Richard G Grundy

Richard G Grundy

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Richard G Grundy

Richard G Grundy

Publications by authors named "Richard G Grundy"

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72Publications

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Germline mutations and somatic inactivation of TRIM28 in Wilms tumour.

PLoS Genet 2018 06 18;14(6):e1007399. Epub 2018 Jun 18.

Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

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June 2018

Vascular stenosis in a child with visual pathway glioma treated with bevacizumab: a case report and review of literature.

Childs Nerv Syst 2018 Apr 16;34(4):781-785. Epub 2017 Dec 16.

Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.

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April 2018

Metabolite Levels in Paediatric Brain Tumours Correlate with Histological Features.

Pathobiology 2018 10;85(3):157-168. Epub 2018 Feb 10.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

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February 2018

Radiomics in paediatric neuro-oncology: A multicentre study on MRI texture analysis.

NMR Biomed 2018 Jan 26;31(1). Epub 2017 Oct 26.

Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK.

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January 2018

Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures.

Oncotarget 2017 Dec 14;8(70):115570-115581. Epub 2017 Dec 14.

Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

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December 2017

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours.

Acta Neuropathol Commun 2017 06 6;5(1):45. Epub 2017 Jun 6.

Children's Brain Tumour Research Centre (CBTRC), School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

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June 2017

The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors.

Oncotarget 2017 Jan;8(2):2083-2095

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

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January 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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December 2016

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups.

Neuro Oncol 2016 06 28;18(6):790-6. Epub 2016 Jan 28.

Institute of Neuropathology, University Hospital Münster, Münster, Germany (C.T., V.R., A.J., W.P., M.H.); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany (M.S.); Core Facility Genomics of the Medical Faculty Münster, Münster, Germany (A.W.); Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (S.H., U.K.); Department of Neuropathology, Institute for Pathology and Neuropathology, University of Tübingen, Tübingen, Germany (R.B.); Faculty of Medicine, Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany (K.K.); Department of Neuropathology, Klinikum Bremen-Mitte, Bremen, Germany (M.B.); Institute of Neurology (Edinger Institute), Goethe University, Frankfurt, Germany (M.M.); Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany (T.P.); Department of Neuropathology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (J.F.); Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken (CCCM), Würzburg, Germany (C.M.M.); Department of Neuropathology, Sainte-Anne Hospital, Paris, France (P.V.); 2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary (P.H.); Department of Hematopathology, Molecular Diagnostic Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.O.); Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK (R.G.G.); Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic Children's Hospital, Cleveland, Ohio (J.E.W.); Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany (A.K., A.v.D., D.C.); Clinical Cooperation Unit Neuropathology, German Research Center (DKFZ), Heidelberg, Germany (A.K., A.v.D., D.C.); German Cancer Consortium (DKTK), German Cancer Research Ce

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June 2016

Proton beam therapy for medulloblastoma.

Lancet Oncol 2016 05 27;17(5):e174. Epub 2016 Apr 27.

University of Nottingham, Nottingham, UK.

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May 2016

Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response.

Oncotarget 2015 Sep;6(26):22191-205

Children's Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

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September 2015

Expression alterations define unique molecular characteristics of spinal ependymomas.

Oncotarget 2015 Aug;6(23):19780-91

Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre University of Nottingham, Nottingham, UK.

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August 2015

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.

Lancet Oncol 2015 May 14;16(5):569-82. Epub 2015 Apr 14.

Division of Hematology-Oncology, University of Toronto, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, University of Toronto, Toronto, ON, Canada. Electronic address:

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May 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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March 2015

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.

PLoS One 2014 15;9(1):e86187. Epub 2014 Jan 15.

Children's Brain Tumour Research Centre, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom.

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September 2014

Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix.

PLoS One 2013 14;8(10):e77435. Epub 2013 Oct 14.

Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.

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June 2014

Texture analysis of T1 - and T2 -weighted MR images and use of probabilistic neural network to discriminate posterior fossa tumours in children.

NMR Biomed 2014 Jun 13;27(6):632-9. Epub 2014 Apr 13.

Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK; School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

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June 2014

Overcoming multiple drug resistance mechanisms in medulloblastoma.

Acta Neuropathol Commun 2014 May 30;2:57. Epub 2014 May 30.

Children's Brain Tumour Research Centre, Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, QMC, Nottingham NG7 2UH, UK.

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May 2014

The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.

Acta Neuropathol Commun 2014 Feb 18;2:23. Epub 2014 Feb 18.

Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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February 2014

PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival.

Clin Cancer Res 2013 Dec 27;19(23):6450-60. Epub 2013 Sep 27.

Authors' Affiliation: Children's Brain Tumour Research Centre, D Floor Medical School, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

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December 2013

Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro.

Cancer Res 2013 Sep 25;73(18):5834-44. Epub 2013 Jul 25.

