Richard F Schlenk

Richard F Schlenk

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Richard F Schlenk

Publications by authors named "Richard F Schlenk"

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Adjusting Simon's optimal two-stage design for heterogeneous populations based on stratification or using historical controls.

Biom J 2019 Sep 25. Epub 2019 Sep 25.

Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/bimj.201800390DOI Listing
September 2019

Midostaurin: A Multiple Tyrosine Kinases Inhibitor in Acute Myeloid Leukemia and Systemic Mastocytosis.

Recent Results Cancer Res 2018;212:199-214

Department of Internal Medicine V, University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-3-319-91439-8_10DOI Listing
May 2019

What's new in consolidation therapy in AML?

Semin Hematol 2019 Apr 29;56(2):96-101. Epub 2018 Aug 29.

Department of Hematology, Oncology, and Rheumatology at Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1053/j.seminhematol.2018.08.005DOI Listing
April 2019

Targeting FLT3 mutations in AML: review of current knowledge and evidence.

Leukemia 2019 02 16;33(2):299-312. Epub 2019 Jan 16.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

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http://www.nature.com/articles/s41375-018-0357-9
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http://dx.doi.org/10.1038/s41375-018-0357-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365380PMC
February 2019

Improving consolidation therapy in acute myeloid leukemia - a tough nut to crack.

Haematologica 2018 10;103(10):1579-1581

Department of Hematology, Oncology, and Rheumatology at Heidelberg University Hospital, University of Heidelberg, Germany.

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http://dx.doi.org/10.3324/haematol.2018.200485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165816PMC
October 2018

Acute myelogenous leukemia in adolescents and young adults.

Pediatr Blood Cancer 2018 09 18;65(9):e27089. Epub 2018 Apr 18.

Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.27089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105504PMC
September 2018

Management of patients with acute promyelocytic leukemia.

Leukemia 2018 06 24;32(6):1277-1294. Epub 2018 Apr 24.

Medical Clinic I, University Hospital Carl-Gustav-Carus, Dresden, Germany.

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http://dx.doi.org/10.1038/s41375-018-0139-4DOI Listing
June 2018

A new option for remission induction in acute myeloid leukaemia.

Lancet Oncol 2018 02 12;19(2):156-157. Epub 2018 Jan 12.

Trial Center, National Center for Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(18)30012-3DOI Listing
February 2018

Relapsed/refractory acute myeloid leukemia: any progress?

Curr Opin Oncol 2017 Nov;29(6):467-473

aNCT-Trial Center, German Cancer Research Center bDepartment of Hematology and Oncology, University of Heidelberg cDivision of Biostatistics, German Cancer Research Center dInstitute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/CCO.0000000000000404DOI Listing
November 2017

Midostaurin treatment in FLT3-mutated acute myeloid leukemia and systemic mastocytosis.

Expert Rev Clin Pharmacol 2017 Nov 10;10(11):1177-1189. Epub 2017 Oct 10.

d National Center for Tumor Diseases , Heidelberg , Germany.

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http://dx.doi.org/10.1080/17512433.2017.1387051DOI Listing
November 2017

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation.

N Engl J Med 2017 08 23;377(5):454-464. Epub 2017 Jun 23.

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (R.M.S.); the Division of Biomedical Statistics and Informatics (S.J.M., K.L.) and the Alliance Statistics and Data Center (S.J.M., K.L., S.G.), Mayo Clinic, Rochester, MN; the Alliance Statistics and Data Center, Duke University, Durham, NC (B.L.S.); the Ohio State University Comprehensive Cancer Center, Columbus (S.G., C.D.B., T.W.P., G.M., R.B.K.); Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden (C.T., G.E.), Department of Internal Medicine III, University Hospital of Ulm, Ulm (K.D., R.F.S., H.D.), Hematology and Oncology, University of Leipzig, Leipzig (D.N.), Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover (J.K., A.G.), and Department of Medicine II, Hematology-Oncology, Goethe University Hospital Frankfurt, Frankfurt am Main (H.S.) - all in Germany; the Department of Biomedicine and Prevention, University Tor Vergata, Rome (F.L.-C., S.A.); the Department of Clinical Haematology, Alfred Hospital and Monash University, Melbourne, VIC, Australia (A.W.); Hospital de la Santa Creu i Sant Pau, Hematology Department, Autonomous University of Barcelona, Barcelona (J.S.), and Hospital Universitario la Fe, Hematology Department, Department of Medicine, University of Valencia, Valencia (M.A.S.) - both in Spain; the Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto (J.M.B.); Radboud Institute Molecular Studies, Radboud University Medical Center, Nijmegen, the Netherlands (T.W.); the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle (F.R.A.); the Division of Hematology-Oncology, Stanford Comprehensive Cancer Center, Stanford University, Stanford, CA (B.C.M.); the Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York (M.S.T.); and the Department of Medicine, University of Chicago, Chicago (R.A.L.).

