Richard Grundy

Richard Grundy

UNVERIFIED PROFILE

Are you Richard Grundy?   Register this Author

Register author
Richard Grundy

Richard Grundy

Publications by authors named "Richard Grundy"

Are you Richard Grundy?   Register this Author

100Publications

2937Reads

21Profile Views

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 Jul;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.

Sci Rep 2019 Jul 16;9(1):10290. Epub 2019 Jul 16.

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-46700-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635358PMC
July 2019

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high-grade glioma.

Brain Pathol 2019 Apr 23. Epub 2019 Apr 23.

Brain Tumour Research Centre, Institute of Biomedical and Biomolecular Sciences, IBBS, University of Portsmouth, Portsmouth, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12729DOI Listing
April 2019

Neurocognitive, academic and functional outcomes in survivors of infant ependymoma (UKCCSG CNS 9204).

Childs Nerv Syst 2019 Mar 15;35(3):411-420. Epub 2018 Dec 15.

Children's Brain Tumour Research Centre, Academic Division of Child Health, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2RD, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00381-018-4015-3
Publisher Site
http://dx.doi.org/10.1007/s00381-018-4015-3DOI Listing
March 2019

Outcomes of non-anaplastic stage III and 'inoperable' Wilms tumour treated in the UKW3 trial.

Radiother Oncol 2019 02 15;131:1-7. Epub 2018 Dec 15.

Cancer Section, Developmental Biology & Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2018.10.026DOI Listing
February 2019

Metabolite Levels in Paediatric Brain Tumours Correlate with Histological Features.

Pathobiology 2018 10;85(3):157-168. Epub 2018 Feb 10.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000458423DOI Listing
October 2018

Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors.

Oncotarget 2018 Oct 16;9(81):35266-35277. Epub 2018 Oct 16.

Children's Brain Tumor Research Centre, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/26186
Publisher Site
http://dx.doi.org/10.18632/oncotarget.26186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219655PMC
October 2018

Electrical impedance tomography effectively used in a case of paediatric pulmonary Langerhans cell histiocytosis.

BMJ Case Rep 2018 Sep 5;2018. Epub 2018 Sep 5.

Department of Haematology and Oncology, Nottingham Children's Hospital, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2017-224040DOI Listing
September 2018

Vascular stenosis in a child with visual pathway glioma treated with bevacizumab: a case report and review of literature.

Childs Nerv Syst 2018 04 16;34(4):781-785. Epub 2017 Dec 16.

Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-017-3676-7DOI Listing
April 2018

Radiomics in paediatric neuro-oncology: A multicentre study on MRI texture analysis.

NMR Biomed 2018 Jan 26;31(1). Epub 2017 Oct 26.

Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/nbm.3781DOI Listing
January 2018

Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures.

Oncotarget 2017 Dec 14;8(70):115570-115581. Epub 2017 Dec 14.

Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.23311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777794PMC
December 2017

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours.

Acta Neuropathol Commun 2017 06 6;5(1):45. Epub 2017 Jun 6.

Children's Brain Tumour Research Centre (CBTRC), School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-017-0449-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461722PMC
June 2017

3D Texture Analysis of Heterogeneous MRI Data for Diagnostic Classification of Childhood Brain Tumours.

Stud Health Technol Inform 2015 ;213:19-22

Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK.

View Article

Download full-text PDF

Source
April 2017

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease.

J Neurooncol 2017 04 21;132(2):255-266. Epub 2017 Jan 21.

Department of Paediatrics, Division of Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11060-016-2363-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378734PMC
April 2017

The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors.

Oncotarget 2017 Jan;8(2):2083-2095

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/13781
Publisher Site
http://dx.doi.org/10.18632/oncotarget.13781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356782PMC
January 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Assessing 'second-look' tumour resectability in childhood posterior fossa ependymoma-a centralised review panel and staging tool for future studies.

Childs Nerv Syst 2016 Nov 1;32(11):2189-2196. Epub 2016 Sep 1.

Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-016-3225-9DOI Listing
November 2016

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups.

Neuro Oncol 2016 06 28;18(6):790-6. Epub 2016 Jan 28.

Institute of Neuropathology, University Hospital Münster, Münster, Germany (C.T., V.R., A.J., W.P., M.H.); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany (M.S.); Core Facility Genomics of the Medical Faculty Münster, Münster, Germany (A.W.); Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (S.H., U.K.); Department of Neuropathology, Institute for Pathology and Neuropathology, University of Tübingen, Tübingen, Germany (R.B.); Faculty of Medicine, Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany (K.K.); Department of Neuropathology, Klinikum Bremen-Mitte, Bremen, Germany (M.B.); Institute of Neurology (Edinger Institute), Goethe University, Frankfurt, Germany (M.M.); Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany (T.P.); Department of Neuropathology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (J.F.); Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken (CCCM), Würzburg, Germany (C.M.M.); Department of Neuropathology, Sainte-Anne Hospital, Paris, France (P.V.); 2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary (P.H.); Department of Hematopathology, Molecular Diagnostic Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.O.); Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK (R.G.G.); Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic Children's Hospital, Cleveland, Ohio (J.E.W.); Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany (A.K., A.v.D., D.C.); Clinical Cooperation Unit Neuropathology, German Research Center (DKFZ), Heidelberg, Germany (A.K., A.v.D., D.C.); German Cancer Consortium (DKTK), German Cancer Research Ce

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/nov322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864264PMC
June 2016

Proton beam therapy for medulloblastoma.

