Richard A Larson

Richard A Larson

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Richard A Larson

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Patients' perspectives on the definition of cure in chronic myeloid leukemia.

Leuk Res 2019 May 28;80:40-42. Epub 2019 Mar 28.

Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee 53226, United States.

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http://dx.doi.org/10.1016/j.leukres.2019.03.007DOI Listing
May 2019

Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL.

N Engl J Med 2018 12 1;379(26):2517-2528. Epub 2018 Dec 1.

From Ohio State University Comprehensive Cancer Center, Columbus (J.A.W., A.S.R., N.A.H., W.Z., K.A.R., G.L., J.S.B., H.G.O., J.C.B.); the Alliance Statistics and Data Center (A.S.R., A.M.B., B.M.-E., B.F., S.J.M.), Mayo Clinic (W.D., S.A.P., M.L.), Rochester, MN; Washington University School of Medicine, St. Louis (N.L.B.); Duke Cancer Institute, Duke University Medical Center, Durham (D.M.B., H.E.), and First Health of the Carolinas Cancer Center, Pinehurst (C.K.) - both in North Carolina; the University of Rochester Medical Center, Rochester, NY (P.M.B.); Stanford University School of Medicine, Stanford (S.C.), and the City of Hope Comprehensive Cancer Center, Duarte (A.H.) - both in California; Dana-Farber Partners CancerCare (J.R.B., R.M.S.) and the Massachusetts General Hospital Cancer Center (J.S.A.) - both in Boston; Fort Wayne Medical Oncology and Hematology, Fort Wayne, IN (S.N.); University of Chicago Comprehensive Cancer Center (R.A.L.) and Loyola University Chicago (S.E.S.) - both in Chicago; the University of Calgary, Tom Baker Cancer Centre, Calgary, AB, Canada (C.O.); and the Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD (R.F.L.).

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http://dx.doi.org/10.1056/NEJMoa1812836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325637PMC
December 2018

Imatinib is still recommended for frontline therapy for CML.

Blood Adv 2018 12;2(24):3648-3652

Department of Medicine and Comprehensive Cancer Center, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1182/bloodadvances.2018018614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306882PMC
December 2018

Pepsi® or Coke®? Influence of acid on dasatinib absorption.

J Oncol Pharm Pract 2018 Mar 28;24(2):156-158. Epub 2017 Feb 28.

2 Department of Medicine, University of Chicago Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1177/1078155217692152DOI Listing
March 2018

Managing CNS disease in adults with acute lymphoblastic leukemia.

Authors:
Richard A Larson

Leuk Lymphoma 2018 01 23;59(1):3-13. Epub 2017 May 23.

a Department of Medicine, Section of Hematology/Oncology, and Comprehensive Cancer Center , The University of Chicago , Chicago , IL , USA.

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http://dx.doi.org/10.1080/10428194.2017.1326597DOI Listing
January 2018

Midostaurin in FLT3-Mutated Acute Myeloid Leukemia.

N Engl J Med 2017 11;377(19):1903

University Hospital of Ulm, Ulm, Germany

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http://dx.doi.org/10.1056/NEJMc1711340DOI Listing
November 2017

Efficacy of single-agent decitabine in relapsed and refractory acute myeloid leukemia.

Leuk Lymphoma 2017 09 20;58(9):1-7. Epub 2017 Feb 20.

b Department of Medicine , Section of Hematology/Oncology, The University of Chicago Medicine , Chicago , IL , USA.

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http://dx.doi.org/10.1080/10428194.2017.1289524DOI Listing
September 2017

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation.

N Engl J Med 2017 08 23;377(5):454-464. Epub 2017 Jun 23.

