Richard A Young

Richard A Young

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Family Medicine and Obstetrics: Let's Stop Pretending.

J Am Board Fam Med 2018 May-Jun;31(3):328-331

From the JPS Family Medicine Residency Program, Fort Worth, TX.

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http://dx.doi.org/10.3122/jabfm.2018.03.180087DOI Listing
September 2019

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs.

Mol Cell 2019 Sep 15;75(5):905-920.e6. Epub 2019 Aug 15.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731151PMC
September 2019

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.

Mol Cell 2019 Sep 19. Epub 2019 Sep 19.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.016DOI Listing
September 2019

Enhancer Features that Drive Formation of Transcriptional Condensates.

Mol Cell 2019 Aug;75(3):549-561.e7

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690378PMC
August 2019

Coding Family Medicine Residency Clinic Visits, 99213 or 99214? A Residency Research Network of Texas Study.

Fam Med 2019 Jun 23;51(6):477-483. Epub 2019 Apr 23.

University of Texas Health Science Center at San Antonio, Department of Family and Community Medicine.

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http://dx.doi.org/10.22454/FamMed.2019.862757DOI Listing
June 2019

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma.

Cell Rep 2018 12;25(13):3693-3705.e6

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; VA Boston Healthcare System, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407615PMC
December 2018

Transition to Adulthood as a Joint Parent-Youth Project for Young Persons With Intellectual and Developmental Disabilities.

Intellect Dev Disabil 2018 08;56(4):263-277

Anat Zaidman-Zait, University of Tel Aviv; and Richard A. Young, University of British Columbia.

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http://dx.doi.org/10.1352/1934-9556-56.5.263DOI Listing
August 2018

The Full Scope of Family Physicians' Work Is Not Reflected by Current Procedural Terminology Codes.

J Am Board Fam Med 2017 Nov-Dec;30(6):724-732

From the Department of Family Medicine, JPS Health Network, Fort Worth, TX (RAY); Department of Family Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX (SB, KAK); Baylor Family Medicine Residency, Garland, TX (JW).

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http://dx.doi.org/10.3122/jabfm.2017.06.170155DOI Listing
July 2018

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma.

J Invest Dermatol 2018 07 8;138(7):1582-1590. Epub 2018 Feb 8.

Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019629PMC
July 2018

Primary Care Physician Characteristics Associated with Low Value Care Spending.

J Am Board Fam Med 2019 Mar-Apr;32(2):218-225

From Robert Graham Center, Washington, DC (TWB, YC, SP, AB, WL); Department of Family and Community Medicine, UT Health San Antonio, San Antonio, TX (TWB); University of Pittsburgh School of Medicine, Pittsburgh, PA (PW) John Peter Smith Hospital Family Medicine Residency Program, Fort Worth (RAY); Department of Health Systems and Population Health Sciences, College of Medicine, University of Houston, Houston (WL).

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http://dx.doi.org/10.3122/jabfm.2019.02.180111DOI Listing
April 2018

The transition to adulthood of young adults with IDD: Parents' joint projects.

J Appl Res Intellect Disabil 2018 Mar 23;31 Suppl 2:224-233. Epub 2017 Aug 23.

University of Tel Aviv, Tel Aviv, Israel.

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http://dx.doi.org/10.1111/jar.12395DOI Listing
March 2018

Crafting continuity and change in Saudi society: Joint parent-youth transition-to-adulthood projects.

J Adolesc 2018 02 5;63:142-152. Epub 2018 Jan 5.

Counselling Psychology, University of Victoria, Canada.

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http://dx.doi.org/10.1016/j.adolescence.2017.12.014DOI Listing
February 2018

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.

Cancer Cell 2018 02 18;33(2):202-216.e6. Epub 2018 Jan 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173056
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http://dx.doi.org/10.1016/j.ccell.2017.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846483PMC
February 2018

A Time-Motion Study of Primary Care Physicians' Work in the Electronic Health Record Era.

Fam Med 2018 02;50(2):91-99

University of Texas Health Science Center at San Antonio.

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http://dx.doi.org/10.22454/FamMed.2018.184803DOI Listing
February 2018

BET bromodomain proteins regulate enhancer function during adipogenesis.

