Publications by authors named "Richard B Lock"

100Publications

Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia.

Leukemia 2020 Oct 16. Epub 2020 Oct 16.

Cancer Research Program, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia.

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http://dx.doi.org/10.1038/s41375-020-01050-yDOI Listing
October 2020

Targeting TSLP-Induced Tyrosine Kinase Signaling Pathways in CRLF2-Rearranged Ph-like ALL.

Mol Cancer Res 2020 Aug 14. Epub 2020 Aug 14.

Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, Australia.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-1098DOI Listing
August 2020

Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer.

Front Oncol 2020 20;10:285. Epub 2020 Mar 20.

Children's Cancer Institute, School of Women's and Children's Health, Lowy Cancer Centre, University of New South Wales (UNSW), Sydney, NSW, Australia.

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http://dx.doi.org/10.3389/fonc.2020.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099402PMC
March 2020

Reversal of glucocorticoid resistance in paediatric acute lymphoblastic leukaemia is dependent on restoring BIM expression.

Br J Cancer 2020 Jun 3;122(12):1769-1781. Epub 2020 Apr 3.

Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1038/s41416-020-0824-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283241PMC
June 2020

Thiol-Reactive Star Polymers Functionalized with Short Ethoxy-Containing Moieties Exhibit Enhanced Uptake in Acute Lymphoblastic Leukemia Cells.

Int J Nanomedicine 2019 11;14:9795-9808. Epub 2019 Dec 11.

Leukemia Biology Program, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.2147/IJN.S220326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914812PMC
April 2020

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.

Cell Rep 2019 11;29(6):1675-1689.e9

Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880934PMC
November 2019

Preclinical activity of the antibody-drug conjugate denintuzumab mafodotin (SGN-CD19A) against pediatric acute lymphoblastic leukemia xenografts.

Pediatr Blood Cancer 2019 08 23;66(8):e27765. Epub 2019 Apr 23.

Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/pbc.27765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588422PMC
August 2019

Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression.

Br J Cancer 2018 04 13;118(7):1000-1004. Epub 2018 Mar 13.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.

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http://dx.doi.org/10.1038/s41416-018-0022-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931087PMC
April 2018

Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia.

Oncotarget 2016 09;7(37):58728-42

Leukaemia Biology Program, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.18632/oncotarget.11233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312271PMC
September 2016

The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects.

Clin Cancer Res 2016 05 5;22(10):2534-44. Epub 2016 Jan 5.

Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales Australia, Randwick, New South Wales, Australia. School of Women's & Children's Health, University of New South Wales Australia, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1666DOI Listing
May 2016

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.

Cancer Res 2016 Mar 1;76(5):1158-69. Epub 2015 Dec 1.

Gene Regulation Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1070DOI Listing
March 2016

p21(WAF1) modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia.

Cell Cycle 2015 ;14(22):3602-12

a Children's Cancer Institute ; Lowy Cancer Research Centre; UNSW Australia ; Sydney , NSW , Australia.

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http://dx.doi.org/10.1080/15384101.2015.1100774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825786PMC
September 2016

Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts.

Org Biomol Chem 2015 Jun;13(22):6299-312

School of Women's and Children's Health, UNSW Australia, Sydney 2052, Australia.

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http://xlink.rsc.org/?DOI=C5OB00779H
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http://dx.doi.org/10.1039/c5ob00779hDOI Listing
June 2015

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

Nat Commun 2015 Jan 7;6:5794. Epub 2015 Jan 7.

1] Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University, Ghent B-9052, Belgium [2] Department for Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium [3] Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1038/ncomms6794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354161PMC
January 2015

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.

Cell Stem Cell 2014 Dec;15(6):775-90

Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317339PMC
December 2014

Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.

Exp Hematol 2015 Jan 29;43(1):32-43.e1-35. Epub 2014 Oct 29.

Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California, Los Angeles, School of Medicine, Los Angeles, CA, United States; National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.exphem.2014.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894481PMC
January 2015

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells.

Blood 2015 Jan 21;125(2):273-83. Epub 2014 Oct 21.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, and the.

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http://dx.doi.org/10.1182/blood-2014-05-576470DOI Listing
January 2015

High-throughput screening of human leukemia xenografts to identify dexamethasone sensitizers.

J Biomol Screen 2014 Dec 7;19(10):1391-401. Epub 2014 Aug 7.

Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, Australia School of Women's and Children's Health, University of New South Wales, Sydney, Australia

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http://dx.doi.org/10.1177/1087057114546550DOI Listing
December 2014

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.

Biochem Pharmacol 2014 Mar 13;88(1):36-45. Epub 2014 Jan 13.

Auckland Cancer Society Research Centre, the University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, the University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.12.019DOI Listing
March 2014

Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress.

