Richard A Morgan

Richard A Morgan

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Richard A Morgan

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Improved Titer and Gene Transfer by Lentiviral Vectors Using Novel, Small β-Globin Locus Control Region Elements.

Mol Ther 2020 Jan 28;28(1):328-340. Epub 2019 Sep 28.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; The Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953778PMC
January 2020

Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models.

J Immunother Cancer 2020 Jan;8(1)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1136/jitc-2019-000210DOI Listing
January 2020

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma.

N Engl J Med 2019 05;380(18):1726-1737

From the Massachusetts General Hospital Cancer Center (N.R., M.V.M.), Beth Israel Deaconess Medical Center (J.R.), and Dana-Farber Cancer Institute and Veterans Affairs Boston Healthcare System (N.M.), Boston, and Bluebird Bio, Cambridge (A.T., L.-P.L., R.A.M., K.F., M.M., F.P., M.T.Q.) - all in Massachusetts; Sarah Cannon Research Institute and Tennessee Oncology, Nashville (J.B.); Mayo Clinic, Rochester, MN (Y.L.); Hackensack University Medical Center, Hackensack (D.S.), and Celgene, Summit (J.W., G.R., Z.Y.) - both in New Jersey; Mount Sinai Medical Center, New York (S.J., D.M.); Stanford University Medical Center, Palo Alto (M.L.), and Celgene, San Francisco (T.C., K.H.) - both in California; and the Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (J.N.K.).

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http://www.nejm.org/doi/10.1056/NEJMoa1817226
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http://dx.doi.org/10.1056/NEJMoa1817226DOI Listing
May 2019

Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned.

Cell Stem Cell 2017 Nov;21(5):574-590

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA, 90095; Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA, 90095; Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, CA, 90095; The Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, University of California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039108PMC
November 2017

Hypermutation In Pancreatic Cancer.

Gastroenterology 2017 01 15;152(1):68-74.e2. Epub 2016 Nov 15.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; Department of Surgery, Bankstown Hospital, Bankstown, Sydney, New South Wales, Australia; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales Australia, Liverpool, New South Wales, Australia; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085163518
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http://dx.doi.org/10.1053/j.gastro.2016.09.060DOI Listing
January 2017

Genetic Modification of T Cells.

Biomedicines 2016 Apr 20;4(2). Epub 2016 Apr 20.

Bluebird bio, 150 Second Street, Cambridge, MA 02141, USA.

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http://dx.doi.org/10.3390/biomedicines4020009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344249PMC
April 2016

Salient Features of Endonuclease Platforms for Therapeutic Genome Editing.

Mol Ther 2016 Mar 22;24(3):422-9. Epub 2016 Jan 22.

bluebird bio, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/mt.2016.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786926PMC
March 2016

Genomic analyses identify molecular subtypes of pancreatic cancer.

Authors:
Peter Bailey David K Chang Katia Nones Amber L Johns Ann-Marie Patch Marie-Claude Gingras David K Miller Angelika N Christ Tim J C Bruxner Michael C Quinn Craig Nourse L Charles Murtaugh Ivon Harliwong Senel Idrisoglu Suzanne Manning Ehsan Nourbakhsh Shivangi Wani Lynn Fink Oliver Holmes Venessa Chin Matthew J Anderson Stephen Kazakoff Conrad Leonard Felicity Newell Nick Waddell Scott Wood Qinying Xu Peter J Wilson Nicole Cloonan Karin S Kassahn Darrin Taylor Kelly Quek Alan Robertson Lorena Pantano Laura Mincarelli Luis N Sanchez Lisa Evers Jianmin Wu Mark Pinese Mark J Cowley Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Lorraine A Chantrill Amanda Mawson Jeremy Humphris Angela Chou Marina Pajic Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Lovell Neil D Merrett Christopher W Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Kim Moran-Jones Nigel B Jamieson Janet S Graham Fraser Duthie Karin Oien Jane Hair Robert Grützmann Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Borislav Rusev Paola Capelli Roberto Salvia Giampaolo Tortora Debabrata Mukhopadhyay Gloria M Petersen Donna M Munzy William E Fisher Saadia A Karim James R Eshleman Ralph H Hruban Christian Pilarsky Jennifer P Morton Owen J Sansom Aldo Scarpa Elizabeth A Musgrove Ulla-Maja Hagbo Bailey Oliver Hofmann Robert L Sutherland David A Wheeler Anthony J Gill Richard A Gibbs John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2016 Mar 24;531(7592):47-52. Epub 2016 Feb 24.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1038/nature16965DOI Listing
March 2016

