Publications by authors named "Reza Hosseini"

56 Publications

Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy.

Mol Cancer 2022 Jan 14;21(1):15. Epub 2022 Jan 14.

Department of Immunology School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and metastasis without a need for additional activation. Based on this rationale, adoptive transfer of ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention and is widely studied as a promising immunotherapy for cancer treatment. However, by exploiting various strategies, including secretion of exosomes, cancer cells are able to subvert NK cell responses. This paper reviews the roles of TDEs in cancer-induced NK cells impairments with mechanistic insights. The clinical significance and potential approaches to nullify the effects of TDEs on NK cells in cancer immunotherapy are also discussed.
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http://dx.doi.org/10.1186/s12943-021-01492-7DOI Listing
January 2022

A Metabolomic Investigation of Eugenol on Colorectal Cancer Cell Line HT-29 by Modifying the Expression of APC, p53, and KRAS Genes.

Evid Based Complement Alternat Med 2021 18;2021:1448206. Epub 2021 Nov 18.

Department of Biochemistry, Pasteur Institute of Iran, Pasteur Avenue, Tehran, Iran.

Colorectal cancer is one of the most lethal cancers with a high mortality rate. Chemotherapy results in drug resistance in some cases; hence, herbal medicines are sometimes used in adjunct with it. Eugenol has been reported to have anti-inflammatory, antioxidant, and anticancer properties. Metabolomics is a study of metabolic changes within an organism using high-throughput technology. The purpose of this research was to investigate the anticancer effects of eugenol and variations in p53, KRAS, and APC gene expression and metabolic changes associated with the abovementioned gene expressions using HNMR spectroscopy. The MTT method was used to determine cell viability and its IC50 detected. After treating HT-29 cells with IC50 concentration of eugenol, RNA was extracted and cDNA was obtained from them and the expression of p53, KRAS, and APC genes was measured using the qRT-PCR technique. Metabolites were extracted using the chloroform-ethanol method, lyophilized, and sent for HNMR spectroscopy using the 1D-NOESY protocol. Chemometrics analysis such as PLS-DA was performed, and differentiated metabolites were identified using the Human Metabolome Database. Integrated metabolic analysis using the metabolites and gene expression was performed by the MetaboAnalyst website. The observed IC50 for eugenol was 500 M, and the relative expression of APC and p53 genes in the treated cells increased compared to the control group, and the expression of KRAS oncogene gene decreased significantly. The crucial changes in convergent metabolic phenotype with genes were identified. The results indicate that eugenol exhibits its antitumor properties by targeting a specific biochemical pathway in the cell's metabolome profile due to changes in genes involved in colon cancer.
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http://dx.doi.org/10.1155/2021/1448206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616688PMC
November 2021

The Cost Burden of Safety Risk Incidents on Construction: A Probabilistic Quantification Method.

Risk Anal 2021 Nov 27. Epub 2021 Nov 27.

Donald Cant Watts Corke, Melbourne, Australia.

The construction sector is vulnerable to safety risk incidents due to its dynamic nature. Although numerous research efforts and technological advancements have focused on addressing workplace injuries, most of the studies perform empirical and deterministic postimpact evaluations on construction project performance. The effective modeling of the safety risk impacts on project performance provides decisionmakers with a valuable tool toward incidents prevention and proper safety risk management. Therefore, this study collected Australian incident records from the construction industry from 2016 onwards and conducted discrete event simulation to quantitatively measure the impact of safety risk incidents on project cost performance. Moreover, this study investigated the correlation between safety risk incidents and the age of injured workers. The findings show a strong correlation between the middle-aged workforce and the severity of incidents on project cost overruns. The ex-ante, nondeterministic analysis of safety risk impacts on project performance provides insightful results that will advance safety management theory in the direction of achieving zero harm workplace environments.
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http://dx.doi.org/10.1111/risa.13865DOI Listing
November 2021

Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study.

Int J Reprod Biomed 2021 Aug 9;19(8):741-750. Epub 2021 Sep 9.

Biochemistry Department, Metabolomics Lab, Pasture Institute of Iran, Tehran, Iran.

Background: Prostate cancer (PCa) is a common health problem worldwide. The rate of this disease is likely to grow by 2021. PCa is a heterogeneous disorder, and various biochemical factors contribute to the development of this disease. The metabolome is the complete set of metabolites in a cell or biological sample and represents the downstream end product of the omics. Hence, to model PCa by computational systems biology, a preliminary metabolomics-based study was used to compare the metabolome profile pattern between healthy and PCa men.

Objective: This study was carried out to highlight energy metabolism modification and assist the prognosis and treatment of disease with unique biomarkers.

Materials And Methods: In this cross-sectional research, 26 men diagnosed with stage-III PCa and 26 healthy men with normal PSA levels were enrolled. Urine was analyzed with proton nuclear magnetic resonance ( H-NMR) spectroscopy, accompanied by the MetaboAnalyst web-based platform tool for metabolomics data analysis. Partial least squares regression discriminant analysis was applied to clarify the separation between the two groups. Outliers were documented and metabolites determined, followed by identifying biochemical pathways.

Results: Our findings reveal that modifications in aromatic amino acid metabolism and some of their metabolites have a high potential for use as urinary PCa biomarkers. Tryptophan metabolism (p 0.001), tyrosine metabolism (p 0.001), phenylalanine, tyrosine and tryptophan biosynthesis (p 0.001), phenylalanine metabolism (p = 0.01), ubiquinone and other terpenoid-quinone biosynthesis (p = 0.19), nitrogen metabolism (p = 0.21), and thiamine metabolism (p = 0.41) with Q (0.198) and R (0.583) were significantly altered.

