Publications by authors named "Richard J Crockett"

2 Publications

  • Page 1 of 1

Effects of cyclic strain on rat tail tenocytes.

Mol Biol Rep 2010 Jul 15;37(6):2629-34. Epub 2009 Sep 15.

Department of Surgery (Section of Plastic Surgery), Yale University School of Medicine, P.O. Box 208041, New Haven, CT 06520-8041, USA.

Cyclical mechanical strain is considered an important component in flexor tendon cell activation to prevent adhesions and enhance the healing process after tissue injury or surgery, but the biochemical events associated with this remain unclear. To address this, we examined the effects of cyclic tension on the expression of hyaluronic acid, an important lubricant and signal transducer in tendon, on its receptor (CD44), and on total glycosaminoglycan content in rat tail derived tendon fibroblasts in vitro. Tenocytes were plated on fibronectin coated silastic membranes and the cultures were held static or subjected to vacuum induced deformation for a period of 5 min once every 8 h as a model of cyclic mechanical stress. After 24 h medium and cell layers were collected for analyses by product specific ELISA, Western blot, and colorimetric dye-binding assays. Strained tenocytes produced a nearly two-fold increase in hyaluronic acid and a greater than 60% increase in CD44, but had an insignificant effect on total glycosaminoglycan content. Our results predict that high levels of strain may therefore rapidly enhance the expression of hyaluronic acid and cause, albeit still unresolved, downstream effects on CD44 activation, to influence tendon cell activity and enhance the process of tendon repair.
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http://dx.doi.org/10.1007/s11033-009-9788-8DOI Listing
July 2010

The influence of plastic surgery "reality TV" on cosmetic surgery patient expectations and decision making.

Plast Reconstr Surg 2007 Jul;120(1):316-324

New Haven and Hamden, Conn. From the Section of Plastic and Reconstructive Surgery, Yale University School of Medicine, and the Department of Psychology, Quinnipiac University.

Background: The aim of this study was to survey first-time patients seeking cosmetic surgery and examine what role "reality TV" played in their perception of the risks and benefits of surgery and their overall decision-making process.

Methods: Information on demographics, television viewing patterns, and patients' self-assessed plastic surgery knowledge was collected from 42 patients. They were asked how similar they believed the shows were to real life and what degree of influence the shows had on their decision to pursue cosmetic surgery. Patients were then divided into groups by program viewing intensity.

Results: Fifty-seven percent of patients were "high-intensity" viewers of plastic surgery reality television shows. When compared with low-intensity viewers, high-intensity viewers believed themselves to be more knowledgeable about plastic surgery (p < 0.05) and believed the shows were more similar to real life (p < 0.05). Overall, four of five patients reported that television influenced them to pursue a cosmetic surgery procedure, with nearly one-third feeling "very much" or "moderately" influenced.

Conclusions: Plastic surgery reality television plays a significant role in cosmetic surgery patient perceptions and decision making. Patients who regularly watched one or more reality television show reported a greater influence from television and media to pursue cosmetic surgery, felt more knowledgeable about cosmetic surgery in general, and felt that plastic surgery reality television was more similar to real life than did low-intensity viewers.
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http://dx.doi.org/10.1097/01.prs.0000264339.67451.71DOI Listing
July 2007