Richard C Boucher

Richard C Boucher

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Richard C Boucher

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Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.

Am J Physiol Lung Cell Mol Physiol 2020 Feb 4;318(2):L356-L365. Epub 2019 Dec 4.

Marsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1152/ajplung.00449.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052677PMC
February 2020

Phenotypic Characterization and Comparison of Phe508del and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Rat Models of Cystic Fibrosis Generated by Clustered Regularly Interspaced Short Palindromic Repeats/Clustered Regularly Interspaced Short Palindromic Repeats-Associated Protein 9 Gene Editing.

Am J Pathol 2020 Feb 18. Epub 2020 Feb 18.

Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, South Australia, Australia; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2020.01.009DOI Listing
February 2020

Muco-Obstructive Lung Diseases. Reply.

N Engl J Med 2019 09;381(10):e20

Marsico Lung Institute, Chapel Hill, NC

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http://dx.doi.org/10.1056/NEJMc1907962DOI Listing
September 2019

Muco-Obstructive Lung Diseases.

N Engl J Med 2019 05;380(20):1941-1953

From the Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill.

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http://dx.doi.org/10.1056/NEJMra1813799DOI Listing
May 2019

Roles of mucus adhesion and cohesion in cough clearance.

Proc Natl Acad Sci U S A 2018 12 12;115(49):12501-12506. Epub 2018 Nov 12.

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7248;

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http://dx.doi.org/10.1073/pnas.1811787115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298066PMC
December 2018

Emerging Concepts and Therapies for Mucoobstructive Lung Disease.

Ann Am Thorac Soc 2018 11;15(Suppl 3):S216-S226

4 Marsico Lung Institute, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.

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https://www.atsjournals.org/doi/10.1513/AnnalsATS.201806-368
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http://dx.doi.org/10.1513/AnnalsATS.201806-368AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322026PMC
November 2018

Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice.

Am J Respir Cell Mol Biol 2018 09;59(3):383-396

Marsico Lung Institute and University of North Carolina Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1165/rcmb.2017-0127OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189647PMC
September 2018

The N terminus of α-ENaC mediates ENaC cleavage and activation by furin.

J Gen Physiol 2018 08 6;150(8):1179-1187. Epub 2018 Jul 6.

Marsico Lung Institute, Cystic Fibrosis Center and Department of Medicine, University of North Carolina, Chapel Hill, NC

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http://dx.doi.org/10.1085/jgp.201711860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080898PMC
August 2018

The effect of nebulised hypertonic saline on human bronchial epithelium.

Eur Respir J 2018 05 17;51(5). Epub 2018 May 17.

Cystic Fibrosis Research and Treatment Center/Marsico Lung Institute, Chapel Hill, NC, USA.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02652
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http://dx.doi.org/10.1183/13993003.02652-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000726PMC
May 2018

Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis.

Physiol Rep 2018 04;6(8):e13677

Marsico Lung Institute/Cystic Fibrosis Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.14814/phy2.13677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904692PMC
April 2018

Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways.

Am J Physiol Lung Cell Mol Physiol 2018 02 26;314(2):L318-L331. Epub 2017 Oct 26.

Marsico Lung Institute, University of North Carolina Cystic Fibrosis Center, School of Medicine, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.

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http://dx.doi.org/10.1152/ajplung.00382.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866504PMC
February 2018

An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.

J Theor Biol 2018 02 15;438:34-45. Epub 2017 Nov 15.

Department of Mechanical and Industrial Engineering, The University of Iowa, 2406 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2017.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764545PMC
February 2018

Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.

Am J Pathol 2018 01 26;188(1):95-110. Epub 2017 Oct 26.

Marsico Lung Institute/University of North Carolina Cystic Fibrosis Research Center, School of Medicine, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745530PMC
January 2018

Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography.

Biomed Opt Express 2017 Oct 26;8(10):4729-4741. Epub 2017 Sep 26.

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1364/BOE.8.004729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654813PMC
October 2017

Airway Mucin Concentration as a Marker of Chronic Bronchitis.

