Publications by authors named "Richard J B Dobson"

52Publications

Mining Social Media Data to Study the Consequences of Dementia Diagnosis on Caregivers and Relatives.

Dement Geriatr Cogn Disord 2020 27;49(3):295-302. Epub 2020 Aug 27.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom,

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http://dx.doi.org/10.1159/000509123DOI Listing
August 2020

A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis.

Genes (Basel) 2020 Jun 19;11(6). Epub 2020 Jun 19.

Department of Biostatistics & Health Informatics, King's College London, 16 De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.3390/genes11060668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349022PMC
June 2020

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack.

J Vis Exp 2020 05 15(159). Epub 2020 May 15.

Early Psychosis: Interventions and Clinical-detection (EPIC) lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London; National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley National Health Service (NHS) Foundation Trust; OASIS service, South London and Maudsley National Health Service (NHS) Foundation Trust; Department of Brain and Behavioral Sciences, University of Pavia.

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http://dx.doi.org/10.3791/60794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272223PMC
May 2020

Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence.

Commun Biol 2020 Apr 2;3(1):157. Epub 2020 Apr 2.

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1038/s42003-020-0844-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118127PMC
April 2020

Working Towards a Blood-Derived Gene Expression Biomarker Specific for Alzheimer's Disease.

J Alzheimers Dis 2020 ;74(2):545-561

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.3233/JAD-191163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175937PMC
January 2020

On classifying sepsis heterogeneity in the ICU: insight using machine learning.

J Am Med Inform Assoc 2020 03;27(3):437-443

Department of Anaesthesia and Intensive Care, Luigi Sacco Hospital, Milan, Italy.

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http://dx.doi.org/10.1093/jamia/ocz211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025363PMC
March 2020

Differential gene expression analysis in blood of first episode psychosis patients.

Schizophr Res 2019 07 19;209:88-97. Epub 2019 May 19.

MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK.

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http://dx.doi.org/10.1016/j.schres.2019.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677921PMC
July 2019

Transcriptomic analysis of probable asymptomatic and symptomatic alzheimer brains.

Brain Behav Immun 2019 08 4;80:644-656. Epub 2019 May 4.

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, UK; Health Data Research UK London, University College London, 222 Euston Road, London, UK; Institute of Health Informatics, University College London, 222 Euston Road, London, UK; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, 222 Euston Road, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.05.009DOI Listing
August 2019

A Meta-Analysis of Alzheimer's Disease Brain Transcriptomic Data.

J Alzheimers Dis 2019 ;68(4):1635-1656

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.3233/JAD-181085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484273PMC
August 2020

A patient flow simulator for healthcare management education.

BMJ Simul Technol Enhanc Learn 2019 Jan 7;5(1):46-48. Epub 2017 Oct 7.

Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1136/bmjstel-2017-000251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312944PMC
January 2019

In response to Ballantyne and Schaefer's 'Consent and the ethical duty to participate in health data research'.

J Med Ethics 2019 05 7;45(5):351-352. Epub 2019 Jan 7.

Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, London, UK.

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http://dx.doi.org/10.1136/medethics-2018-105271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583136PMC
May 2019

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

Neurobiol Aging 2018 09 17;69:151-166. Epub 2018 May 17.

Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075941PMC
September 2018

A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations.

J Alzheimers Dis 2018 ;64(s1):S289-S297

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.3233/JAD-179904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010156PMC
June 2019

Author Correction: Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

Sci Rep 2018 Mar 6;8(1):4284. Epub 2018 Mar 6.

Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-22521-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840371PMC
March 2018

Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

Sci Rep 2017 11 27;7(1):16416. Epub 2017 Nov 27.

Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-16674-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703951PMC
November 2017

ADEPt, a semantically-enriched pipeline for extracting adverse drug events from free-text electronic health records.

PLoS One 2017 9;12(11):e0187121. Epub 2017 Nov 9.

The Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187121PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679515PMC
November 2017

Network analysis of patient flow in two UK acute care hospitals identifies key sub-networks for A&E performance.

PLoS One 2017 2;12(10):e0185912. Epub 2017 Oct 2.

Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185912PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624623PMC
October 2017

Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort.

PLoS One 2017 7;12(6):e0178562. Epub 2017 Jun 7.

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178562PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462385PMC
September 2017

Automated PDF highlighting to support faster curation of literature for Parkinson's and Alzheimer's disease.

Database (Oxford) 2017 01;2017(1)

Department of Biostatistics and Health Informatics, King's College London, De Crespigny Park, Denmark Hill London SE5 8AF, UK.

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http://dx.doi.org/10.1093/database/bax027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467557PMC
January 2017

Analysis of diagnoses extracted from electronic health records in a large mental health case register.

PLoS One 2017 16;12(2):e0171526. Epub 2017 Feb 16.

NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171526PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312950PMC
August 2017

Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid.

J Alzheimers Dis 2017 ;55(4):1417-1427

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.3233/JAD-160707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181674PMC
February 2018

Alzheimer's disease: are blood and brain markers related? A systematic review.

Ann Clin Transl Neurol 2016 06 11;3(6):455-62. Epub 2016 May 11.

MRC Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London London United Kingdom; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia London United Kingdom.

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http://dx.doi.org/10.1002/acn3.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891999PMC
June 2016

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.

