Richard F Loeser

Richard F Loeser

UNVERIFIED PROFILE

Are you Richard F Loeser?   Register this Author

Register author
Richard F Loeser

Richard F Loeser

Publications by authors named "Richard F Loeser"

Are you Richard F Loeser?   Register this Author

95Publications

757Reads

-Profile Views

Vitamin K status and mobility limitation and disability in older adults: The Health, Aging, and Body Composition Study.

J Gerontol A Biol Sci Med Sci 2019 May 6. Epub 2019 May 6.

USDA Human Nutrition Research Center on Aging at Tufts University, Boston MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/gerona/glz108DOI Listing
May 2019

Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2.

Am J Pathol 2019 Apr 19;189(4):868-885. Epub 2019 Jan 19.

Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446226PMC
April 2019

Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017.

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland. Research for this article was supported by the NIHR Oxford BRC (T.O. Smith) and the Leeds BRC (Prof. P.G. Conaghan). The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the UK Department of Health. C.H. Ladel is an employee of Merck Biopharma, Merck KgaA, and Dr. G. Kalsi is an employee of TissueGene Inc. T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC. Address correspondence to Professor P.G. Conaghan, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Chapeltown Road, Leeds, LS4 7SA, UK. E-mail: Accepted for publication December 3, 2018.

View Article

Download full-text PDF

Source
http://www.jrheum.org/lookup/doi/10.3899/jrheum.181066
Publisher Site
http://dx.doi.org/10.3899/jrheum.181066DOI Listing
March 2019

Reactive oxygen species, aging and articular cartilage homeostasis.

Free Radic Biol Med 2019 Feb 31;132:73-82. Epub 2018 Aug 31.

Division of Rheumatology, Allergy, and Immunology, University of North Carolina, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342625PMC
February 2019

Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes.

Free Radic Biol Med 2019 Jan 9;134:139-152. Epub 2019 Jan 9.

Division of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08915849183252
Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.005DOI Listing
January 2019

The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; NIHR Leeds Biomedical Research Centre, Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; Inner West Psychology; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, Approches Épidémiologiques et Psychologiques (APEMAC), Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston, Massachusetts; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland. This research was supported by the NIHR Oxford Biomedical Research Centre (T.O. Smith) and the NIHR Leeds Biomedical Research Centre (Prof. Conaghan). The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology, Chair of Institute of Bone and Joint Research, Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers, location VUmc; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; S. Dodd, PhD, Lecturer in Biostatistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, Sydney, Australia, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritius Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre. Address correspondence to Professor P.G. Conaghan, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Chapeltown Road, Leeds, LS4 7SA, UK. E-mail: Requests can be made to the corresponding author for access to data relating to the work conducted. Accepted for publication December 3, 2018.

View Article

Download full-text PDF

Source
http://www.jrheum.org/lookup/doi/10.3899/jrheum.181194
Publisher Site
http://dx.doi.org/10.3899/jrheum.181194DOI Listing
January 2019

Does Joint Injury Make Young Joints Old?

J Am Acad Orthop Surg 2018 Nov;26(21):e455-e456

From the Departments of Biomedical Engineering (Dr. Diekman) and Medicine (Dr. Collins and Dr. Loeser), Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5435/JAAOS-D-18-00394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203621PMC
November 2018

The Role of Aging in the Development of Osteoarthritis.

Authors:
Richard F Loeser

Trans Am Clin Climatol Assoc 2017 ;128:44-54

CHAPEL HILL, NORTH CAROLINA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525396PMC
May 2018

Is osteoarthritis one disease or a collection of many?

Rheumatology (Oxford) 2018 05;57(suppl_4):iv34-iv42

Division of Rheumatology, Allergy, and Immunology, Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kex417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251697PMC
May 2018

Expression of p16 is a biomarker of chondrocyte aging but does not cause osteoarthritis.

Aging Cell 2018 May 9:e12771. Epub 2018 May 9.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.12771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052464PMC
May 2018

Time between anterior cruciate ligament injury and reconstruction and cartilage metabolism six-months following reconstruction.

Knee 2018 Mar 7;25(2):296-305. Epub 2018 Mar 7.

Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.knee.2018.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886724PMC
March 2018

Targeting aging for disease modification in osteoarthritis.