Authors' Affiliations: Division of Neuropathology, Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London; Department of Histopathology, Neural Development Unit, and UCL Genomics, UCL Institute of Child Health, Great Ormond Street Hospital, London; and Children's Brain Tumour Research Centre, Queen's Medical Centre, Nottingham, United Kingdom.

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September 2013

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics.

Neuro Oncol 2013 Aug 12;15(8):981-9. Epub 2013 Apr 12.

Division of Radiological and Imaging Sciences, University of Nottingham, Nottingham, United Kingdom.

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August 2013

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

PLoS One 2012 18;7(12):e52335. Epub 2012 Dec 18.

Children's Brain Tumour Research Centre, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom.

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June 2013

Loss of INI1 protein expression defines a subgroup of aggressive central nervous system primitive neuroectodermal tumors.

Brain Pathol 2013 Jan 25;23(1):19-27. Epub 2012 Jun 25.

Children's Brain Tumour Research Centre, School of Clinical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

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January 2013

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma.

Acta Neuropathol 2012 Jul 7;124(1):99-110. Epub 2012 Feb 7.

Children's Brain Tumour Research Centre, Medical School, Queen's Medical Centre Campus, University of Nottingham, Nottingham, UK.

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July 2012

Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target.

Neuro Oncol 2011 Nov 17;13(11):1171-7. Epub 2011 Aug 17.

Children's Brain Tumor Research Centre, University of Nottingham, Nottingham, UK.

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November 2011

Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.

Neuro Oncol 2011 Aug;13(8):866-79

Children’s Brain Tumour Research Centre, School of Clinical Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

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August 2011

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion.

Neuro Oncol 2011 Jan 25;13(1):70-83. Epub 2010 Oct 25.

Children's Brain Tumour Research Centre, School of Clinical Sciences, University of Nottingham, CBTRC, D32 Medical School, QMC, Clifton Boulevard, Nottingham NG7 2UH, UK.

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January 2011

Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high-grade childhood brain tumor cells.

Mol Cancer Ther 2010 Sep 19;9(9):2568-81. Epub 2010 Jul 19.

Children's Brain Tumor Research Centre, Medical School, University of Nottingham, Nottingham, United Kingdom.

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September 2010

On the importance of accounting for competing risks in pediatric cancer trials designed to delay or avoid radiotherapy: I. Basic concepts and first analyses.

Int J Radiat Oncol Biol Phys 2010 Apr 4;76(5):1493-9. Epub 2009 Jul 4.

Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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April 2010

A quantitative comparison of metabolite signals as detected by in vivo MRS with ex vivo 1H HR-MAS for childhood brain tumours.

NMR Biomed 2009 Feb;22(2):213-9

Academic Department of Paediatrics and Child Health, University of Birmingham, UK.

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February 2009

High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours.

Mol Cancer 2009 Feb 10;8. Epub 2009 Feb 10.

Cancer Sciences, University of Birmingham, Birmingham, UK.

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February 2009

Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothalamic damage in children.

Eur J Endocrinol 2008 Dec 26;159(6):791-7. Epub 2008 Sep 26.

Department of Endocrinology, Birmingham Children's Hospital, Birmingham, B4 6NH, UK.

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December 2008

Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas.

Eur J Cancer 2008 Nov 1;44(17):2640-7. Epub 2008 Oct 1.

Department of Academic Paediatrics and Child Health, University of Birmingham, Birmingham, UK.

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November 2008

Reductions in basal metabolic rate and physical activity contribute to hypothalamic obesity.

J Clin Endocrinol Metab 2008 Jul 15;93(7):2588-93. Epub 2008 Apr 15.

Department of Endocrinology, Birmingham Children's Hospital, Birmingham, United Kingdom.

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July 2008

The use of short-echo-time 1H MRS for childhood cerebellar tumours prior to histopathological diagnosis.

Pediatr Radiol 2007 Nov 7;37(11):1101-9. Epub 2007 Sep 7.

Academic Department of Paediatrics and Child Health, University of Birmingham, Whittall Street, Birmingham, B4 6NH, UK.

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November 2007

Magnetic resonance spectroscopy suggests key differences in the metastatic behaviour of medulloblastoma.

Eur J Cancer 2007 Apr 8;43(6):1037-44. Epub 2007 Mar 8.

Academic Department of Paediatrics and Child Health, University of Birmingham, Whittall Street, Birmingham B4 6NH, UK.

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April 2007

Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior.

Brain Pathol 2007 Apr;17(2):151-64

Northern Institute for Cancer Research, University of Newcastle, and Department of Neuropathology, Newcastle-upon-Tyne Hospitals Trust, Newcastle-upon-Tyne, UK.

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April 2007

Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy.

Cancer Chemother Pharmacol 2004 Oct 4;54(4):295-300. Epub 2004 May 4.

Northern Institute for Cancer Research, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK.

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October 2004

Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer.

Oncogene 2002 Oct;21(47):7277-82

Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, UK.

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October 2002