Richard H Myers

Richard H Myers

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Richard H Myers

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A glycomics and proteomics study of aging and Parkinson's disease in human brain.

Sci Rep 2020 Jul 30;10(1):12804. Epub 2020 Jul 30.

Graduate Program in Molecular and Translational Medicine, Boston University School of Medicine, Boston, 02118, USA.

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http://dx.doi.org/10.1038/s41598-020-69480-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393382PMC
July 2020

The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington's disease brain.

BMC Med Genomics 2019 10 16;12(1):137. Epub 2019 Oct 16.

Bioinformatics Nexus, Boston University, Boston, 02118, USA.

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http://dx.doi.org/10.1186/s12920-019-0581-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796419PMC
October 2019

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Authors:
Annah B Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N Nguyen Lies Lahousse Jeanne C Latourelle Albert Vernon Smith Traci M Bartz Mary F Feitosa Wei Gao Tarunveer S Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E Jackson Tianyuan Wang Ma'en Obeidat Brian D Hobbs Tianxiao Huan Hongsheng Gui Margaret M Parker Donglei Hu Lauren S Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B Harris Ravi Kalhan Susan R Heckbert Lavinia Paternoster Kristin M Burkart Yongmei Liu Elizabeth G Holliday James G Wilson Judith M Vonk Jason L Sanders R Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H H Adams Maarten van den Berge Roby Joehanes Albert M Levin Jennifer Liberto Lenore J Launer Alanna C Morrison Colleen M Sitlani Juan C Celedón Stephen B Kritchevsky Rodney J Scott Kaare Christensen Jerome I Rotter Tobias N Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A Brody Robert C Kaplan Kurt Lohman Mark McEvoy Michael A Province Frits R Rosendaal Kent D Taylor David C Nickle L Keoki Williams Esteban G Burchard Heather E Wheeler Don D Sin Vilmundur Gudnason Kari E North Myriam Fornage Bruce M Psaty Richard H Myers George O'Connor Torben Hansen Cathy C Laurie Patricia A Cassano Joohon Sung Woo Jin Kim John R Attia Leslie Lange H Marike Boezen Bharat Thyagarajan Stephen S Rich Dennis O Mook-Kanamori Bernardo Lessa Horta André G Uitterlinden Hae Kyung Im Michael H Cho Guy G Brusselle Sina A Gharib Josée Dupuis Ani Manichaikul Stephanie J London

Nat Commun 2018 07 30;9(1):2976. Epub 2018 Jul 30.

Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1038/s41467-018-05369-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065313PMC
July 2018

MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study.

Neurology 2018 01 27;90(4):e264-e272. Epub 2017 Dec 27.

From the Bioinformatics Program (E.R.R., R.H.M.), Boston University; Department of Neurology (J.C.L., J.B., R.H.M.), Boston University School of Medicine, MA; and Departments of Neurology and Psychiatry (J.H.B., J.S.P.) and Internal Medicine (J.S.), Carver College of Medicine, University of Iowa, Iowa City.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798654PMC
January 2018

Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles.

Front Mol Neurosci 2017 11;10:430. Epub 2018 Jan 11.

Bioinformatics Program, Boston University, Boston, MA, United States.

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http://dx.doi.org/10.3389/fnmol.2017.00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768647PMC
January 2018

Haplotype-based stratification of Huntington's disease.

Eur J Hum Genet 2017 11 23;25(11):1202-1209. Epub 2017 Aug 23.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/ejhg.2017.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643960PMC
November 2017

A modifier of Huntington's disease onset at the MLH1 locus.

Hum Mol Genet 2017 10;26(19):3859-3867

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddx286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455020PMC
October 2017

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.

Sci Rep 2017 05 2;7(1):1307. Epub 2017 May 2.

UCL Huntington's Disease Centre, Sobell Department of Motor Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-01510-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431000PMC
May 2017

Evaluation of logistic regression models and effect of covariates for case-control study in RNA-Seq analysis.

BMC Bioinformatics 2017 Feb 6;18(1):91. Epub 2017 Feb 6.

Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1186/s12859-017-1498-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294900PMC
February 2017

Novel microRNA discovery using small RNA sequencing in post-mortem human brain.

BMC Genomics 2016 10 4;17(1):776. Epub 2016 Oct 4.