Lancet Oncol 2016 05 27;17(5):e174. Epub 2016 Apr 27.

University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(16)00102-9DOI Listing
May 2016

Expression alterations define unique molecular characteristics of spinal ependymomas.

Oncotarget 2015 Aug;6(23):19780-91

Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637320PMC
http://dx.doi.org/10.18632/oncotarget.3715DOI Listing
August 2015

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.

Lancet Oncol 2015 May 14;16(5):569-82. Epub 2015 Apr 14.

Division of Hematology-Oncology, University of Toronto, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(15)70114-2DOI Listing
May 2015

microRNA network analysis identifies miR-29 cluster as key regulator of LAMA2 in ependymoma.

Acta Neuropathol Commun 2015 May 10;3:26. Epub 2015 May 10.

Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-015-0206-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425904PMC
May 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.

PLoS One 2014 15;9(1):e86187. Epub 2014 Jan 15.

Children's Brain Tumour Research Centre, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086187PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893285PMC
September 2014

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era.

Oncotarget 2014 Jul;5(14):5764-81

Academic Unit of Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham University Hospitals, Nottingham, UK; Department of Oncology, Nottingham University Hospitals, City Hospital Campus, Nottingham, UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170616PMC
http://dx.doi.org/10.18632/oncotarget.2180DOI Listing
July 2014

Texture analysis of T1 - and T2 -weighted MR images and use of probabilistic neural network to discriminate posterior fossa tumours in children.

NMR Biomed 2014 Jun 13;27(6):632-9. Epub 2014 Apr 13.

Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK; School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/nbm.3099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529665PMC
June 2014

MRI texture analysis in paediatric oncology: a preliminary study.

Stud Health Technol Inform 2013 ;190:169-71

University of Birmingham, Birmingham, United Kingdom.

View Article

Download full-text PDF

Source
May 2014

Overcoming multiple drug resistance mechanisms in medulloblastoma.

Acta Neuropathol Commun 2014 May 30;2:57. Epub 2014 May 30.

Children's Brain Tumour Research Centre, Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, QMC, Nottingham NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2051-5960-2-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229867PMC
May 2014

The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.

Acta Neuropathol Commun 2014 Feb 18;2:23. Epub 2014 Feb 18.

Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2051-5960-2-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938307PMC
February 2014

PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival.

Clin Cancer Res 2013 Dec 27;19(23):6450-60. Epub 2013 Sep 27.

Authors' Affiliation: Children's Brain Tumour Research Centre, D Floor Medical School, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-0222DOI Listing
December 2013

Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro.

Cancer Res 2013 Sep 25;73(18):5834-44. Epub 2013 Jul 25.

Authors' Affiliations: Division of Neuropathology, Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Department of Histopathology, Neural Development Unit, and UCL Genomics, UCL Institute of Child Health, Great Ormond Street Hospital, London; and Children's Brain Tumour Research Centre, Queen's Medical Centre, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-1299DOI Listing
September 2013

Loss of INI1 protein expression defines a subgroup of aggressive central nervous system primitive neuroectodermal tumors.

Brain Pathol 2013 Jan 25;23(1):19-27. Epub 2012 Jun 25.

Children's Brain Tumour Research Centre, School of Clinical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1750-3639.2012.00610.xDOI Listing
January 2013

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma.

Acta Neuropathol 2012 Jul 7;124(1):99-110. Epub 2012 Feb 7.

Children's Brain Tumour Research Centre, Medical School, Queen's Medical Centre Campus, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF

Source
http://search.proquest.com/openview/cdda196d4f16986cb0e051cf
Web Search
http://link.springer.com/10.1007/s00401-012-0952-1
Publisher Site
http://dx.doi.org/10.1007/s00401-012-0952-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377898PMC
July 2012

Progression from first symptom to diagnosis in childhood brain tumours.

Eur J Pediatr 2012 Jan 20;171(1):87-93. Epub 2011 May 20.

Department of Paediatric Oncology, Nottingham University Hospitals' NHS Trust Queen's Medical Centre, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-011-1485-7DOI Listing
January 2012

Histone deacetylase inhibition as an anticancer telomerase-targeting strategy.

Int J Cancer 2011 Dec 8;129(12):2765-74. Epub 2011 Aug 8.

Children's Brain Tumor Research Centre, University of Nottingham, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ijc.26241
Publisher Site
http://dx.doi.org/10.1002/ijc.26241DOI Listing
December 2011

RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines.

Neuro Oncol 2011 Dec 31;13(12):1265-76. Epub 2011 Aug 31.

Children's Brain Tumour Research Centre, Queen's Medical Centre, Medical School, Nottingham University, Nottingham NG7 2UH, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/neuro-oncology/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/neuonc/nor129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223089PMC
December 2011

Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.