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (R.M.S.); the Division of Biomedical Statistics and Informatics (S.J.M., K.L.) and the Alliance Statistics and Data Center (S.J.M., K.L., S.G.), Mayo Clinic, Rochester, MN; the Alliance Statistics and Data Center, Duke University, Durham, NC (B.L.S.); the Ohio State University Comprehensive Cancer Center, Columbus (S.G., C.D.B., T.W.P., G.M., R.B.K.); Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden (C.T., G.E.), Department of Internal Medicine III, University Hospital of Ulm, Ulm (K.D., R.F.S., H.D.), Hematology and Oncology, University of Leipzig, Leipzig (D.N.), Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover (J.K., A.G.), and Department of Medicine II, Hematology-Oncology, Goethe University Hospital Frankfurt, Frankfurt am Main (H.S.) - all in Germany; the Department of Biomedicine and Prevention, University Tor Vergata, Rome (F.L.-C., S.A.); the Department of Clinical Haematology, Alfred Hospital and Monash University, Melbourne, VIC, Australia (A.W.); Hospital de la Santa Creu i Sant Pau, Hematology Department, Autonomous University of Barcelona, Barcelona (J.S.), and Hospital Universitario la Fe, Hematology Department, Department of Medicine, University of Valencia, Valencia (M.A.S.) - both in Spain; the Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto (J.M.B.); Radboud Institute Molecular Studies, Radboud University Medical Center, Nijmegen, the Netherlands (T.W.); the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle (F.R.A.); the Division of Hematology-Oncology, Stanford Comprehensive Cancer Center, Stanford University, Stanford, CA (B.C.M.); the Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York (M.S.T.); and the Department of Medicine, University of Chicago, Chicago (R.A.L.).

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http://dx.doi.org/10.1056/NEJMoa1614359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754190PMC
August 2017

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia.

N Engl J Med 2017 03;376(10):917-927

From Abteilung Hämatologie-Onkologie, Universitätsklinikum Jena, Jena, Germany (A.H.); the Department of Medicine, University of Chicago, Chicago (R.A.L.); INSERM Centre d'Investigation Clinique 1402, Centre Hospitalier Universitaire de Poitiers, Poitiers, France (F.G.); Fred Hutchinson Cancer Research Center, Seattle (J.P.R.); Centre for Cancer Biology, SA Pathology, University of South Australia and University of Adelaide (S.B.), and the South Australian Health and Medical Research Institute and University of Adelaide (T.P.H.), Adelaide, SA, Australia; University of Bologna, Bologna, Italy (M.B.); the University of Utah Huntsman Cancer Institute, Salt Lake City (M.W.D.); the Hematology Department, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona (F.C.); Novartis, Basel, Switzerland (S.F., C.-E.O., H.D.M.); M.D. Anderson Cancer Center, Houston (H.K.); the University of Newcastle, Newcastle, United Kingdom (S.G.O.); and Knight Cancer Institute, Oregon Health and Science University and Howard Hughes Medical Institute, Portland (B.J.D.).

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http://dx.doi.org/10.1056/NEJMoa1609324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901965PMC
March 2017

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N-Methyladenosine RNA Demethylase.

Cancer Cell 2017 01 22;31(1):127-141. Epub 2016 Dec 22.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108163056
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http://dx.doi.org/10.1016/j.ccell.2016.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234852PMC
January 2017

Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy.

Biol Blood Marrow Transplant 2016 11 4;22(11):2100-2103. Epub 2016 Aug 4.

Section of Hematology/Oncology, Department of Medicine, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois; Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592729PMC
November 2016

Is there a best TKI for chronic phase CML?

Authors:
Richard A Larson

Hematology Am Soc Hematol Educ Program 2015 ;2015:250-6

Section of Hematology/Oncology, Department of Medicine, and Comprehensive Cancer Center, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1182/asheducation-2015.1.250DOI Listing
October 2016

miR-141-Mediated Regulation of Brain Metastasis From Breast Cancer.

J Natl Cancer Inst 2016 08 13;108(8). Epub 2016 Apr 13.

Affiliation of authors: Departments of Experimental Radiation Oncology (BGD, LLa, PD, RAL, ARW, WX, DLS, LLi), Hematopathology (SA, JMR), Experimental Therapeutics (KC, CI, GAC), Pathology (LH, SK), Biostatistics (CW, WW), Radiation Oncology (AB, PKA, TAB, WAW), and Breast Medical Oncology (NTU), The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (XHZ); Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, TX (BGD, LLa, SA, LH, RAL, ARW, WX, DLS, LLi, SK, TAB, NTU, JMR, WAW).

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http://dx.doi.org/10.1093/jnci/djw026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017951PMC
August 2016

Cost-effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase After Generic Entry of Imatinib in the United States.