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity.

J Virol 2015 Jul 15;89(13):6685-94. Epub 2015 Apr 15.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.00474-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468509PMC
July 2015

Whole genomes redefine the mutational landscape of pancreatic cancer.

Nature 2015 Feb;518(7540):495-501

1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nature14169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523082PMC
February 2015

Genetic modification of T cells.

Cancer J 2014 Mar-Apr;20(2):145-50

From Bluebird Bio, Cambridge, MA.R.A.M. and S.K. are employees of and own equity in Bluebird Bio.

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http://dx.doi.org/10.1097/PPO.0000000000000033DOI Listing
November 2014

Gamma-retroviral vector design for the co-expression of artificial microRNAs and therapeutic proteins.

Nucleic Acid Ther 2014 Oct 14;24(5):356-63. Epub 2014 Jul 14.

Surgery Branch, Center for Cancer Research, National Cancer Institute , Bethesda, Maryland.

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http://dx.doi.org/10.1089/nat.2014.0486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162432PMC
October 2014

Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells.

J Immunother Cancer 2014 19;2:25. Epub 2014 Aug 19.

Surgery Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive, Building 10 Hatfield CRC, Rm 3-5930, 20892-1201 Bethesda, MD, USA ; Current address: Bluebird bio, 150 Second St, Cambridge, MA 02141, USA.

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http://dx.doi.org/10.1186/2051-1426-2-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155770PMC
September 2014

Boolean immunotherapy: reversal of fortune.

Authors:
Richard A Morgan

Mol Ther 2014 Jun;22(6):1073-1074

Immunotherapy, bluebird bio, Cambridge, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2014.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048909PMC
June 2014

Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies.

Oncoimmunology 2014 18;3:e29194. Epub 2014 Jun 18.

bluebird bio; Cambridge, MA USA.

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http://dx.doi.org/10.4161/onci.29194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108460PMC
June 2014

EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.

Clin Cancer Res 2014 Feb 18;20(4):972-84. Epub 2013 Dec 18.

Authors' Affiliations: Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery; Department of Pathology; The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina; and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943170PMC
February 2014

Risky business: target choice in adoptive cell therapy.

Authors:
Richard A Morgan

Blood 2013 Nov;122(20):3392-4

NATIONAL INSTITUTES OF HEALTH.

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http://dx.doi.org/10.1182/blood-2013-09-527622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829111PMC
November 2013

Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy.

Clin Cancer Res 2013 Sep 10;19(18):4941-50. Epub 2013 Sep 10.

Authors' Affiliation: Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778100PMC
September 2013

Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes.

Blood 2013 Aug 16;122(8):1399-410. Epub 2013 Jul 16.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2013-04-495531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750338PMC
August 2013

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

Mol Ther 2013 Jul 9;21(7):1369-77. Epub 2013 Apr 9.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2013.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702103PMC
July 2013

FAM190A deficiency creates a cell division defect.

Am J Pathol 2013 Jul 10;183(1):296-303. Epub 2013 May 10.

Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1016/j.ajpath.2013.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702746PMC
July 2013

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia.

J Exp Med 2013 Jun 27;210(6):1125-35. Epub 2013 May 27.

