Richard G Brennan

Richard G Brennan

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MarR family proteins are important regulators of clinically relevant antibiotic resistance.

Protein Sci 2020 03 14;29(3):647-653. Epub 2019 Nov 14.

Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1002/pro.3769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020996PMC
March 2020

c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.

Mol Cell 2020 02 3;77(3):586-599.e6. Epub 2019 Dec 3.

Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005675PMC
February 2020

When is a transcription factor a NAP?

Curr Opin Microbiol 2020 Feb 28;55:26-33. Epub 2020 Feb 28.

Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2020.01.019DOI Listing
February 2020

The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3.

Cell Host Microbe 2020 01 31;27(1):129-139.e4. Epub 2019 Dec 31.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Duke University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952535PMC
January 2020

Dissection of the molecular circuitry controlling virulence in .

Genes Dev 2017 08 1;31(15):1549-1560. Epub 2017 Sep 1.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.303701.117
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http://dx.doi.org/10.1101/gad.303701.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630020PMC
August 2017

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.

Microbiol Mol Biol Rev 2017 06 15;81(2). Epub 2017 Mar 15.

Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

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http://dx.doi.org/10.1128/MMBR.00053-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485801PMC
June 2017

The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.

Nucleic Acids Res 2017 Jun;45(11):6923-6933

Institut für Biologie/Mikrobiologie, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.

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http://dx.doi.org/10.1093/nar/gkx287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499655PMC
June 2017

Trehalose pathway as an antifungal target.

Virulence 2017 02 1;8(2):143-149. Epub 2016 Jun 1.

a Departments of Medicine and Biochemistry , Duke University Medical Center , Durham , NC , USA.

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http://dx.doi.org/10.1080/21505594.2016.1195529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383216PMC
February 2017

Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA).

PLoS One 2015 29;10(6):e0128225. Epub 2015 Jun 29.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128225PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488300PMC
March 2016

HipBA-promoter structures reveal the basis of heritable multidrug tolerance.

Nature 2015 Aug 29;524(7563):59-64. Epub 2015 Jul 29.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nature14662DOI Listing
August 2015

Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus.

J Bacteriol 2015 Mar 12;197(6):1104-14. Epub 2015 Jan 12.

The John D. Dingell Department of Veterans Affairs Medical Center, Detroit, Michigan, USA Department of Medicine, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA

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http://dx.doi.org/10.1128/JB.02558-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336350PMC
March 2015

Glutathione activates virulence gene expression of an intracellular pathogen.

Nature 2015 Jan;517(7533):170-3

1] Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA [2] School of Public Health, University of California, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nature14029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305340PMC
January 2015

Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes.

RNA 2014 Oct 22;20(10):1548-59. Epub 2014 Aug 22.

Department of Biochemistry, Duke University, Durham, North Carolina 27110, USA

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http://dx.doi.org/10.1261/rna.044032.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174437PMC
October 2014

Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.

Cell 2014 Aug;158(5):1136-1147

Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151990PMC
August 2014

Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching.

Nucleic Acids Res 2014 Feb 27;42(4):2736-49. Epub 2013 Nov 27.

Department of Biochemistry, Duke University, Durham, NC 27710, USA and Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/nar/gkt1171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936774PMC
February 2014

Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.

Nucleic Acids Res 2014 Feb 28;42(4):2774-88. Epub 2013 Nov 28.

Department of Biochemistry, Duke University School of Medicine, 307 Research Drive, Durham, NC 27710, USA, The John D. Dingell Department of Veterans Affairs Medical Center, B4333 JD Dingel VA Medical Center, 4646 John R, Detroit, MI 48201, USA and Department of Internal Medicine, Division of Infectious Diseases, Wayne State University School of Medicine, 5 Hudson, Harper University Hospital, 3990 John R, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1093/nar/gkt1215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936728PMC
February 2014

The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.

mBio 2013 Aug 27;4(5):e00528-13. Epub 2013 Aug 27.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.

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http://dx.doi.org/10.1128/mBio.00528-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760248PMC
August 2013

Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.

Laryngoscope 2013 Jun 26;123(6):1416-23. Epub 2013 Apr 26.

Departments of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/lary.23846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664100PMC
June 2013

Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity.

Nat Struct Mol Biol 2013 Jun 5;20(6):740-7. Epub 2013 May 5.

Genomic Medicine Program, The Methodist Hospital Research Institute, Houston, Texas, USA.

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http://dx.doi.org/10.1038/nsmb.2568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676455PMC
June 2013

Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis.

PLoS One 2012 15;7(6):e39185. Epub 2012 Jun 15.

Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039185PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376134PMC
December 2012

Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract.

Nucleic Acids Res 2012 Nov 10;40(21):11023-35. Epub 2012 Sep 10.

Department of Biochemistry and Molecular Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/nar/gks809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505971PMC
November 2012

The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding.

Nucleic Acids Res 2011 Nov 10;39(21):9433-47. Epub 2011 Aug 10.

Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

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http://dx.doi.org/10.1093/nar/gkr640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241653PMC
November 2011

C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation.

J Mol Biol 2010 Nov 1;404(2):173-82. Epub 2010 Oct 1.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S002228361001037
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http://dx.doi.org/10.1016/j.jmb.2010.09.038DOI Listing
November 2010

Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.

J Mol Biol 2010 Apr 15;398(2):264-75. Epub 2010 Mar 15.

Department of Biochemistry and Molecular Biology, Center for Biomolecular Structure and Function, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00222836100024
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http://dx.doi.org/10.1016/j.jmb.2010.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856848PMC
April 2010

A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection.

PLoS Pathog 2010 Mar 19;6(3):e1000817. Epub 2010 Mar 19.

Department of Infectious Diseases, MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841617PMC
March 2010

Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit.

PLoS One 2010 Jan 13;5(1):e8664. Epub 2010 Jan 13.

Department of Science & Engineering, School of Medicine, Oregon Health & Science University, Beaverton, Oregon, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008664PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801614PMC
January 2010

Structure of Escherichia coli Hfq bound to polyriboadenylate RNA.

Proc Natl Acad Sci U S A 2009 Nov 4;106(46):19292-7. Epub 2009 Nov 4.

Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1073/pnas.0908744106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773200PMC
November 2009

Optimized production and analysis of the staphylococcal multidrug efflux protein QacA.

Protein Expr Purif 2009 Apr 6;64(2):118-24. Epub 2008 Dec 6.

School of Biological Sciences, University of Sydney, Sydney, NSW, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S104659280800318
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http://dx.doi.org/10.1016/j.pep.2008.11.009DOI Listing
April 2009

Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.

Nucleic Acids Res 2009 Mar 7;37(4):1211-24. Epub 2009 Jan 7.

Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkn1046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651776PMC
March 2009

Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.

Science 2009 Jan;323(5912):396-401

Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Unit 1000, Houston, TX 77030, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1163806
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http://dx.doi.org/10.1126/science.1163806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764309PMC
January 2009

Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion.

J Biol Chem 2008 Sep 25;283(39):26795-804. Epub 2008 Jul 25.

Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA.

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http://dx.doi.org/10.1074/jbc.M804191200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546531PMC
September 2008

QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.

Biochemistry 2008 Aug 11;47(31):8122-9. Epub 2008 Jul 11.

School of Biological Sciences, A12, University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1021/bi8008246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646753PMC
August 2008

Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis.

Mol Microbiol 2008 Jul;69(2):436-52

Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2008.06290.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761070PMC
July 2008

A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus.

Proc Natl Acad Sci U S A 2008 Feb 29;105(5):1698-703. Epub 2008 Jan 29.

Departments of Medicine and Pathology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0711767105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234207PMC
February 2008

Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.

Mol Cell 2007 Nov;28(4):652-64

Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650700628
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http://dx.doi.org/10.1016/j.molcel.2007.09.016DOI Listing
November 2007

Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions.

J Am Chem Soc 2007 Jul 13;129(26):8389-95. Epub 2007 Jun 13.

Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Unit 1000, Houston, TX 77030, USA.

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http://dx.doi.org/10.1021/ja072576vDOI Listing
July 2007

Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate.

J Mol Biol 2007 May 27;368(4):1042-50. Epub 2007 Feb 27.

Department of Biochemistry and Molecular Biology, Unit 1000, University of Texas, MD Anderson Cancer Center University, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.02.054DOI Listing
May 2007

Hfq structure, function and ligand binding.

Curr Opin Microbiol 2007 Apr 28;10(2):125-33. Epub 2007 Mar 28.

Department of Biochemistry and Molecular Biology, Unit 1000 University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1016/j.mib.2007.03.015DOI Listing
April 2007

Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.

J Biol Chem 2006 Dec 18;281(49):37942-51. Epub 2006 Sep 18.

Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1074/jbc.M605198200DOI Listing
December 2006

Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.

J Biol Chem 2006 Mar 29;281(10):6793-800. Epub 2005 Nov 29.

Department of Biochemistry & Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M509977200DOI Listing
March 2006

Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase.

