Richard Casaburi

Richard Casaburi

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Richard Casaburi

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A New Bronchodilator Response Grading Strategy Identifies Distinct Patient Populations.

Ann Am Thorac Soc 2019 Aug 12. Epub 2019 Aug 12.

Harbor-UCLA Medical Center, Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute, Torrance, California, United States;

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http://dx.doi.org/10.1513/AnnalsATS.201901-030OCDOI Listing
August 2019

Physiologic Insights from the COPD Genetic Epidemiology Study.

Chronic Obstr Pulm Dis 2019 07;6(3):256-266

Los Angeles Biomedical Research Institute, Harbor-University of California, Los Angeles Medical Center, Torrance.

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http://dx.doi.org/10.15326/jcopdf.6.3.2019.0128DOI Listing
July 2019

Physiologic Effects of Oxygen Supplementation During Exercise in Chronic Obstructive Pulmonary Disease.

Clin Chest Med 2019 Jun;40(2):385-395

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Building CDCRC, Torrance, CA 90502, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccm.2019.02.004DOI Listing
June 2019

Healing Pulmonary Rehabilitation in the United States. A Call to Action for ATS Members.

Am J Respir Crit Care Med 2019 Apr;199(8):944-946

4 Rehabilitation Clinical Trials Center Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles Medical Center Torrance, California and.

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http://dx.doi.org/10.1164/rccm.201809-1711EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467299PMC
April 2019

Exercise Training in Patients With Non-Small Cell Lung Cancer During In-Hospital Chemotherapy Treatment: A RANDOMIZED CONTROLLED TRIAL.

J Cardiopulm Rehabil Prev 2019 Mar;39(2):127-133

Institute of Physiotherapy, Department of Physical Education and Physiotherapy, Opole University of Technology, Opole, Poland (Drs Rutkowska, Rutkowski, and Szczegielniak); School of Medicine with the Division of Dentistry, Department of Lung Diseases and Tuberculosis, Medical University of Silesia, Zabrze, Poland (Drs Jastrzebski and Ziora); Department of Physiology and Medicine of Sport (Dr Żebrowska) and Department of Individual Sport (Dr Stanula), Academy of Physical Education, Katowice, Poland; and Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California (Dr Casaburi).

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http://dx.doi.org/10.1097/HCR.0000000000000410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407827PMC
March 2019

Noninvasive prediction of Blood Lactate through a machine learning-based approach.

Sci Rep 2019 Feb 18;9(1):2180. Epub 2019 Feb 18.

Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1038/s41598-019-38698-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379358PMC
February 2019

Whither pulmonary rehabilitation? Will alternative modes help or hurt?

Authors:
Richard Casaburi

Eur Respir J 2018 10 18;52(4). Epub 2018 Oct 18.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1183/13993003.01678-2018DOI Listing
October 2018

Genetic variants predicting aerobic capacity response to training are also associated with skeletal muscle oxidative capacity in moderate-to-severe COPD.

Physiol Genomics 2018 09 25;50(9):688-690. Epub 2018 May 25.

Rehabilitation Clinical Trials Center, Division of Pulmonary and Critical Care, Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance, California.

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http://dx.doi.org/10.1152/physiolgenomics.00140.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172613PMC
September 2018

Oxygen Uptake and Lactate Kinetics in Patients with Chronic Obstructive Pulmonary Disease during Heavy Intensity Exercise: Role of Pedaling Cadence.

COPD 2018 06 29;15(3):283-293. Epub 2018 Aug 29.

b Rehabilitation Clinical Trials Center , Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance , California , USA.

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1487391DOI Listing
June 2018

Pulmonary Rehabilitation: Where We've Succeeded and Where We've Failed.

Authors:
Richard Casaburi

COPD 2018 06 5;15(3):219-222. Epub 2018 Sep 5.

a Rehabilitation Clinical Trials Center , Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance , California , USA.

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http://dx.doi.org/10.1080/15412555.2018.1503245DOI Listing
June 2018

Effect of tiotropium on spontaneous expiratory flow-volume curves during exercise in GOLD 1-2 COPD.

Respir Physiol Neurobiol 2018 05 10;251:8-15. Epub 2018 Feb 10.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15699048173035
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http://dx.doi.org/10.1016/j.resp.2018.02.006DOI Listing
May 2018

Reply: Further Need for Evidence in Long-Term Oxygen Therapy.