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http://dx.doi.org/10.1056/NEJMoa1614359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754190PMC
August 2017

Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling.

PLoS One 2016 9;11(5):e0155226. Epub 2016 May 9.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861340PMC
July 2017

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial.

J Clin Oncol 2017 Feb 31;35(6):605-612. Epub 2016 Oct 31.

Uwe Platzbecker, Christian Thiede, Christoph Röllig, and Gerhard Ehninger, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden; Uwe Platzbecker and Gerhard Ehninger, Study Alliance Leukemia, Dresden; Walter Fiedler, University Hospital Hamburg-Eppendorf; Norbert Schmitz, Asklepios Klinik St Georg Hamburg, Hamburg; Peter Brossart, Innere Medizin mit deSchwerpunkten Onkologie, Haematollogie un Rheumatologie, Bonn; Bernd Hertenstein, Klinikum Bremen Mitte, Bremen; Helmut R. Salih, University Hospital Tubingen; Mohammed Wattad, Kliniken Essen Süd, Essen; Michael Lübbert, University Medical Center, Freiburg; Christian H. Brandts, Goethe University Frankfurt, Frankfurt; Mathias Hänel, Klinikum Chemnitz gGmbH, Chemnitz; Hartmut Link, Klinik für Innere Medizin I, Westpfalz-Klinikum, Kaiserslautern; Konstanze Döhner, Hartmut Döhner, and Richard F. Schlenk, University Hospital Ulm, Ulm; Arnold Ganser, Hannover Medical School, Hannover, Germany; Giuseppe Avvisati, University Campus Bio-Medico; Laura Cicconi, Mariadomenica Divona, Sergio Amadori, and Francesco Lo-Coco, University Tor Vergata; Francesca Paoloni, Marco Vignetti, Fabio Efficace, Paola Fazi, and Franco Mandelli, Gruppo Italiano Malattie Ematologiche dell'Adulto Central Office; Marco Vignetti and Massimo Breccia, Sapienza University, Rome; Felicetto Ferrara, Cardarelli Hospital, Naples; Francesco Albano, University of Bari, Bari; Marco Sborgia, U.O. di Ematologia Clinica, Pescara; Eros Di Bona, San Bortolo Hospital, Vicenza; Erika Borlenghi, U.O. di Ematologia, Spedali Civili, Brescia; Roberto Cairoli, Ospedale Niguarda, Ca' Granda, SC Ematologia; Agostino Cortelezzi, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milano; Alessandro Rambaldi, Azienda Opsedaliera Papa Giovanni XXIII, Bergamo; Lorella Melillo, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo; Giorgio La Nasa, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, Università di Cagliari, Cagliari; Chiara Frairia, Hematology, Città della Salute e della Scienza, Torino; Enrico Maria Pogliani, Ospedale San Gerardo, Università degli Studi Milano Bicocca, Monza; Claudio Fozza, University of Sassari, Sassari; Alfonso Maria D'Arco, U.O. Medicina Interna e Onco-Ematologica P.O. "Umberto I," Nocera Inferiore, Nocera Inferiore; Nicola Di Renzo, Ospedale Vito Fazzi, Lecce; and Francesco Fabbiano, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.

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http://dx.doi.org/10.1200/JCO.2016.67.1982DOI Listing
February 2017

Is there justification for 4 cycles of consolidation therapy in AML?

Best Pract Res Clin Haematol 2016 12 20;29(4):341-344. Epub 2016 Oct 20.

National Center of Tumor Diseases, Clinical Trials Center, Im Neuenheimer Feld 130.3, Marsilius Arkaden, Heidelberg 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.10.008DOI Listing
December 2016

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

Targeted Therapy Alone for Acute Promyelocytic Leukemia.

N Engl J Med 2016 Mar;374(12):1197-8

University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1056/NEJMc1513710DOI Listing
March 2016

How I treat refractory and early relapsed acute myeloid leukemia.

Blood 2015 Jul 7;126(3):319-27. Epub 2015 Apr 7.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany; and.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-10-55
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http://dx.doi.org/10.1182/blood-2014-10-551911DOI Listing
July 2015

Minimal residual disease in acute myeloid leukemia--current status and future perspectives.