Curr Opin Rheumatol 2018 Jan;30(1):101-107

Division of Rheumatology, Allergy, and Immunology.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BOR.0000000000000456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886778PMC
January 2018

A mouse model for chronic pain-induced increase in ethanol consumption.

Pain 2017 03;158(3):457-462

aBowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA bDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA cThurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA dDivision of Rheumatology, Allergy and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, Department of Medicine eDepartment of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA fCurriculum in Neurobiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA gThe UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000000780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303149PMC
March 2017

Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor.

Arthritis Rheumatol 2017 Feb;69(2):352-361

Wake Forest School of Medicine, Winston-Salem, North Carolina, and University of North Carolina at Chapel Hill.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.39844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274570PMC
February 2017

Relationship of Objectively-Measured Habitual Physical Activity to Chronic Inflammation and Fatigue in Middle-Aged and Older Adults.

J Gerontol A Biol Sci Med Sci 2016 11 5;71(11):1437-1443. Epub 2016 Jul 5.

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055652PMC
http://dx.doi.org/10.1093/gerona/glw131DOI Listing
November 2016

Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.

J Gerontol A Biol Sci Med Sci 2016 10 17;71(10):1348-55. Epub 2015 Nov 17.

Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/gerona/glv209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018560PMC
October 2016

Ageing and the pathogenesis of osteoarthritis.

Nat Rev Rheumatol 2016 07 19;12(7):412-20. Epub 2016 May 19.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, 450 West Drive, Campus Box 7295, Chapel Hill, North Carolina 27599-7295, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrrheum.2016.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938009PMC
July 2016

Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.

J Biol Chem 2016 Mar 21;291(13):6641-54. Epub 2016 Jan 21.

From the Division of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.693523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807251PMC
March 2016

Editorial: inflammatory activity in symptomatic knee osteoarthritis: not all inflammation is local.

Arthritis Rheumatol 2015 Nov;67(11):2797-800

University of North Carolina School of Medicine, Chapel Hill.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.39304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093334PMC
November 2015

Redox regulation of Rac1 by thiol oxidation.

Free Radic Biol Med 2015 Feb 5;79:237-50. Epub 2014 Oct 5.

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2014.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708892PMC
February 2015

Integrins and chondrocyte-matrix interactions in articular cartilage.

Authors:
Richard F Loeser

Matrix Biol 2014 Oct 25;39:11-6. Epub 2014 Aug 25.

Division of Rheumatology, Allergy, and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7280, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.matbio.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699681PMC
October 2014

Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat.

Med Sci Sports Exerc 2014 Sep;46(9):1677-83

1Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC; 2Department of Biostatistical Sciences, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC; 3Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC; 4Department of Exercise and Sport Science, East Carolina University, Greenville, NC; 5Department of Radiology, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC; 6Department of Rheumatology, Royal North Shore Hospital and Kolling Institute, University of Sydney, Sydney, AUSTRALIA; 7Section on Molecular Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC; and 8Department of Rheumatology and Immunology, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1249/MSS.0000000000000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137500PMC
September 2014

Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor 1 and osteogenic protein 1.

Arthritis Rheumatol 2014 Aug;66(8):2201-9

University of North Carolina, Chapel Hill, and Wake Forest University School of Medicine, Winston-Salem, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.38641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116467PMC
August 2014

Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis.

Gene 2014 May 12;542(1):38-45. Epub 2014 Mar 12.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2014.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031746PMC
May 2014

Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis.

PLoS One 2013 28;8(1):e54633. Epub 2013 Jan 28.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054633PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557277PMC
August 2013

Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments.

Arthritis Rheum 2013 Jun;65(6):1561-8

Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.37922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672376PMC
June 2013

Ionizing radiation causes active degradation and reduces matrix synthesis in articular cartilage.

Int J Radiat Biol 2013 Apr 12;89(4):268-77. Epub 2012 Dec 12.

Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/09553002.2013.747015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788671PMC
April 2013

Aging processes and the development of osteoarthritis.

Authors:
Richard F Loeser

Curr Opin Rheumatol 2013 Jan;25(1):108-13

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BOR.0b013e32835a9428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713615PMC
January 2013

Effects of aging on articular cartilage homeostasis.

Bone 2012 Aug 28;51(2):241-8. Epub 2012 Mar 28.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282120074
Publisher Site
http://dx.doi.org/10.1016/j.bone.2012.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372644PMC
August 2012

Osteoarthritis: a disease of the joint as an organ.

