Publications by authors named "Richard Bindernagel"

5 Publications

  • Page 1 of 1

Multicentric reticulohistiocytosis masquerading as cutaneous connective tissue disease.

Dermatol Online J 2021 Mar 15;27(3). Epub 2021 Mar 15.

Department of Dermatology, HCA Healthcare/USF Morsani College of Medicine Largo, FL.

Multicentric reticulohistiocytosis (MRH) is a rare type of non-Langerhans cell histiocytosis characterized by coral-toned papules with predilection for dorsal surfaces in addition to severe arthropathy. It sometimes proves difficult to differentiate these joint and skin findings clinically from certain rheumatologic diseases, primarily dermatomyositis. Herein, we present an 82-year-old woman who presented with the clinical findings described above and was subsequently diagnosed with MRH after biopsy and review of relevant clinical history. Because about 25% of patients diagnosed with MRH have an underlying occult malignancy, our patient underwent a complete malignancy workup that was negative. She was treated with systemic corticosteroids and methotrexate, which resulted in an improvement of the arthritis and constitutional symptoms. This case demonstrates that in patients with both rheumatologic and dermatologic symptoms, particularly on acral surfaces, MRH must be a diagnostic consideration. Identifying this disease early in its course can prevent negative consequences for the patients, specifically arthritis mutilans and upper airway involvement.
View Article and Find Full Text PDF

Download full-text PDF

Source
March 2021

Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia.

Sci Rep 2021 Feb 4;11(1):3148. Epub 2021 Feb 4.

Department of Biology, University of Miami, 1301 Memorial Drive, Coral Gables, FL, 33146, USA.

Delayed emergence from anesthesia was previously reported in a case study of a child with Glycine Encephalopathy. To investigate the neural basis of this delayed emergence, we developed a zebrafish glial glycine transporter (glyt1 - / -) mutant model. We compared locomotor behaviors; dose-response curves for tricaine, ketamine, and 2,6-diisopropylphenol (propofol); time to emergence from these anesthetics; and time to emergence from propofol after craniotomy in glyt1-/- mutants and their siblings. To identify differentially active brain regions in glyt1-/- mutants, we used pERK immunohistochemistry as a proxy for brain-wide neuronal activity. We show that glyt1-/- mutants initiated normal bouts of movement less frequently indicating lethargy-like behaviors. Despite similar anesthesia dose-response curves, glyt1-/- mutants took over twice as long as their siblings to emerge from ketamine or propofol, mimicking findings from the human case study. Reducing glycine levels rescued timely emergence in glyt1-/- mutants, pointing to a causal role for elevated glycine. Brain-wide pERK staining showed elevated activity in hypnotic brain regions in glyt1-/- mutants under baseline conditions and a delay in sensorimotor integration during emergence from anesthesia. Our study links elevated activity in preoptic brain regions and reduced sensorimotor integration to lethargy-like behaviors and delayed emergence from propofol in glyt1-/- mutants.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-021-82342-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862283PMC
February 2021

Use of topical 2.4% glycopyrronium tosylate in familial benign pemphigus (Hailey-Hailey disease).

Dermatol Online J 2020 Oct 15;26(10). Epub 2020 Oct 15.

Department of Dermatology, University of Kansas Medical Center, Kansas City, KS.

View Article and Find Full Text PDF

Download full-text PDF

Source
October 2020

Severe scalp sarcoidosis in an unlikely patient.

JAAD Case Rep 2020 Nov 24;6(11):1165-1166. Epub 2020 Apr 24.

Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, Texas.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2020.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588657PMC
November 2020

TIDieR checklist evaluation of clinical trial intervention reporting for recent FDA-approved anticancer medications.

BMJ Evid Based Med 2020 06 25;25(3):97-101. Epub 2019 Oct 25.

Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, USA.

Importance: Clear and comprehensive descriptions of clinical trial interventions are necessary to translate new results into clinical practice. The TIDieR checklist was developed to be a minimum set of key items considered essential to high-quality reporting of clinical trial interventions.

Objective: To determine the quality of reporting of recent Food and Drug Administration (FDA)-approved oncology interventions.

Design: Cross-sectional investigation.

Setting/participants/intervention: Recent, FDA-approved haematology/oncology anticancer interventions.

Main Outcome Measure: Quality of reporting.

Results: Across all included trials (n=96), a median of 8-9 (out of 12) TIDieR items were reported. Seven TIDieR items had >90% adherence, including individual-level and study-level modifications of drugs and dosing schedules. Three items were less often reported: intervention provider, including training and expertise (7/192, 3.6%); trial institution infrastructure (0/192, 0.0%); and how intervention compliance was assessed (59/192, 30.7%). Publication of a protocol improved intervention reporting (p<0.001).

Conclusions: In this analysis of clinical trials of recent, FDA-approved anticancer interventions, we found good adherence to the TIDieR checklist. These studies were homogeneous in their structure and included information; some TIDieR items were always or never/rarely reported. Clinical trial effect sizes may not translate to real-world practice for a number of reasons. Thus, to aid the translation of trial effect sizes to real-world practice, we recommend authors adhere to the TIDieR checklist and describe the infrastructure of trial centres and describe who provided the intervention, along with their expertise.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjebm-2019-111249DOI Listing
June 2020