Department of Neurology, Boston University School of Medicine, Boston, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050850PMC
http://dx.doi.org/10.1186/s12864-016-3114-3DOI Listing
October 2016

Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing.

PLoS One 2015 23;10(10):e0141298. Epub 2015 Oct 23.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America; Genome Science Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141298PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619731PMC
June 2016

The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease.

PLoS One 2015 4;10(12):e0144398. Epub 2015 Dec 4.

Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144398PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670094PMC
June 2016

microRNA Profiles in Parkinson's Disease Prefrontal Cortex.

Front Aging Neurosci 2016 1;8:36. Epub 2016 Mar 1.

Department of Neurology, Boston University School of MedicineBoston, MA, USA; Graduate Program in Genetics and Genomics, Boston University School of MedicineBoston, MA, USA; Bioinformatics Program, Boston UniversityBoston, MA, USA; Genome Science Institute, Boston University School of MedicineBoston, MA, USA.

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http://dx.doi.org/10.3389/fnagi.2016.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772525PMC
March 2016

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Authors:
Tuomas O Kilpeläinen Jayne F Martin Carli Alicja A Skowronski Qi Sun Jennifer Kriebel Mary F Feitosa Åsa K Hedman Alexander W Drong James E Hayes Jinghua Zhao Tune H Pers Ursula Schick Niels Grarup Zoltán Kutalik Stella Trompet Massimo Mangino Kati Kristiansson Marian Beekman Leo-Pekka Lyytikäinen Joel Eriksson Peter Henneman Jari Lahti Toshiko Tanaka Jian'an Luan Fabiola Del Greco M Dorota Pasko Frida Renström Sara M Willems Anubha Mahajan Lynda M Rose Xiuqing Guo Yongmei Liu Marcus E Kleber Louis Pérusse Tom Gaunt Tarunveer S Ahluwalia Yun Ju Sung Yolande F Ramos Najaf Amin Antoinette Amuzu Inês Barroso Claire Bellis John Blangero Brendan M Buckley Stefan Böhringer Yii-Der I Chen Anton J N de Craen David R Crosslin Caroline E Dale Zari Dastani Felix R Day Joris Deelen Graciela E Delgado Ayse Demirkan Francis M Finucane Ian Ford Melissa E Garcia Christian Gieger Stefan Gustafsson Göran Hallmans Susan E Hankinson Aki S Havulinna Christian Herder Dena Hernandez Andrew A Hicks David J Hunter Thomas Illig Erik Ingelsson Andreea Ioan-Facsinay John-Olov Jansson Nancy S Jenny Marit E Jørgensen Torben Jørgensen Magnus Karlsson Wolfgang Koenig Peter Kraft Joanneke Kwekkeboom Tiina Laatikainen Karl-Heinz Ladwig Charles A LeDuc Gordon Lowe Yingchang Lu Pedro Marques-Vidal Christa Meisinger Cristina Menni Andrew P Morris Richard H Myers Satu Männistö Mike A Nalls Lavinia Paternoster Annette Peters Aruna D Pradhan Tuomo Rankinen Laura J Rasmussen-Torvik Wolfgang Rathmann Treva K Rice J Brent Richards Paul M Ridker Naveed Sattar David B Savage Stefan Söderberg Nicholas J Timpson Liesbeth Vandenput Diana van Heemst Hae-Won Uh Marie-Claude Vohl Mark Walker Heinz-Erich Wichmann Elisabeth Widén Andrew R Wood Jie Yao Tanja Zeller Yiying Zhang Ingrid Meulenbelt Margreet Kloppenburg Arne Astrup Thorkild I A Sørensen Mark A Sarzynski D C Rao Pekka Jousilahti Erkki Vartiainen Albert Hofman Fernando Rivadeneira André G Uitterlinden Eero Kajantie Clive Osmond Aarno Palotie Johan G Eriksson Markku Heliövaara Paul B Knekt Seppo Koskinen Antti Jula Markus Perola Risto K Huupponen Jorma S Viikari Mika Kähönen Terho Lehtimäki Olli T Raitakari Dan Mellström Mattias Lorentzon Juan P Casas Stefanie Bandinelli Winfried März Aaron Isaacs Ko W van Dijk Cornelia M van Duijn Tamara B Harris Claude Bouchard Matthew A Allison Daniel I Chasman Claes Ohlsson Lars Lind Robert A Scott Claudia Langenberg Nicholas J Wareham Luigi Ferrucci Timothy M Frayling Peter P Pramstaller Ingrid B Borecki Dawn M Waterworth Sven Bergmann Gérard Waeber Peter Vollenweider Henrik Vestergaard Torben Hansen Oluf Pedersen Frank B Hu P Eline Slagboom Harald Grallert Tim D Spector J W Jukema Robert J Klein Erik E Schadt Paul W Franks Cecilia M Lindgren Rudolph L Leibel Ruth J F Loos