Conclusion: The discriminated metabolites and their pathways play an essential role in PCa causes and harmony.
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http://dx.doi.org/10.18502/ijrm.v19i8.9622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458921PMC
August 2021

Shirazi thyme () extract can alleviate allergic rhinitis: a randomized clinical trial.

Postepy Dermatol Alergol 2021 Jun 26;38(3):520-525. Epub 2021 Jul 26.

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Atopic diseases are global concerns in the today's industrialized world. Allergic rhinitis is the most common allergic condition affecting 20% of individuals. This disorder is associated with remarkable morbidity and rising healthcare expenditure.

Aim: Considering the anti-inflammatory properties of a plant (ZM) with the common name of Shirazi thyme, a randomized clinical trial was designed to evaluate the alleviation of the symptoms of allergic rhinitis.

Material And Methods: A total of 30 allergic rhinitis patients were randomly and equally assigned to experimental and control groups. Afterwards, the case group was treated with an extract of ZM and the control group with placebo for 2 months. Finally, the clinical signs and symptoms before and after the treatment according to the SNOT22 questionnaire were analysed.

Results: Comparing the symptoms of allergic rhinitis and an average score of SNOT22 questionnaire between the two groups before the intervention provided some difference, which was significantly greater after the treatment. Based on this questionnaire, our patients in the ZM syrup group had lower grades than before the treatment and experienced amelioration.

Conclusions: Regarding the significant effect of the ZM syrup in reducing symptoms of allergic rhinitis, its use is highly recommended. Since allergic rhinitis is a multifactorial condition, the use of herbal antioxidants along with conventional treatment would result in a more effective improvement of the disease.
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http://dx.doi.org/10.5114/ada.2020.102295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330855PMC
June 2021

The Effect of Oral Magnesium Supplementation on Inflammatory Biomarkers in Adults: A Comprehensive Systematic Review and Dose-response Meta-analysis of Randomized Clinical Trials.

Biol Trace Elem Res 2021 Jun 18. Epub 2021 Jun 18.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) among adults. The major databases including PubMed, Web of Science, Embase, and Google Scholar were searched for relevant publications until December 14, 2020, using appropriate keywords. The Cochrane Collaboration tool was used to assess the quality of each study. We also performed a subgroup analysis to identify probable sources of heterogeneity. A total of 18 studies with 927 participants fulfilled the eligibility criteria and included in this meta-analysis. Our results indicate that the supplementation with magnesium had no statistically significant effect on serum concentrations of CRP (WMD, - 0.49; 95% CI, - 1.72 to 0.75 mg/L; P = 0.44), IL-6 (WMD, - 0.03; 95% CI, - 0.40 to 0.33 pg/mL; P = 0.86), and TNF-α (WMD, 0.12; 95% CI, - 0.08 to 0.31 pg/mL; P = 0.24) compared with controls. In addition, based on dose-response assessment, no significant non-linear association was found between magnesium supplementation dosage or duration on serum CRP and IL-6 concentrations. The findings of the present systematic review and meta-analysis did not support the notion that oral magnesium supplementation could have favorable effects on CRP, IL-6, and TNF-α in the adult population.
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http://dx.doi.org/10.1007/s12011-021-02783-2DOI Listing
June 2021

The roles of tumor-derived exosomes in altered differentiation, maturation and function of dendritic cells.

Mol Cancer 2021 06 2;20(1):83. Epub 2021 Jun 2.

Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Tumor-derived exosomes (TDEs) have been shown to impede anti-tumor immune responses via their immunosuppressive cargo. Since dendritic cells (DCs) are the key mediators of priming and maintenance of T cell-mediated responses; thus it is logical that the exosomes released by tumor cells can exert a dominant influence on DCs biology. This paper intends to provide a mechanistic insight into the TDEs-mediated DCs abnormalities in the tumor context. More importantly, we discuss extensively how tumor exosomes induce subversion of DCs differentiation, maturation and function in separate sections. We also briefly describe the importance of TDEs at therapeutic level to help guide future treatment options, in particular DC-based vaccination strategy, and review advances in the design and discovery of exosome inhibitors. Understanding the exosomal content and the pathways by which TDEs are responsible for immune evasion may help to revise treatment rationales and devise novel therapeutic approaches to overcome the hurdles in cancer treatment.
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http://dx.doi.org/10.1186/s12943-021-01376-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170799PMC
June 2021

Age-specific reference ranges of prostate-specific antigen in the elderly of Amirkola: A population-based study.

Asian J Urol 2021 Apr 7;8(2):183-188. Epub 2020 Mar 7.

Babol University of Medical Sciences, Babol, Iran.

Objective: To determine the age-specific reference ranges of prostate-specific antigen (PSA) in the older men in the city of Amirkola.

Methods: This cross-sectional study is a part of Amirkola Health and Ageing Project (AHAP) which has been conducted as a cohort study since 2011 in Amirkola, a city in northern Iran. The demographic information of all men aged 60 and older were collected through questionnaires and interviews and the PSA measurements were performed using ELISA and Diametra kit. The acquired data were analyzed afterwards.

Results: A number of 837 elderly men with a mean age of 69.99±7.72 years participated in this study. The serum PSA level (95th percentile) was determined to be 0.9 (0-4.89) ng/mL in the age group of 60-64 years, 1.1 (0-4.88) ng/mL in the age group of 65-69 years, 0.93 (0-9.01) ng/mL in the age group of 70-74 years, 1.3 (0-7.95) ng/mL in the age group of 75-79 years, 1.9 (0-11.98 ng/mL) in the age group of 80-84 years, and 1.45 (0-33.17) ng/mL in the 85 and older group. The serum PSA level was significantly correlated with age (=0.000).

