Publications by authors named "Ricardo Teixeira"

75 Publications

18F-FDG PET/CT in Patients with Vulvar and Vaginal Cancer: A Preliminary Study of 20 Cases.

Acta Med Port 2021 Nov 24. Epub 2021 Nov 24.

Serviço de Medicina Nuclear. Centro Hospitalar de São João. Porto. Portugal.

Introduction: Despite the growing evidence supporting the use of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in cervical and ovarian malignant tumours, data on vulvar and vaginal cancer is sparse. Our aim was to assess the role of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in patients with vulvar and vaginal cancer.

Material And Methods: A retrospective study was conducted on a cohort of 20 patients with biopsy-proven vulvar (n = 17) and vaginal (n = 3) cancer who performed 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography, between January 2013 and April 2018. We collected the clinical data of all patients, as well as the indication for 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography, its results, and the main lesion maximum standard uptake value (SUVmax). In addition, we correlated the results of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography with other diagnostic modalities, namely histological findings, computed tomography and magnetic resonance imaging. Patients were divided into two groups, one with newly diagnosed disease and another with recurrent disease.

Results: Six patients had newly diagnosed disease and 14 had recurrent disease. The main lesion was detected by 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in five out of six patients with newly diagnosed disease and in all 14 patients with recurrent disease. Additional sites of 2-[F-18]-fluor-2-desoxi-D-glucose uptake were identified in inguinal and iliac lymph nodes and in distant lesions. Magnetic resonance imaging and computed tomography were performed in 12 cases. In four patients with recurrent disease, abnormalities (main lesion/ metastatic lymph nodes) identified by 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography were not detected as suspicious by computed tomography.

Discussion: In our study, 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography identified abnormalities more often than conventional computed tomography scans in recurrent disease. In comparison with histology, 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography had a sensitivity of 95% and a positive predictive value of 100% in identifying the primary tumour and the recurrent main lesion. Little data is available regarding the usefulness of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in the management of vulvar and vaginal cancers. The existing evidence supports a high accuracy in detecting lymph node metastases and a change of 36.0% - 61.5% in patient management. Our findings reinforce the usefulness of this technique in vulvar and vaginal cancer. Limitations of our study include its retrospective nature and the rareness of both vulvar and vaginal cancer, which leads to a small sample size and few comparative imaging tests.

Conclusion: In this preliminary study, 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography demonstrated it can be a useful method in patients with vulvar and vaginal cancers, namely in defining the extent of disease and contributing to accurate staging and restaging.
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http://dx.doi.org/10.20344/amp.12510DOI Listing
November 2021

Global process-based characterization factors of soil carbon depletion for life cycle impact assessment.

Sci Data 2021 09 9;8(1):237. Epub 2021 Sep 9.

MARETEC - Marine, Environment and Technology Centre, LARSyS, Instituto Superior Técnico, Universidade de Lisboa, 1049-001, Lisbon, Portugal.

Regionalization of land use (LU) impact in life cycle assessment (LCA) has gained relevance in recent years. Most regionalized models are statistical, using highly aggregated spatial units and LU classes (e.g. one unique LU class for cropland). Process-based modelling is a powerful characterization tool but so far has never been applied globally for all LU classes. Here, we propose a new set of spatially detailed characterization factors (CFs) for soil organic carbon (SOC) depletion. We used SOC dynamic curves and attainable SOC stocks from a process-based model for more than 17,000 world regions and 81 LU classes. Those classes include 63 agricultural (depending on 4 types of management/production), and 16 forest sub-classes, and 1 grassland and 1 urban class. We matched the CFs to LU elementary flows used by LCA databases at country-level. Results show that CFs are highly dependent on the LU sub-class and management practices. For example, transformation into cropland in general leads to the highest SOC depletion but SOC gains are possible with specific crops.
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http://dx.doi.org/10.1038/s41597-021-01018-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429584PMC
September 2021

Professional Training in Integrative and Complementary Practices: the meanings attributed by Primary Health Care workers.

Cien Saude Colet 2021 Feb 28;26(2):399-408. Epub 2020 May 28.

Programa de Pós-Graduação em Saúde Coletiva, Universidade Federal de Goiás. Av. Esperança s/n, Chácaras de Recreio Samambaia. 74690-900 Goiânia GO Brasil.

Objective: To understand the meanings attributed by Primary Health Care workers to the professional training process in Integrative and Complementary Practices.

Method: Descriptive, exploratory study with a qualitative approach, carried out with 20 professionals from 14 health units in three municipalities in the Metropolitan Region of Goiânia, state of Goiás, Brazil. Data were collected through semi-structured interviews, transcribed and analyzed using the thematic content analysis.

Results: Based on the analysis, the thematic category about training trajectories in Integrative and Complementary Practices emerged. It discusses that the training takes place through training provided by federal and municipal management or professional councils, via distance, semi-presential learning or in-person training. Furthermore, training courses are held at private educational institutions funded by the professionals themselves. Additionally, informal sources of information are used to obtain knowledge (internet, books and magazines).

Conclusion: The results show, on the one hand, insufficient and diffuse training, with limited supply and quality and, on the other hand, the need to increase educational strategies to improve the training of health professionals aiming at providing different Integrative and Complementary Practices in the Primary Health Care.
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http://dx.doi.org/10.1590/1413-81232021262.40732020DOI Listing
February 2021

Half-Sandwich Ru(-cymene) Compounds with Diphosphanes: and Evaluation As Potential Anticancer Metallodrugs.

