorectal cancer: 4-year analysis.

Asian Pac J Cancer Prev 2014 Jan;14(11):6585-90

University Department of Medicine, Queen Mary Hospital, Hong Kong, China E-mail :

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http://dx.doi.org/10.7314/apjcp.2013.14.11.6585DOI Listing
January 2014

The unpluggable in pursuit of the undruggable: tackling the dark matter of the cancer therapeutics universe.

Front Oncol 2013 Dec 12;3:304. Epub 2013 Dec 12.

Laboratory of Genome Evolution & Informatics, The Kinghorn Cancer Centre, and Clinical Informatics & Research Centre, Department of Oncology, St Vincent's Hospital, UNSW Clinical School , Sydney, NSW , Australia.

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http://dx.doi.org/10.3389/fonc.2013.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859984PMC
December 2013

Conserved nonsense-prone CpG sites in apoptosis-regulatory genes: conditional stop signs on the road to cell death.

Evol Bioinform Online 2013 14;9:275-83. Epub 2013 Jul 14.

Department of Genetics, Mount Sinai School of Medicine, New York, USA.

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http://dx.doi.org/10.4137/EBO.S11759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728200PMC
August 2013

Modernising the regulation of medical migration: moving from national monopolies to international markets.

BMC Med Ethics 2012 Oct 5;13:26. Epub 2012 Oct 5.

Conjoint Professor, Faculty of Medicine, University of New South Wales, St Vincent's Hospital, Victoria St, Darlinghurst, Sydney, 2010, Australia.

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http://dx.doi.org/10.1186/1472-6939-13-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563447PMC
October 2012

Adaptive Evolution Hotspots at the GC-Extremes of the Human Genome: Evidence for Two Functionally Distinct Pathways of Positive Selection.

Adv Bioinformatics 2010 3:856825. Epub 2010 May 3.

Laboratory of Computational Oncology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1155/2010/856825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862947PMC
July 2011

Unexpected functional similarities between gatekeeper tumour suppressor genes and proto-oncogenes revealed by systems biology.

J Hum Genet 2011 May 3;56(5):369-76. Epub 2011 Mar 3.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/jhg.2011.21DOI Listing
May 2011

Transient carcinoembryonic antigen elevations during adjuvant chemotherapy for colorectal cancer reflect the burden of residual micrometastatic disease.

Clin Colorectal Cancer 2010 Apr;9(2):108-12

Division of Haematology/Oncology, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.3816/CCC.2010.n.015DOI Listing
April 2010

PPI-delayed diagnosis of gastrinoma: oncologic victim of pharmacologic success.

Pathol Oncol Res 2010 Mar 20;16(1):87-91. Epub 2009 Aug 20.

Division of Hematology/Oncology, Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1007/s12253-009-9192-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953631PMC
March 2010

Digitization and its discontents: future shock in predictive oncology.

Semin Oncol 2010 Feb;37(1):60-4

Department of Oncology, St Vincent's Hospital, Sydney, Australia.

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http://dx.doi.org/10.1053/j.seminoncol.2009.12.006DOI Listing
February 2010

Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma.

J Clin Oncol 2010 Jan 14;28(3):475-80. Epub 2009 Dec 14.

Baylor-Sammons/Texas Oncology Physician's Association, Dallas, TX 75246, USA.

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http://dx.doi.org/10.1200/JCO.2008.21.6994DOI Listing
January 2010

Visual impairment in myopic patients with breast cancer receiving adjuvant therapy with aromatase inhibitors.

Clin Breast Cancer 2009 Aug;9(3):184-6

Medical Oncology Unit, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

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http://dx.doi.org/10.3816/CBC.2009.n.030DOI Listing
August 2009

Unblocking blockbusters: using boolean text-mining to optimise clinical trial design and timeline for novel anticancer drugs.

Cancer Inform 2009 Aug 17;7:231-8. Epub 2009 Aug 17.