Conclusion: This study indicated that there is a direct correlation between the age and serum PSA levels. The use of age-specific reference range could guide clinicians on the incidence of prostate cancer in this population and perhaps reduce the number of unnecessary tests in this population group.
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http://dx.doi.org/10.1016/j.ajur.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099648PMC
April 2021

Association between prenatal phthalate exposure and anthropometric measures of newborns in a sample of Iranian population.

Environ Sci Pollut Res Int 2021 Sep 9;28(36):50696-50706. Epub 2021 May 9.

Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Phthalates or phthalic acid esters (PAEs) are a group of compounds which they can be entered into the human body through the various pathways. The aim of this study was to examine associations between prenatal phthalates exposure with anthropometric measures of neonates. Urine samples were obtained from 121 Iranian pregnant women at their first trimester of pregnancy, and the levels of monobutyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), and mono (2-ethyl-5hydroxyhexyl) phthalate (MEHHP) metabolites were determined by gas chromatography mass spectrometry (GC/MS). The correlations between the maternal urinary concentrations of phthalate metabolites with anthropometric measures of neonates as well as with the socio-demographic factors of participants (maternal education, age, family income, pre-pregnancy body mass index), their lifestyle variables (smoking habit, food pattern, and physical activity), and use of cleaning products (cosmetic and household cleaning products) were investigated. MBzP, MBP, MEHP, and MEHHP were detected in 100% of the participants with the concentration ranged 120 to 860 μg/g creatinine. Significant correlations were observed between the urinary levels of maternal MBzP (adjusted β = 0.3 (0.001), p = 0.03) and MEHHP (adjusted β = 0.3 (0.001), p = 0.04) with the birth weight of female neonates. MBP (adjusted β = -0.3 (0.02), p = 0.04) and MBzP (adjusted β = -0.3 (0.001), p = 0.02) had negative associations with the head circumference in male and female newborns, respectively. Furthermore, plastic packaging for pickle and passive smoking during pregnancy were identified to be significantly associated with low birth weight (p value < 0.05). Iranian pregnant women had higher concentrations of urinary phthalates compared to the other countries. Based on the findings, the higher prenatal exposure to phthalates could adversely impact the health status of newborns.
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http://dx.doi.org/10.1007/s11356-021-14182-0DOI Listing
September 2021

Community Behavioral and Perceived Responses in the COVID-19 Outbreak in Afghanistan: A Cross-Sectional Study.

Disaster Med Public Health Prep 2021 May 5:1-7. Epub 2021 May 5.

Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal.

Objective: Community responses are important for the management of early-phase outbreaks of coronavirus disease 2019 (COVID-19). Perceived susceptibility and severity are considered key elements that motivate people to adopt nonpharmaceutical interventions. This study aimed to (i) explore perceived susceptibility and severity of the COVID-19 pandemic, (ii) examine the practice of nonpharmaceutical interventions, and (iii) assess the potential association of perceived COVID-19 susceptibility and severity with the practice of nonpharmaceutical interventions among people living in Afghanistan.

Methods: A cross-sectional design was used, using online surveys disseminated from April to May 2020. Convenience sampling was used to recruit the participants of this study. The previously developed scales were used to assess the participants' demographic information, perceived risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and perceived severity of COVID-19. Multivariate analyses were conducted to assess the potential association of perceived COVID-19 susceptibility and severity with the practice of nonpharmaceutical interventions.

Results: The Internet was the main source for obtaining COVID-19 information among participants in this study. While 45.8% of the participants believed it was "very unlikely" for them to get infected with COVID-19, 76.7% perceived COVID-19 as a severe disease. Similarly, 37.5% believed the chance of being cured if infected with COVID-19 is "unlikely/very unlikely." The majority of participants (95.6%) perceived their health to be in "good" and "very good" status. Overall, 74.2% mentioned that they stopped visiting public places, 49.7% started using gloves, and 70.4% started wearing a mask. Participants who believed they have a low probability of survival if infected with COVID-19 were more likely to wear masks and practice hand washing.

Conclusions: It appears that communities' psychological and behavioral responses were affected by the early phase of the COVID-19 pandemic in Afghanistan, especially among young Internet users. The findings gained from a timely behavioral assessment of the community might be useful to develop interventions and risk communication strategies in epidemics within and beyond COVID-19.
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http://dx.doi.org/10.1017/dmp.2021.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185426PMC
May 2021

Reverse supply chain conceptual model for construction and demolition waste.

Waste Manag Res 2021 Nov 11;39(11):1341-1355. Epub 2021 Mar 11.

Technology Institute - ITEC, Federal University of Pará - UFPA, Belém, Para, Brazil.