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20130110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674706PMC
June 2013

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.

Cancer Immunol Immunother 2013 Apr 4;62(4):727-36. Epub 2012 Dec 4.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, CRC 3 W-3864, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00262-012-1378-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354242PMC
April 2013

Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.

Blood 2013 Feb 14;121(7):1165-74. Epub 2012 Dec 14.

Pediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2012-06-438002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575759PMC
February 2013

Faster, cheaper, safer, T-cell engineering.

Authors:
Richard A Morgan

J Immunother 2013 Jan;36(1):1-2

Surgery Branch, National Cancer Institute, Bethesda, MD. 20892, USA.

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http://dx.doi.org/10.1097/CJI.0b013e3182791257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521862PMC
January 2013

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors:
Andrew V Biankin Nicola Waddell Karin S Kassahn Marie-Claude Gingras Lakshmi B Muthuswamy Amber L Johns David K Miller Peter J Wilson Ann-Marie Patch Jianmin Wu David K Chang Mark J Cowley Brooke B Gardiner Sarah Song Ivon Harliwong Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Milena Gongora Marina Pajic Christopher J Scarlett Anthony J Gill Andreia V Pinho Ilse Rooman Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Katia Nones J Lynn Fink Angelika Christ Tim Bruxner Nicole Cloonan Gabriel Kolle Felicity Newell Mark Pinese R Scott Mead Jeremy L Humphris Warren Kaplan Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Angela Chou Venessa T Chin Lorraine A Chantrill Amanda Mawson Jaswinder S Samra James G Kench Jessica A Lovell Roger J Daly Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nipun Kakkar Fengmei Zhao Yuan Qing Wu Min Wang Donna M Muzny William E Fisher F Charles Brunicardi Sally E Hodges Jeffrey G Reid Jennifer Drummond Kyle Chang Yi Han Lora R Lewis Huyen Dinh Christian J Buhay Timothy Beck Lee Timms Michelle Sam Kimberly Begley Andrew Brown Deepa Pai Ami Panchal Nicholas Buchner Richard De Borja Robert E Denroche Christina K Yung Stefano Serra Nicole Onetto Debabrata Mukhopadhyay Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Steven Gallinger Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Paola Capelli Vincenzo Corbo Maria Scardoni Giampaolo Tortora Margaret A Tempero Karen M Mann Nancy A Jenkins Pedro A Perez-Mancera David J Adams David A Largaespada Lodewyk F A Wessels Alistair G Rust Lincoln D Stein David A Tuveson Neal G Copeland Elizabeth A Musgrove Aldo Scarpa James R Eshleman Thomas J Hudson Robert L Sutherland David A Wheeler John V Pearson John D McPherson Richard A Gibbs Sean M Grimmond

Nature 2012 Nov 24;491(7424):399-405. Epub 2012 Oct 24.

The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1038/nature11547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898PMC
November 2012

Audiovestibular dysfunction associated with adoptive cell immunotherapy for melanoma.

Otolaryngol Head Neck Surg 2012 Oct 17;147(4):744-9. Epub 2012 May 17.

Department of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1177/0194599812448356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318787PMC
October 2012

Genetic engineering with T cell receptors.

Adv Drug Deliv Rev 2012 Jun 9;64(8):756-62. Epub 2011 Dec 9.

National Institutes of Health, National Cancer Institute, Surgery Branch, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.addr.2011.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404458PMC
June 2012

Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical application.

J Immunother 2012 Jun;35(5):430-9

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1097/CJI.0b013e31825898e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358728PMC
June 2012

Cancer therapy with genetically-modified T cells for the treatment of melanoma.

J Gene Med 2012 Jun;14(6):400-4

National Institutes of Health, National Cancer Institute, Surgery Branch, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/jgm.2636DOI Listing
June 2012

Human tumor xenografts: the good, the bad, and the ugly.

