Richard J Coward

Richard J Coward

UNVERIFIED PROFILE

Are you Richard J Coward?   Register this Author

Register author
Richard J Coward

Richard J Coward

Publications by authors named "Richard J Coward"

Are you Richard J Coward?   Register this Author

34Publications

625Reads

29Profile Views

The Evolving Importance of Insulin Signaling in Podocyte Health and Disease.

Front Endocrinol (Lausanne) 2018 21;9:693. Epub 2018 Nov 21.

Bristol Renal, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2018.00693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258712PMC
November 2018

The molecular biology of pelvi-ureteric junction obstruction.

Pediatr Nephrol 2018 04 13;33(4):553-571. Epub 2017 Mar 13.

Bristol Renal Group, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-017-3629-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859056PMC
April 2018

Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress.

Sci Rep 2018 03 2;8(1):3902. Epub 2018 Mar 2.

Bristol Renal, Bristol Medical School, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-22233-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834602PMC
March 2018

Peroxisome proliferator activating receptor-γ and the podocyte.

Nephrol Dial Transplant 2017 03;32(3):423-433

Department of Paediatric Nephrology, Bristol Royal Hospital for Children, Bristol, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfw320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837724PMC
March 2017

DBA2J db/db mice are susceptible to early albuminuria and glomerulosclerosis that correlate with systemic insulin resistance.

Am J Physiol Renal Physiol 2017 Feb 16;312(2):F312-F321. Epub 2016 Nov 16.

Bristol Renal, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00451.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336587PMC
February 2017

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms.

Trends Endocrinol Metab 2016 11 25;27(11):820-830. Epub 2016 Jul 25.

Developmental Biology and Cancer Programme, Institute of Child Health, University College London, London, WC1N 1EH, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tem.2016.07.002DOI Listing
November 2016

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.

Biochim Biophys Acta 2015 Dec 16;1853(12):3224-34. Epub 2015 Sep 16.

Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, (CIBERDEM) ISCIII, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2015.09.020DOI Listing
December 2015

Paediatrics, insulin resistance and the kidney.

Pediatr Nephrol 2015 Aug 25;30(8):1217-24. Epub 2014 Jul 25.

Institute of Child Health, University College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007%2Fs00467-014-28
Web Search
http://link.springer.com/10.1007/s00467-014-2890-8
Publisher Site
http://dx.doi.org/10.1007/s00467-014-2890-8DOI Listing
August 2015

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.

Cardiovasc Res 2015 Jul 22;107(1):9-19. Epub 2015 Apr 22.

School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, University Walk, Medical Sciences Building, Bristol BS8 1TD, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvv132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476412PMC
July 2015

Clinical and genetic analysis of patients with cystinuria in the United Kingdom.

Clin J Am Soc Nephrol 2015 Jul 11;10(7):1235-45. Epub 2015 May 11.

Academic and Children's Renal Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.10981114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491297PMC
July 2015

Recent advances in our understanding of insulin signalling to the podocyte.

Nephrol Dial Transplant 2014 Jun 27;29(6):1127-33. Epub 2013 Nov 27.

Academic Renal Unit, Learning and Research Building, Southmead Hospital, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gft471DOI Listing
June 2014

Initial steroid sensitivity in children with steroid-resistant nephrotic syndrome predicts post-transplant recurrence.

J Am Soc Nephrol 2014 Jun 7;25(6):1342-8. Epub 2014 Feb 7.

Department of Paediatric Nephrology, Bristol Royal Hospital for Children, Bristol, United Kingdom; Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2013080852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033379PMC
June 2014

Podocytes, signaling pathways, and vascular factors in diabetic kidney disease.

Adv Chronic Kidney Dis 2014 May;21(3):304-10

Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI; and Children's Renal Unit, University of Bristol, Bristol, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.ackd.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075065PMC
May 2014

Glomerular involvement in the arthrogryposis, renal dysfunction and cholestasis syndrome.

Clin Kidney J 2013 Apr 29;6(2):183-8. Epub 2013 Jan 29.

