Richard E Carson

Richard E Carson

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Richard E Carson

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Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [C] MRB.

Int J Obes (Lond) 2019 Oct 21. Epub 2019 Oct 21.

Department of Internal Medicine/Section of Endocrinology, Yale University School of Medicine, New Haven, CT, 06519, USA.

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http://dx.doi.org/10.1038/s41366-019-0471-4DOI Listing
October 2019

Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy.

Bull Math Biol 2019 Sep 11;81(9):3508-3541. Epub 2017 Dec 11.

PET Center, Department of Radiology and Biomedical Imaging, Yale University, 15 York Street/LMP 89A, P. O. Box 208048, New Haven, CT, 06520-8048, USA.

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http://dx.doi.org/10.1007/s11538-017-0374-2DOI Listing
September 2019

Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.

Neuropsychopharmacology 2019 09 26;44(10):1720-1727. Epub 2019 Apr 26.

Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41386-019-0398-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785004PMC
September 2019

Assessment of a white matter reference region for C-UCB-J PET quantification.

J Cereb Blood Flow Metab 2019 Sep 30:271678X19879230. Epub 2019 Sep 30.

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1177/0271678X19879230DOI Listing
September 2019

Event-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distribution.

Phys Med Biol 2019 Aug 21;64(16):165014. Epub 2019 Aug 21.

Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America. Department of Biomedical Engineering, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States of America. Author to whom any correspondence should be addressed.

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http://dx.doi.org/10.1088/1361-6560/ab0bc9DOI Listing
August 2019

Synthesis and in vivo evaluation of [F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).

Eur J Nucl Med Mol Imaging 2019 Aug 7;46(9):1952-1965. Epub 2019 Jun 7.

PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1007/s00259-019-04357-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810698PMC
August 2019

In vivo imaging of D receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird.

Sci Rep 2019 Jul 18;9(1):10407. Epub 2019 Jul 18.

Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41598-019-46845-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639298PMC
July 2019

Quantification of PET infusion studies without true equilibrium: A tissue clearance correction.

J Cereb Blood Flow Metab 2019 May 14:271678X19850000. Epub 2019 May 14.

1 Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1177/0271678X19850000DOI Listing
May 2019

Human Positron Emission Tomography Neuroimaging.

Annu Rev Biomed Eng 2019 Jun;21:551-581

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut 06520, USA; email:

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121056DOI Listing
June 2019

Quantification of PET infusion studies without true equilibrium: A tissue clearance correction.

J Cereb Blood Flow Metab 2019 May 14:271678X19850000. Epub 2019 May 14.

1 Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1177/0271678X19850000DOI Listing
May 2019

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.

ACS Chem Neurosci 2019 03 16;10(3):1544-1554. Epub 2018 Nov 16.

PET Center, Department of Radiology and Biomedical Imaging , Yale University School of Medicine , New Haven , Connecticut 06520 , United States.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00526
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http://dx.doi.org/10.1021/acschemneuro.8b00526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810685PMC
March 2019

Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET.

Phys Med Biol 2019 03 8;64(6):065002. Epub 2019 Mar 8.

Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America. Author to whom any correspondence should be addressed.

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http://dx.doi.org/10.1088/1361-6560/ab02c2DOI Listing
March 2019

First in-human PET study and kinetic evaluation of [F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.

J Cereb Blood Flow Metab 2019 Mar 21:271678X19838633. Epub 2019 Mar 21.

2 Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1177/0271678X19838633DOI Listing
March 2019

Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.

Biol Psychiatry 2018 09 31;84(6):413-421. Epub 2018 Jan 31.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut; Yale-New Haven Hospital, New Haven, Connecticut; Mental Health Service Line, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1016/j.biopsych.2017.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068006PMC
September 2018

Kappa opioid receptor binding in major depression: A pilot study.

Synapse 2018 09 17;72(9):e22042. Epub 2018 Jul 17.

Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, 1051 Riverside Drive #42, New York, New York.

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http://dx.doi.org/10.1002/syn.22042DOI Listing
September 2018

Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static F-FDG PET as a function of injected dose.

Phys Med Biol 2018 09 6;63(17):175015. Epub 2018 Sep 6.

Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America. Department of Engineering Physics, Tsinghua University, Beijing, People's Republic of China. Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Tsinghua University, Beijing, People's Republic of China.

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http://dx.doi.org/10.1088/1361-6560/aad97fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158045PMC
September 2018

Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia.