Nat Commun 2016 Feb 1;7:10494. Epub 2016 Feb 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms10494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740377PMC
February 2016

Study of plasma-derived miRNAs mimic differences in Huntington's disease brain.

Mov Disord 2015 Dec 17;30(14):1961-4. Epub 2015 Nov 17.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.26457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715548PMC
December 2015

Sequence-Level Analysis of the Major European Huntington Disease Haplotype.

Am J Hum Genet 2015 Sep 27;97(3):435-44. Epub 2015 Aug 27.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564985PMC
September 2015

Directional dominance on stature and cognition in diverse human populations.

Authors:
Peter K Joshi Tonu Esko Hannele Mattsson Niina Eklund Ilaria Gandin Teresa Nutile Anne U Jackson Claudia Schurmann Albert V Smith Weihua Zhang Yukinori Okada Alena Stančáková Jessica D Faul Wei Zhao Traci M Bartz Maria Pina Concas Nora Franceschini Stefan Enroth Veronique Vitart Stella Trompet Xiuqing Guo Daniel I Chasman Jeffery R O'Connel Tanguy Corre Suraj S Nongmaithem Yuning Chen Massimo Mangino Daniela Ruggiero Michela Traglia Aliki-Eleni Farmaki Tim Kacprowski Andrew Bjonnes Ashley van der Spek Ying Wu Anil K Giri Lisa R Yanek Lihua Wang Edith Hofer Cornelius A Rietveld Olga McLeod Marilyn C Cornelis Cristian Pattaro Niek Verweij Clemens Baumbach Abdel Abdellaoui Helen R Warren Dragana Vuckovic Hao Mei Claude Bouchard John R B Perry Stefania Cappellani Saira S Mirza Miles C Benton Ulrich Broeckel Sarah E Medland Penelope A Lind Giovanni Malerba Alexander Drong Loic Yengo Lawrence F Bielak Degui Zhi Peter J van der Most Daniel Shriner Reedik Mägi Gibran Hemani Tugce Karaderi Zhaoming Wang Tian Liu Ilja Demuth Jing Hua Zhao Weihua Meng Lazaros Lataniotis Sander W van der Laan Jonathan P Bradfield Andrew R Wood Amelie Bonnefond Tarunveer S Ahluwalia Leanne M Hall Erika Salvi Seyhan Yazar Lisbeth Carstensen Hugoline G de Haan Mark Abney Uzma Afzal Matthew A Allison Najaf Amin Folkert W Asselbergs Stephan J L Bakker R Graham Barr Sebastian E Baumeister Daniel J Benjamin Sven Bergmann Eric Boerwinkle Erwin P Bottinger Archie Campbell Aravinda Chakravarti Yingleong Chan Stephen J Chanock Constance Chen Y-D Ida Chen Francis S Collins John Connell Adolfo Correa L Adrienne Cupples George Davey Smith Gail Davies Marcus Dörr Georg Ehret Stephen B Ellis Bjarke Feenstra Mary F Feitosa Ian Ford Caroline S Fox Timothy M Frayling Nele Friedrich Frank Geller Generation Scotland Irina Gillham-Nasenya Omri Gottesman Misa Graff Francine Grodstein Charles Gu Chris Haley Christopher J Hammond Sarah E Harris Tamara B Harris Nicholas D Hastie Nancy L Heard-Costa Kauko Heikkilä Lynne J Hocking Georg Homuth Jouke-Jan Hottenga Jinyan Huang Jennifer E Huffman Pirro G Hysi M Arfan Ikram Erik Ingelsson Anni Joensuu Åsa Johansson Pekka Jousilahti J Wouter Jukema Mika Kähönen Yoichiro Kamatani Stavroula Kanoni Shona M Kerr Nazir M Khan Philipp Koellinger Heikki A Koistinen Manraj K Kooner Michiaki Kubo Johanna Kuusisto Jari Lahti Lenore J Launer Rodney A Lea Benjamin Lehne Terho Lehtimäki David C M Liewald Lars Lind Marie Loh Marja-Liisa Lokki