J Natl Cancer Inst 2016 Jul 4;108(7). Epub 2016 Mar 4.

Affiliations of authors:Department of Health Policy and Management, Johns Hopkins University , Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center , and Cecil G. Sheps Center for Health Services Research, University of North Carolina , Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College , London , UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna , Bologna , Italy ; Department of Haematology and Oncology, University Hospital , Jena , Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno , Brno , Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig , Leipzig , Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University , Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center , New York, NY (RTS); Uppsala University , Uppsala , Sweden (BS).

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http://dx.doi.org/10.1093/jnci/djw003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948567PMC
July 2016

Positron Emission Tomography-Computed Tomography Imaging of a Patient With Several Myeloid Sarcomas With FLT3-ITD and NPM1 Mutations.

J Clin Oncol 2016 05 14;34(13):e123-5. Epub 2014 Apr 14.

University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1200/JCO.2013.50.0140DOI Listing
May 2016

Dasatinib-Related Pulmonary Toxicity Mimicking an Atypical Infection.

J Clin Oncol 2016 Feb 23;34(6):e46-8. Epub 2014 Jun 23.

The University of Chicago, Chicago IL.

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http://dx.doi.org/10.1200/JCO.2013.50.1981DOI Listing
February 2016

Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502.

J Clin Oncol 2015 Dec 2;33(35):4167-75. Epub 2015 Nov 2.

Steven M. Devine and William Blum, Ohio State University, Columbus, OH; Kouros Owzar, Flora Mulkey, Vera Hars, and Alexander B. Sibley, Alliance Statistics and Data Center, Duke University, Durham; Thomas C. Shea, University of North Carolina, Chapel Hill, NC; Richard M. Stone, Robert J. Soiffer, and Edwin P. Alyea, Dana-Farber Cancer Institute; Yi-Bin Chen, Massachusetts General Hospital, Boston, MA; Jack W. Hsu, University of Florida, Gainesville, FL; Richard E. Champlin, MD Anderson Cancer Research Center, Houston, TX; Ravi Vij, Washington University, St. Louis, MO; James Slack, Mayo Clinic, Scottsdale, AZ; Richard A. Larson, University of Chicago, Chicago, IL; Sergio Giralt, Memorial Sloan Kettering Cancer Center, New York, NY; Shelly Carter, The EMMES Corporation, Bethesda, MD; Mary M. Horowitz, Medical College of Wisconsin, Milwaukee, WI; and Charles Linker, University of California at San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1200/JCO.2015.62.7273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658453PMC
December 2015

Is there a best TKI for chronic phase CML?

Authors:
Richard A Larson

Blood 2015 Nov;126(21):2370-5

Section of Hematology/Oncology, Department of Medicine, and Comprehensive Cancer Center, The University of Chicago, Chicago IL.

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http://dx.doi.org/10.1182/blood-2015-06-641043DOI Listing
November 2015

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Authors:
Ayalew Tefferi Hagop Kantarjian S Vincent Rajkumar Lawrence H Baker Jan L Abkowitz John W Adamson Ranjana Hira Advani James Allison Karen H Antman Robert C Bast John M Bennett Edward J Benz Nancy Berliner Joseph Bertino Ravi Bhatia Smita Bhatia Deepa Bhojwani Charles D Blanke Clara D Bloomfield Linda Bosserman Hal E Broxmeyer John C Byrd Fernando Cabanillas George Peter Canellos Bruce A Chabner Asher Chanan-Khan Bruce Cheson Bayard Clarkson Susan L Cohn Gerardo Colon-Otero Jorge Cortes Steven Coutre Massimo Cristofanilli Walter J Curran George Q Daley Daniel J DeAngelo H Joachim Deeg Lawrence H Einhorn Harry P Erba Francisco J Esteva Elihu Estey Isaiah J Fidler James Foran Stephen Forman Emil Freireich Charles Fuchs James N George Morie A Gertz Sergio Giralt Harvey Golomb Peter Greenberg Jordan Gutterman Robert I Handin Samuel Hellman Paulo Marcelo Hoff Ronald Hoffman Waun Ki Hong Mary Horowitz Gabriel N Hortobagyi Clifford Hudis Jean Pierre Issa Bruce Evan Johnson Philip W Kantoff Kenneth Kaushansky David Khayat Fadlo R Khuri Thomas J Kipps Margaret Kripke Robert A Kyle Richard A Larson Theodore S Lawrence Ross Levine Michael P Link Scott M Lippman Sagar Lonial Gary H Lyman Maurie Markman John Mendelsohn Neal J Meropol Yoav Messinger Therese M Mulvey Susan O'Brien Roman Perez-Soler Raphael Pollock Josef Prchal Oliver Press Jerald Radich Kanti Rai Saul A Rosenberg Jacob M Rowe Hope Rugo Carolyn D Runowicz Brenda M Sandmaier Alan Saven Andrew I Schafer Charles Schiffer Mikkael A Sekeres Richard T Silver Lillian L Siu David P Steensma F Marc Stewart Wendy Stock Richard Stone Rainer Storb Louise C Strong Martin S Tallman Michael Thompson Naoto T Ueno Richard A Van Etten Julie M Vose Peter H Wiernik Eric P Winer Anas Younes Andrew D Zelenetz Charles A LeMaistre