Construction and demolition waste (CDW) substantially contributes to environmental degradation because of its intrinsic characteristics of fast and high generation volume, low recycling rate, and low revenue margins. A systemic problem is that recycling facilities are not usually a part of a reverse supply chain (RSC) specific for CDW. This makes the recovery process costs prohibitive, especially where companies are unable to receive and process large volumes of waste continuously. This paper presents a systematic analysis of the extant literature and utilizes the results accrued to develop a conceptual RSC model for CDW. In so doing, the research seeks to provide clarity on this phenomenon, while simultaneously stimulating wider academic discourse and further research endeavours. A mixed philosophies epistemological design was adopted using both interpretavism and constructivism to undertake a qualitative systematic analysis of the literature. A process diagram was produced to represent the conceptual model (CM) and thematically group the nodes into three key swim lanes that delineate the boundaries between distribution, manufacturing, and sourcing and warehousing processes. Within each swim lane, stakeholders were incorporated as key actors. A further layer of nuanced complexity was added to illustrate the key actors involved in the process, government strategies, and activity flow paths. This novel CM offers both practical and theoretical contributions to existing knowledge and signposts a future research direction. Such work will demystify reverse logistics for managing CDW, and assist government policy-makers to develop informed policies that reduce the negative environmental impact of construction activities.
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http://dx.doi.org/10.1177/0734242X21998730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521372PMC
November 2021

The effects of nano-curcumin supplementation on Th2/tregulatory axis in migraine patients: a randomized, double-blind, placebo-controlled trial.

Int J Neurosci 2021 Mar 16:1-7. Epub 2021 Mar 16.

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Aim: In the present study we aimed to investigate the effects of nano-curcumin supplementation on gene expression and serum levels of IL-4 and TGF-β in migraine patients.

Methods: Forty participants with episodic migraine were randomly allocated to receive 80 mg nano-curcumin ( = 20) or placebo ( = 20) in a randomized double-blind clinical trial for two months. At the beginning and the end of the study, the interictal serum levels and gene expression of IL-4 and TGF-β in peripheral blood mononuclear cells (PBMCs) isolated from migraine patients were measured, using ELISA and real-time PCR methods, respectively.

Results: Intra-group assays showed a significant rise in the gene expression of both IL-4 and TGF-β ( < 0.05) in nano-curcumin group after two months of treatment, however the serum levels were only significantly changed for IL-4 ( < 0.05). On the contrast, inter-group assays revealed no statistical differences between nano-curcumin and placebo group in terms of IL-4 and TGF-β gene expression, while the serum levels of IL-4 was observed to be increased significantly ( 0.03) following two month nano-curcumin supplementation.

Conclusion: The findings of the present trial suggest that the treatment with nano-curcumin could induce significant levels of IL-4, in favour of anti-inflammatory effects, while has a minimal effects on the both gene expression and serum levels of TGF-β. Further studies are required to determine the exact mechanism of action of curcumin in patients with migraine.
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http://dx.doi.org/10.1080/00207454.2021.1897587DOI Listing
March 2021

A significant association between CXCL10 -1447 A > G and IL18 -607 C > A gene polymorphism with human T-cell lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM-TSP), a case-control report from city of Mashhad, Iran.

J Neurovirol 2021 04 2;27(2):249-259. Epub 2021 Mar 2.

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Human T-cell lymphotropic virus type 1 (HTLV-1) is the first isolated retrovirus from humans, and 2-3% of infected individuals suffer from HTLV-1 associated myelopathy tropical spastic paraparesis (HAM-TSP). Previous studies indicated that the risk of HAM-TSP could be correlated with the individuals' genetic alterations. Mashhad is one of the areas infected with HTLV-1 in Iran. This study designed to examine the association between several important gene polymorphisms and HAM-TSP. Genotypes of 232 samples from controls, HTLV-1 carriers, and HAM-TSP patients were examined for FAS-670 (A > G), CXCL10-1447 (A > G), Foxp3-3279 (C > A), IL-18 -137 (C > G), and IL-18 -607 (C > A) gene polymorphisms by different polymerase chain reaction (PCR) techniques. A non-significant association was observed between FAS-670 A > G, Foxp3-3279 C > A, and IL-18 -137 C > G gene polymorphisms and HAM-TSP. Nevertheless, a significant (P < 0.001) association between CXCL10-1447 A > G and IL-18 -607 C > A gene polymorphisms with HAM-TSP was observed in our study population. As previous studies revealed that the CXCL10 level in the cerebrospinal fluid of HAM-TSP patients was associated with the disease progression, and as we noticed, a direct association was observed between CXCL10-1447 A > G polymorphism and HAM-TSP. These polymorphisms might be recommended as a valuable prediction criterion for the severity of the disease. The contradiction between our findings and other studies regarding IL-18 -607 C > A gene polymorphism might be associated with various factors such as genotypes frequency in diverse races and population heterogeneity in the city of Mashhad.
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http://dx.doi.org/10.1007/s13365-021-00946-4DOI Listing
April 2021

Developing an Ensemble Predictive Safety Risk Assessment Model: Case of Malaysian Construction Projects.

Int J Environ Res Public Health 2020 11 13;17(22). Epub 2020 Nov 13.

Universiti Malaysia Kelantan, Beg Bercunci No. 01, Bachok, Kelantan 16300, Malaysia.

Occupational Health and Safety (OHS)-related injuries are vexing problems for construction projects in developing countries, mostly due to poor managerial-, governmental-, and technical safety-related issues. Though some studies have been conducted on OHS-associated issues in developing countries, research on this topic remains scarce. A review of the literature shows that presenting a predictive assessment framework through machine learning techniques can add much to the field. As for Malaysia, despite the ongoing growth of the construction sector, there has not been any study focused on OHS assessment of workers involved in construction activities. To fill these gaps, an Ensemble Predictive Safety Risk Assessment Model (EPSRAM) is developed in this paper as an effective tool to assess the OHS risks related to workers on construction sites. The developed EPSRAM is based on the integration of neural networks with fuzzy inference systems. To show the effectiveness of the EPSRAM developed, it is applied to several Malaysian construction case projects. This paper contributes to the field in several ways, through: (1) identifying major potential safety risks, (2) determining crucial factors that affect the safety assessment for construction workers, (3) predicting the magnitude of identified safety risks accurately, and (4) predicting the evaluation strategies applicable to the identified risks. It is demonstrated how EPSRAM can provide safety professionals and inspectors concerned with well-being of workers with valuable information, leading to improving the working environment of construction crew members.
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http://dx.doi.org/10.3390/ijerph17228395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696253PMC
November 2020

The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial.

