Richard A Flavell

Richard A Flavell

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Richard A Flavell

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Publisher Correction: HER2 joins AKT to inhibit STING immunity.

Nat Cell Biol 2019 Oct;21(10):1301

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/s41556-019-0395-1DOI Listing
October 2019

Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease.

Crit Rev Immunol 2018 ;38(5):415-431

Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1615/CritRevImmunol.2018026850DOI Listing
September 2019

HER2 joins AKT to inhibit STING immunity.

Nat Cell Biol 2019 Aug;21(8):917-918

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/s41556-019-0368-4DOI Listing
August 2019

hnRNPA2B1: a nuclear DNA sensor in antiviral immunity.

Cell Res 2019 Aug 30. Epub 2019 Aug 30.

Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1038/s41422-019-0226-8DOI Listing
August 2019

Immunity, microbiota and kidney disease.

Nat Rev Nephrol 2019 May;15(5):263-274

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41581-019-0118-7DOI Listing
May 2019

Antiviral immunity: a link to bile acids.

Cell Res 2019 Mar;29(3):177-178

Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.

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http://dx.doi.org/10.1038/s41422-019-0148-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460437PMC
March 2019

Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.

Elife 2018 11 21;7. Epub 2018 Nov 21.

Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, United States.

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http://dx.doi.org/10.7554/eLife.39494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289572PMC
November 2018

cGAS activation in phased droplets.

Cell Res 2018 10;28(10):967-968

Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06520-8055, USA.

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http://dx.doi.org/10.1038/s41422-018-0087-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170418PMC
October 2018

Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells.

Proc Natl Acad Sci U S A 2018 09 20;115(38):E8939-E8947. Epub 2018 Aug 20.

Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158;

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http://dx.doi.org/10.1073/pnas.1808320115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156615PMC
September 2018

RNA mA modification and its function in diseases.

Front Med 2018 Aug 10;12(4):481-489. Epub 2018 Aug 10.

Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China.

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http://dx.doi.org/10.1007/s11684-018-0654-8DOI Listing
August 2018

KLRG1 Effector CD8 T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

Immunity 2018 04 3;48(4):716-729.e8. Epub 2018 Apr 3.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465538PMC
April 2018

Harnessing the power of regulatory T-cells to control autoimmune diabetes: overview and perspective.

Immunology 2018 02 11;153(2):161-170. Epub 2017 Dec 11.

Department of Immunobiology, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1111/imm.12867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765377PMC
February 2018

mA mRNA methylation sustains Treg suppressive functions.

Cell Res 2018 Feb 5;28(2):253-256. Epub 2018 Jan 5.

Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, PR China.

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http://www.nature.com/doifinder/10.1038/cr.2018.7
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http://dx.doi.org/10.1038/cr.2018.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799823PMC
February 2018

Circuit Design Features of a Stable Two-Cell System.

Cell 2018 02 1;172(4):744-757.e17. Epub 2018 Feb 1.

Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.015DOI Listing
February 2018

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

Proc Natl Acad Sci U S A 2017 12 20;114(49):E10578-E10585. Epub 2017 Nov 20.

Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1710877114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724266PMC
December 2017

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8 TILs.

Cancer Cell 2017 09;32(3):280-281

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.08.013DOI Listing
September 2017

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

Immunity 2017 09;47(3):435-449.e8

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761663PMC
September 2017

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

Cell Rep 2017 Sep;20(12):2775-2783

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Howard Hughes Medical Institute, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659285PMC
September 2017

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression.

Immunity 2017 08;47(2):284-297.e5

Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale Cancer Center, Yale Cooperative Center of Excellence in Hematology, Yale University, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710009PMC
August 2017

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome.

Cell Rep 2017 07;20(4):794-805

Department of Cell Biology, Medical School of Ribeirão Preto, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.086DOI Listing
July 2017

Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin.

Front Cell Infect Microbiol 2017 16;7:35. Epub 2017 Feb 16.

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University Clayton, VIC, Australia.

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http://dx.doi.org/10.3389/fcimb.2017.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311068PMC
June 2017

Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation.

Cell Rep 2017 06;19(11):2319-2330

Microbial Immune Regulation Research Group, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.058DOI Listing
June 2017

Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease.

Cell Host Microbe 2017 Jun;21(6):682-694.e5

Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.05.005DOI Listing
June 2017

Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice.