Stephanie J London Stephanie J Loomis Anu Loukola Yingchang Lu Thomas Lumley Annamari Lundqvist Satu Männistö Pedro Marques-Vidal Corrado Masciullo Angela Matchan Rasika A Mathias Koichi Matsuda James B Meigs Christa Meisinger Thomas Meitinger Cristina Menni Frank D Mentch Evelin Mihailov Lili Milani May E Montasser Grant W Montgomery Alanna Morrison Richard H Myers Rajiv Nadukuru Pau Navarro Mari Nelis Markku S Nieminen Ilja M Nolte George T O'Connor Adesola Ogunniyi Sandosh Padmanabhan Walter R Palmas James S Pankow Inga Patarcic Francesca Pavani Patricia A Peyser Kirsi Pietilainen Neil Poulter Inga Prokopenko Sarju Ralhan Paul Redmond Stephen S Rich Harri Rissanen Antonietta Robino Lynda M Rose Richard Rose Cinzia Sala Babatunde Salako Veikko Salomaa Antti-Pekka Sarin Richa Saxena Helena Schmidt Laura J Scott William R Scott Bengt Sennblad Sudha Seshadri Peter Sever Smeeta Shrestha Blair H Smith Jennifer A Smith Nicole Soranzo Nona Sotoodehnia Lorraine Southam Alice V Stanton Maria G Stathopoulou Konstantin Strauch Rona J Strawbridge Matthew J Suderman Nikhil Tandon Sian-Tsun Tang Kent D Taylor Bamidele O Tayo Anna Maria Töglhofer Maciej Tomaszewski Natalia Tšernikova Jaakko Tuomilehto Andre G Uitterlinden Dhananjay Vaidya Astrid van Hylckama Vlieg Jessica van Setten Tuula Vasankari Sailaja Vedantam Efthymia Vlachopoulou Diego Vozzi Eero Vuoksimaa Melanie Waldenberger Erin B Ware William Wentworth-Shields John B Whitfield Sarah Wild Gonneke Willemsen Chittaranjan S Yajnik Jie Yao Gianluigi Zaza Xiaofeng Zhu The BioBank Japan Project Rany M Salem Mads Melbye Hans Bisgaard Nilesh J Samani Daniele Cusi David A Mackey Richard S Cooper Philippe Froguel Gerard Pasterkamp Struan F A Grant Hakon Hakonarson Luigi Ferrucci Robert A Scott Andrew D Morris Colin N A Palmer George Dedoussis Panos Deloukas Lars Bertram Ulman Lindenberger Sonja I Berndt Cecilia M Lindgren Nicholas J Timpson Anke Tönjes Patricia B Munroe Thorkild I A Sørensen Charles N Rotimi Donna K Arnett Albertine J Oldehinkel Sharon L R Kardia Beverley Balkau Giovanni Gambaro Andrew P Morris Johan G Eriksson Margie J Wright Nicholas G Martin Steven C Hunt John M Starr Ian J Deary Lyn R Griffiths Henning Tiemeier Nicola Pirastu Jaakko Kaprio Nicholas J Wareham Louis Pérusse James G Wilson Giorgia Girotto Mark J Caulfield Olli Raitakari Dorret I Boomsma Christian Gieger Pim van der Harst Andrew A Hicks Peter Kraft Juha Sinisalo Paul Knekt Magnus Johannesson Patrik K E Magnusson Anders Hamsten Reinhold Schmidt Ingrid B Borecki Erkki Vartiainen Diane M Becker Dwaipayan Bharadwaj Karen L Mohlke Michael Boehnke Cornelia M van Duijn Dharambir K Sanghera Alexander Teumer Eleftheria Zeggini Andres Metspalu Paolo Gasparini Sheila Ulivi Carole Ober Daniela Toniolo Igor Rudan David J Porteous Marina Ciullo Tim D Spector Caroline Hayward Josée Dupuis Ruth J F Loos Alan F Wright Giriraj R Chandak Peter Vollenweider Alan Shuldiner Paul M Ridker Jerome I Rotter Naveed Sattar Ulf Gyllensten Kari E North Mario Pirastu Bruce M Psaty David R Weir Markku Laakso Vilmundur Gudnason Atsushi Takahashi John C Chambers Jaspal S Kooner David P Strachan Harry Campbell Joel N Hirschhorn Markus Perola Ozren Polašek James F Wilson