Inorg Chem 2021 Mar 11;60(5):2914-2930. Epub 2021 Feb 11.

Departamento de Química & Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da Coruña, 15008 A Coruña, Spain.

Ruthenium(II) complexes are currently considered attractive alternatives to the widely used platinum-based drugs. We present herein the synthesis and characterization of half-sandwich ruthenium compounds formulated as [Ru(-cymene)(L)Cl][CFSO] (L = 1,1-bis(methylenediphenylphosphano)ethylene, ; L = 1,1-bis(diphenylphosphano)ethylene, ), which were characterized by elemental analysis, mass spectrometry, H and P{H} NMR, UV-vis and IR spectroscopy, conductivity measurements and cyclic voltammetry. The molecular structures for both complexes were determined by single-crystal X-ray diffraction. Their cytotoxic activity was evaluated using the MTT assay against human tumor cells, namely ovarian (A2780) and breast (MCF7 and MDA-MB-231). Both complexes were active against breast adenocarcinoma cells, with complex exhibiting a quite remarkable cytotoxicity in the submicromolar range. Interestingly, at concentrations equivalent to the IC values in the MCF7 cancer cells, complexes and presented lower cytotoxicity in normal human primary fibroblasts. The antiproliferative effects of and in MCF7 cells might be associated with the induction of reactive oxygen species (ROS), leading to a combined cell death mechanism via apoptosis and autophagy. Despite the fact that a partial intercalation between complexes and DNA was observed, no MCF7 cell cycle delay or arrest was observed, indicating that DNA might not be a direct target. Complexes and both exhibited a moderate to strong interaction with human serum albumin, suggesting that protein targets may be involved in their mode of action. Their acute toxicity was evaluated in the zebrafish model. Complex (the most toxic of the two) exhibited a lethal toxicity LC value about 1 order of magnitude higher than any IC concentrations found for the cancer cell models used, highlighting its therapeutic relevance as a drug candidate in cancer chemotherapy.
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http://dx.doi.org/10.1021/acs.inorgchem.0c02768DOI Listing
March 2021

Early COVID-19 infection after lung transplantation in a patient with cystic fibrosis.

Clinics (Sao Paulo) 2020 11 30;75:e2274. Epub 2020 Nov 30.

Divisao Pulmonar, Instituto do Coracao (InCor), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

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http://dx.doi.org/10.6061/clinics/2020/e2274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688076PMC
November 2020

[Self-mutilation among adolescents: an integrative review of the literature].

Cien Saude Colet 2020 Oct 24;25(10):3945-3954. Epub 2019 Jan 24.

Programa de Pós-Graduação em Saúde Coletiva, Universidade Federal de Goiás (UFG). R. 235 s/n, Setor Universitário. 74605-050 Goiânia GO Brasil.

This study involves an integrative review of the literature regarding the knowledge produced by the scientific community about self-mutilation among adolescents in the period between January 2012 and June 2017. A search was conducted in the SCIELO and CAPES Portal databases in Portuguese, English and Spanish with a final sample of 71 articles. This study revealed a large number of publications at international level, with an emphasis on epidemiological articles and deficiency in the publication of intervention studies that investigate the efficacy of therapies and prevention programs.
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http://dx.doi.org/10.1590/1413-812320202510.31362018DOI Listing
October 2020

Bilateral Sesamoiditis as First Manifestation of Gout.

Case Rep Orthop 2020 5;2020:8890549. Epub 2020 Sep 5.

Hospital Renascentista, Pouso Alegre, MG, Brazil.

Sesamoiditis secondary to gout is an extremely rare condition with few case reports in the literature. It is an important differential diagnosis because the treatment depends on targeted therapy, unlike the main causes of sesamoiditis that often involves immobilization with special orthoses and prescription of anti-inflammatory drugs. We report here a case of a 38-year-old male, athlete, with bipartite medial sesamoid, who had insidious pain in the base of the left hallux. Laboratory tests showed no alterations, and imaging examinations demonstrated sesamoiditis with suspicion of stress fracture. The patient was initially prescribed an immobilization boot and analgesic and anti-inflammatory drugs, but he did not respond to the measures taken. After the onset of the same condition in the contralateral foot and getting the same imaging findings, we began an investigation of systemic disease, focusing on gout, because of a positive family history, which was confirmed by dual-energy computed tomography.
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http://dx.doi.org/10.1155/2020/8890549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499288PMC
September 2020

Extracorporeal Membrane Oxygenation and Lung Transplantation: Initial Experience at a Single Brazilian Center.

Clinics (Sao Paulo) 2020 30;75:e1698. Epub 2020 Apr 30.

Programa de Transplante Pulmonar, Hospital Israelita Albert Einstein, Sao Paulo, SP, BR.

Objective: To report initial experience from the use of extracorporeal membrane oxygenation (ECMO) in patients who received lung transplantation.

Methods: Retrospective study of a single tertiary center in the Brazilian state of São Paulo, a national reference in lung transplantation, based on the prospective collection of data from electronic medical records. The period analyzed extended from January 2009 (beginning of the program) until December 2018.