J Oncol 2010 11;2010:251231. Epub 2010 Apr 11.

Children's Brain Tumour Research Centre, Medical School, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2010/251231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855058PMC
July 2011

On the importance of accounting for competing risks in pediatric brain cancer: II. Regression modeling and sample size.

Int J Radiat Oncol Biol Phys 2011 Mar 14;79(4):1139-46. Epub 2010 May 14.

Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2009.12.024DOI Listing
March 2011

Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas.

Neuro Oncol 2011 Feb 7;13(2):212-22. Epub 2010 Dec 7.

Children's Brain Tumour Research Centre, School of Clinical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/noq158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064619PMC
February 2011

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion.

Neuro Oncol 2011 Jan 25;13(1):70-83. Epub 2010 Oct 25.

Children's Brain Tumour Research Centre, School of Clinical Sciences, University of Nottingham, CBTRC, D32 Medical School, QMC, Clifton Boulevard, Nottingham NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/noq144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018909PMC
January 2011

The development of cell line models of childhood brain tumours.

Authors:
Richard Grundy

Altern Lab Anim 2010 Dec;38 Suppl 1:11-3

Human Development, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/026119291003801S09DOI Listing
December 2010

Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high-grade childhood brain tumor cells.

Mol Cancer Ther 2010 Sep 19;9(9):2568-81. Epub 2010 Jul 19.

Children's Brain Tumor Research Centre, Medical School, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-10-0272DOI Listing
September 2010

The diagnosis of brain tumours in children: a guideline to assist healthcare professionals in the assessment of children who may have a brain tumour.

Arch Dis Child 2010 Jul 6;95(7):534-9. Epub 2010 Apr 6.

Department of Paediatric Oncology, Birmingham Children's Hospital NHS Trust, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/adc.2009.162057DOI Listing
July 2010

Medulloblastoma in childhood: revisiting intrathecal therapy in infants and children.

Cancer Chemother Pharmacol 2010 May 24;65(6):1173-89. Epub 2009 Oct 24.

Children's Brain Tumour Research Centre, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00280-009-1127-1
Publisher Site
http://dx.doi.org/10.1007/s00280-009-1127-1DOI Listing
May 2010

On the importance of accounting for competing risks in pediatric cancer trials designed to delay or avoid radiotherapy: I. Basic concepts and first analyses.

Int J Radiat Oncol Biol Phys 2010 Apr 4;76(5):1493-9. Epub 2009 Jul 4.

Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2009.03.035DOI Listing
April 2010

Pediatric ependymoma: biological perspectives.

Mol Cancer Res 2009 Jun 16;7(6):765-86. Epub 2009 Jun 16.

The Children's Brain Tumour Research Centre, University of Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-08-0584DOI Listing
June 2009

The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.

Cancer Res 2009 Apr 7;69(8):3249-55. Epub 2009 Apr 7.

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-4710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836891PMC
April 2009

Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm.

Biochim Biophys Acta 2009 Apr 31;1792(4):280-8. Epub 2009 Jan 31.

School of Clinical Sciences, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2009.01.011DOI Listing
April 2009

A quantitative comparison of metabolite signals as detected by in vivo MRS with ex vivo 1H HR-MAS for childhood brain tumours.

NMR Biomed 2009 Feb;22(2):213-9

Academic Department of Paediatrics and Child Health, University of Birmingham, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/nbm.1306
Publisher Site
http://dx.doi.org/10.1002/nbm.1306DOI Listing
February 2009

Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothalamic damage in children.

Eur J Endocrinol 2008 Dec 26;159(6):791-7. Epub 2008 Sep 26.

Department of Endocrinology, Birmingham Children's Hospital, Birmingham, B4 6NH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-08-0533DOI Listing
December 2008

Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas.

Eur J Cancer 2008 Nov 1;44(17):2640-7. Epub 2008 Oct 1.

Department of Academic Paediatrics and Child Health, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2008.08.012DOI Listing
November 2008

Reductions in basal metabolic rate and physical activity contribute to hypothalamic obesity.

J Clin Endocrinol Metab 2008 Jul 15;93(7):2588-93. Epub 2008 Apr 15.

Department of Endocrinology, Birmingham Children's Hospital, Birmingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2007-2672DOI Listing
July 2008

The use of short-echo-time 1H MRS for childhood cerebellar tumours prior to histopathological diagnosis.

Pediatr Radiol 2007 Nov 7;37(11):1101-9. Epub 2007 Sep 7.

Academic Department of Paediatrics and Child Health, University of Birmingham, Whittall Street, Birmingham, B4 6NH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00247-007-0571-5DOI Listing
November 2007

Presentation of childhood CNS tumours: a systematic review and meta-analysis.

Lancet Oncol 2007 Aug;8(8):685-95

Children's Brain Tumour Research Centre, Academic Division of Child Health, University of Nottingham, Queen's Medical Centre, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14702045077020
Publisher Site
http://dx.doi.org/10.1016/S1470-2045(07)70207-3DOI Listing
August 2007