Publications by authors named "Reza Alipoor"

7 Publications

  • Page 1 of 1

Effects of metformin and insulin therapy regimens on postpartum oral glucose tolerance test results in pregnant women with gestational diabetes mellitus: a comparative study.

Horm Mol Biol Clin Investig 2020 Nov 25;41(4). Epub 2020 Nov 25.

Department of Obstetrics and Gynecology, School of Medicine, Sayyad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Islamic Republic of Iran.

Objectives: The main purpose of this study was to compare the effects of two regimens of metformin and insulin therapy on postpartum oral glucose tolerance test (OGTT) results in pregnant women with gestational diabetes mellitus (GDM).

Methods: In this single-blind randomized clinical trial (RCT), a total number of 60 pregnant women meeting the inclusion criteria were assigned to two groups with a randomized block design (RBD): insulin therapy (IT) group (30 patients) and metformin therapy (MT) group (30 patients). At baseline, the data were comprised of prenatal maternal age, gestational age, GDM diagnosis, and maternal weight/height. During the postpartum period, 5-cc blood samples were taken from the pregnant women concerned to analyze their fasting blood sugar (FBS) levels. Then, the patients were asked to come back four days and six weeks later after delivery to check the OGTT results. At six weeks postpartum, in addition to OGTT, the glycated hemoglobin (HbAC) test was performed for all mothers. Finally, six weeks after delivery, these mothers were evaluated with regard to weight loss and body mass index (BMI).

Results: Six weeks postpartum, the maternal weight and BMI significantly decreased in the MT group compared with the IT one, while there was no significant difference between both groups at baseline. On the fourth day, the OGTT results in the MT group were significantly lower in comparison with those in the IT group (p=0.012). At sixth weeks postpartum, the OGTT results were comparably lower in the MT group than those reported for the IT one; however, such a difference was not statistically significant (p=0.087).

Conclusions: According to the study results, metformin could be an effective and safe treatment for pregnant women suffering from GDM instead of insulin therapy.
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http://dx.doi.org/10.1515/hmbci-2020-0018DOI Listing
November 2020

The role of adipose tissue secretion in the creation and pain level in osteoarthritis.

Endocr Regul 2020 Jan;54(1):6-13

Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Objectives: With increasing evidence regarding the metabolic basis of osteoarthritis (OA), we studied the relationship between adipose tissue and OA.

Methods: This study is part of an OA registry in the eastern part of Fars Province, Iran. Overall, 150 patients with OA and 300 sex matched individuals were selected as a control group. They were compared regarding adipokine concentration (leptin, adiponectin, resistin and visfatin), anthropo-metric indices, the Western Ontario and McMaster universities arthritis index score (WOMAC).

Results: All adipokine levels were higher among OA patients (p<0.001). After adjusting for age, sex, and body mass index (BMI), adipokines showed a significant and positive association with OA (B: 14.12, B: 9.92, B: 24.71 and B: 12.29 for leptin, adiponectin, visfatin, and resistin, respectively; p<0.001). Except the adiponectin that had a negative relationship with BMI in the OA group (r=-0.570, p<0.001), other adipokines had positive relationships with BMI (r=0.781, p<0.001; r=0.530, p<0.001; r=0.549, p<0.001 for leptin, visfatin, and resistin, respectively). Only leptin and adiponectin levels were correlated with pain (B: 0.045, -0.079 and p<0.05).

Conclusion: The present study shows that aside to the well-known role of mechanical stress in OA pathogenesis (weight load), leptin, adiponectin, visfatin, and resistin, which represent the adi-pose tissue independent on the weight, may play a chemical role in OA pathogenesis. In addition, leptin and adiponectin may be involved in the pain levels among patients with OA.
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http://dx.doi.org/10.2478/enr-2020-0002DOI Listing
January 2020

Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms.

Cell Mol Neurobiol 2020 Jan 6;40(1):15-23. Epub 2019 Aug 6.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

Parkinson disease (PD) is a chronic and neurodegenerative disease with motor and nonmotor symptoms. Multiple pathways are involved in the pathophysiology of PD, including apoptosis, autophagy, oxidative stress, inflammation, α-synuclein aggregation, and changes in the neurotransmitters. Preclinical and clinical studies have shown that melatonin supplementation is an appropriate therapy for PD. Administration of melatonin leads to inhibition of some pathways related to apoptosis, autophagy, oxidative stress, inflammation, α-synuclein aggregation, and dopamine loss in PD. In addition, melatonin improves some nonmotor symptom in patients with PD. Limited studies, however, have evaluated the role of melatonin on molecular mechanisms and clinical symptoms in PD. This review summarizes what is known regarding the impact of melatonin on PD in preclinical and clinical studies.
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http://dx.doi.org/10.1007/s10571-019-00720-5DOI Listing
January 2020

The effects of acupuncture and electroacupuncture on Parkinson's disease: Current status and future perspectives for molecular mechanisms.

J Cell Biochem 2019 08 2;120(8):12156-12166. Epub 2019 Apr 2.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

Among the progressive neurodegenerative disorders, Parkinson's disease (PD) is the second most common. Different factors have critical role in pathophysiology of PD such as apoptosis pathways, inflammatory cytokines, oxidative stress, and neurotransmitters and its receptors abnormalities. Acupuncture and electroacupuncture were considered as nondrug therapies for PD. Although numerous studies has been conducted for assessing the mechanism underlying electroacupuncture and acupuncture, various principal aspects of these treatment procedures remain not well-known. There have also been few investigations on the molecular mechanism of acupuncture and electroacupuncture therapy effects in PD. This review evaluates the effects of electroacupuncture and acupuncture on the molecular mechanism in PD.
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http://dx.doi.org/10.1002/jcb.28654DOI Listing
August 2019

and rs35929607 polymorphisms and risk of Hypertension in Iranian Population.