Complement Ther Clin Pract 2020 Nov 29;41:101256. Epub 2020 Oct 29.

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The present study was aimed to evaluate the nano-curcumin supplementation on Th1/Th17 balance by assessment of gene expression and serum level of interferon gamma (IFN-γ) and interleukin-17 (IL-17) in migraine patients.

Methods: Forty participants with episodic migraine were randomly allocated to receive 80 mg nano-curcumin (n = 20) or placebo (n = 20) in a randomized double-blind clinical trial for two months. The expression of IFN-γ and IL-17 from peripheral blood mononuclear cells and IFN-γ and IL-17 serum levels were measured, using a real-time PCR and ELISA methods, respectively.

Results: Compared to placebo group, two month nano-curcumin supplementation led to a significant reduction in serum levels and expression of IL-17 mRNA (P = 0.006 & 0.04, respectively), while there was no statistical difference regarding serum levels and expression of IFN-γ mRNA.

Conclusion: Nano-curcumin supplementation in migraine patients led to a significant reduction in gene expression and plasma levels of IL-17 compared to control group.
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http://dx.doi.org/10.1016/j.ctcp.2020.101256DOI Listing
November 2020

Vertagopus (Collembola, Isotomidae) of Iran and Caucasus.

Zootaxa 2020 Jun 4;4786(4):zootaxa.4786.4.9. Epub 2020 Jun 4.

Department of Plant Protection, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran..

The materials on the genus Vertagopus Börner from the Caucasus and Iran are revised. Two new species, V. persicus sp. nov. and V. nunataki sp. nov., are described and fauna of the genus in the Western Asia is commented.
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http://dx.doi.org/10.11646/zootaxa.4786.4.9DOI Listing
June 2020

Morphological and molecular identification of the Iranian bark and ambrosia beetles (Coleoptera, Curculionidae, Scolytinae).

Zootaxa 2020 Sep 16;4852(3):zootaxa.4852.3.1. Epub 2020 Sep 16.

Department of Plant Protection, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran. Department of Agronomy, Food, Natural resources, Animals and Environment, University of Padua, Legnaro, Italy..

A faunal and molecular taxonomic study of Iranian bark and ambrosia beetle species based on field collections, museum specimens and literature data was carried out from in the period 2011-2016. A total of 29 genera and 84 species were found for Iran. A morphological key for species identification is provided. Molecular identification based on mitochondrial cytochrome c oxidase I (CO1) barcoding region gene was also performed for the collected specimens to confirm morphological identification, and an exclusive DNA barcode was provided and registered for the samples collected in this study. Host plants and distribution of each species in the Palearctic region and in Iran are reported in the key.
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http://dx.doi.org/10.11646/zootaxa.4852.3.1DOI Listing
September 2020

The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: a Systematic Review and Meta-analysis of Randomized Controlled Trials.

Biol Trace Elem Res 2021 Feb 8;199(2):413-424. Epub 2020 May 8.

Halal Research Centre of IRI, FDA, Tehran, Iran.

In this study, we aimed to systematically review the literature to evaluate the effects of magnesium (Mg) supplementation on blood pressure (BP) and obesity measure among patients with type 2 diabetes mellitus (T2DM). Major electronic databases of Web of Science, the Cochrane library, PubMed, and Scopus were searched completely from the inception until 15 October 2019 to identify randomized clinical trials (RCTs) pertaining to the topic of interest. All outcomes were pooled using a random-effects model and expressed as weighted mean differences (WMD) with 95% confidential intervals (CI). Heterogeneity, sensitivity analysis, and publication bias were also assessed using standard methods. The pooled analysis of five RCTs showed that Mg supplementation did not affect body weight (WMD: - 0.01 kg, 95% CI: - 0.36 to 0.33), BMI (WMD: - 0.07, 95% CI: - 0.18 to 0.04), and waist circumference (WMD: 0.12, 95% CI: - 1.24 to 1.48) in T2DM patients compared to the control groups of the patients who received placebo. However, pooling seven RCTs together showed significant reduction of systolic blood pressure (WMD: - 5.78 mmHg, 95% CI: - 11.37 to - 0.19) and diastolic blood pressure (WMD: - 2.50 mmHg, 95% CI: - 4.58 to - 0.41) in T2DM patients. Furthermore, subgroup analysis by dose of intervention, intervention duration, and type of intervention suggested that Mg supplementation for > 12 weeks, in doses higher than 300 mg/day or inorganic forms, could significantly decrease both systolic and diastolic BP in T2DM patients. Based on the findings, Mg supplementation has beneficial effects on BP in type 2 diabetes patients independent of body weight status. However, further investigations are needed to provide more reliable evidences.
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http://dx.doi.org/10.1007/s12011-020-02157-0DOI Listing
February 2021

A Confusing Picture: Refractory Encephalopathy Complicating Nonalcoholic Steatohepatitis.