Arthritis Rheum 2012 Jun 5;64(6):1697-707. Epub 2012 Mar 5.

Wake Forest University School of Medicine, Winston-Salem, NC, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/art.34453
Publisher Site
http://dx.doi.org/10.1002/art.34453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366018PMC
June 2012

The effects of aging on the development of osteoarthritis.

Authors:
Richard F Loeser

HSS J 2012 Feb 23;8(1):18-9. Epub 2011 Dec 23.

Section of Molecular Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11420-011-9237-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295946PMC
February 2012

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes.

Arthritis Res Ther 2012 Jan 30;14(1):R23. Epub 2012 Jan 30.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/ar3705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392816PMC
January 2012

A Comprehensive Histological Assessment of Osteoarthritis Lesions in Mice.

Cartilage 2011 Oct;2(4):354-63

Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1947603511402665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297143PMC
October 2011

Aging and osteoarthritis.

Authors:
Richard F Loeser

Curr Opin Rheumatol 2011 Sep;23(5):492-6

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BOR.0b013e3283494005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377970PMC
September 2011

A comprehensive 3-year internal medicine residency research curriculum.

Am J Med 2011 May;124(5):469-73

Department of Internal Medicine, Section of General Internal Medicine, Winston Salem, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2011.01.006DOI Listing
May 2011

Regulation of chondrocyte gene expression by osteogenic protein-1.

Arthritis Res Ther 2011 Mar 29;13(2):R55. Epub 2011 Mar 29.

Department of Biochemistry, Rush University Medical Center, 1653 W, Congress Parkway, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://arthritis-research.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/ar3300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132046PMC
March 2011

Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13.

J Biol Chem 2010 Oct 4;285(41):31517-24. Epub 2010 Aug 4.

Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.125898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951226PMC
October 2010

Age-related changes in the musculoskeletal system and the development of osteoarthritis.

Authors:
Richard F Loeser

Clin Geriatr Med 2010 Aug;26(3):371-86

Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cger.2010.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920876PMC
August 2010

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes.

J Cell Biochem 2010 Jun;110(3):573-80

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.22604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883292PMC
June 2010

Why is osteoarthritis an age-related disease?

Best Pract Res Clin Rheumatol 2010 Feb;24(1):15-26

Section of Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.berh.2009.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818253PMC
February 2010

Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.

J Biol Chem 2009 Nov 17;284(46):31972-81. Epub 2009 Sep 17.

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/content/284/46/31972.full.pdf
Web Search
http://www.jbc.org/cgi/doi/10.1074/jbc.M109.056838
Publisher Site
http://dx.doi.org/10.1074/jbc.M109.056838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797269PMC
November 2009

Cost-effectiveness of exercise and diet in overweight and obese adults with knee osteoarthritis.

Med Sci Sports Exerc 2009 Jun;41(6):1167-74

1Center for Health Equity Research and Promotion of the VA Pittsburgh Healthcare System, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1249/MSS.0b013e318197ece7DOI Listing
June 2009

Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.

Arthritis Rheum 2009 Mar;60(3):792-800

Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.24295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676111PMC
March 2009

Mitogen-activated protein kinases as therapeutic targets in osteoarthritis.

Curr Opin Rheumatol 2008 Sep;20(5):581-6

Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BOR.0b013e3283090463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892710PMC
September 2008

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13.

Arthritis Res Ther 2008 20;10(1):R23. Epub 2008 Feb 20.

Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/ar2376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374453PMC
July 2008

Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy.

J Am Geriatr Soc 2008 Apr 28;56(4):644-51. Epub 2008 Feb 28.

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109-7868, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1532-5415.2007.01636.x
Publisher Site
http://dx.doi.org/10.1111/j.1532-5415.2007.01636.xDOI Listing
April 2008

Cell death in osteoarthritis.

Curr Rheumatol Rep 2008 Jan;10(1):37-42

Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

View Article

Download full-text PDF

Source
January 2008

Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc.

J Orthop Res 2007 Jun;25(6):829-40

Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jor.20343DOI Listing
June 2007

Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.

Arthritis Rheum 2006 Dec;54(12):3850-8

Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.22254DOI Listing
December 2006

Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.

Arthritis Rheum 2006 Sep;54(9):2901-11

Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.22042DOI Listing
September 2006

Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis.