Results: A total of 75 lung transplants were performed, with ECMO used in 8 (10.7%) cases. Of the patients, 4 (50%) were female. The mean age was 46.4±14.3 years. The causes of the end-stage lung disease that led to transplantation were pulmonary arterial hypertension in 3 (37.5%) patients, bronchiectasis in 2 (25%) patients, pulmonary fibrosis in 2 (25%) patients, and pulmonary emphysema in 1 (12.5%) patient. In our series, 7 (87.5%) cases were sequential bilateral transplantations. Prioritization was necessary in 4 (50%) patients, and in 1 patient, ECMO was used as a bridge to transplantation. The ECMO route was central in 4 (50%), peripheral venovenous in 2 (25%) and peripheral venoarterial in 2 (25%) patients. The mean length of the intensive care unit (ICU) stay was 14±7.5 days and of the hospital stay was 34.1±34.2 days. The mean ECMO duration was 9.3±6.6 days with a 50% decannulation rate. Three patients were discharged (37.5%).

Conclusion: Lung transplantation requires complex treatment, and ECMO has allowed extending the indications for transplantation and provided adjuvant support in the clinical management of these patients.
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http://dx.doi.org/10.6061/clinics/2020/e1698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196780PMC
August 2020

Food systems in a zero-deforestation world: Dietary change is more important than intensification for climate targets in 2050.

Sci Total Environ 2020 Sep 12;735:139353. Epub 2020 May 12.

Institute of Social Ecology, University of Natural Resources and Life Sciences, Schottenfeldgasse 29, A-1070 Vienna, Austria.

Global food systems contribute to climate change, the transgression of planetary boundaries and deforestation. An improved understanding of the environmental impacts of different food system futures is crucial for forging strategies to sustainably nourish a growing world population. We here quantify the greenhouse gas (GHG) emissions of global food system scenarios within a biophysically feasible "option space" in 2050 comprising all scenarios in which biomass supply - calculated as function of agricultural area and yields - is sufficient to cover biomass demand - derived from human diets and the feed demand of livestock. We assessed the biophysical feasibility of 520 scenarios in a hypothetical no-deforestation world. For all feasible scenarios, we calculate (in) direct GHG emissions related to agriculture. We also include (possibly negative) GHG emissions from land-use change, including changes in soil organic carbon (SOC) and carbon sinks from vegetation regrowth on land spared from food production. We identify 313 of 520 scenarios as feasible. Agricultural GHG emissions (excluding land use change) of feasible scenarios range from 1.7 to 12.5 Gt COe yr. When including changes in SOC and vegetation regrowth on spare land, the range is between -10.7 and 12.5 Gt COe yr. Our results show that diets are the main determinant of GHG emissions, with highest GHG emissions found for scenarios including high meat demand, especially if focused on ruminant meat and milk, and lowest emissions for scenarios with vegan diets. Contrary to frequent claims, our results indicate that diets and the composition and quantity of livestock feed, not crop yields, are the strongest determinants of GHG emissions from food-systems when existing forests are to be protected.
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http://dx.doi.org/10.1016/j.scitotenv.2020.139353DOI Listing
September 2020

Constraints and advances in high-solids enzymatic hydrolysis of lignocellulosic biomass: a critical review.

Biotechnol Biofuels 2020 23;13:58. Epub 2020 Mar 23.

2Bioethanol Laboratory, Department of Biochemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-909 Brazil.

The industrial production of sugar syrups from lignocellulosic materials requires the conduction of the enzymatic hydrolysis step at high-solids loadings (i.e., with over 15% solids [w/w] in the reaction mixture). Such conditions result in sugar syrups with increased concentrations and in improvements in both capital and operational costs, making the process more economically feasible. However, this approach still poses several technical hindrances that impact the process efficiency, known as the "high-solids effect" (i.e., the decrease in glucan conversion yields as solids load increases). The purpose of this review was to present the findings on the main limitations and advances in high-solids enzymatic hydrolysis in an updated and comprehensive manner. The causes for the rheological limitations at the onset of the high-solids operation as well as those influencing the "high-solids effect" will be discussed. The subject of water constraint, which results in a highly viscous system and impairs mixing, and by extension, mass and heat transfer, will be analyzed under the perspective of the limitations imposed to the action of the cellulolytic enzymes. The "high-solids effect" will be further discussed vis-à-vis enzymes end-product inhibition and the inhibitory effect of compounds formed during the biomass pretreatment as well as the enzymes' unproductive adsorption to lignin. This review also presents the scientific and technological advances being introduced to lessen high-solids hydrolysis hindrances, such as the development of more efficient enzyme formulations, biomass and enzyme feeding strategies, reactor and impeller designs as well as process strategies to alleviate the end-product inhibition. We surveyed the academic literature in the form of scientific papers as well as patents to showcase the efforts on technological development and industrial implementation of the use of lignocellulosic materials as renewable feedstocks. Using a critical approach, we expect that this review will aid in the identification of areas with higher demand for scientific and technological efforts.
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http://dx.doi.org/10.1186/s13068-020-01697-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092515PMC
March 2020

Detailed global modelling of soil organic carbon in cropland, grassland and forest soils.

PLoS One 2019 19;14(9):e0222604. Epub 2019 Sep 19.