N Engl J Med 2017 09;377(10):911-922

From the Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill (M.K., A.A.F., A.C., G.R., R.C., C.W.D., C.M.D., N.E.A., W.H.A., A.G.H., W.K.O., R.C.B.), and the Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem (E.R.B., A.T.H.) - both in North Carolina; the Department of Medicine, Columbia University Medical Center, and the Department of Epidemiology, Mailman School of Public Health at Columbia University (R.G.B.), and the Department of Medicine, Weill Cornell Medical College (F.M.), New York; the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco Medical Center, San Francisco (S.A.C., P.G.W.); the Department of Medicine and Physiology, David Geffen School of Medicine, University of California, Los Angeles (C.B.C.); the Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor (M.K.H.); the Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore (N.N.H.); the Department of Radiology, Division of Physiologic Imaging, University of Iowa Hospitals and Clinics, Iowa City (E.A.H.); and the Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, Veterans Affairs Medical Center, Salt Lake City (R.E.K., R.P.).

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http://dx.doi.org/10.1056/NEJMoa1701632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706541PMC
September 2017

A Trans-Nasal Aerosol Delivery Device for Efficient Pulmonary Deposition.

J Aerosol Med Pulm Drug Deliv 2017 Aug 3;30(4):223-229. Epub 2017 Feb 3.

1 University of North Carolina at Chapel Hill , Chapel Hill, North Carolina, Marsico Lung Institute.

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http://dx.doi.org/10.1089/jamp.2016.1333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564034PMC
August 2017

Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis.

Proc Natl Acad Sci U S A 2017 08 14;114(35):E7272-E7281. Epub 2017 Aug 14.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1617383114
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http://dx.doi.org/10.1073/pnas.1617383114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584404PMC
August 2017

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.

Mucosal Immunol 2017 03 20;10(2):395-407. Epub 2016 Jul 20.

University of North Carolina Marsico Lung Institute/ Cystic Fibrosis Center, School of Medicine, The University of North Carolina at Chapel Hill, 125 Mason Farm Rd. 27599, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/mi.2016.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250616PMC
March 2017

Sialic acid-to-urea ratio as a measure of airway surface hydration.

Am J Physiol Lung Cell Mol Physiol 2017 03 6;312(3):L398-L404. Epub 2017 Jan 6.

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1152/ajplung.00398.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374301PMC
March 2017

Metabolomic biomarkers predictive of early structural lung disease in cystic fibrosis.

Eur Respir J 2016 12 11;48(6):1612-1621. Epub 2016 Nov 11.

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1183/13993003.00524-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766264PMC
December 2016

Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.

Ann Am Thorac Soc 2016 04;13 Suppl 2:S156-62

1 Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, and.

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http://dx.doi.org/10.1513/AnnalsATS.201507-455KVDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015722PMC
April 2016

Characterization of Rat Meibomian Gland Ion and Fluid Transport.

Invest Ophthalmol Vis Sci 2016 Apr;57(4):2328-43

Marsico Lung Institute/UNC Cystic Fibrosis Research Center School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

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http://dx.doi.org/10.1167/iovs.15-17945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855829PMC
April 2016

Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.

Am J Respir Cell Mol Biol 2016 Feb;54(2):210-21

1 Marsico Lung Institute/University of North Carolina Cystic Fibrosis Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and.

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http://dx.doi.org/10.1165/rcmb.2014-0111OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821038PMC
February 2016

On the Pathogenesis of Acute Exacerbations of Mucoobstructive Lung Diseases.

Ann Am Thorac Soc 2015 Nov;12 Suppl 2:S160-3

1 Marsico Lung Institute/Cystic Fibrosis Research Center, and.

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http://dx.doi.org/10.1513/AnnalsATS.201507-460AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722836PMC
November 2015

Metabolomic Evaluation of Neutrophilic Airway Inflammation in Cystic Fibrosis.

Chest 2015 Aug;148(2):507-515

Cystic Fibrosis and Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1378/chest.14-1800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524329PMC
August 2015

A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease.