Am J Med 2020 10 19;133(10):e546-e548. Epub 2020 Feb 19.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.amjmed.2020.01.026DOI Listing
October 2020

Interleukin 10, lipid profile, vitamin D, selenium, metabolic syndrome, and serum antioxidant capacity in elderly people with and without cardiovascular disease: Amirkola health and ageing project cohort-based study.

ARYA Atheroscler 2019 Sep;15(5):233-240

Associate Professor, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Background: The age-related autoinflammation-mediated atherosclerosis is associated with some immunological, nutritional, and metabolic parameters and redox status. Here, we evaluated the association of circulatory interleukin 10 (IL-10) levels with lipid profile, some nutrients, and total anti-oxidant capacity in elderly people who presented cardiovascular disease (CVD) with or without metabolic syndrome (MetS) and in healthy subjects.

Methods: In this cross-sectional case-control study, 258 sera prepared from elderly people (144 healthy and 114 patient subjects) who participated in a community-based study, the Amirkola Health and Ageing Project (AHAP), were analyzed for IL-10, lipid profile, vitamin D, selenium (Se), antioxidant capacity, and MetS.

Results: Compared to patients, the healthy subjects exhibited higher levels of circulatory IL-10 among individuals with detectable serum IL-10 (P = 0.036). However, this difference was not observed when total subjects from both groups were compared, since more than 90% of those people were IL-10-negative. Se, vitamin D, and antioxidant levels were similar in both groups. There was a negative association between IL-10 and body mass index (BMI) (P < 0.050) and an equivocal association with vitamin D levels, whereas the association between IL-10 and other indicated variables was not significant. Significant association was observed between MetS and CVD prevalence (P < 0.001). There was a positive correlation between Se and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) (P < 0.010) in healthy subjects and with TC in patients (P < 0.050).

Conclusion: A major proportion of elderly people were serum IL-10-negative, whereas independently to IL-10, MetS was most common in patients with CVD. Weight loss may have the potential to increase IL-10 levels in the elderly.
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http://dx.doi.org/10.22122/arya.v15i5.1623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954357PMC
September 2019

Effect of Rosa canina Distilled Water on Tamoxifen-treated Male Wistar Rats.

Pak J Biol Sci 2020 Jan;23(2):173-180

Background And Objective: In spite of therapeutic effect of tamoxifen on the breast cancer, it has some side effects on the liver including non-alcoholic fatty liver disease. In this study the effects of Rosa canina distilled water on the tamoxifen-induced fatty liver and oxidative stress status in male rats were investigated.

Materials And Methods: Twenty four adult male Wistar rats were randomly divided into 4 groups of 6: 1st group: Untreated control rats (C), 2nd group (T): The rats received tamoxifen, 3rd group (T+R): Rats received tamoxifen and Rosa canina distilled water and 4th group (R): Rats received only Rosa canina distilled water. Tamoxifen at 1 mg kg-1/day was injected subcutaneously for 7 days and the rats received orally Rosa canina distilled water at 1 mL/rat/daily for 14 days. At the end of the study, animals were studied for serum biochemical parameters (glucose, lipid profile, BUN, creatinine, uric acid, urea, ALT, AST, ALP, total protein, bilirubin, oxidative stress indices, sperm analysis and histology of the liver. The data were analyzed with SPSS software version 20 and expressed as Mean±SD.

Results: Rosa canina distilled water improved liver enzyme and renal function indices which disturbed due to tamoxifen treatment. While tamoxifen enhanced lipid peroxidation, Rosa canina distilled water reduced it. In addition, tamoxifen reduced the mobility, morphology and viability of sperms, but the Rosa canina distilled water enhanced the sperm parameters. Histological results also confirmed the adverse effect of tamoxifen and the favorable impact of the Rosa canina distilled water on the liver structures of animals.

Conclusion: Rosa canina distilled water could modulate tamoxifen-induced fatty liver as well as improving the sperm parameters.
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http://dx.doi.org/10.3923/pjbs.2020.173.180DOI Listing
January 2020

Two new species of the genus Phytocoris (Hemiptera: Miridae), with a revised identification key to species of the subgenus Compsocerocoris found in Iran.

Zootaxa 2019 Jul 29;4648(1):zootaxa.4648.1.6. Epub 2019 Jul 29.

Department of Plant Protection, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran. P.O. Box: 41635-1314..

Two new species, Phytocoris (Compsocerocoris) amardus sp. nov. and Phytocoris (Compsocerocoris) hyrcaniaensis sp. nov. are described from Guilan province, Iran. Description, diagnoses, male color habitus image and illustrations of male genitalia are presented for each taxon to aid in unequivocal identification. A revised taxonomic key to the species of subgenus Compsocerocoris Reuter known in Iran is also provided. The type specimens were deposited in the insect collection of the University of Guilan, Rasht, Iran.
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http://dx.doi.org/10.11646/zootaxa.4648.1.6DOI Listing
July 2019

A new species of the genus Phytocoris (Hemiptera: Miridae), with an identification key to amygdali-group species of the subgenus Compsocerocoris found in Iran.

Zootaxa 2019 Feb 28;4563(2):zootaxa.4563.2.8. Epub 2019 Feb 28.

Department of Plant Protection, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran. P.O. Box: 41635-1314..

A new species, Phytocoris (Compsocerocoris) darakiensis sp. nov. is described from Kurdistan province, Iran. A taxonomic key to the species of amygdali-group of the subgenus Compsocerocoris Reuter known in Iran, male and female habitus photographs and illustrations of male genitalia of the new taxon are provided. Diagnosis of the new species is based on a comparison with other congeneric found from Iran. The type specimens were deposited in the insect collection of the University of Guilan, Rasht, Iran.
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http://dx.doi.org/10.11646/zootaxa.4563.2.8DOI Listing
February 2019

Investigation of the relationship between atopy and psoriasis.