Proc Natl Acad Sci U S A 2005 Nov 25;102(44):15839-44. Epub 2005 Oct 25.

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239.

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http://dx.doi.org/10.1073/pnas.0506592102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266077PMC
November 2005

Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family.

Mol Cell 2005 Oct;20(1):131-41

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.09.013DOI Listing
October 2005

Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif.

Biochemistry 2005 Sep;44(37):12515-24

Department of Molecular Microbiology and Immunology, School of Medicine, Oregon Health and Sciences University, 3181 SE Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1021/bi0511080DOI Listing
September 2005

Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae.

J Bacteriol 2005 Jul;187(14):5008-12

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, 97239-3098, USA.

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http://dx.doi.org/10.1128/JB.187.14.5008-5012.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1169513PMC
July 2005

Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.

Cell 2004 Sep;118(6):731-41

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland 97239, USA.

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http://dx.doi.org/10.1016/j.cell.2004.08.027DOI Listing
September 2004

Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein.

EMBO J 2004 Aug 15;23(15):2923-30. Epub 2004 Jul 15.

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97201-3098, USA.

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http://emboj.embopress.org/content/embojnl/23/15/2923.full.p
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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600288
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http://dx.doi.org/10.1038/sj.emboj.7600288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514915PMC
August 2004

The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.

J Biol Chem 2004 May 24;279(19):20356-62. Epub 2004 Feb 24.

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1074/jbc.M400960200DOI Listing
May 2004

Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.

J Biol Chem 2004 Apr 15;279(14):14365-71. Epub 2004 Jan 15.

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313870200
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http://dx.doi.org/10.1074/jbc.M313870200DOI Listing
April 2004

Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.

Nat Struct Biol 2003 Aug;10(8):652-7

Department of Chemistry, Reed College, 3203 SE Woodstock Blvd., Portland, Oregon 97202, USA.

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http://dx.doi.org/10.1038/nsb951DOI Listing
August 2003

Deciphering the molecular basis of multidrug recognition: crystal structures of the Staphylococcus aureus multidrug binding transcription regulator QacR.

Res Microbiol 2003 Mar;154(2):69-77

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1016/S0923-2508(02)00013-XDOI Listing
March 2003

Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae.

J Mol Biol 2003 Feb;326(4):1203-17

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1016/s0022-2836(02)01378-5DOI Listing
February 2003

Structural biology of bacterial multidrug resistance gene regulators.

J Biol Chem 2002 Oct 22;277(43):40169-72. Epub 2002 Aug 22.

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1074/jbc.R200018200DOI Listing
October 2002

Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors.

Mol Microbiol 2002 Aug;45(4):885-93

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201, USA.

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http://dx.doi.org/10.1046/j.1365-2958.2002.03039.xDOI Listing
August 2002

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.

EMBO J 2002 Jul;21(13):3546-56

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201-3098, USA.

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http://dx.doi.org/10.1093/emboj/cdf322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126077PMC
July 2002

Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae.

Acta Crystallogr D Biol Crystallogr 2002 Mar 21;58(Pt 3):515-8. Epub 2002 Feb 21.

Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstrasse 5, D-91058 Erlangen, Germany.

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http://dx.doi.org/10.1107/s090744490102145xDOI Listing
March 2002

Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.

EMBO J 2002 Mar;21(5):1210-8

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97201-3098, USA.

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http://dx.doi.org/10.1093/emboj/21.5.1210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125875PMC
March 2002

Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani.

Biochemistry 2002 Mar;41(12):4020-31

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201-3098, USA.

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http://dx.doi.org/10.1021/bi0158730DOI Listing
March 2002

Prokaryotic transcription regulators: more than just the helix-turn-helix motif.

Curr Opin Struct Biol 2002 Feb;12(1):98-106

Department of Biochemistry and Molecular Biology, L-224, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA.

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http://dx.doi.org/10.1016/s0959-440x(02)00295-6DOI Listing
February 2002

The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase.

Proc Natl Acad Sci U S A 2002 Jan 2;99(1):78-83. Epub 2002 Jan 2.

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201-3098, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.012399599
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http://dx.doi.org/10.1073/pnas.012399599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117517PMC
January 2002

Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.

Biochemistry 2002 Jan;41(2):511-20

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1021/bi0156660DOI Listing
January 2002

Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.

Mol Cell 2002 Jan;9(1):23-30

Department of Biochemistry and Molecular Biology, University of Southern Denmark-Odense, Campusvej 55, DK-5230 M, Odense, Denmark.

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http://dx.doi.org/10.1016/s1097-2765(01)00436-1DOI Listing
January 2002