MARETEC-Marine, Environment and Technology Centre, LARSyS, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

Assessments of the global carbon (C) cycle typically rely on simplified models which consider large areas as homogeneous in terms of the response of soils to land use or consider very broad land classes. For example, "cropland" is typically modelled as an aggregation of distinct practices and individual crops over large regions. Here, we use the process-based Rothamsted soil Carbon Model (RothC model), which has a history of being successfully applied at a global scale, to calculate attainable SOC stocks and C mineralization rates for each of c. 17,000 regions (combination of soil type and texture, climate type, initial land use and country) in the World, under near-past climate conditions. We considered 28 individual crops and, for each, multiple production practices, plus 16 forest types and 1 grassland class (total of 80 classes). We find that conversion to cropland can result in SOC increases, particularly when the soil remains covered with crop residues (an average gain of 12 t C/ha) or using irrigation (4 t C/ha), which are mutually reinforcing effects. Attainable SOC stocks vary significantly depending on the land use class, particularly for cropland. Common aggregations in global modelling of a single agricultural class would be inaccurate representations of these results. Attainable SOC stocks obtained here were compared to long-term experiment data and are well aligned with the literature. Our results provide a regional and detailed understanding of C sequestration that will also enable better greenhouse gas reporting at national level as alternatives to IPCC tier 2 defaults.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222604PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752864PMC
March 2020

O “direito à memória”: Escola Eunice Weaver, memória individual e a constituição de um arquivo histórico em Goiás.

Hist Cienc Saude Manguinhos 2019 09 16;26(3):1039-1049. Epub 2019 Sep 16.

Professor, Programa de Pós-graduação em Educação / Universidade Federal de Goiás . Goiânia - GO - Brasil

This article describes the construction of a documentary archive for the Eunice Weaver School, part of the Educandário/Preventório Afrânio de Azevedo Training Complex (inaugurated in Goiânia in 1943). We stress the importance of creating similar archives to provide access to the memories of those subjected to policies related to preventing Hansen's disease (leprosy). The documentation covers the period 1945-1990, depicting the everyday lives of blameless children who were institutionalized as part of state policies to prevent this disease. The material is regionally focused, expanding the number of known sources for the history of institutions and this disease in the state of Goiás, and served as a potential resource for patients attempting to gain release.
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http://dx.doi.org/10.1590/S0104-59702019000300018DOI Listing
September 2019

Overcoming treatment-resistant major depressive disorder outside of the doctor´s office.

Psychiatry Res 2019 09 4;279:397-398. Epub 2019 Jun 4.

Hospital de Magalhães Lemos, Porto, Portugal.

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http://dx.doi.org/10.1016/j.psychres.2019.06.004DOI Listing
September 2019

Brief emotional screening in oncology: Specificity and sensitivity of the emotion thermometers in the Portuguese cancer population.

Palliat Support Care 2020 02;18(1):39-46

University of Minho, School of Psychology, Braga, Portugal.

Objective: This study aimed to determine the cutoff and the specificity and sensitivity of the Emotion Thermometers (ET) in a Portuguese sample of cancer patients.

Method: A total of 147 patients (mean age = 49.2; SD = 12.6) completed the ET, the Brief Symptom Inventory (BSI), and the Subjective Experiences of Illness Suffering Inventory. Data were collected in a cancer support institution and in a major hospital in the North of Portugal.

Result: The optimal cutoff for the Anxiety Thermometer was 5v6 (until 5 and 6 or more), which identified 74% of the BSI-anxiety cases and 70% of noncases. The Depression Thermometer cutoff was 4v5 (until 4 and 5 or more), which identified 85% of BSI-depression cases and 82% of noncases. Cutoff for the Anger Thermometer was 4v5 (until 4 and 5 or more), which identified 83% of BSI-hostility cases and 73% of noncases; for the Distress Thermometer, the optimal cutoff was 4v5 (until 4 and 5 or more), which identified 84% of the suffering cases and 73% of noncases. Finally, for the Help Thermometer, it was 3v4 (until 3 and 4 or more), which helped to identify 93% of the suffering cases and 64% of noncases.

Significance Of Results: Results supported the Portuguese version of the ET as an important screening tool for identifying the emotional distress in cancer patients.
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http://dx.doi.org/10.1017/S1478951519000208DOI Listing
February 2020

The impact of informal cancer caregiving: A literature review on psychophysiological studies.

Eur J Cancer Care (Engl) 2019 Jul 16;28(4):e13042. Epub 2019 Apr 16.

Departamento de Psicologia, Centro de Investigação em Psicologia (CIP-UAL), Universidade Autónoma de Lisboa Luís de Camões, Lisboa, Portugal.

Caregiving can be experienced as a stressful process, which can cause psychological and physical consequences. The combination of prolonged stress and the physical demands of caregiving may impair the physiological functioning of caregivers and increase the risk of health problems creating considerable stress in the life of caregivers regarding emotional, physical, social and financial areas. This literature review explored studies that used measures of the autonomic nervous system in caregivers of oncology patients such as electrodermal and cardiovascular (re)activity. The results revealed that caregivers had elevated stress levels and a serious autonomic imbalance that may, in the long term, trigger negative health consequences such as infectious diseases, cancer progression, cardiovascular disease and even premature death. The results showed the need to carry out preventive strategies in this population, in order to improve the autonomic profile of caregivers of cancer patients.
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http://dx.doi.org/10.1111/ecc.13042DOI Listing
July 2019

68Ga-PSMA Uptake in Prostate Cancer Sciatic Nerve Metastasis.