Proc Natl Acad Sci U S A 2018 02 14;115(9):2144-2149. Epub 2018 Feb 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1711155115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834672PMC
February 2018

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.

Cell 2018 02 15;172(5):979-992.e6. Epub 2018 Feb 15.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183004
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http://dx.doi.org/10.1016/j.cell.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375087PMC
February 2018

YY1 Is a Structural Regulator of Enhancer-Promoter Loops.

Cell 2017 Dec 7;171(7):1573-1588.e28. Epub 2017 Dec 7.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785279PMC
December 2017

New Insights into Genome Structure: Genes of a Feather Stick Together.

Mol Cell 2017 Sep;67(5):730-731

Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638658PMC
September 2017

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.

Nat Commun 2017 04 5;8:14802. Epub 2017 Apr 5.

Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/ncomms14802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382276PMC
April 2017

Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.

Cell 2017 Mar;168(6):1000-1014.e15

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173019
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http://dx.doi.org/10.1016/j.cell.2017.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350633PMC
March 2017

The Challenges of Measuring, Improving, and Reporting Quality in Primary Care.

Ann Fam Med 2017 03;15(2):175-182

Indiana University School of Informatics and Computing, Bloomington, Indiana.

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http://dx.doi.org/10.1370/afm.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348238PMC
March 2017

A Phase Separation Model for Transcriptional Control.

Cell 2017 03;169(1):13-23

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432200PMC
March 2017

Transcriptional Addiction in Cancer.

Cell 2017 02;168(4):629-643

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308559PMC
February 2017

Prospective content in the friendship conversations of young adults.

J Adolesc 2017 Jan 10;54:9-17. Epub 2016 Nov 10.

University of British Columbia, Canada.

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http://dx.doi.org/10.1016/j.adolescence.2016.11.001DOI Listing
January 2017

Maternity Care Services Provided by Family Physicians in Rural Hospitals.

Authors:
Richard A Young

J Am Board Fam Med 2017 01;30(1):71-77

From the JPS Health Network, Fort Worth, TX.

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http://dx.doi.org/10.3122/jabfm.2017.01.160072DOI Listing
January 2017

Prospective content in the friendship conversations of young adults.

J Adolesc 2017 Jan 10;54:9-17. Epub 2016 Nov 10.

University of British Columbia, Canada.

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http://dx.doi.org/10.1016/j.adolescence.2016.11.001DOI Listing
January 2017

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control.

Cell 2016 11;167(5):1188-1200

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163144
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http://dx.doi.org/10.1016/j.cell.2016.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125522PMC
November 2016

Editing DNA Methylation in the Mammalian Genome.

Cell 2016 Sep;167(1):233-247.e17

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062609PMC
http://dx.doi.org/10.1016/j.cell.2016.08.056DOI Listing
September 2016

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.

Genes Dev 2016 08 4;30(15):1698-703. Epub 2016 Aug 4.

Howard Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;

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http://dx.doi.org/10.1101/gad.282756.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002975PMC
August 2016

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Mol Cell 2016 Apr;62(1):34-46

Howard Hughes Medical Institute, Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836061PMC
April 2016

Models of human core transcriptional regulatory circuitries.

Genome Res 2016 Mar 3;26(3):385-96. Epub 2016 Feb 3.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

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http://dx.doi.org/10.1101/gr.197590.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772020PMC
March 2016

3D Chromosome Regulatory Landscape of Human Pluripotent Cells.

Cell Stem Cell 2016 Feb 10;18(2):262-75. Epub 2015 Dec 10.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(15)00505-6
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http://www.cell.com/cms/attachment/2045959822/2057172160/mmc
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http://dx.doi.org/10.1016/j.stem.2015.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848748PMC
February 2016

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.

Science 2016 Jan 28;351(6272):aad2197. Epub 2016 Jan 28.

Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA. Harvard Stem Cell Institute, Boston, MA 02115, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02115, USA. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.aad2197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868069PMC
January 2016

Driver Compensation: Impairment or Improvement?