Laboratory of Computational Oncology, Department of Medicine, The University of Hong Kong, Hong Kong.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791493PMC
http://dx.doi.org/10.4137/cin.s2666DOI Listing
August 2009

TNM: therapeutically not mandatory.

Eur J Cancer 2009 May 26;45(7):1111-1116. Epub 2009 Mar 26.

Division of Haematology/Oncology, Department of Medicine, The University of Hong Kong, 4/F, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2009.02.020DOI Listing
May 2009

Growth inhibition of human cancer cells by 5-aza-2'-deoxycytidine does not correlate with its effects on INK4a/ARF expression or initial promoter methylation status.

Mol Cancer Ther 2009 Apr;8(4):779-85

Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR China.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0926DOI Listing
April 2009

Complications of traditional Chinese/herbal medicines (TCM)--a guide for perplexed oncologists and other cancer caregivers.

Support Care Cancer 2009 Mar 14;17(3):231-40. Epub 2008 Nov 14.

Division of Hematology/Oncology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1007/s00520-008-0526-xDOI Listing
March 2009

Evidence for a programming effect of early menarche on the rise of breast cancer incidence in Hong Kong.

Cancer Detect Prev 2008 16;32(2):156-61. Epub 2008 Jul 16.

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1016/j.cdp.2008.05.004DOI Listing
September 2008

Programmed genetic instability: a tumor-permissive mechanism for maintaining the evolvability of higher species through methylation-dependent mutation of DNA repair genes in the male germ line.

Mol Biol Evol 2008 Aug 4;25(8):1737-49. Epub 2008 Jun 4.

Laboratory of Computational Oncology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1093/molbev/msn126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464741PMC
August 2008

Loading doses for costly cancer biologicals: sound pharmacology or unnecessary extravagance?

Eur J Cancer 2008 Jul 14;44(11):1488-92. Epub 2008 Jan 14.

Division of Haematology/Oncology, Room 802, Administrative Block, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1016/j.ejca.2007.12.006DOI Listing
July 2008

Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma.

Oncology 2007 13;72 Suppl 1:67-71. Epub 2007 Dec 13.

Department of Medicine, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China.

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https://www.karger.com/Article/FullText/111709
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http://dx.doi.org/10.1159/000111709DOI Listing
January 2008

VEGF signaling inhibitors: more pro-apoptotic than anti-angiogenic.

Cancer Metastasis Rev 2007 Dec;26(3-4):443-52

Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1007/s10555-007-9071-1DOI Listing
December 2007

Growth of the Asian health-care market: global implications for the pharmaceutical industry.

Nat Rev Drug Discov 2007 10;6(10):785-92

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1038/nrd2360DOI Listing
October 2007

A structural split in the human genome.

PLoS One 2007 Jul 11;2(7):e603. Epub 2007 Jul 11.

Laboratory of Computational Oncology, Department of Medicine, University of Hong Kong, Pokfulam, Hong Kong, Hong Kong.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000603PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904255PMC
July 2007

Clinicopathological correlates in a cohort of Hong Kong breast cancer patients presenting with screen-detected or symptomatic disease.

Hong Kong Med J 2007 Jun;13(3):194-8

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.

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June 2007

Adjuvant breast cancer chemotherapy during late-trimester pregnancy: not quite a standard of care.

BMC Cancer 2007 May 30;7:92. Epub 2007 May 30.

Division of Haematology/Oncology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1186/1471-2407-7-92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894980PMC
May 2007

Reversing hepatocellular carcinoma progression by using networked biological therapies.

Clin Cancer Res 2007 Jan;13(1):11-7

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1619DOI Listing
January 2007

Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy.

Cancer Chemother Pharmacol 2006 Dec 11;58(6):835-7. Epub 2006 Mar 11.