Clin Nucl Med 2019 Apr;44(4):e301-e302

Nuclear Medicine Department, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal.

Most prostate cancers spread to regional lymph nodes, axial skeleton and lungs. Perineural malignant involvement is very rare. We present a Ga-PSMA PET/CT image of a sciatic nerve metastasis in a 65-year-old man with recurrent prostate cancer.
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http://dx.doi.org/10.1097/RLU.0000000000002476DOI Listing
April 2019

Potencialities of ciberspaSUS: social networks as devices of public health policies in Brazil.

Cien Saude Colet 2018 Oct;23(10):3277-3286

Programa de Pós-Graduação em Terapia Ocupacional, UFSCAR. São Carlos SP Brasil.

Objective: This paper examines two experiences of social networks developed as a space for strengthening public health policies in the Brazilian context. To describe and analyze some possibilities of using social networks as devices linked to public health policies based on the experience of two comparative cases currently underway in Brazil: The HumanizaSUS Network and the Community of Primary Care Practices.

Methods: This is qualitative research with a comparative case study approach, with emphasis on the exploitation of data available in the public platform of both networks and publications around these two experiences.

Results: Webometric data of the cases studied will be shown, pointing out aspects of differentiation and similarity between them from three axes of analysis: (1) theoretical-conceptual framework; (2) the design of the platform, its functionalities and its daily support process; (3) the singularities of the related policies. The discussion of these points indicates that social networks can function as devices for education, production of a collection of experiences, clinical collaboration and especially a collaborative creation of spaces for sharing experiences and collective reflection on the daily construction of public policy.
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http://dx.doi.org/10.1590/1413-812320182310.14082018DOI Listing
October 2018

Consolidating Regionalized Global Characterization Factors for Soil Organic Carbon Depletion Due to Land Occupation and Transformation.

Environ Sci Technol 2018 11 9;52(21):12436-12444. Epub 2018 Oct 9.

MARETEC - Marine, Environment and Technology Centre, LARSyS , Instituto Superior Técnico, Universidade de Lisboa , Av. Rovisco Pais, 1 , 1049-001 Lisbon , Portugal.

Land occupation and transformation change soil organic carbon (SOC) stocks, which are a priority indicator for biotic production potential (BPP) in life cycle impact assessment (LCIA). SOC is a potential umbrella indicator for land use-related impacts, but global LCIA characterization models have never been sufficiently regionalized. Regeneration times required for the calculation of transformation impacts are unknown and can only be estimated through expert judgment or using additional assumptions. In this paper, we calculate global midpoint characterization factors (CF) for SOC depletion following land use and land use change using data from the European Soil Data Center with a resolution of 30 arc second. We used three possible calculation procedures to determine regeneration times: (1) estimations based on literature; (2) equal regeneration duration for all land uses; (3) equal regeneration rates for all land uses. We then propose an innovative approach for LCIA that combines all CFs in this paper as well as prior models using a spatial consolidation approach to arrive at a single set of CFs. We show that this procedure combines the strengths of each individual model and dilutes their shortcomings, and recommend the use of these consolidated CFs rather than individual sets of factors. For endpoints, we applied a nutrient replacement method using fertilizer input to compensate for organic matter depletion and obtained monetary CFs for SOC-related damages caused by land use on BPP.
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http://dx.doi.org/10.1021/acs.est.8b00721DOI Listing
November 2018

Chikungunya surveillance in Brazil: challenges in the context of Public Health.

Epidemiol Serv Saude 2018 09 3;27(3):e2017127. Epub 2018 Sep 3.

Universidade Federal de Goiás, Instituto de Ciências Biológicas, Goiânia, GO, Brasil.

Objective: to describe the challenges in implementing the chikungunya surveillance and prevention system in Brazil.

Methods: this was a descriptive study of suspected cases of the disease based on records held on the Notifiable Diseases Information System (Sinan) for the period 2014-2016.

Results: more than 100,000 probable chikungunya cases were notified in Brazil in this period, with the largest concentration in the Northeast states (83.3% between 2014 and 2015; 91.0% in 2016); Sinan provided an excellent opportunity for closing records of cases occurring between 2014 and 2015 (85%) and high completeness of obligatory variables.

Conclusion: given the imminence of the introduction of chikungunya in Brazil in 2014, advance public health preparation took place in order to minimize its effects on society; implementation of the surveillance system improved collection of information regarding the disease, however many challenges can be seen in practice, in view of increasing case incidence. This requires greater handling capacity in this sector.
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http://dx.doi.org/10.5123/S1679-49742018000300003DOI Listing
September 2018

The impact of coping strategies of cancer caregivers on psychophysiological outcomes: an integrative review.

Psychol Res Behav Manag 2018 24;11:207-215. Epub 2018 May 24.

Departamento de Psicologia, Centro de Investigação em Psicologia (CIP-UAL), Universidade Autónoma de Lisboa Luís de Camões, Lisboa, Portugal.

Purpose: A growing number of studies have explored the psychosocial burden experienced by cancer caregivers, but less attention has been given to the psychophysiological impact of caregiving and the impact of caregivers' coping strategies on this association. This paper reviews existing research on the processes underlying distress experienced by cancer caregivers, with a specific focus on the role of coping strategies on psychophysiological correlates of burden.