Obesity (Silver Spring) 2006 Jul;14(7):1219-30

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2006.139DOI Listing
July 2006

Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI.

Am J Physiol Cell Physiol 2006 Mar 19;290(3):C802-11. Epub 2005 Oct 19.

Department of Medicine, Section of Rheumatology and Department of Biochemistry, Rush Medical College, Chicago, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00214.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482466PMC
March 2006

Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes.

Arthritis Rheum 2005 Dec;52(12):3910-7

Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.21472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482464PMC
December 2005

Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.

J Gerontol A Biol Sci Med Sci 2005 Sep;60(9):1118-24

Department of Internal Medicine, Rush Medical College, Rush University Medical Center, Chicago, Illinois, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482465PMC
http://dx.doi.org/10.1093/gerona/60.9.1118DOI Listing
September 2005

IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

Biochem J 2005 Aug;389(Pt 3):723-9

Department of Biochemistry, Rush Medical College of Rush University Medical Center, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20041636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180722PMC
August 2005

Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.

Endocrinology 2005 Jul 24;146(7):2920-32. Epub 2005 Mar 24.

Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157-1083, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2005-0058DOI Listing
July 2005

Osteoarthritis.

Sci Aging Knowledge Environ 2004 Sep 1;2004(35):dn2. Epub 2004 Sep 1.

Section of Rheumatology, Rush Medical College of Rush University Medical Center, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sageke.2004.35.dn2DOI Listing
September 2004

Aging cartilage and osteoarthritis--what's the link?

Authors:
Richard F Loeser

Sci Aging Knowledge Environ 2004 Jul 21;2004(29):pe31. Epub 2004 Jul 21.

Department of Medicine, Rush Medical College, Rush University Medical Center, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sageke.2004.29.pe31DOI Listing
July 2004

Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels.

Arthritis Rheum 2003 Dec;48(12):3419-30

Rush Medical College of Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.11338DOI Listing
December 2003

Aging or osteoarthritis: which is the problem?

Rheum Dis Clin North Am 2003 Nov;29(4):653-73

Section of Rheumatology, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison, Suite 1017, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
November 2003

The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results.

Control Clin Trials 2003 Aug;24(4):462-80

Department of Health and Exercise Science Wake Forest University, Winston-Salem, North Carolina 27109, USA.

View Article

Download full-text PDF

Source
http://ac.els-cdn.com/S0197245603000631/1-s2.0-S019724560300
Web Search
August 2003

The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes.

Arthritis Rheum 2003 Aug;48(8):2188-96

Rheumatology, Rush Medical College of Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison, Suite 1017, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.11209DOI Listing
August 2003

Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.

J Biol Chem 2003 Jul 30;278(27):24577-85. Epub 2003 Apr 30.

Department of Internal Medicine, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M304530200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008552PMC
July 2003

Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.

J Biol Chem 2003 Jul 6;278(28):25386-94. Epub 2003 May 6.

Department of Biochemistry, Section of Rheumatology, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M302048200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895259PMC
July 2003

Prolonged treatment of human osteoarthritic chondrocytes with insulin-like growth factor-I stimulates proteoglycan synthesis but not proteoglycan matrix accumulation in alginate cultures.

J Rheumatol 2003 Jul;30(7):1565-70

Department of Medicine, Rush Medical College of Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
July 2003

Integrin-mediated adhesion of human articular chondrocytes to cartilage.

Arthritis Rheum 2003 Jan;48(1):110-8

University of California, San Diego, La Jolla, California 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.10704DOI Listing
January 2003

Integrins and cell signaling in chondrocytes.

Authors:
Richard F Loeser

Biorheology 2002 ;39(1-2):119-24

Department of Internal Medicine, Section of Rheumatology, Rush Medical College of Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
October 2002

Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys.

Arthritis Rheum 2002 Jul;46(7):1956-64

Dpartment of Veterinary Pathology, College of Veterinary Medicine, University of Minnesota, St. Paul, 55108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.10406DOI Listing
July 2002

The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro.

Arthritis Rheum 2002 Jun;46(6):1528-35

Rush Medical College of Rush-Presbyterian-St. Luke's Medical Center, 1725 W. Harrison Street, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/art.10334
Publisher Site
http://dx.doi.org/10.1002/art.10334DOI Listing
June 2002

Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species.

Arthritis Rheum 2002 Feb;46(2):394-403

College of Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison Avenue, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
February 2002