Nature 2015 Jul 1;523(7561):459-462. Epub 2015 Jul 1.

Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/nature14618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516141PMC
July 2015

Correction for multiple testing in a gene region.

Eur J Hum Genet 2014 Mar 10;22(3):414-8. Epub 2013 Jul 10.

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/ejhg.2013.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925272PMC
March 2014

Feasibility of Huntington disease trials in the disease prodrome.

Neurology 2014 Mar 7;82(10):824-5. Epub 2014 Feb 7.

From the Department of Neurology (E.A.M.), Westmead Hospital, and Sydney Medical School, University of Sydney, Australia; and Department of Neurology (R.H.M), Genome Science Institute, Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000000197DOI Listing
March 2014

MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.

PLoS Genet 2014 Feb 27;10(2):e1004188. Epub 2014 Feb 27.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America ; Genome Science Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937267PMC
February 2014

Evaluation of Parkinson disease risk variants as expression-QTLs.

PLoS One 2012 5;7(10):e46199. Epub 2012 Oct 5.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046199PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465315PMC
April 2013

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

Am J Respir Crit Care Med 2012 Oct 26;186(7):622-32. Epub 2012 Jul 26.

Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA.

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http://dx.doi.org/10.1164/rccm.201202-0366OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480517PMC
October 2012

Copy number variation in familial Parkinson disease.

PLoS One 2011 2;6(8):e20988. Epub 2011 Aug 2.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020988PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149037PMC
December 2011

Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease.

Exp Neurol 2010 Nov 9;226(1):207-17. Epub 2010 Sep 9.

Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, 02118, USA.

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http://dx.doi.org/10.1016/j.expneurol.2010.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108022PMC
November 2010