Authors:
Richard Casaburi

Ann Am Thorac Soc 2018 04;15(4):512-513

1 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Torrance, California.

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http://dx.doi.org/10.1513/AnnalsATS.201801-047LEDOI Listing
April 2018

Simultaneous LC-MS/MS analysis of eicosanoids and related metabolites in human serum, sputum and BALF.

Biomed Chromatogr 2018 Mar 17;32(3). Epub 2017 Oct 17.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1002/bmc.4102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003856PMC
March 2018

Reliability and Physiological Interpretation of Pulmonary Gas Exchange by "Circulatory Equivalents" in Chronic Heart Failure.

J Am Heart Assoc 2018 03 27;7(7). Epub 2018 Mar 27.

Division of Respiratory and Critical Care Physiology and Medicine, Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.

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http://dx.doi.org/10.1161/JAHA.117.008072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907590PMC
March 2018

Long-Term Oxygen Therapy: The Three Big Questions.

Authors:
Richard Casaburi

Ann Am Thorac Soc 2018 01;15(1):14-15

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California.

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http://dx.doi.org/10.1513/AnnalsATS.201709-715EDDOI Listing
January 2018

Pulmonary rehabilitation relieves dyspnea, but does it reduce mortality?

Authors:
Richard Casaburi

Rev Med Suisse 2018 Jan;14(591):176-177

Professor of Medicine, UCLA School of Medicine, Medical Director, Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute, 1124 W Carson St, Building CDCRC, Torrance, CA 90502, California, USA.

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January 2018

Spirometry, Static Lung Volumes, and Diffusing Capacity.

Respir Care 2017 Sep 11;62(9):1137-1147. Epub 2017 Jul 11.

Yale University School of Medicine, Department of Internal Medicine, New Haven, CT.

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http://dx.doi.org/10.4187/respcare.05515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373859PMC
September 2017

Effects of combined tiotropium/olodaterol on inspiratory capacity and exercise endurance in COPD.

Eur Respir J 2017 04 19;49(4). Epub 2017 Apr 19.

Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC, Canada.

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http://dx.doi.org/10.1183/13993003.01348-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898947PMC
April 2017

Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD.

Respir Physiol Neurobiol 2017 01 19;235:18-26. Epub 2016 Sep 19.

Rehabilitation Clinical Trials Center, Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.resp.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136338PMC
January 2017

Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD.

J Appl Physiol (1985) 2016 12 22;121(6):1365-1373. Epub 2016 Sep 22.

Division of Respiratory & Critical Care Physiology & Medicine, Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California;

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http://dx.doi.org/10.1152/japplphysiol.00660.2016DOI Listing
December 2016

Relation of concavity in the expiratory flow-volume loop to dynamic hyperinflation during exercise in COPD.

Respir Physiol Neurobiol 2016 12 26;234:79-84. Epub 2016 Aug 26.

Rehabilitation Clinical Trials Center, Division of Respiratory and Critical Care, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1016/j.resp.2016.08.005DOI Listing
December 2016

A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria.

Chest 2016 Nov 22;150(5):1080-1090. Epub 2016 Jul 22.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.

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http://dx.doi.org/10.1016/j.chest.2016.06.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103018PMC
November 2016

Exercise, ageing and the lung.

Eur Respir J 2016 11 6;48(5):1471-1486. Epub 2016 Oct 6.

Rehabilitation Clinical Trials Center, Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Torrance, CA, USA

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http://dx.doi.org/10.1183/13993003.00347-2016DOI Listing
November 2016

Phenotype of Spirometric Impairment in an Aging Population.

Am J Respir Crit Care Med 2016 Apr;193(7):727-35

1 Veterans Affairs Clinical Epidemiology Research Center, West Haven, Connecticut.

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http://dx.doi.org/10.1164/rccm.201508-1603OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824933PMC
April 2016

Cluster Analysis in Patients with GOLD 1 Chronic Obstructive Pulmonary Disease.

PLoS One 2015 23;10(4):e0123626. Epub 2015 Apr 23.

Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123626PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407903PMC
January 2016

Pulmonary Rehabilitation: Improvement with Movement.

Chronic Obstr Pulm Dis 2016 Jan 15;3(1):479-484. Epub 2016 Jan 15.

Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance.

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http://dx.doi.org/10.15326/jcopdf.3.1.2015.0169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559130PMC
January 2016

Biological quality control for cardiopulmonary exercise testing in multicenter clinical trials.