J Biol Chem 2013 Apr 28;288(17):12032-41. Epub 2013 Feb 28.

Cancer Cell Development Group, Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia.

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http://dx.doi.org/10.1074/jbc.M112.447821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636889PMC
April 2013

Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program.

Pediatr Blood Cancer 2013 Apr 2;60(4):633-41. Epub 2012 Jul 2.

Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/pbc.24235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495996PMC
April 2013

Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia.

BMC Genomics 2011 Nov 17;12:565. Epub 2011 Nov 17.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1186/1471-2164-12-565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228854PMC
November 2011

Induction of vascular endothelial growth factor secretion by childhood acute lymphoblastic leukemia cells via the FLT-3 signaling pathway.

Mol Cancer Ther 2012 Jan 14;11(1):183-93. Epub 2011 Nov 14.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-11
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http://dx.doi.org/10.1158/1535-7163.MCT-11-0503DOI Listing
January 2012

Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia.

J Paediatr Child Health 2012 Aug 3;48(8):634-40. Epub 2011 Nov 3.

Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1111/j.1440-1754.2011.02212.xDOI Listing
August 2012

p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia.

J Biol Chem 2011 Oct 7;286(43):37639-50. Epub 2011 Sep 7.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1074/jbc.M111.272336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199508PMC
October 2011

Small ubiquitin-related modifier-1: Wrestling with protein regulation.

Int J Biochem Cell Biol 2011 Jan 12;43(1):37-40. Epub 2010 Oct 12.

The Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S13572725100034
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http://dx.doi.org/10.1016/j.biocel.2010.09.022DOI Listing
January 2011

Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells.

Biochim Biophys Acta 2010 Oct 7;1803(10):1142-53. Epub 2010 Jul 7.

Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia.

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http://dx.doi.org/10.1016/j.bbamcr.2010.06.010DOI Listing
October 2010

Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia.

BMC Genomics 2010 Apr 21;11:256. Epub 2010 Apr 21.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Perth, Western Australia.

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http://dx.doi.org/10.1186/1471-2164-11-256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876122PMC
April 2010

The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs.

Mol Pharmacol 2010 Mar 28;77(3):483-94. Epub 2009 Dec 28.

Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1124/mol.109.060780DOI Listing
March 2010

Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma.

Br J Haematol 2009 May 7;145(3):389-93. Epub 2009 Mar 7.

Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07631.xDOI Listing
May 2009

siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth.

Int J Oncol 2008 Jul;33(1):175-83

Children's Cancer Institute Australia for Medical Research, Randwick, Australia.

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July 2008

Reduced immunogenicity of first-trimester human fetal pancreas.

Diabetes 2008 Mar 7;57(3):627-34. Epub 2007 Dec 7.

Diabetes Transplant Unit, The Prince of Wales Hospital and The University of New South Wales, Sydney, New South Wales 2031, Australia.

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http://dx.doi.org/10.2337/db07-0720aDOI Listing
March 2008

Preclinical chemotherapeutic tumor models of common childhood cancers: solid tumors, acute lymphoblastic leukemia, and disseminated neuroblastoma.

Curr Protoc Pharmacol 2007 Dec;Chapter 14:Unit14.8

St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/0471141755.ph1408s39DOI Listing
December 2007

p53 determines multidrug sensitivity of childhood neuroblastoma.

Cancer Res 2007 Nov;67(21):10351-60

Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4345DOI Listing
November 2007

In vivo models of childhood leukemia for preclinical drug testing.

Curr Drug Targets 2007 Jun;8(6):773-83

Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.2174/138945007780830809DOI Listing
June 2007

Initial testing of cisplatin by the pediatric preclinical testing program.

Pediatr Blood Cancer 2008 May;50(5):992-1000

Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia.

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http://doi.wiley.com/10.1002/pbc.21263
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http://dx.doi.org/10.1002/pbc.21263DOI Listing
May 2008

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

Blood 2007 Sep 29;110(6):2057-66. Epub 2007 May 29.

Developmental Therapeutics Program, Childrens Hospital Los Angeles and University of Southern California Institute for Pediatric Clinical Research, Los Angeles, CA 90027, USA.

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http://www.bloodjournal.org/content/110/6/2057.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-03-08
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http://dx.doi.org/10.1182/blood-2007-03-080325DOI Listing
September 2007

Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.

Cancer Res 2007 May;67(9):4482-90

Children's Cancer Institute Australia for Medical Research, The University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4244DOI Listing
May 2007

Xenograft models for the preclinical evaluation of new therapies in acute leukemia.

Leuk Lymphoma 2007 Apr;48(4):659-68

Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1080/10428190601113584DOI Listing
April 2007