Publications by authors named "Richard A Klinghoffer"

17Publications

Multiplexed Evaluation of Microdosed Antineoplastic Agents in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma.

Authors:

Kenneth R Gundle Gary B Deutsch Howard J Goodman Seth M Pollack Matthew J Thompson Jessica L Davis Mee-Young Lee Daniel C Ramirez William Kerwin Jessica A Bertout Marc O Grenley Kimberly H W Sottero Emily Beirne Jason Frazier Joyoti Dey Micah Ellison Richard A Klinghoffer Robert G Maki

Clin Cancer Res 2020 Aug 16;26(15):3958-3968. Epub 2020 Apr 16.

Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

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August 2020

A modified gene trap approach for improved high-throughput cancer drug discovery.

Authors:

Shelli M Morris Andrew J Mhyre Savanna S Carmack Carrie H Myers Connor Burns Wenjuan Ye Marc Ferrer James M Olson Richard A Klinghoffer

Oncogene 2018 08 2;37(31):4226-4238. Epub 2018 May 2.

Presage Biosciences, Seattle, WA, USA.

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August 2018

Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition.

Authors:

Joyoti Dey Thomas L Deckwerth William S Kerwin Joseph R Casalini Angela J Merrell Marc O Grenley Connor Burns Sally H Ditzler Chantel P Dixon Emily Beirne Kate C Gillespie Edward F Kleinman Richard A Klinghoffer

Sci Rep 2017 12 21;7(1):18007. Epub 2017 Dec 21.

Presage Biosciences, Inc, Seattle, WA, USA.

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December 2017

Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation.

Cancer Res 2017 06 31;77(11):2869-2880. Epub 2017 Mar 31.

Presage Biosciences, Inc., Seattle, Washington.

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June 2017

A Platform for Rapid, Quantitative Assessment of Multiple Drug Combinations Simultaneously in Solid Tumors In Vivo.

Authors:

Joyoti Dey William S Kerwin Marc O Grenley Joseph R Casalini Ilona Tretyak Sally H Ditzler Derek J Thirstrup Jason P Frazier Daniel W Pierce Michael Carleton Richard A Klinghoffer

PLoS One 2016 30;11(6):e0158617. Epub 2016 Jun 30.

Presage Biosciences, Inc., Seattle, Washington, United States of America.

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July 2017

Predicting responses to chemotherapy in the context that matters - the patient.

Authors:

Alicia Moreno-Gonzalez James M Olson Richard A Klinghoffer

Mol Cell Oncol 2016 Jan 10;3(1):e1057315. Epub 2015 Jun 10.

Presage Biosciences , Seattle, WA, USA.

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January 2016

Minimally invasive in tumor multidrug comparative analysis with contrast-enhanced MRI in mice.

Authors:

William S Kerwin Ilona Tretyak Marc O Grenley Sheng You Beryl A Hatton Alicia Moreno-Gonzalez Derek J Thirstrup Richard A Klinghoffer

Magn Reson Med 2016 09 12;76(3):946-52. Epub 2015 Sep 12.

Presage Biosciences, Inc., Seattle, Washington, USA.

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September 2016

Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration.

Authors:

Nianhang Chen Carrie Brachmann Xiping Liu Daniel W Pierce Joyoti Dey William S Kerwin Yan Li Simon Zhou Shihe Hou Michael Carleton Richard A Klinghoffer Maria Palmisano Rajesh Chopra

Cancer Chemother Pharmacol 2015 Oct 1;76(4):699-712. Epub 2015 Aug 1.

Celgene Corporation, 86 Morris Avenue, Summit, NJ, 07901, USA.

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October 2015

A technology platform to assess multiple cancer agents simultaneously within a patient's tumor.

Sci Transl Med 2015 Apr;7(284):284ra58

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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April 2015

Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial.

Authors:

Serena Di Cosimo Sriram Sathyanarayanan Johanna C Bendell Andrés Cervantes Mark N Stein Irene Braña Desamparados Roda Brian B Haines Theresa Zhang Christopher G Winter Sharda Jha Youyuan Xu Jason Frazier Richard A Klinghoffer Ann Leighton-Swayze Yang Song Scot Ebbinghaus José Baselga

Clin Cancer Res 2015 Jan 15;21(1):49-59. Epub 2014 Oct 15.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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January 2015

Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner.

Authors:

Liat Rousso-Noori Hilla Knobler Einat Levy-Apter Yael Kuperman Adi Neufeld-Cohen Yonat Keshet Vasudheva R Akepati Richard A Klinghoffer Alon Chen Ari Elson

Cell Metab 2011 May;13(5):562-72

Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel.

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May 2011

Reduced seed region-based off-target activity with lentivirus-mediated RNAi.

Authors:

Richard A Klinghoffer Jill Magnus Janell Schelter Michele Mehaffey Casey Coleman Michele A Cleary

RNA 2010 May 26;16(5):879-84. Epub 2010 Mar 26.

Presage Biosciences, Seattle, WA 98109, USA.

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May 2010

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling.

Authors:

Richard A Klinghoffer Jason Frazier James Annis Jason D Berndt Brian S Roberts William T Arthur Raul Lacson Xiaohua Douglas Zhang Marc Ferrer Randall T Moon Michele A Cleary

PLoS One 2009 Sep 3;4(9):e6892. Epub 2009 Sep 3.

Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America.

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September 2009

An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity.

Authors:

Richard A Klinghoffer Brian Roberts James Annis Jason Frazier Patrick Lewis Peter S Linsley Michele A Cleary

Assay Drug Dev Technol 2008 Feb;6(1):105-19

Rosetta Inpharmatics LLC, Merck & Co., Inc., Seattle, WA 98109, USA.

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February 2008

Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms.

Authors:

T Guy Hamilton Richard A Klinghoffer Philip D Corrin Philippe Soriano

Mol Cell Biol 2003 Jun;23(11):4013-25

Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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June 2003

SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.

Authors:

Leslie A Cary Richard A Klinghoffer Christoph Sachsenmaier Jonathan A Cooper

Mol Cell Biol 2002 Apr;22(8):2427-40

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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April 2002

An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.

Authors:

Richard A Klinghoffer T Guy Hamilton Renée Hoch Philippe Soriano

Dev Cell 2002 Jan;2(1):103-13

Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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January 2002