BMC Pulm Med 2016 Jan 16;16:13. Epub 2016 Jan 16.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124W Carson Street, Building CDCRC, Torrance, CA, 90502, USA.

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http://dx.doi.org/10.1186/s12890-016-0174-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715309PMC
January 2016

Effect of Megestrol Acetate and Testosterone on Body Composition and Hormonal Responses in COPD Cachexia.

Chronic Obstr Pulm Dis 2015 Nov 9;3(1):389-397. Epub 2015 Nov 9.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance.

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http://dx.doi.org/10.15326/jcopdf.3.1.2015.0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559120PMC
November 2015

Phenotype of normal spirometry in an aging population.

Am J Respir Crit Care Med 2015 Oct;192(7):817-25

1 Veterans Affairs Clinical Epidemiology Research Center, West Haven, Connecticut.

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http://dx.doi.org/10.1164/rccm.201503-0463OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613896PMC
October 2015

Effect of endurance and/or strength training on muscle fiber size, oxidative capacity, and capillarity in hemodialysis patients.

J Appl Physiol (1985) 2015 Oct 16;119(8):865-71. Epub 2015 Jul 16.

Los Angeles Biomedical Research, Institute at Harbor-UCLA Medical Center, Torrance, California; David Geffen School of Medicine at UCLA, Los Angeles, California; and The UCLA Fielding School of Public Health, Los Angeles, California.

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http://dx.doi.org/10.1152/japplphysiol.01084.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610005PMC
October 2015

Exercise limitation in chronic obstructive pulmonary disease. The O'Donnell threshold.

Am J Respir Crit Care Med 2015 Apr;191(8):873-5

1 Rehabilitation Clinical Trials Center Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Medical Center Torrance, California.

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http://dx.doi.org/10.1164/rccm.201501-0084EDDOI Listing
April 2015

Re-Defining Lower Limit of Normal for FEV/FEV, FEV/FVC, FEV/FEV and FEV/FVC to Improve Detection of Airway Obstruction.

Chronic Obstr Pulm Dis 2015 Mar 10;2(2):94-102. Epub 2015 Mar 10.

Respiratory and Critical Care Division, Department of Medicine, Los Angeles Biomedical Research Institute-Harbor, University of California -Los Angeles Medical Center,Torrance, California; University of California-Los Angeles David Geffen School of Medicine, Los Angeles.

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http://dx.doi.org/10.15326/jcopdf.2.2.2014.0144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556964PMC
March 2015

Effects of tiotropium on hyperinflation and treadmill exercise tolerance in mild to moderate chronic obstructive pulmonary disease.

Ann Am Thorac Soc 2014 Nov;11(9):1351-61

1 Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, California.

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http://dx.doi.org/10.1513/AnnalsATS.201404-174OCDOI Listing
November 2014

Improving early-stage diagnosis and management of COPD in primary care.

Postgrad Med 2014 Jul;126(4):141-54

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.

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http://dx.doi.org/10.3810/pgm.2014.07.2792DOI Listing
July 2014

Selecting constant work rates for endurance testing in COPD: the role of the power-duration relationship.

COPD 2014 Jun 1;11(3):267-76. Epub 2013 Nov 1.

1Department of Pulmonology, University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3109/15412555.2013.840572DOI Listing
June 2014

Increased difference between slow and forced vital capacity is associated with reduced exercise tolerance in COPD patients.

BMC Pulm Med 2014 Feb 7;14:16. Epub 2014 Feb 7.

Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, No, 95 Yong An Road, Xichen District, Beijing 100050, China.

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http://dx.doi.org/10.1186/1471-2466-14-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938036PMC
February 2014

Physiologic effects of an ambulatory ventilation system in chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2013 Aug;188(3):334-42

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1164/rccm.201210-1773OCDOI Listing
August 2013

Sinusoidal high-intensity exercise does not elicit ventilatory limitation in chronic obstructive pulmonary disease.

Exp Physiol 2013 Jun 18;98(6):1102-14. Epub 2013 Jan 18.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1113/expphysiol.2012.070375DOI Listing
June 2013

Noninvasive assessment of normality of VD/VT in clinical cardiopulmonary exercise testing utilizing incremental cycle ergometry.

Eur J Appl Physiol 2013 Jan 6;113(1):33-40. Epub 2012 May 6.

Division of Pulmonary Medicine, University of Calgary, Calgary, Canada.