J Clin Endocrinol Metab 2018 06;103(6):2244-2252

Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1210/jc.2017-02717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456998PMC
June 2018

Evaluation of (-)-[ F]Flubatine-specific binding: Implications for reference region approaches.

Synapse 2018 03 17;72(3). Epub 2017 Nov 17.

Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/syn.22016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547815PMC
March 2018

Cardiac-gated parametric images from Rb PET from dynamic frames and direct 4D reconstruction.

Med Phys 2018 Feb 30;45(2):639-654. Epub 2017 Dec 30.

Department of Biomedical Engineering, Yale University, P. O. Box 208048, New Haven, CT, 06520-8048, USA.

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http://dx.doi.org/10.1002/mp.12710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807225PMC
February 2018

A 3D-printed modular device for imaging the brain of small birds.

J Neurosci Methods 2018 Jan 6;293:183-190. Epub 2017 Oct 6.

Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2017.10.005DOI Listing
January 2018

Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.

Neurobiol Aging 2018 01 6;61:207-214. Epub 2017 Oct 6.

Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722236PMC
January 2018

Microglial depletion and activation: A [C]PBR28 PET study in nonhuman primates.

EJNMMI Res 2017 Dec 24;7(1):59. Epub 2017 Jul 24.

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, 06520, USA.

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http://ejnmmires.springeropen.com/articles/10.1186/s13550-01
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http://dx.doi.org/10.1186/s13550-017-0305-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524658PMC
December 2017

Estradiol modulates neural response to conspecific and heterospecific song in female house sparrows: An in vivo positron emission tomography study.

PLoS One 2017 23;12(8):e0182875. Epub 2017 Aug 23.

Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182875PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568339PMC
October 2017

Direct reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levels.

Phys Med Biol 2017 Jul 15;62(13):5344-5364. Epub 2017 May 15.

Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America.

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http://dx.doi.org/10.1088/1361-6560/aa731fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783541PMC
July 2017

PET Imaging for Early Detection of Alzheimer's Disease: From Pathologic to Physiologic Biomarkers.

PET Clin 2017 Jul 2;12(3):329-350. Epub 2017 May 2.

Department of Radiology and Biomedical Imaging, PET Center, Yale University School of Medicine, PO Box 208048, New Haven, CT 06520-8048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cpet.2017.03.001DOI Listing
July 2017

Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution.

Phys Med Biol 2017 Jun 18;62(12):4741-4755. Epub 2017 May 18.

Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America.

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http://dx.doi.org/10.1088/1361-6560/aa700cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048592PMC
June 2017

Experimentally reducing corticosterone mitigates rapid captivity effects on behavior, but not body composition, in a wild bird.

Horm Behav 2017 03 5;89:121-129. Epub 2017 Jan 5.

Department of Radiology and Biomedical Imaging, Yale University, 801 Howard Avenue, PO Box 208048, New Haven, CT 06520-8048, United States.

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http://dx.doi.org/10.1016/j.yhbeh.2016.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359069PMC
March 2017

First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430.

J Nucl Med 2016 09 21;57(9):1388-95. Epub 2016 Apr 21.

Department of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, Connecticut; and.

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http://dx.doi.org/10.2967/jnumed.115.166850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093918PMC
September 2016

Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging.

J Nucl Med 2016 07 23;57(7):1084-90. Epub 2016 Feb 23.

Department of Diagnostic Radiology, Yale University, New Haven, Connecticut Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut; and

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http://dx.doi.org/10.2967/jnumed.115.167676DOI Listing
July 2016

Imaging synaptic density in the living human brain.

Sci Transl Med 2016 07;8(348):348ra96

Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA. Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf6667DOI Listing
July 2016

Reduced Brain Cannabinoid Receptor Availability in Schizophrenia.

Biol Psychiatry 2016 06 29;79(12):997-1005. Epub 2015 Aug 29.

Schizophrenia and Neuropharmacology Research Group, Veterans Affairs Connecticut Healthcare System, West Haven; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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https://linkinghub.elsevier.com/retrieve/pii/S00063223150068
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http://dx.doi.org/10.1016/j.biopsych.2015.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884543PMC
June 2016

OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding.

J Affect Disord 2016 May 9;196:87-96. Epub 2016 Feb 9.

Department of Diagnostic Radiology, Yale University School of Medicine, USA; Department of Biomedical Engineering, Yale University School of Medicine, USA; Yale PET Center, Yale University School of Medicine, USA.

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http://dx.doi.org/10.1016/j.jad.2016.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808438PMC
May 2016

Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.