Authors:
Genevera I Allen Nicola Amoroso Catalina Anghel Venkat Balagurusamy Christopher J Bare Derek Beaton Roberto Bellotti David A Bennett Kevin L Boehme Paul C Boutros Laura Caberlotto Cristian Caloian Frederick Campbell Elias Chaibub Neto Yu-Chuan Chang Beibei Chen Chien-Yu Chen Ting-Ying Chien Tim Clark Sudeshna Das Christos Davatzikos Jieyao Deng Donna Dillenberger Richard J B Dobson Qilin Dong Jimit Doshi Denise Duma Rosangela Errico Guray Erus Evan Everett David W Fardo Stephen H Friend Holger Fröhlich Jessica Gan Peter St George-Hyslop Satrajit S Ghosh Enrico Glaab Robert C Green Yuanfang Guan Ming-Yi Hong Chao Huang Jinseub Hwang Joseph Ibrahim Paolo Inglese Anandhi Iyappan Qijia Jiang Yuriko Katsumata John S K Kauwe Arno Klein Dehan Kong Roland Krause Emilie Lalonde Mario Lauria Eunjee Lee Xihui Lin Zhandong Liu Julie Livingstone Benjamin A Logsdon Simon Lovestone Tsung-Wei Ma Ashutosh Malhotra Lara M Mangravite Taylor J Maxwell Emily Merrill John Nagorski Aishwarya Namasivayam Manjari Narayan Mufassra Naz Stephen J Newhouse Thea C Norman Ramil N Nurtdinov Yen-Jen Oyang Yudi Pawitan Shengwen Peng Mette A Peters Stephen R Piccolo Paurush Praveen Corrado Priami Veronica Y Sabelnykova Philipp Senger Xia Shen Andrew Simmons Aristeidis Sotiras Gustavo Stolovitzky Sabina Tangaro Andrea Tateo Yi-An Tung Nicholas J Tustison Erdem Varol George Vradenburg Michael W Weiner Guanghua Xiao Lei Xie Yang Xie Jia Xu Hojin Yang Xiaowei Zhan Yunyun Zhou Fan Zhu Hongtu Zhu Shanfeng Zhu

Alzheimers Dement 2016 06 11;12(6):645-53. Epub 2016 Apr 11.

School of Computer Science, Fudan University, Shanghai, Shanghai, China; Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China; Centre for Computational Systems Biology, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1016/j.jalz.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474755PMC
June 2016

Microduplications at the pseudoautosomal SHOX locus in autism spectrum disorders and related neurodevelopmental conditions.

J Med Genet 2016 08 12;53(8):536-47. Epub 2016 Apr 12.

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK Adult Autism Spectrum and ADHD Services, Behavioural and Developmental Psychiatry, Clinical Academic Group, King's Health Partners, London, UK National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2015-103621DOI Listing
August 2016

Identification of Adverse Drug Events from Free Text Electronic Patient Records and Information in a Large Mental Health Case Register.

PLoS One 2015 14;10(8):e0134208. Epub 2015 Aug 14.

MRC Social, Genetic & Developmental Psychiatry Centre (SGDP), King's College London, London, United Kingdom; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation, London, United Kingdom; Biomedical Research Unit for Dementia, South London and Maudsley NHS Foundation, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134208PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537312PMC
May 2016

CohortExplorer: A Generic Application Programming Interface for Entity Attribute Value Database Schemas.

JMIR Med Inform 2014 Dec 1;2(2):e32. Epub 2014 Dec 1.

Institute of Psychiatry, NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia, South London and Maudsley NHS Foundation Trust & Institute of Psychiatry, Kings College London, London, United Kingdom.

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http://dx.doi.org/10.2196/medinform.3339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288104PMC
December 2014

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology.

Alzheimers Dement 2014 Nov 25;10(6):724-34. Epub 2014 Apr 25.

King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2013.09.016DOI Listing
November 2014

TextHunter--A User Friendly Tool for Extracting Generic Concepts from Free Text in Clinical Research.

AMIA Annu Symp Proc 2014 14;2014:729-38. Epub 2014 Nov 14.

King's College London (Institute of Psychiatry), London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420012PMC
September 2015

Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study.

J Alzheimers Dis 2014 ;38(3):515-31

King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK.

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http://dx.doi.org/10.3233/JAD-130380DOI Listing
July 2014

BBGRE: brain and body genetic resource exchange.

Database (Oxford) 2013 27;2013:bat067. Epub 2013 Sep 27.

Department of Cytogenetics, Guy's and St Thomas NHS Foundation Trust, London, SE1 9RT, UK, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF and NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation, London, SE5 8AF.

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http://dx.doi.org/10.1093/database/bat067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785255PMC
March 2014

Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion.

Hum Mol Genet 2012 Mar 11;21(5):1018-24. Epub 2011 Nov 11.

Department of Neuroscience, Institute of Psychiatry, King’s College London, London, UK.

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http://dx.doi.org/10.1093/hmg/ddr532DOI Listing
March 2012

Global sequence properties for superfamily prediction: a machine learning approach.

J Integr Bioinform 2009 Aug 23;6(1):109. Epub 2009 Aug 23.

The William Harvey Research Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.2390/biecoll-jib-2009-109DOI Listing
August 2009

An approach to pathway reconstruction using whole genome metabolic models and sensitive sequence searching.

J Integr Bioinform 2009 Jul 5;6(1):107. Epub 2009 Jul 5.

Barts and The London School of Medicine, Queen Mary, University of London, UK.

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http://dx.doi.org/10.2390/biecoll-jib-2009-107DOI Listing
July 2009