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http://link.springer.com/10.1007/s00421-012-2407-8
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http://dx.doi.org/10.1007/s00421-012-2407-8DOI Listing
January 2013

Comment on 'the effect of temperature on exhaled breath condensate collection'.

J Breath Res 2012 Dec;6(4):048001; author reply 048002

Department of Medicine, LABiomed/Harbor-UCLA, Torrance, CA, USA.

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December 2012

The mechanism of the exercise hyperpnea: the ultrasecret revisited.

Authors:
Richard Casaburi

Am J Respir Crit Care Med 2012 Oct;186(7):578-9

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http://dx.doi.org/10.1164/rccm.201207-1278EDDOI Listing
October 2012

Severe exercise-induced hypoxemia.

Respir Care 2012 Jul 10;57(7):1154-60. Epub 2012 Feb 10.

Pulmonary Rehabilitation Program, Seton Medical Center, Daly City, CA, USA.

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http://openurl.ingenta.com/content/xref?genre=article&is
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http://dx.doi.org/10.4187/respcare.01469DOI Listing
July 2012

Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.

Chest 2012 Apr 29;141(4):867-875. Epub 2011 Sep 29.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA. Electronic address:

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http://dx.doi.org/10.1378/chest.11-0870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318949PMC
April 2012

Cardiopulmonary exercise testing: does it improve perioperative care and outcome?

Curr Opin Anaesthesiol 2012 Apr;25(2):178-84

Department of Medicine, Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, Torrance, California, USA.

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http://dx.doi.org/10.1097/ACO.0b013e32834f6c32DOI Listing
April 2012

Exhaled breath condensates: analyzing the expiratory plume.

Am J Respir Crit Care Med 2012 Apr;185(8):803-4

Department of Medicine, LA BioMed/Harbor-UCLA, Torrance, CA, USA.

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http://dx.doi.org/10.1164/rccm.201109-1702EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360569PMC
April 2012

Testosterone and resistance training effects on muscle nitric oxide synthase isoforms in COPD men.

Respir Med 2012 Feb 16;106(2):269-75. Epub 2011 Aug 16.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1016/j.rmed.2011.07.018DOI Listing
February 2012

Metabolic and morphometric profile of muscle fibers in chronic hemodialysis patients.

J Appl Physiol (1985) 2012 Jan 20;112(1):72-8. Epub 2011 Oct 20.

Division of Pulmonary/Critical Care Medicine, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://www.physiology.org/doi/10.1152/japplphysiol.00556.201
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http://dx.doi.org/10.1152/japplphysiol.00556.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290422PMC
January 2012

Why conventional exhaled breath condensate pH studies cannot provide reliable estimates of airway acidification.

Chest 2011 Oct;140(4):1099

Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor, University of California, Los Angeles Medical Center, Torrance, CA.

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http://dx.doi.org/10.1378/chest.11-0974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415116PMC
October 2011

Activity promotion: a paradigm shift for chronic obstructive pulmonary disease therapeutics.

Authors:
Richard Casaburi

Proc Am Thorac Soc 2011 Aug;8(4):334-7

Rehabilitation Clinical Trial Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1513/pats.201101-001RMDOI Listing
August 2011

Effect of indacaterol on exercise endurance and lung hyperinflation in COPD.

Respir Med 2011 Jul 16;105(7):1030-6. Epub 2011 Apr 16.

Queen's University and Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada.

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http://dx.doi.org/10.1016/j.rmed.2011.03.014DOI Listing
July 2011

Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD.

Respir Med 2011 Apr 22;105(4):580-7. Epub 2010 Dec 22.

Centre de recherche, Institut Universitaire de cardiologie et de pneumologie de Québec, Université Laval, 2725 Chemin Sainte-Foy, Québec G1V 4G5, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S09546111100049
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http://dx.doi.org/10.1016/j.rmed.2010.11.019DOI Listing
April 2011

Assessment of exhaled breath condensate pH.

Am J Respir Crit Care Med 2011 Apr;183(7):952; author reply 952-3

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http://dx.doi.org/10.1164/ajrccm.183.7.952aDOI Listing
April 2011

Breath-by-breath quantification of progressive airflow limitation during exercise in COPD: a new method.

Respir Med 2010 Mar;104(3):389-96

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1016/j.rmed.2009.10.014DOI Listing
March 2010

Constant work rate exercise testing: a tricky measure of exercise tolerance.

COPD 2009 Oct;6(5):317-9

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October 2009