Med J Islam Repub Iran 2018 20;32:14. Epub 2018 Feb 20.

Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.

ATP2B1 and STK39 have been introduced as essential hypertension candidate genes. The association of these genes' variations have not been studied in Iranian population yet. Here we aimed to investigate the association of ATP2B1 rs2681472 and STK39 rs35929607 polymorphisms with the risk of hypertension in an Iranian population. We included 400 individuals in our case-control study: 200 cases with essential hypertension and 200 healthy sex and age matched controls. All subjects were genotyped for rs2681472 and rs35929607 using a PCR-RFLP method. Genotype and allele frequencies were compared between the two groups using chi-squared test. The association was further assessed under log-additive, dominant and recessive genetic models. There was no association between rs2681472 and rs35929607 polymorphisms and risk of essential hypertension in our population (p>0.05). There was also no association between the studied polymorphisms and hypertension under different genetic models. Our study indicated that rs2681472 of ATP2B1 and rs35929607 of STK39 may not have a significant effect on the risk of essential hypertension in Iranian population. More studies are still needed to validate our results.
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http://dx.doi.org/10.14196/mjiri.32.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108259PMC
February 2018

Modelling the regional vulnerability to Echinococcosis based on environmental factors using fuzzy inference system: A case study of Lorestan Province, west of Iran.

Electron Physician 2017 Dec 25;9(12):6094-6101. Epub 2017 Dec 25.

Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.

Background And Aim: Echinococcosis as a zoonosis disease is one of the most important parasitic helminth that is affected by many risk factors such as the environmental factors. Thus, we predicted the regional vulnerability to Echinococcosis based on environmental factors using a fuzzy inference system (FIS) in Lorestan Province.

Methods: Our study was cross-sectional study on 200 patients from Lorestan Province (west of Iran) who underwent surgery for hydatidosis between October 2005 and November 2014. In order to model the vulnerability to Echinococcosis, first we determined the effective environmental variables. In the next step, the FIS was designed and implemented using MATLAB v.2012 software. Thus, definition and determination of linguistic variables, linguistic values, and their range were performed based on expert knowledge. Then, the membership functions of inputs (environmental variables) and output (vulnerability to Echinococcosis) were defined. A fuzzy rules base was formed. Also, the defuzzification of output was done using a centroid defuzzification function. To test the accuracy of the predictive model, we calculated the AUC (to this purpose, we used four different thresholds, 5%, 10%, 15%, and 20%) using IDRISI Selva v.17.0 software.

Results: Based on the results of this study, Aligoudarz and Koohdasht counties were identified as a highest and lowest risk area in Lorestan, respectively. The results showed that a predictive model was more efficient than a random model (AUC>0.5). Also, potential vulnerable areas cover 78.29% at threshold of 5%, 60.72% at threshold of 10%, 43.54% at threshold of 15%, and 39.82% at threshold of 20% of the study area.

Conclusion: According to the success of this research, we emphasized the necessity of attention to fuzzy approach to model vulnerability to hydatidosis. This approach can provide a practical economic basis for making informed preventive services decisions and the allocation of health resources.
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http://dx.doi.org/10.19082/6094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843439PMC
December 2017

Influenza A (H1N1) in Hamedan Province, Western Iran in 2009: A Case-Control Study.

J Res Health Sci 2010 Jun 24;10(1):15-21. Epub 2010 Jun 24.

Department of Epidemiology & Biostatistics, School of Public Heath, Hamedan University of Medical Sciences, Hamedan, Iran.

Background: The novel influenza A (H1N1) virus was first detected in March 2009 in Mexico and then disseminated to many other countries worldwide. In this study, we assessed the potential risk factors of swine flu as well as the most important clinical manifestations of this infectious disease among confirmed cases during early phase of pandemic H1N1.

Methods: Subjects (cases and controls) were selected from those patients with signs and symptoms of respiratory tract infection who referred to health centers of eight cities throughout Hamedan Province, western Iran form July to December 2009. Characteristics of the participants were obtained by interviewers using pre-determined questionnaire. Cases were distinguished by pharyngeal soap speci-mens positive for influenza A virus using polymerase chain reaction (PCR). Logistic regression model was conducted at 0.05 significance level using Stata 9.1 statistical software to assess the effects of various risk factors on H1N1 influenza infection.

Results: Totally, 245 confirmed cases of H1N1 influenza were compared with 388 controls. Case fatality rate of influenza infection was about 2.86%. In comparison with age group of 1-19 yr old, adjusted odds ratio estimates was 1.91 [95% CI: 1.06, 3.46] for age group of 20-39 yr old, 0.94 [0.37, 2.38] for age group of 40-59 yr old, and 0.34 [0.09, 1.37] for age group of 60-79 yr old. Adjusted odds ratio estimates of influenza A infection was 8.12 [95% CI: 3.11, 21.6] for pregnant women compared to non-pregnant women; 1.84 [95% CI: 1.32, 2.86] for high educated individuals in comparison with low educated individuals; 2.11 [95% CI: 1.25, 3.57] for whose who had close contact with suspected influenza patients; and 2.15 [95% CI: 1.16, 3.98] for individuals with normal body mass index (BMI= 25-30) compared with underweight individuals (BMI< 20). There were no significant differences in clinical manifestations between cases and controls.

Conclusion: The risk of influenza A infection is highest among children and adolescents, pregnant women, high educated individuals, and those who had close contact with suspected influenza patients during pandemic phase. In addition, there is no pathogonomonic sign or symptom to distinguish influenza infection clinically from other kinds of respiratory track infections.
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June 2010