Cell Discov 2017 20;3:17020. Epub 2017 Jun 20.

The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.1038/celldisc.2017.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477007PMC
June 2017

The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier.

Cell 2017 01;168(3):362-375

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163165
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http://dx.doi.org/10.1016/j.cell.2016.11.040DOI Listing
January 2017

Apoptosis in response to microbial infection induces autoreactive TH17 cells.

Nat Immunol 2016 09 25;17(9):1084-92. Epub 2016 Jul 25.

Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079524PMC
http://dx.doi.org/10.1038/ni.3512DOI Listing
September 2016

Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease.

Differentiation 2016 Sep 7;92(3):116-131. Epub 2016 May 7.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03014681163001
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http://dx.doi.org/10.1016/j.diff.2016.05.002DOI Listing
September 2016

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.

Cytokine Growth Factor Rev 2016 08 8;30:87-93. Epub 2016 Mar 8.

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA; Howard Hughes Medical Institute, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.cytogfr.2016.02.003DOI Listing
August 2016

Microbiome: Ecology of eczema.

Nat Microbiol 2016 08 26;1(9):16135. Epub 2016 Aug 26.

Department of Immunobiology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA.

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http://www.nature.com/articles/nmicrobiol2016135
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http://dx.doi.org/10.1038/nmicrobiol.2016.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035744PMC
August 2016

Plasticity of Th17 Cells in Autoimmune Kidney Diseases.

J Immunol 2016 07 6;197(2):449-57. Epub 2016 Jun 6.

III. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany;

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http://dx.doi.org/10.4049/jimmunol.1501831DOI Listing
July 2016

Role of OCT-1 and partner proteins in T cell differentiation.

Biochim Biophys Acta 2016 Jun 26;1859(6):825-31. Epub 2016 Apr 26.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.04.006DOI Listing
June 2016

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset.

J Exp Med 2016 06 20;213(7):1223-39. Epub 2016 Jun 20.

Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, 14049-900 Ribeirão Preto, São Paulo, Brazil

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http://dx.doi.org/10.1084/jem.20150744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925011PMC
June 2016

Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity.

J Biol Chem 2016 Apr 30;291(17):8931-50. Epub 2015 Dec 30.

From the Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, the Departments of Immunobiology and

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http://dx.doi.org/10.1074/jbc.M115.695304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861462PMC
April 2016

Mex3B: a coreceptor to present dsRNA to TLR3.

Cell Res 2016 Apr 4;26(4):391-2. Epub 2016 Mar 4.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1038/cr.2016.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822127PMC
April 2016

Recent advances in dynamic m6A RNA modification.

Open Biol 2016 Apr 13;6(4):160003. Epub 2016 Apr 13.

Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA

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http://dx.doi.org/10.1098/rsob.160003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852458PMC
April 2016

Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System.

Cold Spring Harb Protoc 2016 Feb 1;2016(2):pdb.prot090704. Epub 2016 Feb 1.

Departments of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.

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http://www.cshprotocols.org/lookup/doi/10.1101/pdb.prot09070
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http://dx.doi.org/10.1101/pdb.prot090704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905559PMC
February 2016

Editing the Mouse Genome Using the CRISPR-Cas9 System.

Cold Spring Harb Protoc 2016 Feb 1;2016(2):pdb.top087536. Epub 2016 Feb 1.

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520.

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http://dx.doi.org/10.1101/pdb.top087536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898480PMC
February 2016

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.

EMBO J 2016 Jan 26;35(1):89-101. Epub 2015 Nov 26.

Department of Neurology, Focus Program Translational Neurosciences (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn²) University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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http://dx.doi.org/10.15252/embj.201591488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718005PMC
January 2016

Humanized hemato-lymphoid system mice.

Haematologica 2016 Jan;101(1):5-19

Hematology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland

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http://dx.doi.org/10.3324/haematol.2014.115212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697887PMC
January 2016

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

Infect Immun 2015 Dec 28;83(12):4740-9. Epub 2015 Sep 28.

Departments of Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/IAI.00856-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645370PMC
December 2015

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.

Cell 2015 Dec;163(6):1444-56

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01428-2.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501428
Publisher Site
http://dx.doi.org/10.1016/j.cell.2015.10.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943028PMC
December 2015