PLoS One 2014 18;9(2):e87681. Epub 2014 Feb 18.

Departments of Mathematics and Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087681PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928107PMC
January 2015

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration.

BMC Genomics 2014 Sep 10;15:726. Epub 2014 Sep 10.

Marsico Lung Institute/University of North Carolina Cystic Fibrosis Center, School of Medicine, University of North Carolina at Chapel Hill, 7011 Thurston Bowles Building, Chapel Hill, NC 27599-7248, USA.

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http://dx.doi.org/10.1186/1471-2164-15-726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247008PMC
September 2014

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis.

Sci Transl Med 2014 Jul;6(246):246ra96

Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272825PMC
July 2014

Computational model for the regulation of extracellular ATP and adenosine in airway epithelia.

Subcell Biochem 2011 ;55:51-74

Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA,

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http://dx.doi.org/10.1007/978-94-007-1217-1_3DOI Listing
February 2014

Non-invasive airway health assessment: synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo.

Sci Rep 2014 Jan 14;4:3689. Epub 2014 Jan 14.

1] Respiratory and Sleep Medicine, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, 5006, Australia [2] Centre for Stem Cell Research, University of Adelaide, SA, 5001, Australia [3] School of Paediatrics and Reproductive Health, University of Adelaide, SA, 5001, Australia.

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http://dx.doi.org/10.1038/srep03689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891397PMC
January 2014

Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease.

Am J Respir Cell Mol Biol 2013 Sep;49(3):410-7

Department of Translational Pulmonology, Translational Lung Research Center, University of Heidelberg, Im Neuenheimer Feld 350, Heidelberg, Germany.

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http://dx.doi.org/10.1165/rcmb.2013-0050OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824058PMC
September 2013

Mechanosensitive ATP release maintains proper mucus hydration of airways.

Sci Signal 2013 Jun 11;6(279):ra46. Epub 2013 Jun 11.

Cystic Fibrosis Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599-7248, USA.

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http://dx.doi.org/10.1126/scisignal.2003755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791865PMC
June 2013

Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation.

Am J Respir Crit Care Med 2013 May;187(10):1118-26

Cystic Fibrosis and Airways Microbiology Research Group, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201210-1937OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734618PMC
May 2013

Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis.

Am J Physiol Lung Cell Mol Physiol 2013 Apr 25;304(7):L504-9. Epub 2013 Jan 25.

Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1152/ajplung.00344.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627937PMC
April 2013

Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.

Am J Physiol Lung Cell Mol Physiol 2013 Apr 1;304(7):L469-80. Epub 2013 Feb 1.

Cystic Fibrosis/Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, 6029 Thurston Bowles Bldg., Chapel Hill, NC 25799-7248, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00150.2012
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http://dx.doi.org/10.1152/ajplung.00150.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627939PMC
April 2013

Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities.

Biophys J 2013 Feb;104(3):716-26

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/j.bpj.2012.12.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566454PMC
February 2013

Regional differences in rat conjunctival ion transport activities.

Am J Physiol Cell Physiol 2012 Oct 18;303(7):C767-80. Epub 2012 Jul 18.

Cystic Fibrosis/Pulmonary Research and Treatment Center. Univ. of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00195.2012
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http://dx.doi.org/10.1152/ajpcell.00195.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469597PMC
October 2012

Expression profiles of aquaporins in rat conjunctiva, cornea, lacrimal gland and Meibomian gland.

Exp Eye Res 2012 Oct 22;103:22-32. Epub 2012 Jul 22.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, 7011 Thurston-Bowles Building, 96 Manning Drive, NC 27599, United States.

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http://dx.doi.org/10.1016/j.exer.2012.07.005DOI Listing
October 2012

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

Proc Natl Acad Sci U S A 2012 Oct 24;109(41):16528-33. Epub 2012 Sep 24.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1073/pnas.1206552109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478656PMC
October 2012

Significance of the microbiome in obstructive lung disease.