Methods: A broad literature search was conducted in health-related databases namely MEDLINE, Science Citations Index Expanded, Scopus, and PsycINFO, using relevant search terms. All types of studies published in English were considered for inclusion.

Results: We found that cancer caregiving was related to increased blood pressure, dysregulation of autonomic nervous system, hypothalamic-pituitary-axis dysregulation, immune changes, and poor health-related behaviors. We also found that problem-focused coping was associated with decreased caregiver burden, decreased depression, and better adjustment, while emotion-focused coping was related to higher levels of posttraumatic growth and psychological distress. The way coping impacts psychophysiological correlates of burden, however, remains unexplored.

Conclusion: A better understanding of the psychophysiological elements of caregiver burden is needed. We propose a model that attends specifically to factors that may impact psychophysiological correlates of burden among cancer caregivers. Based on the proposed model, psychosocial interventions that specifically target caregivers' coping and emotion regulation skills, family functioning, and self-care are endemic to the preservation of the health and well-being of this vulnerable population.
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http://dx.doi.org/10.2147/PRBM.S164946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973462PMC
May 2018

Assessment of Pulmonary Function before and after Sinus Surgery in Lung Transplant Recipients.

Int Arch Otorhinolaryngol 2018 Apr 19;22(2):157-160. Epub 2017 Sep 19.

Department of Otolaryngology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

 The association between sinus and lung diseases is well known. However, there are scarce studies regarding the effects of sinus surgery on pulmonary function in lung transplant recipients. The present study describes our experience with sinus surgery in lung transplant recipients with chronic rhinosinusitis.  To assess the impact of sinus surgery for chronic rhinosinusitis on pulmonary function and on inpatient hospitalization days due to lower respiratory tract infection in lung transplant recipients.  A retrospective study conducted between 2006 and 2012 on a sample of lung transplant recipients undergoing sinus surgery for chronic rhinosinusitis. Pulmonary function, measured by forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1), as well as inpatient hospitalization days due to lower respiratory tract infection, were compared 6 months before and 6 months after sinus surgery.  The FEV1 values increased significantly, and the inpatient hospitalization days due to bronchopneumonia decreased significantly 6 months after sinus surgery. The preoperative and postoperative median FEV1 values were and respectively (  =  ). The median number of inpatient hospitalization days due to bronchopneumonia 6 months before and 6 months after surgery were and respectively (  =  ).  In this sample of lung transplant recipients with chronic rhinosinusitis, sinus surgery led to an improvement in pulmonary function and a decrease in inpatient hospitalization days due to bronchopneumonia.
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http://dx.doi.org/10.1055/s-0037-1606600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882367PMC
April 2018

Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential.

Inorg Chem 2018 Apr 3;57(8):4629-4639. Epub 2018 Apr 3.

Centro de Química Estrutural , Faculdade de Ciências da Universidade de Lisboa , Campo Grande , 1749-016 Lisboa , Portugal.

New ruthenium methyl-cyclopentadienyl compounds bearing bipyridine derivatives with the general formula [Ru(η-MeCp)(PPh)(4,4'-R-2,2'-bpy)] (Ru1, R = H; Ru2, R = CH; and Ru3, R = CHOH) have been synthesized and characterized by spectroscopic and analytical techniques. Ru1 crystallized in the monoclinic P2/ c, Ru2 in the triclinic P1̅, and Ru3 in the monoclinic P2/ n space group. In all molecular structures, the ruthenium center adopts a "piano stool" distribution. Density functional theory calculations were performed for all complexes, and the results support spectroscopic data. Ru1 and Ru3 were poor substrates of the main multidrug resistance human pumps, ABCB1, ABCG2, ABCC1, and ABCC2, while Ru2 displayed inhibitory properties of ABCC1 and ABCC2 pumps. Importantly, all compounds displayed a very high cytotoxic profile for ovarian cancer cells (sensitive and resistant) that was much more pronounced than that observed with cisplatin, making them very promising anticancer agents.
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http://dx.doi.org/10.1021/acs.inorgchem.8b00358DOI Listing
April 2018

A cohort study of cardiac resynchronization therapy in patients with chronic Chagas cardiomyopathy.

Europace 2018 11;20(11):1813-1818

Heart Institute (InCor), University of São Paulo Medical School, Av. Enéas de Carvalho Aguiar, São Paulo, SP, Brazil.

Aims: Cardiac resynchronization therapy (CRT) is an established procedure for patients with heart failure. However, trials evaluating its efficacy did not include patients with chronic Chagas cardiomyopathy (CCC). We aimed to assess the role of CRT in a cohort of patients with CCC.

Methods And Results: This retrospective study compared the outcomes of CCC patients who underwent CRT with those of dilated (DCM) and ischaemic cardiomyopathies (ICM). The primary endpoint was all-cause mortality and the secondary endpoints were the rate of non-advanced New York Heart Association (NYHA) class 12 months after CRT and echocardiographic changes evaluated at least 6 months after CRT. There were 115 patients in the CCC group, 177 with DCM, and 134 with ICM. The annual mortality rates were 25.4%, 10.4%, and 11.3%, respectively (P < 0.001). Multivariate analysis adjusted for potential confounders showed that the CCC group had a two-fold [hazard ratio 2.34 (1.47-3.71), P < 0.001] higher risk of death compared to the DCM group. The rate of non-advanced NYHA class 12 months after CRT was significantly higher in non-CCC groups than in the CCC group (DCM 74.0% vs. ICM 73.9% vs. 56.5%, P < 0.001). Chronic Chagas cardiomyopathy and ICM patients had no improvement in the echocardiographic evaluation, but patients in the DCM group had an increase in left ventricular ejection fraction and a decrease in left ventricular end-diastolic diameter.