Authors:
Richard A Young

Hum Factors 2015 Dec;57(8):1334-8

Wayne State University, Detroit, Michigan

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http://dx.doi.org/10.1177/0018720815585053DOI Listing
December 2015

Transcription factor trapping by RNA in gene regulatory elements.

Science 2015 Nov 29;350(6263):978-81. Epub 2015 Oct 29.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.aad3346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720525PMC
November 2015

A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity.

Stem Cell Reports 2015 Nov;5(5):763-775

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649293PMC
November 2015

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.

Stem Cell Reports 2013 24;1(5):371-8. Epub 2013 Oct 24.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841252PMC
October 2015

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Cell 2015 Sep;163(1):174-86

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583659PMC
September 2015

Inpatient Hand-Offs in Family Medicine Residency Programs: A CERA Study.

Fam Med 2015 May;47(5):362-6

Texas Tech University Health Sciences Center, Lubbock, TX.

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May 2015

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.

Mol Cell 2015 Apr 19;58(2):362-70. Epub 2015 Mar 19.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402134PMC
April 2015

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.

Proc Natl Acad Sci U S A 2015 Mar 9;112(12):3841-6. Epub 2015 Mar 9.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1502971112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378427PMC
March 2015

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

Science 2014 Dec 13;346(6215):1373-7. Epub 2014 Nov 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Division of Pediatric Hematology-Oncology, Boston Children's Hospital, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1259037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720521PMC
December 2014

Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells.

Stem Cell Reports 2014 Dec 6;3(6):948-56. Epub 2014 Nov 6.

The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264067PMC
December 2014

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

Cell 2014 Nov 6;159(5):1126-1139. Epub 2014 Nov 6.

Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243043PMC
November 2014

The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.

Cell Stem Cell 2014 Sep;15(3):295-309

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Skolkovo Institute of Science and Technology (Skoltech), Novaya strazha 100, Skolkovo Moscow Region 143025, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170792PMC
September 2014

D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.

Dev Cell 2014 Aug 31;30(3):255-67. Epub 2014 Jul 31.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134362PMC
August 2014

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Nature 2014 Jul 22;511(7511):616-20. Epub 2014 Jun 22.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244910PMC
July 2014

Family physicians' suggestions to improve the documentation, coding, and billing system: a study from the residency research network of Texas.

Fam Med 2014 Jun;46(6):470-2

Family Medicine Residency Program, John Peter Smith, Fort Worth, TX.

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June 2014

Family physicians' opinions on the primary care documentation, coding, and billing system: a qualitative study from the residency research network of Texas.

Fam Med 2014 May;46(5):378-84

Family Medicine Residency Program, John Peter Smith, Fort Worth, TX.

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May 2014

Distracted driving and crash risk.

Authors:
Richard A Young

N Engl J Med 2014 04;370(16):1564

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http://dx.doi.org/10.1056/NEJMc1401241DOI Listing
April 2014

SMC complexes link gene expression and genome architecture.

Curr Opin Genet Dev 2014 Apr 8;25:131-7. Epub 2014 May 8.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045092PMC
http://dx.doi.org/10.1016/j.gde.2013.11.009DOI Listing
April 2014

Genome-wide localization of small molecules.

Nat Biotechnol 2014 Jan 15;32(1):92-6. Epub 2013 Dec 15.

1] Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA. [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189815PMC
January 2014

MYC and transcription elongation.

Cold Spring Harb Perspect Med 2014 Jan 1;4(1):a020990. Epub 2014 Jan 1.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.

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http://dx.doi.org/10.1101/cshperspect.a020990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869279PMC
January 2014

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.

Cell Rep 2014 Jan 16;6(2):313-24. Epub 2014 Jan 16.

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041390PMC
January 2014

Super-enhancers in the control of cell identity and disease.

Cell 2013 Nov 10;155(4):934-47. Epub 2013 Oct 10.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.cell.2013.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841062PMC
November 2013

Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals.

Nat Neurosci 2013 Sep 18;16(9):1191-1198. Epub 2013 Aug 18.

Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia Stem Cell Initiative, Columbia University Medical Center, 630 W 168 Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1038/nn.3490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799941PMC
September 2013