Richard A Flavell

Richard A Flavell

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Richard A Flavell

Richard A Flavell

Publications by authors named "Richard A Flavell"

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Metabolic signaling in T cells.

Cell Res 2020 Aug 24;30(8):649-659. Epub 2020 Jul 24.

Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41422-020-0379-5DOI Listing
August 2020

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.

Cell Metab 2020 Jul 8;32(1):128-143.e5. Epub 2020 Jun 8.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.05.003DOI Listing
July 2020

CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity.

Cell Mol Immunol 2020 Jul 15. Epub 2020 Jul 15.

Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, 519000, Guangdong, China.

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http://dx.doi.org/10.1038/s41423-020-0499-3DOI Listing
July 2020

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.

Nat Immunol 2020 Jun 18;21(6):626-635. Epub 2020 May 18.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41590-020-0681-xDOI Listing
June 2020

mA Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.

Immunity 2020 Jun 3;52(6):1007-1021.e8. Epub 2020 Jun 3.

Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2020.05.003DOI Listing
June 2020

Expression Efficiency of Multiple Reporter Alleles Is Determined by Cell Lineage.

Immunohorizons 2020 May 21;4(5):282-291. Epub 2020 May 21.

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202;

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http://dx.doi.org/10.4049/immunohorizons.1900082DOI Listing
May 2020

mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.

Science 2020 03;367(6483):1255-1260

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/science.aax0194DOI Listing
March 2020

hnRNPA2B1: a nuclear DNA sensor in antiviral immunity.

Cell Res 2019 11;29(11):879-880

Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1038/s41422-019-0226-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889404PMC
November 2019

Publisher Correction: HER2 joins AKT to inhibit STING immunity.

Nat Cell Biol 2019 Oct;21(10):1301

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/s41556-019-0395-1DOI Listing
October 2019

Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease.

Crit Rev Immunol 2018 ;38(5):415-431

Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1615/CritRevImmunol.2018026850DOI Listing
September 2019

HER2 joins AKT to inhibit STING immunity.

Nat Cell Biol 2019 08;21(8):917-918

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/s41556-019-0368-4DOI Listing
August 2019

Immunity, microbiota and kidney disease.

Nat Rev Nephrol 2019 05;15(5):263-274

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41581-019-0118-7DOI Listing
May 2019

Antiviral immunity: a link to bile acids.

Cell Res 2019 03;29(3):177-178

Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.

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http://dx.doi.org/10.1038/s41422-019-0148-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460437PMC
March 2019

Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.

Elife 2018 11 21;7. Epub 2018 Nov 21.

Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, United States.

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http://dx.doi.org/10.7554/eLife.39494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289572PMC
November 2018

cGAS activation in phased droplets.

Cell Res 2018 10;28(10):967-968

Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06520-8055, USA.

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http://dx.doi.org/10.1038/s41422-018-0087-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170418PMC
October 2018

Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells.

Proc Natl Acad Sci U S A 2018 09 20;115(38):E8939-E8947. Epub 2018 Aug 20.

Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158;

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http://dx.doi.org/10.1073/pnas.1808320115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156615PMC
September 2018

RNA mA modification and its function in diseases.

Front Med 2018 Aug 10;12(4):481-489. Epub 2018 Aug 10.

Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China.

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http://dx.doi.org/10.1007/s11684-018-0654-8DOI Listing
August 2018

Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice.

Oncoimmunology 2019 7;8(10):e981995. Epub 2018 May 7.

Department of Immunobiology; Yale University School of Medicine; New Haven, CT USA.

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http://dx.doi.org/10.4161/2162402X.2014.981995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791415PMC
May 2018

KLRG1 Effector CD8 T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

Immunity 2018 04 3;48(4):716-729.e8. Epub 2018 Apr 3.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465538PMC
April 2018

Harnessing the power of regulatory T-cells to control autoimmune diabetes: overview and perspective.

Immunology 2018 02 11;153(2):161-170. Epub 2017 Dec 11.

Department of Immunobiology, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1111/imm.12867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765377PMC
February 2018

mA mRNA methylation sustains Treg suppressive functions.

Cell Res 2018 Feb 5;28(2):253-256. Epub 2018 Jan 5.

Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, PR China.

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http://www.nature.com/doifinder/10.1038/cr.2018.7
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http://dx.doi.org/10.1038/cr.2018.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799823PMC
February 2018

Circuit Design Features of a Stable Two-Cell System.

Cell 2018 02 1;172(4):744-757.e17. Epub 2018 Feb 1.

Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377352PMC
February 2018

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

Proc Natl Acad Sci U S A 2017 12 20;114(49):E10578-E10585. Epub 2017 Nov 20.

Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1710877114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724266PMC
December 2017

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8 TILs.

Cancer Cell 2017 09;32(3):280-281

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939383PMC
September 2017

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

Immunity 2017 09;47(3):435-449.e8

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761663PMC
September 2017

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

Cell Rep 2017 Sep;20(12):2775-2783

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Howard Hughes Medical Institute, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659285PMC
September 2017

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression.

Immunity 2017 08;47(2):284-297.e5

Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale Cancer Center, Yale Cooperative Center of Excellence in Hematology, Yale University, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710009PMC
August 2017

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome.

Cell Rep 2017 07;20(4):794-805

Department of Cell Biology, Medical School of Ribeirão Preto, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.086DOI Listing
July 2017

Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin.

Front Cell Infect Microbiol 2017 16;7:35. Epub 2017 Feb 16.

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University Clayton, VIC, Australia.

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http://dx.doi.org/10.3389/fcimb.2017.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311068PMC
June 2017

Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation.

Cell Rep 2017 06;19(11):2319-2330

Microbial Immune Regulation Research Group, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.058DOI Listing
June 2017

Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease.

Cell Host Microbe 2017 Jun;21(6):682-694.e5

Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.05.005DOI Listing
June 2017

Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice.

Cell Discov 2017 20;3:17020. Epub 2017 Jun 20.

The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.1038/celldisc.2017.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477007PMC
June 2017

The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier.

Cell 2017 01;168(3):362-375

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163165
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http://dx.doi.org/10.1016/j.cell.2016.11.040DOI Listing
January 2017

Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease.

Differentiation 2016 Sep 7;92(3):116-131. Epub 2016 May 7.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03014681163001
Publisher Site
http://dx.doi.org/10.1016/j.diff.2016.05.002DOI Listing
September 2016

Microbiome: Ecology of eczema.

Nat Microbiol 2016 08 26;1(9):16135. Epub 2016 Aug 26.

Department of Immunobiology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA.

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http://www.nature.com/articles/nmicrobiol2016135
Publisher Site
http://dx.doi.org/10.1038/nmicrobiol.2016.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035744PMC
August 2016