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Authors:
Elizabeth K Speliotes Cristen J Willer Sonja I Berndt Keri L Monda Gudmar Thorleifsson Anne U Jackson Hana Lango Allen Cecilia M Lindgren Jian'an Luan Reedik Mägi Joshua C Randall Sailaja Vedantam Thomas W Winkler Lu Qi Tsegaselassie Workalemahu Iris M Heid Valgerdur Steinthorsdottir Heather M Stringham Michael N Weedon Eleanor Wheeler Andrew R Wood Teresa Ferreira Robert J Weyant Ayellet V Segrè Karol Estrada Liming Liang James Nemesh Ju-Hyun Park Stefan Gustafsson Tuomas O Kilpeläinen Jian Yang Nabila Bouatia-Naji Tõnu Esko Mary F Feitosa Zoltán Kutalik Massimo Mangino Soumya Raychaudhuri Andre Scherag Albert Vernon Smith Ryan Welch Jing Hua Zhao Katja K Aben Devin M Absher Najaf Amin Anna L Dixon Eva Fisher Nicole L Glazer Michael E Goddard Nancy L Heard-Costa Volker Hoesel Jouke-Jan Hottenga Asa Johansson Toby Johnson Shamika Ketkar Claudia Lamina Shengxu Li Miriam F Moffatt Richard H Myers Narisu Narisu John R B Perry Marjolein J Peters Michael Preuss Samuli Ripatti Fernando Rivadeneira Camilla Sandholt Laura J Scott Nicholas J Timpson Jonathan P Tyrer Sophie van Wingerden Richard M Watanabe Charles C White Fredrik Wiklund Christina Barlassina Daniel I Chasman Matthew N Cooper John-Olov Jansson Robert W Lawrence Niina Pellikka Inga Prokopenko Jianxin Shi Elisabeth Thiering Helene Alavere Maria T S Alibrandi Peter Almgren Alice M Arnold Thor Aspelund Larry D Atwood Beverley Balkau Anthony J Balmforth Amanda J Bennett Yoav Ben-Shlomo Richard N Bergman Sven Bergmann Heike Biebermann Alexandra I F Blakemore Tanja Boes Lori L Bonnycastle Stefan R Bornstein Morris J Brown Thomas A Buchanan Fabio Busonero Harry Campbell Francesco P Cappuccio Christine Cavalcanti-Proença Yii-Der Ida Chen Chih-Mei Chen Peter S Chines Robert Clarke Lachlan Coin John Connell Ian N M Day Martin den Heijer Jubao Duan Shah Ebrahim Paul Elliott Roberto Elosua Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Maurizio F Facheris Stephan B Felix Pamela Fischer-Posovszky Aaron R Folsom Nele Friedrich Nelson B Freimer Mao Fu Stefan Gaget Pablo V Gejman Eco J C Geus Christian Gieger Anette P Gjesing Anuj Goel Philippe Goyette Harald Grallert Jürgen Grässler Danielle M Greenawalt Christopher J Groves Vilmundur Gudnason Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Alistair S Hall Aki S Havulinna Caroline Hayward Andrew C Heath Christian Hengstenberg Andrew A Hicks Anke Hinney Albert Hofman Georg Homuth Jennie Hui Wilmar Igl Carlos Iribarren Bo Isomaa Kevin B Jacobs Ivonne Jarick Elizabeth Jewell Ulrich John Torben Jørgensen Pekka Jousilahti Antti Jula Marika Kaakinen Eero Kajantie Lee M Kaplan Sekar Kathiresan Johannes Kettunen Leena Kinnunen Joshua W Knowles Ivana Kolcic Inke R König Seppo Koskinen Peter Kovacs Johanna Kuusisto Peter Kraft Kirsti Kvaløy Jaana Laitinen Olivier Lantieri Chiara Lanzani Lenore J Launer Cecile Lecoeur Terho Lehtimäki Guillaume Lettre Jianjun Liu Marja-Liisa Lokki Mattias Lorentzon Robert N Luben Barbara Ludwig Paolo Manunta Diana Marek Michel Marre Nicholas G Martin Wendy L McArdle Anne McCarthy Barbara McKnight Thomas Meitinger Olle Melander David Meyre Kristian Midthjell Grant W Montgomery Mario A Morken Andrew P Morris Rosanda Mulic Julius S Ngwa Mari Nelis Matt J Neville Dale R Nyholt Christopher J O'Donnell Stephen O'Rahilly Ken K Ong Ben Oostra Guillaume Paré Alex N Parker Markus Perola Irene Pichler Kirsi H Pietiläinen Carl G P Platou Ozren Polasek Anneli Pouta Suzanne Rafelt Olli Raitakari Nigel W Rayner Martin Ridderstråle Winfried Rief Aimo Ruokonen Neil R Robertson Peter Rzehak Veikko Salomaa Alan R Sanders Manjinder S Sandhu Serena Sanna Jouko Saramies Markku J Savolainen Susann Scherag Sabine Schipf Stefan Schreiber Heribert Schunkert Kaisa Silander Juha Sinisalo David S Siscovick Jan H Smit Nicole Soranzo Ulla Sovio Jonathan Stephens Ida Surakka Amy J Swift Mari-Liis Tammesoo Jean-Claude Tardif Maris Teder-Laving Tanya M Teslovich John R Thompson Brian Thomson Anke Tönjes Tiinamaija Tuomi Joyce B 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Nat Genet 2010 Nov 10;42(11):937-48. Epub 2010 Oct 10.

Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648PMC
November 2010

Estrogen-related and other disease diagnoses preceding Parkinson's disease.

Clin Epidemiol 2010 Aug 9;2:153-70. Epub 2010 Aug 9.

Department of Neurology, Boston University School of Medicine, Boston MA, USA;

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http://dx.doi.org/10.2147/clep.s9621DOI Listing
August 2010

Genetic signatures of exceptional longevity in humans.

Science 2010 Jul 1;2010. Epub 2010 Jul 1.

Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.

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July 2010

Risk of Parkinson's disease after tamoxifen treatment.

BMC Neurol 2010 Apr 12;10:23. Epub 2010 Apr 12.

Department of Neurology, Boston University School of Medicine, 85 East Concord Street, Boston, MA 02118, USA.