ACS Nano 2016 04 16;10(4):4209-18. Epub 2016 Mar 16.

Department of Neurosurgery, #Department of Biomedical Engineering, ‡PET Center, Department of Diagnostic Radiology, §Department of Neurology, and ⊥Department of Pathology, Yale University , New Haven, Connecticut 06511, United States.

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http://dx.doi.org/10.1021/acsnano.5b07573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5257033PMC
April 2016

Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK-6577 in baboons.

Synapse 2016 Mar 6;70(3):112-20. Epub 2016 Jan 6.

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, PET Center, New Haven, Connecticut.

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http://dx.doi.org/10.1002/syn.21879DOI Listing
March 2016

Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050.

J Pharmacol Exp Ther 2016 Feb 1;356(2):260-6. Epub 2015 Dec 1.

PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut (M.N., M.Z., S.H., N.N., S.L., J.R., Y.H., R.C.); Eli Lilly and Company, Indianapolis, Indiana (G.D., J.W., R.B., J.T.); ClinBAY, Belgium (F.V.); and Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut (A.N., M.R.).

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http://dx.doi.org/10.1124/jpet.115.229278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727157PMC
February 2016

Rapid Changes in Cannabinoid 1 Receptor Availability in Cannabis-Dependent Male Subjects After Abstinence From Cannabis.

Biol Psychiatry Cogn Neurosci Neuroimaging 2016 Jan 22;1(1):60-67. Epub 2015 Oct 22.

Schizophrenia and Neuropharmacology Research Group, Department of Veterans Affairs Connecticut Healthcare System, West Haven; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.bpsc.2015.09.008DOI Listing
January 2016

Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis.

Biol Psychiatry Cogn Neurosci Neuroimaging 2016 Jan;1(1):60-67

Schizophrenia and Neuropharmacology Research Group, VA Connecticut Healthcare System, West Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S24519022150000
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http://dx.doi.org/10.1016/j.bpsc.2015.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742341PMC
January 2016

Measurement of Bmax and Kd with the glycine transporter 1 radiotracer ¹⁸F-MK6577 using a novel multi-infusion paradigm.

J Cereb Blood Flow Metab 2015 Dec 22;35(12):2001-9. Epub 2015 Jul 22.

PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://journals.sagepub.com/doi/10.1038/jcbfm.2015.163
Publisher Site
http://dx.doi.org/10.1038/jcbfm.2015.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671121PMC
December 2015

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.

Proc Natl Acad Sci U S A 2015 Oct 18;112(40):12468-73. Epub 2015 Sep 18.

Department of Psychiatry, Yale University, New Haven, CT 06511; PET Center, Diagnostic Radiology, Yale University, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1511003112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603509PMC
October 2015

Test-retest reproducibility of the metabotropic glutamate receptor 5 ligand [¹⁸F]FPEB with bolus plus constant infusion in humans.

Eur J Nucl Med Mol Imaging 2015 Sep 5;42(10):1530-41. Epub 2015 Jun 5.

PET Center, Department of Diagnostic Radiology, Yale School of Medicine, 801 Howard Avenue, PO Box 208048, New Haven, CT, 06520-8048, USA,

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http://dx.doi.org/10.1007/s00259-015-3094-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467218PMC
September 2015

In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5.

Biol Psychiatry 2015 Feb 10;77(3):266-275. Epub 2014 Jul 10.

Department of Psychiatry, Columbia University, New York, New York; Departments of Biomedical Engineering, Yale University, New Haven; Child Study Center, Yale University, New Haven.

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http://dx.doi.org/10.1016/j.biopsych.2014.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277907PMC
February 2015

Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.

Proc Natl Acad Sci U S A 2014 Dec 1;111(50):18031-6. Epub 2014 Dec 1.

Departments of Psychiatry and Clinical Neuroscience Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516; National Institute on Alcohol Abuse and Alcoholism Center for the Translational Neuroscience of Alcoholism, New Haven, CT 06510; Neurobiology, and.

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http://dx.doi.org/10.1073/pnas.1413947111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273348PMC
December 2014

Association of in vivo κ-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology.

JAMA Psychiatry 2014 Nov;71(11):1262-70

Department of Psychiatry, New York University School of Medicine, New York5Department of Radiology, New York University School of Medicine, New York8Steven and Alexandra Cohen Veterans Center, New York, New York.

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http://dx.doi.org/10.1001/jamapsychiatry.2014.1221DOI Listing
November 2014