Authors:
Richard A Morgan

Mol Ther 2012 May;20(5):882-4

Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/mt.2012.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345993PMC
May 2012

Protein L: a novel reagent for the detection of chimeric antigen receptor (CAR) expression by flow cytometry.

J Transl Med 2012 Feb 13;10:29. Epub 2012 Feb 13.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1479-5876-10-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299624PMC
February 2012

Protein L: a novel reagent for the detection of chimeric antigen receptor (CAR) expression by flow cytometry.

J Transl Med 2012 Feb 13;10:29. Epub 2012 Feb 13.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1479-5876-10-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299624PMC
February 2012

The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes.

PLoS One 2011 28;6(7):e22560. Epub 2011 Jul 28.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022560PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145643PMC
December 2011

Treating cancer with genetically engineered T cells.

Trends Biotechnol 2011 Nov 12;29(11):550-7. Epub 2011 Jun 12.

National Institutes of Health, National Cancer Institute, Surgery Branch, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.tibtech.2011.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193849PMC
November 2011

The position of the AUG start codon in MFG-based γ-retroviral vectors has a dramatic effect on translation-dependent protein expression.

J Gene Med 2011 Sep;13(9):478-86

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/jgm.1599DOI Listing
September 2011

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.

Cancer Immunol Immunother 2011 May 9;60(5):739-49. Epub 2011 Feb 9.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://link.springer.com/10.1007/s00262-011-0977-7
Publisher Site
http://dx.doi.org/10.1007/s00262-011-0977-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080434PMC
May 2011

Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment.

Mol Ther 2011 Apr 1;19(4):751-9. Epub 2011 Feb 1.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/mt.2010.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070103PMC
April 2011

Genetic modification of T cells.

Biol Blood Marrow Transplant 2011 Jan;17(1 Suppl):S15-20

Experimental Hematology Unit, Research Division of Regenerative Medicine, Gene Therapy and Stem Cells, Hematology and BMT Unit, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy.

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http://dx.doi.org/10.1016/j.bbmt.2010.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053011PMC
January 2011

A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors.

J Immunother 2010 Jul-Aug;33(6):648-58

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/CJI.0b013e3181e311cbDOI Listing
December 2010

Development of human anti-murine T-cell receptor antibodies in both responding and nonresponding patients enrolled in TCR gene therapy trials.

Clin Cancer Res 2010 Dec;16(23):5852-61

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058233PMC
December 2010

Selected murine residues endow human TCR with enhanced tumor recognition.

J Immunol 2010 Jun 28;184(11):6232-41. Epub 2010 Apr 28.

Laboratory of Tumor Immunology and Immunotherapy, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.

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http://dx.doi.org/10.4049/jimmunol.0902047DOI Listing
June 2010

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.

Mol Ther 2010 Apr 23;18(4):843-51. Epub 2010 Feb 23.

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/mt.2010.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862534PMC
April 2010

Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor.

J Immunother 2009 Sep;32(7):689-702

Surgery Branch of the National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/CJI.0b013e3181ac6138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747302PMC
September 2009

Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less-differentiated cells.

J Immunother 2008 Nov-Dec;31(9):830-9

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/CJI.0b013e31818817c5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399689PMC
July 2009

Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells.

Hum Gene Ther 2008 Nov;19(11):1219-32

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1201, USA.

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http://dx.doi.org/10.1089/hum.2008.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889139PMC
November 2008

Adoptive cell transfer: a clinical path to effective cancer immunotherapy.

Nat Rev Cancer 2008 Apr;8(4):299-308

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrc2355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553205PMC
April 2008

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma.

Blood 2007 Nov 27;110(10):3564-72. Epub 2007 Jul 27.

Department of Immunology, the Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2007-02-075010DOI Listing
November 2007

Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes.

J Immunother 2006 Jul-Aug;29(4):398-406

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/01.cji.0000203082.20365.7fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510955PMC
September 2006