Curr Hematol Malig Rep 2015 Jun;10(2):132-44

Department of Internal Medicine V, University Hospital of Heidelberg, Heidelberg, Germany,

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http://dx.doi.org/10.1007/s11899-015-0260-7DOI Listing
June 2015

Minimal residual disease-directed therapy in acute myeloid leukemia.

Blood 2015 Apr 28;125(15):2331-5. Epub 2015 Jan 28.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and Department of Medicine, Division of Hematology, and Department of Epidemiology, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1182/blood-2014-11-578815DOI Listing
April 2015

Genomic applications in the clinic: use in treatment paradigm of acute myeloid leukemia.

Hematology Am Soc Hematol Educ Program 2013 ;2013:324-30

1Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany.

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http://dx.doi.org/10.1182/asheducation-2013.1.324DOI Listing
December 2014

Post-remission therapy for acute myeloid leukemia.

Haematologica 2014 Nov;99(11):1663-70

Department of Internal Medicine III, University Hospital Ulm, Germany.

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http://dx.doi.org/10.3324/haematol.2014.114611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222459PMC
November 2014

Randomized phase III trial of retinoic acid and arsenic trioxide versus retinoic acid and chemotherapy in patients with acute promyelocytic leukemia: health-related quality-of-life outcomes.

J Clin Oncol 2014 Oct 22;32(30):3406-12. Epub 2014 Sep 22.

Fabio Efficace, Franco Mandelli, Francesco Cottone, and Marco Vignetti, Gruppo Italiano Malattie Ematologiche dell'Adulto; Giuseppe Avvisati, Università Campus Biomedico; Massimo Breccia, Università "La Sapienza,"; Simona Sica, Università Cattolica Sacro Cuore; Sergio Amadori and Francesco Lo-Coco, Università Tor Vergata; Francesco Lo-Coco, Fondazione Santa Lucia, Roma; Felicetto Ferrara, Ospedale Cardarelli; Olimpia Finizio, Ospedale Cardarelli, Napoli; Eros Di Bona, Ospedale San Bortolo, Vicenza; Giorgina Specchia, Università di Bari, Bari; Alessandro Levis, Ospedale SS Antonio e Biagio, Alessandria; Maria Grazia Kropp, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro; Giuseppe Fioritoni, Ospedale Civile, Pescara; Elisa Cerqui, Spedali Civili, Brescia, Italy; Richard F. Schlenk, University of Ulm, Ulm; and Uwe Platzbecker, Universitatsklinikum Carl Gustav Carus, Dresden, Germany.

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http://dx.doi.org/10.1200/JCO.2014.55.3453DOI Listing
October 2014

Gemtuzumab ozogamicin in acute myeloid leukemia revisited.

Expert Opin Biol Ther 2014 Aug 28;14(8):1185-95. Epub 2014 May 28.

Hannover Medical School, Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation , Carl-Neuberg-Str. 1, 30625, Hannover , Germany.

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http://dx.doi.org/10.1517/14712598.2014.922534DOI Listing
August 2014

Gemtuzumab ozogamicin in non-acute promyelocytic acute myeloid leukemia.

Expert Opin Biol Ther 2011 Oct 3;11(10):1369-80. Epub 2011 Aug 3.

University of Ulm, Department of Internal Medicine III, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

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http://dx.doi.org/10.1517/14712598.2011.604630DOI Listing
October 2011

Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML.

Genes Chromosomes Cancer 2011 Jan;50(1):51-8

Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/gcc.20830DOI Listing
January 2011

KIT mutations confer a distinct gene expression signature in core binding factor leukaemia.

Br J Haematol 2010 Mar 8;148(6):925-37. Epub 2010 Jan 8.

Department of Internal Medicine III, Ulm University, Albert-Einstein-Allee 23, Ulm, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2009.08035.xDOI Listing
March 2010

Quantitative DNA methylation predicts survival in adult acute myeloid leukemia.

Blood 2010 Jan 10;115(3):636-42. Epub 2009 Nov 10.

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1182/blood-2009-03-211003DOI Listing
January 2010

Impact of new prognostic markers in treatment decisions in acute myeloid leukemia.

Curr Opin Hematol 2009 Mar;16(2):98-104

Department of Internal Medicine III, University Hospital of Ulm, Germany.

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http://dx.doi.org/10.1097/MOH.0b013e3283257adbDOI Listing
March 2009