Thorax 2012 May 8;67(5):456-63. Epub 2012 Feb 8.

Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5360, USA.

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http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2011-2011
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http://dx.doi.org/10.1136/thoraxjnl-2011-201183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578398PMC
May 2012

Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction.

Physiol Genomics 2012 Apr 6;44(8):470-84. Epub 2012 Mar 6.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://www.physiology.org/doi/10.1152/physiolgenomics.00185.
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http://dx.doi.org/10.1152/physiolgenomics.00185.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339860PMC
April 2012

VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells.

J Physiol 2012 Feb 5;590(3):545-62. Epub 2011 Dec 5.

Cystic Fibrosis/Pulmonary Research and Treatment Centre, The University of North Carolina at Chapel Hill, 4029A Thurston Bowles Building, Chapel Hill, NC 27599-7248, USA.

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http://dx.doi.org/10.1113/jphysiol.2011.222091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379700PMC
February 2012

Elevated airway purines in COPD.

Chest 2011 Oct 31;140(4):954-960. Epub 2011 Mar 31.

CF/Pulmonary Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1378/chest.10-2471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186686PMC
October 2011

Introduction to section I: overview of approaches to study cystic fibrosis pathophysiology.

Methods Mol Biol 2011 ;742:3-14

Department of Physiology and Neuroscience, St. George's University, True Blue Campus, Grenada, West Indies.

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http://dx.doi.org/10.1007/978-1-61779-120-8_1DOI Listing
September 2011

Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.

J Biol Chem 2011 Jul 23;286(30):26277-86. Epub 2011 May 23.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M111.260562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143590PMC
July 2011

Idiopathic pulmonary fibrosis--a sticky business.

N Engl J Med 2011 Apr;364(16):1560-1

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http://dx.doi.org/10.1056/NEJMe1014191DOI Listing
April 2011

Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers.

J Clin Microbiol 2011 Jan 10;49(1):281-91. Epub 2010 Nov 10.

Molecular Microbiology Research Laboratory, Pharmaceutical Science Research Division, King's College London, 150 Stamford Street, Franklin-Wilkins Building, London, SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1128/JCM.01650-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020463PMC
January 2011

Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling.

J Biol Chem 2010 Nov 27;285(45):34939-49. Epub 2010 Aug 27.

Department of Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M110.162933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966108PMC
November 2010

Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses.

Proc Am Thorac Soc 2010 Nov;7(6):387-94

Cystic Fibrosis/Pulmonary Research and Treatment Center and the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1513/pats.201001-017AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136959PMC
November 2010

The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na+ channel.

J Biol Chem 2010 Oct 13;285(42):32227-32. Epub 2010 Aug 13.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M110.155259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952223PMC
October 2010

Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides.

J Physiol 2010 Jun 26;588(Pt 12):2255-67. Epub 2010 Apr 26.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, 4029A Thurston Bowles Building, Chapel Hill, NC 27599-7248, USA.

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http://dx.doi.org/10.1113/jphysiol.2009.186643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911224PMC
June 2010

Osmolytes and ion transport modulators: new strategies for airway surface rehydration.

Curr Opin Pharmacol 2010 Jun 1;10(3):294-9. Epub 2010 May 1.

Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 130 Mason Farm Road, CB#7020, Chapel Hill, NC 27599-7020, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S147148921000039
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http://dx.doi.org/10.1016/j.coph.2010.04.003DOI Listing
June 2010

Bronchiectasis: a continuum of ion transport dysfunction or multiple hits?

Am J Respir Crit Care Med 2010 May;181(10):1017-9

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http://dx.doi.org/10.1164/rccm.201002-0284EDDOI Listing
May 2010

Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways.

J Biol Chem 2009 Jul 12;284(31):20638-48. Epub 2009 May 12.

Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M109.004762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742828PMC
July 2009

Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways.

J Biol Chem 2009 May 10;284(22):14875-80. Epub 2009 Apr 10.

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27708, USA.

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http://dx.doi.org/10.1074/jbc.C109.000869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685669PMC
May 2009