Conclusion: This study showed that CCC patients submitted to CRT have worse prognosis compared to patients with DCM and ICM who undergo CRT. Studies comparing CCC patients with and without CRT are warranted.
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http://dx.doi.org/10.1093/europace/eux375DOI Listing
November 2018

Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells.

Eur J Med Chem 2018 Jan;143:503-514

Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal. Electronic address:

Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η-MeCp)(PPh)Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η-MeCp)(PPh)(L1)][CFSO] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.
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http://dx.doi.org/10.1016/j.ejmech.2017.11.059DOI Listing
January 2018

Predictors of death in chronic Chagas cardiomyopathy patients with pacemaker.

Int J Cardiol 2018 Jan 19;250:260-265. Epub 2017 Oct 19.

Heart Institute (InCor), University of São Paulo Medical School, Brazil.

Background: Chronic Chagas cardiomyopathy (CCC) is the most serious and frequent manifestation of Chagas disease. Conduction abnormalities and bradycardia requiring pacemaker are common. The aim of this study was to determine the rate and predictors of death in CCC patients with pacemaker.

Methods: In this single-center prospective cohort study we assessed the outcome of 396 CCC patients with pacemaker, followed-up for at least 24months. All patients underwent a clinical and device assessment, 12-lead electrocardiography and echocardiography.

Results: During the median follow-up of 1.9years (Interquartile range 1.6-2.4), there were 65 (16.4%) deaths, yielding an annual mortality rate of 8.6%. The major cause was sudden death (33.8%), followed by heart failure (HF), 32.3%. All the investigated variables were examined as potential predictors of death. The final multivariate logistic regression model included five independent variables: advanced HF functional class (OR [odds ratio] 6.71; 95% confidence interval [95% CI] 1.95-23.2; P=0.003), renal disease (OR 5.71; 95% CI 1.80-18.0; P=0.003), QRS ≥150ms (OR 2.80; 95% CI 1.08-7.27; P=0.034), left atrial enlargement (OR 2.75; 95% CI 1.09-6.95; P=0.032) and left ventricular ejection fraction ≤43% (OR 2.31; 95% CI 1.07-4.97; P=0.032). The model had good discrimination, confirmed by bootstrap validation (optimism-adjusted c-statistic of 0.78) and the calibration curve showed a proper calibration (slope=0.972).

Conclusions: CCC patients with pacemaker have a high annual mortality rate despite that the pacemaker related variables were not predictors of death. The independent predictors of death can help us to identify the poor prognosis patients.
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http://dx.doi.org/10.1016/j.ijcard.2017.10.031DOI Listing
January 2018

Experience of Lung Transplantation in Patients with Lymphangioleiomyomatosis at a Brazilian Reference Centre.

Lung 2017 12 19;195(6):699-705. Epub 2017 Aug 19.

Pulmonary Division, Heart Institute (InCor), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar, 44, 5º andar - sala 1, São Paulo, 05403-900, Brazil.

Introduction: Lung transplantation (LT) is the standard of care for patients with advanced lung diseases, including lymphangioleiomyomatosis (LAM). LAM accounts for only 1% of all LTs performed in the international registry. As a result, the global experience, including the use of mechanistic target of rapamycin (mTOR) inhibitors before and after LT in LAM, is still limited.

Methods: We conducted a retrospective review of all LAM patients who underwent LT at our centre between 2003 and 2016. Pre- and post-transplant data were assessed.

Results: Eleven women with LAM underwent LT, representing 3.3% of all procedures. Ten (91%) patients underwent double-LT. The mean age at diagnosis was 39 ± 6 years and the mean FEV before LT was 28 ± 14%. Only one patient underwent pleurodesis for recurrent pneumothorax. Pulmonary hypertension was confirmed in 3 (27%) patients. Four (36%) patients received sirolimus preoperatively; three of them received it until the day of LT, and there was no occurrence of bronchial anastomotic dehiscence after the procedure. Four patients (36%) received mTOR inhibitors post-transplant. The median follow-up from LT was 44 months. There were 3 deaths (27%) during the study and survival probabilities at 1, 3, and 5 years after LT were, 90, 90, and 77%, respectively.

Conclusions: This data reinforces the role of LT for LAM patients with end-stage disease. The use of sirolimus seems to be safe before LT and the occurrence of complications after LT, including those LAM-related, should be continuously monitored.
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http://dx.doi.org/10.1007/s00408-017-0045-yDOI Listing
December 2017

Synthesis of disaccharides using β-glucosidases from Aspergillus niger, A. awamori and Prunus dulcis.

Biotechnol Lett 2017 Nov 1;39(11):1717-1723. Epub 2017 Aug 1.

Biocatalysis Laboratory, National Institute of Technology, Ministry of Science, Technology, Innovation and Communication, Rio de Janeiro, 20081-312, Brazil.

Objective: Glucose conversion into disaccharides was performed with β-glucosidases from Prunus dulcis (β-Pd), Aspergillus niger (β-An) and A. awamori (β-Aa), in reactions containing initial glucose of 700 and 900 g l.