Mayo Clin Proc 2015 Aug 23;90(8):996-1000. Epub 2015 Jul 23.

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http://dx.doi.org/10.1016/j.mayocp.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365030PMC
August 2015

Changing the cost of care for chronic myeloid leukemia: the availability of generic imatinib in the USA and the EU.

Ann Hematol 2015 Apr 27;94 Suppl 2:S249-57. Epub 2015 Mar 27.

Department of Pediatrics, University of Chicago, Chicago, IL, USA,

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http://link.springer.com/10.1007/s00277-015-2319-x
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http://dx.doi.org/10.1007/s00277-015-2319-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598066PMC
April 2015

The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).

Br J Haematol 2014 Aug 13;166(4):550-6. Epub 2014 Jun 13.

Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/bjh.12964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479678PMC
August 2014

Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.

Clin Cancer Res 2014 Jan 31;20(2):490-8. Epub 2013 Oct 31.

Authors' Affiliations: The University of Chicago; Decatur Memorial Hospital, Decatur; Illinois Cancer Care, Peoria; Loyola University Medical Center, Maywood, Illinois; University of California, San Francisco, San Francisco; City of Hope, Duarte, California; University of Michigan Medical Center, Ann Arbor, Michigan; Medical College of Wisconsin, Milwaukee, Wisconsin; and National Cancer Institute, Rockville, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310865PMC
January 2014

The evolving challenge of therapy-related myeloid neoplasms.

Best Pract Res Clin Haematol 2013 Dec 1;26(4):309-17. Epub 2013 Oct 1.

Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA; Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216926130004
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http://dx.doi.org/10.1016/j.beha.2013.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920194PMC
December 2013

Allogeneic Hematopoietic Cell Transplantation for Therapy-Related Myeloid Leukemia following Orthotopic Cardiac Transplantation.

Case Rep Hematol 2013 30;2013:140138. Epub 2013 Mar 30.

Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1155/2013/140138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625539PMC
April 2013

Current practices in the management of chronic myeloid leukemia.

Clin Lymphoma Myeloma Leuk 2013 Feb 25;13(1):48-54. Epub 2012 Oct 25.

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.clml.2012.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645375PMC
February 2013

Gemtuzumab ozogamicin: time to resurrect?

J Clin Oncol 2012 Nov 17;30(32):3921-3. Epub 2012 Sep 17.

Department of Leukemia, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 428, Houston, TX 77030, USA.

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http://dx.doi.org/10.1200/JCO.2012.43.0132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874205PMC
November 2012

Improving outcomes in childhood T-cell acute lymphoblastic leukemia: promising results from the Children's Oncology Group incorporating nelarabine into front-line therapy.

Transl Pediatr 2012 Oct;1(2):120-2

Section of Hematology/Oncology, Department of Medicine and Comprehensive Cancer Center, University of Chicago, Chicago IL 60637, USA.

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http://dx.doi.org/10.3978/j.issn.2224-4336.2012.09.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728878PMC
October 2012