Postepy Dermatol Alergol 2019 Jun 18;36(3):276-281. Epub 2019 Jun 18.

Allergy Research Center, Mashhad University of Medical sciences, Mashhad, Iran.

Introduction: The relationship between allergic and autoimmune diseases is an important issue, which has recently attracted the researchers' interest.

Aim: To determine the relationship between atopy and psoriasis.

Material And Methods: This case-control study was conducted on 102 patients referred to the Ghaem Hospital, Mashhad, Iran, in 2016. The participants were assigned into two groups: experimental and control groups, including the patients suffering from psoriasis and those with no history of cutaneous or other systemic diseases, respectively. Both groups filled in the ISAAC questionnaire and had skin prick tests. In addition, the serum levels of immunoglobulin E (IgE) and blood eosinophil cell count were measured. The data were analysed using the regression test through SPSS version 16.

Results: According to the results of the ISAAC questionnaire, there was a significant difference between the control and experimental groups in terms of asthma ( = 0.04). The mean serum concentrations of IgE and eosinophil cell count were not significantly different between the experimental (153.93 IU/ml and 187.77 cells/μl, respectively) and control groups (152.19 IU/ml and 187.68 cells/μl, respectively) ( = 0.057 and = 0.886, respectively). In addition, there was an indirect correlation between the eosinophil cell count and psoriasis severity ( = 0.032, = -0.297). Furthermore, the comparison of the skin prick test results revealed no significant difference between the two groups regarding the number of positive and negative cases ( = 0.436).

Conclusions: The findings suggested that atopy was not common in the patients with psoriasis and supported the concept that atopy protects against such autoimmune diseases such as psoriasis.
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http://dx.doi.org/10.5114/ada.2019.85639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640011PMC
June 2019

Distinguishing Characteristics of Corruption Risks in Iranian Construction Projects: A Weighted Correlation Network Analysis.

Sci Eng Ethics 2020 02 6;26(1):205-231. Epub 2019 Feb 6.

Department of Construction Management, Faculty of Civil Engineering, University Technology Malaysia, Skudai, Malaysia.

The construction industry consistently ranks amongst the highest contributors to global gross domestic product, as well as, amongst the most corrupt. Corruption therefore inflicts significant risk on construction activities, and overall economic development. These facts are widely known, but the various sources and nature of corruption risks endemic to the Iranian construction industry, along with the degree to which such risks manifest, and the strength of their impact, remain undescribed. To address the gap, a mixed methods approach is used; with a questionnaire, 103 responses were received, and these were followed up with semi-structured interviews. Results were processed using social network analysis. Four major corruption risks were identified: (1) procedural violations in awarding contracts, (2) misuse of contractual arrangements, (3) neglect of project management principles, and, (4) irrational decision making. While corruption risks in Iran align with those found in other countries, with funds being misappropriated for financial gain, Iran also shows a strong inclination to champion projects that serve the government's political agenda. Root cause identification of corruption risks, namely, the noticeable impact of authoritarianism on project selection in Iran, over criterion of economic benefit or social good, is a significant outcome of this study.
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http://dx.doi.org/10.1007/s11948-019-00089-0DOI Listing
February 2020

Prey-Stage Preference and Comparing Reproductive Performance of Aphidoletes aphidimyza (Diptera: Ceccidomyiidae) Feeding on Aphis gossypii (Hemiptera: Aphididae) and Myzus persicae.

J Econ Entomol 2019 05;112(3):1073-1080

Agricultural Entomology Research Department, Iranian Research Institute of Plant Protection, Agricultural Research, Education and Organization (AREEO), Tehran, Iran.

The predacious midge, Aphidoletes aphidimyza (Rondani), is an effective exclusive natural enemy of aphids in greenhouses and field crops. In this study, prey preference of A. aphidimyza was determined using seven treatments including different stages (third-instar nymphs and adults) of two prey species (Aphis gossypii Glover and Myzus persicae (Sulzer)) based on Manly's β preference index. Results of experiments consisting of two different preys showed that A. aphidimyza larvae consumed A. gossypii more than M. persicae, and the third nymphal stage of both species was preferred more, compared with adults. When all four types of prey were studied, Manly's index was 0.379, 0.235, 0.208, and 0.176 for nymphs of A. gossypii and M. persicae and adults of A. gossypii and M. persicae, respectively. Therefore, the nymphs of both species, as the most preferred prey, were used to study the reproductive performance of the predator in microcosm conditions. The significantly longer adult longevity (female: 7.62 ± 0.15, male: 7.42 ± 0.23 d), higher fecundity (93.75 ± 2.94 offspring per female), and higher intrinsic rate of increase (0.175 ± 0.009 d-1) of A. aphidimyza were obtained, while consuming third-instar nymphs of A. gossypii. Finally, this study indicated that third-instar nymphs of A. gossypii are the most suitable food for mass rearing of A. aphidimyza.
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http://dx.doi.org/10.1093/jee/toy425DOI Listing
May 2019

Prevention of EHEC infection by chitosan nano-structure coupled with synthetic recombinant antigen.

J Microbiol Methods 2019 02 8;157:100-107. Epub 2019 Jan 8.