Results: The reactions' time courses were followed regarding glucose and product concentrations. In all cases, there was a predominant formation of gentiobiose over cellobiose and also of oligosaccharides with a higher molecular mass. For reactions containing 700 g glucose l, the final substrate conversions were 33, 38, and 23.5% for β-An, β-Aa, and β-Pd, respectively. The use of β-An yielded 103 g gentiobiose l (15.5% yield), which is the highest reported for a fungal β-glucosidase. The increase in glucose concentration to 900 g l resulted in a significant increase in disaccharide synthesis by β-Pd, reaching 128 g gentiobiose l (15% yield), while for β-An and β-Aa, there was a shift toward the synthesis of higher oligosaccharides.

Conclusion: β-Pd and the fungal β-An and β-Aa β-glucosidases present quite dissimilar kinetics and selective properties regarding the synthesis of disaccharides; while β-Pd showed the highest productivity for gentiobiose synthesis, β-An presented the highest specificity.
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http://dx.doi.org/10.1007/s10529-017-2409-zDOI Listing
November 2017

Posttraumatic Stress Disorder Symptoms and Family Functioning in Adult Children Facing Parental Cancer: A Comparison Study.

Res Theory Nurs Pract 2016 08;30(3):212-228

University of Minho, School of Psychology, Braga, Portugal.

This study analyzed posttraumatic stress disorder (PTSD) symptoms and family functioning in a sample of adult children caregivers of cancer patients and in a group of adult children of nonchronically ill parents. Participants completed measures of family functioning and PTSD symptoms. The parental cancer group was subdivided into PTSD subgroups, and significant differences, on family functioning, were found. In the parental cancer group, the predictors of PTSD symptoms were being a woman and having an enmeshed or chaotic family functioning. Chaotic functioning mediated the relationship between family communication/satisfaction and PTSD symptoms, in the parental cancer group. Finally, there was a higher prevalence of PTSD symptoms in the parental cancer group, and participants with a probable PTSD diagnosis showed higher levels of family imbalance. This study shows that adult children facing parental cancer, who have a poorer family balance, may benefit from interventions that target family functioning.
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http://dx.doi.org/10.1891/1541-6577.30.3.212DOI Listing
August 2016

A step toward regionalized scale-consistent agricultural life cycle assessment inventories.

Integr Environ Assess Manag 2017 Sep 20;13(5):939-951. Epub 2017 Feb 20.

Marine, Environment and Technology Centre (MARETEC), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.

Life cycle inventory (LCI) regionalization (i.e., the determination of input and output flows from production processes at a subcountry scale) is a priority in life cycle assessment (LCA) studies, particularly in the agri-food sector. Many regionalized LCAs fail to ensure that microlevel inventories are consistent with country-level aggregated data-or "scale consistent." They also fail to construct LCIs using international reference guidelines and trustworthy standardized data sources. This failure generates inaccuracies and biases in inventories and can compromise comparability among international LCA studies. Our study introduces scale consistency as a principle for regionalized agri-food LCIs. We present a generic procedure that defines how scale-dependent LCI flows should be regionalized, depending on data availability. We then present a list of inventory flows that require regionalization and their suggested calculation procedures (methods and models) from 2 methodological guides developed by projects Agribalyse and World Food LCA Database. As proof of concept, we apply the procedure to Portugal and assess whether the methods and models proposed for each type of inventory flow in both guides can potentially be applied consistently with the data available. For 17 inventory flows, we apply calculated scale-consistent inventory flows for Portuguese agriculture, covering 260 products that can be used in future LCA studies. Comparing results with international databases, we show that this procedure can improve country-level estimates significantly. Our study is the first step in introducing scale consistency as a guiding principle for regionalized LCIs for agri-food LCA studies. Integr Environ Assess Manag 2017;13:939-951. © 2017 SETAC.
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http://dx.doi.org/10.1002/ieam.1889DOI Listing
September 2017

Control of dengue: Consensus views of Endemic Disease Control Agents and Community Health Agents on their integrated action.

Cien Saude Colet 2016 Aug;21(8):2329-38

Departamento de Saúde Coletiva, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. Campinas SP Brasil.

Dengue is one of Brazil's most important public health challenges. Activities for its prevention and control have been based on the strategy of integrated management proposed in health policies, in which the central actors are the Endemic Disease Control Agent(ACE) and the Community Health Agent (ACS). This study analyzes consensus opinions produced by ACSs and ACEs on theactions for incorporating ACEs into the teams of the Family Health Strategy (ESF). It is a qualitative study from a large municipality in Brazil in which dengue is endemic, using a focus group of professionals that is subsequently analyzed using Collective Subject Discourse Analysis, supported by WebQDA. The results indicate consensus positions in relation to the following subjects: I) difficulty in the process of integration of ACSs and ACEs for control of dengue; II) inclusion of ACEs in the primary healthcare of the ESF; and III) absence of monitoring and assessment of the integrated actions. In conclusion, there are needs: to make participants more aware, seeking changes in behavior; to offer an environment of support to those involved with training courses about dengue; and to monitor the process of integration, and evaluate it periodically, creating indicators of quality and quantity.
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http://dx.doi.org/10.1590/1413-81232015218.05462016DOI Listing
August 2016
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