Division of Haematology/Oncology, Department of Medicine, University of Hong Kong, Room 404, Professorial Block, Queen Mary Hospital, Pokfulam Rd, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1007/s00280-006-0218-5DOI Listing
December 2006

Intron length and accelerated 3' gene evolution.

Genomics 2006 Dec 22;88(6):682-689. Epub 2006 Aug 22.

Laboratory of Computational Oncology, Department of Medicine, Pokfulam, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.ygeno.2006.06.017DOI Listing
December 2006

Multidisciplinary approach to the management of breast cancer in Hong Kong.

World J Surg 2006 Dec;30(12):2095-100

Department of Surgery, University of Hong Kong Medical Centre, Hong Kong, China.

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http://dx.doi.org/10.1007/s00268-005-0370-9DOI Listing
December 2006

Utility of a web-based breast cancer predictive algorithm for adjuvant chemotherapeutic decision making in a multidisciplinary oncology center.

Cancer Invest 2006 Jun-Jul;24(4):367-73

Department of Medicine, The University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1080/07357900600705292DOI Listing
August 2006

Racial differences in lung cancer.

N Engl J Med 2006 May;354(18):1951-3; author reply 1951-3

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http://dx.doi.org/10.1056/NEJMc060512DOI Listing
May 2006

Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan.

Acta Oncol 2005 ;44(7):771-2

Division of Haematology/Oncology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1080/02841860500218652DOI Listing
February 2006

Primary prevention of human papillomavirus-dependent neoplasia: no condom, no sex.

Eur J Cancer 2005 Nov 11;41(17):2595-600. Epub 2005 Oct 11.

Division of Haematology and Medical Oncology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Room 404, Professorial Block, Pokfulam Road, Hong Kong.

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http://dx.doi.org/10.1016/j.ejca.2005.06.023DOI Listing
November 2005

Maintenance therapy to suppress micrometastasis: the new challenge for adjuvant cancer treatment.

Clin Cancer Res 2005 Aug;11(15):5337-41

Department of Medicine, University of Hong Kong, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-05-0437DOI Listing
August 2005

Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention.

Cancer Lett 2005 Jul 15;225(1):53-9. Epub 2004 Dec 15.

Laboratory of Tumor Phosphoproteomics, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1016/j.canlet.2004.11.021DOI Listing
July 2005

Journal impact factors do not equitably reflect academic staff performance in different medical subspecialties.

J Investig Med 2004 Dec;52(8):531-6

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.

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http://dx.doi.org/10.1136/jim-52-08-25DOI Listing
December 2004

The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies.

Nat Rev Cancer 2004 11;4(11):901-9

Department of Medicine, The University of Hong Kong, Room 404, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong.

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http://dx.doi.org/10.1038/nrc1473DOI Listing
November 2004

Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: implications for adjuvant use of kinase-inhibitory drugs.

Clin Cancer Res 2004 Jun;10(12 Pt 1):3980-7

Division of Medical Sciences and Department of Surgical Oncology, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1158/1078-0432.CCR-03-0663DOI Listing
June 2004

Learning from the problems of problem-based learning.

BMC Med Educ 2004 Jan 9;4. Epub 2004 Jan 9.

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1186/1472-6920-4-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC328087PMC
January 2004

Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells.

Mol Cancer Ther 2003 Dec;2(12):1369-77

Laboratory of Tumor Phosphoproteomics, Division of Medical Sciences, National Cancer Centre, Singapore.

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December 2003

Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ.

Lancet 2003 Oct;362(9390):1154-5; author reply 1155-6

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http://dx.doi.org/10.1016/s0140-6736(03)14476-5DOI Listing
October 2003

Hormonal contraception and cervical cancer.

Lancet 2003 May;361(9372):1915

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http://dx.doi.org/10.1016/S0140-6736(03)13531-3DOI Listing
May 2003

Quick-FLIC--a short questionnaire for assessing quality of life of cancer patients.

Acta Oncol 2003 ;42(1):36-42

Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1080/0891060310002212DOI Listing
April 2003