Department of agricultural Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. Electronic address:

One of highly effective methods for prevention and control of Entrohemorragic Esherichia coli (EHEC) infections is to use vaccination against extremely immunogenic part of attachment factors. In this study rEIT (EspA, Intimin, Tir) was produced in bacteria and then encapsulated with chitosan nanoparticle as a candidate nanovaccine. A chimeric trivalent recombinant protein which was previously found to provide reasonable immunogenicity against E.coli O157:H7 was used as a base. Mice immunized orally with chitosan based nanoparticle containing rEIT antigen. The rEIT-specific immune responses (IgG and IgA) were measured by indirect ELISA. In challenging tests different groups of immunized mice were infected orally with E.coli O157:H7. The results showed that the recombinant nanovaccine candidate could induce the strong humoral and mucosal immune responses and protect the mice from live EHEC O157:H7 challenge. Higher titers of serum anti rEIT IgG were achieved after the last immunization in all of the groups. Comparison of the amount of IgA titers in serum and feces showed higher values for the latter. In vitro study of binding inhibition assay on Caco-2 cell monolayers by pre-incubated antisera with EHEC bacteria, showed that immunized mice antibody could reduce adhesion properties of E. coli O157:H7. In a challenging study with EHEC bacteria, reduction in number of colonies was observed in all of the immunized groups for over two weeks. Results from the present study prove that nanovaccine candidate with rEIT can reduce signs and symptoms of EHEC infections. This novel approach can be a new strategy for inducing immunity against E. coli O157:H7. This study suggests the use of oral -injection combined vaccination routes comparing to other methods available in order to achieve higher humoral and mucosal immunogenicity levels.
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http://dx.doi.org/10.1016/j.mimet.2019.01.002DOI Listing
February 2019

Factors driving the implementation of reverse logistics: A quantified model for the construction industry.

Waste Manag 2018 Sep 17;79:48-57. Epub 2018 Jul 17.

Department of Civil Engineering, University of Tabriz, Tabriz, Iran. Electronic address:

In the light of increased environmental concerns and the unsustainability of current construction practices, 'reverse logistics' (RL) has emerged as a remedial strategy, whereby decommissioned buildings are salvaged and returned back through the value chain for recovery, refurbishment and reuse. The drivers that impact the uptake of RL are known, but if sustainability outcomes are to be enhanced, the strength of those drivers must be quantified in order to ascertain where efforts should be focused. This study aims to quantify the effects of known drivers on RL, and in so doing identify action items with the greatest potential to positively improve RL outcomes. RL drivers are culled from extant research, and categorized as economic, environmental, or social forces. A conceptual model is developed and tested against questionnaire results drawn from 49 expert respondents active in the South Australian construction industry. The results are analyzed using structured equation modeling. Economic and environmental drivers, such as the continuing relative high cost of salvaged items, along with expediency of cost, time and quality objectives overshadowing regulatory demands for use of such salvaged items, are shown to predict 34% of the variations in implementing RL. Of particular interest is the finding contradicting previous studies, showing that social drivers, such as perceived benefits from 'going green' had no significant impact. Thus, the road-map to improving RL outcomes lies in reducing costs of salvaged materials, augmenting environmental policies that promoted their use, and to initiate a regulatory framework to generate compliance. This insight will be of interest to industry policymakers and environmental strategists alike.
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http://dx.doi.org/10.1016/j.wasman.2018.07.013DOI Listing
September 2018

A new species of the genus Phytocoris (Hemiptera: Heteroptera: Miridae: Mirinae) from western Iran.

Zootaxa 2018 Jul 19;4446(4):567-574. Epub 2018 Jul 19.

Department of Plant Protection, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran. P.O. Box: 41635-1314..

A new species, Phytocoris (Eckerleinius) hawramanicum sp. nov is described from Iran. A revised dichotomous key to the species of subgenus Eckerleinius Wagner known in Iran and adjacent regions, illustrations of male genitalia and male habitus photographs of this new taxon are provided. Diagnosis of the new species is based on a comparison with other congeneric found from Iran and adjacent countries. The type specimens were deposited in the insect collection of the University of Guilan, Rasht, Iran.
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http://dx.doi.org/10.11646/zootaxa.4446.4.9DOI Listing
July 2018

A multiplex PCR method for identification of two common true cutworm species (Lepidoptera: Noctuidae) tested in the central plain of Guilan province, Iran.

Zootaxa 2018 May 16;4420(2):243-250. Epub 2018 May 16.

Department of Plant protection, Faculty of Agricultural sciences, University of Guilan, Rasht, Iran..

Many species of cutworms (Lepidoptera: Noctuidae) are important agricultural pest. They feed on roots and foliage of their host plants. Traditionally these species are identified based on morphological characteristics of adults. Hence identification of specimens in poor condition, immature stages and also closely related species or cryptic species is a difficult task. The basics of biological and ecological studies largely rely on an accurate species identification; consequently these investigations are impacted by potential misidentifications. In this study, we amplified 5' region of mitochondrial c cytochrome oxidase subunit I (COI) gene (DNA barcode region) of various common true cutworm species including Agrotis ipsilon (Hufnagel, 1766), Agrotis exclamationis (Linnaeus, 1758), Peridroma saucia (Hübner, 1808) and Xestia c-nigrum (Linnaeus, 1758) from agricultural fields of Guilan province (North of Iran). We were able to detect 66 conservative Single Nucleotide Polymorphisms (SNPs) among the targeted pest species and eventually design specific primers and develop a multiplex polymerase chain reaction assay as a molecular diagnostic tool for immature stages of two the most common and abundant species including A. ipsilon and X. c-nigrum in Guilan province.
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http://dx.doi.org/10.11646/zootaxa.4420.2.6DOI Listing
May 2018
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