Department of Paediatric Nephrology , Bristol Royal Hospital for Children , Bristol , UK ; Academic Renal Unit , University of Bristol , Bristol , UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/ckj/article-lookup/doi/10.1093/ckj/
Publisher Site
http://dx.doi.org/10.1093/ckj/sfs182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432437PMC
April 2013

Insulin signalling to the kidney in health and disease.

Clin Sci (Lond) 2013 Mar;124(6):351-70

Academic and Children's Renal Unit, University of Bristol, Learning and Research, Southmead Hospital, Bristol BS10 5NB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/CS20120378DOI Listing
March 2013

Regulation of hypoxia-inducible factor 2-a is essential for integrity of the glomerular barrier.

Am J Physiol Renal Physiol 2013 Jan 10;304(1):F120-6. Epub 2012 Oct 10.

Institute of Medicine Science, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00416.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543619PMC
January 2013

The insulin receptor and the kidney.

Curr Opin Nephrol Hypertens 2013 Jan;22(1):100-6

Academic and Children's Renal Unit, University of Bristol, Learning and Research, Southmead Hospital, Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNH.0b013e32835abb52DOI Listing
January 2013

Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy.

Pediatr Nephrol 2011 Apr 15;26(4):523-33. Epub 2010 Oct 15.

Department of Medical Pediatrics, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-010-1637-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043262PMC
April 2011

Podocytes as a target of insulin.

Curr Diabetes Rev 2011 Jan;7(1):22-7

Academic and Children's Renal Unit, Southmead Hospital, Bristol, UK.

View Article

Download full-text PDF

Source
January 2011

Insulin signaling to the glomerular podocyte is critical for normal kidney function.

Cell Metab 2010 Oct;12(4):329-340

Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2010.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949331PMC
October 2010

Podocytes, glucose and insulin.

Curr Opin Nephrol Hypertens 2010 Jul;19(4):379-84

Academic and Children's Renal Unit, Bristol University, Southmead Hospital, Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNH.0b013e32833ad5e4DOI Listing
July 2010

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.

Nephrol Dial Transplant 2009 Nov 25;24(11):3288-96. Epub 2009 Jun 25.

Academic and Children's, Renal Unit, Paul O'Gorman Lifeline Centre, University of Bristol, Southmead Hospital, Bristol BS10, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/
Publisher Site
http://dx.doi.org/10.1093/ndt/gfp302DOI Listing
November 2009

An initial evaluation of post-cardiopulmonary bypass acute kidney injury in swine.

Eur J Cardiothorac Surg 2009 Nov 18;36(5):849-55. Epub 2009 Aug 18.

Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/ejcts/article-lookup/doi/10.1016/j.
Publisher Site
http://dx.doi.org/10.1016/j.ejcts.2009.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975514PMC
November 2009

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes.

J Am Soc Nephrol 2008 Nov 27;19(11):2140-9. Epub 2008 Aug 27.

Academic and Children's Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom BS10 5NB.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2007080940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573012PMC
November 2008

Nephrin is critical for the action of insulin on human glomerular podocytes.

Diabetes 2007 Apr;56(4):1127-35

AcademicChildren's Renal Unit, University of Bristol, Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db06-0693DOI Listing
April 2007

The human glomerular podocyte is a novel target for insulin action.

Diabetes 2005 Nov;54(11):3095-102

Academic and Children's Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK BS10 5NB.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.54.11.3095DOI Listing
November 2005

Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes.

J Am Soc Nephrol 2005 Mar 19;16(3):629-37. Epub 2005 Jan 19.

Academic and Children's Renal Unit, Southmead Hospital, University of Bristol, Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2004030172DOI Listing
March 2005

Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes.

Am J Physiol Renal Physiol 2003 Jun 4;284(6):F1263-73. Epub 2003 Mar 4.

Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00276.2002DOI Listing
June 2003

A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression.

J Am Soc Nephrol 2002 Mar;13(3):630-8

Children's Renal Unit and Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK.

View Article

Download full-text PDF

Source
March 2002