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April 2010

Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study.

Obesity (Silver Spring) 2009 Dec 21;17(12):2182-9. Epub 2009 May 21.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

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December 2009

Evidence for three novel QTLs for adiposity on chromosome 2 with epistatic interactions: the NHLBI Family Heart Study.

Obesity (Silver Spring) 2009 Dec 11;17(12):2190-5. Epub 2009 Jun 11.

Division of Statistical Genomics, Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, USA.

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December 2009

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.

Hum Mol Genet 2009 Aug 23;18(16):3039-47. Epub 2009 May 23.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.

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August 2009

LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.

Atherosclerosis 2009 May 17;204(1):171-7. Epub 2008 Sep 17.

Division of Statistical Genomics, Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO, 63108-2212, USA.

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May 2009

A QTL on 12q influencing an inflammation marker and obesity in white women: the NHLBI Family Heart Study.

Obesity (Silver Spring) 2009 Mar 25;17(3):525-31. Epub 2008 Dec 25.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.

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March 2009

Genomewide association study for susceptibility genes contributing to familial Parkinson disease.

Hum Genet 2009 Jan 6;124(6):593-605. Epub 2008 Nov 6.

Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202-3002, USA.

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January 2009

Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study.

Hypertension 2009 Jan 24;53(1):35-41. Epub 2008 Nov 24.

Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 S Euclid Ave, St. Louis, MO 63110-1093, USA.

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January 2009

HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies.

Bioinformatics 2007 Aug 22;23(16):2190-2. Epub 2007 Jun 22.

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

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August 2007

LRRK2 is not a significant cause of Parkinson's disease in French-Canadians.

Can J Neurol Sci 2007 Aug;34(3):333-5

Faculty of Medicine, Laval University, Department of Neurological Sciences, CHAUQ-Enfant Jésus, Quebec City, Quebec, Canada.

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August 2007

Sepiapterin reductase expression is increased in Parkinson's disease brain tissue.

Brain Res 2007 Mar 8;1139:42-7. Epub 2007 Jan 8.

Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.

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March 2007

Evidence of QTL on 15q21 for high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS).

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Division of Statistical Genomics, Center for Genome Sciences, Washington University School of Medicine, 660 S. Euclid, Campus Box 8067, St. Louis, MO 63110-1093, USA.

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January 2007

Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study.

Diabetes 2007 Jan;56(1):137-42

Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E. Franklin St., Suite 306, Chapel Hill, NC 27514, USA.

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January 2007

Longitudinal and age trends of metabolic syndrome and its risk factors: the Family Heart Study.

Nutr Metab (Lond) 2006 Dec 5;3:41. Epub 2006 Dec 5.

Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA.

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December 2006

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.

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Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, and Department of Neurology, Boston University School of Medicine, MA 02114, USA.

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November 2006

Genetic analysis of the GRIK2 modifier effect in Huntington's disease.

BMC Neurosci 2006 Sep 7;7:62. Epub 2006 Sep 7.

Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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September 2006

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.

Hum Mol Genet 2006 Jun 10;15(12):2015-24. Epub 2006 May 10.

Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.

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June 2006

Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study.

Obes Res 2005 Nov;13(11):1885-90

Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 South Euclid Avenue, St. Louis, MO 63110-1093, USA.

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November 2005

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.

Hum Mol Genet 2005 Oct 22;14(19):2871-80. Epub 2005 Aug 22.

Molecular Neurogenetics UNIT, Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Center, Boston, MA 02114, USA.

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October 2005

Monozygotic twins discordant for Huntington disease after 7 years.

Arch Neurol 2005 Jun;62(6):995-7

Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA.

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June 2005

Linkage of the cholesterol 7alpha-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study.

Chin Med J (Engl) 2005 Mar;118(5):362-9

Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Salt Lake City, UT 84108-3528, USA.

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March 2005

An evaluation of the metabolic syndrome in the HyperGEN study.

Nutr Metab (Lond) 2005 Jan 18;2(1). Epub 2005 Jan 18.

Division of Biostatistics, Washington University School of Medicine, St, Louis, MO, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549210PMC
January 2005

Huntington's disease genetics.

Authors:
Richard H Myers

NeuroRx 2004 Apr;1(2):255-62

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1602/neurorx.1.2.255DOI Listing
April 2004