Reynold A Panettieri

Reynold A Panettieri

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Reynold A Panettieri

Reynold A Panettieri

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Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.

Xenobiotica 2019 Sep 30;49(9):1106-1115. Epub 2019 Jan 30.

e Division of Clinical Pharmacology and Toxicology, Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.

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http://dx.doi.org/10.1080/00498254.2018.1536814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570570PMC
September 2019

Harmonized outcome measures for use in asthma patient registries and clinical practice.

J Allergy Clin Immunol 2019 Sep 9;144(3):671-681.e1. Epub 2019 Mar 9.

Division of Pulmonary, Allergy, and Critical Care Medicine, NorthShore University HealthSystem, Chicago, Ill.

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http://dx.doi.org/10.1016/j.jaci.2019.02.025DOI Listing
September 2019

Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.

Sci Signal 2019 Sep 3;12(597). Epub 2019 Sep 3.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.aax3332DOI Listing
September 2019

Bnip3 Regulates Airway Smooth Muscle Cell Focal Adhesion and Proliferation.

Am J Physiol Lung Cell Mol Physiol 2019 Sep 11. Epub 2019 Sep 11.

Center for Translational Medicine, Thomas Jefferson University, United States.

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http://dx.doi.org/10.1152/ajplung.00224.2019DOI Listing
September 2019

Airway Smooth Muscle-Specific Transcriptomic Signatures of Glucocorticoid Exposure.

Am J Respir Cell Mol Biol 2019 Jul;61(1):110-120

1 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.

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http://dx.doi.org/10.1165/rcmb.2018-0385OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604213PMC
July 2019

Airway smooth muscle cells are insensitive to the anti-proliferative effects of corticosteroids: The novel role of insulin growth factor binding Protein-1 in asthma.

Immunobiology 2019 07 23;224(4):490-496. Epub 2019 May 23.

Department of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2019.05.006DOI Listing
July 2019

Soluble Guanylate Cyclase Agonists Induce Bronchodilation in Human Small Airways.

Am J Respir Cell Mol Biol 2019 Jul 24. Epub 2019 Jul 24.

Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey, United States.

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http://dx.doi.org/10.1165/rcmb.2019-0001OCDOI Listing
July 2019

Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation.

J Allergy Clin Immunol 2019 Apr 19;143(4):1287-1294. Epub 2018 Jun 19.

Rutgers Institute for Translational Medicine & Science, Robert Wood Johnson School of Medicine, Rutgers, State University of New Jersey, New Brunswick, NJ. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301131PMC
April 2019

Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices.

Respir Res 2019 Apr 11;20(1):72. Epub 2019 Apr 11.

Rutgers Institute for Translational Medicine and Science (RITMS), Rutgers, The State University of New Jersey, Rm# 4276, 89 French Street, New Brunswick, NJ08901, USA.

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http://dx.doi.org/10.1186/s12931-019-1034-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458705PMC
April 2019

CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.

J Clin Invest 2019 Mar 18;129(3):1387-1401. Epub 2019 Feb 18.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.

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http://www.jci.org/articles/view/125456
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http://dx.doi.org/10.1172/JCI125456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391081PMC
March 2019

Modulation of Bronchomotor Tone Pathways in Airway Smooth Muscle Function and Bronchomotor Tone in Asthma.

Clin Chest Med 2019 Mar 19;40(1):51-57. Epub 2018 Dec 19.

Department of Medicine, Rutgers Institute for Translational Medicine and Science, Rutgers University, State University of New Jersey, 89 French Street, Room 4210, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1016/j.ccm.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410362PMC
March 2019

Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma.

J Allergy Clin Immunol 2019 Feb 10;143(2):778-781.e5. Epub 2018 Oct 10.

Department of Pharmacology, Creighton University School of Medicine, Omaha, Neb. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.09.020DOI Listing
February 2019

Non-genomic Effects of Glucocorticoids: An Updated View.

Trends Pharmacol Sci 2019 01 26;40(1):38-49. Epub 2018 Nov 26.

Department of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2018.11.002DOI Listing
January 2019

Clinical Issues in Severe Asthma: Debates and Discussions About Personalizing Patient Management.

Chest 2018 12;154(6):1459-1460

University of Pittsburgh Asthma Institute at UPMC/UPSOM, Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.chest.2018.09.002DOI Listing
December 2018

Obesity increases airway smooth muscle responses to contractile agonists.

Am J Physiol Lung Cell Mol Physiol 2018 11 30;315(5):L673-L681. Epub 2018 Aug 30.

Rutgers Institute for Translational Medicine and Science, Child Health Institute of New Jersey, Rutgers, The State University of New Jersey , New Brunswick, New Jersey.

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http://dx.doi.org/10.1152/ajplung.00459.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295505PMC
November 2018

The Role of Neutrophils in Asthma.

Immunol Allergy Clin North Am 2018 11 18;38(4):629-638. Epub 2018 Sep 18.

Department of Medicine, Robert Wood Johnson Medical School, Rutgers Institute for Translational Medicine and Science, Rutgers, The State University of New Jersey, 89 French Street, Suite 4211, New Brunswick, NJ 08901, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898561183005
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http://dx.doi.org/10.1016/j.iac.2018.06.005DOI Listing
November 2018

Thank you and farewell after 15 years editing respiratory research.

Respir Res 2018 Nov 26;19(1):232. Epub 2018 Nov 26.

Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1186/s12931-018-0929-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258390PMC
November 2018

Clinical Issues in Severe Asthma: Consensus and Controversies on the Road to Precision Medicine.

Chest 2018 10;154(4):982-983

Allergy, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Asthma Institute at UPMC/UPSOM, Pittsburgh, PA.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183222
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http://dx.doi.org/10.1016/j.chest.2018.08.1022DOI Listing
October 2018

Modulation of airway hyperresponsiveness by rhinovirus exposure.

Respir Res 2018 Oct 29;19(1):208. Epub 2018 Oct 29.

Department of Medicine, Rutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, NJ, USA.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0914-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206673PMC
October 2018

Real-world Clinical Characteristics, Treatment Patterns, and Exacerbations in US Patients With Asthma Newly Treated With Omalizumab.

Clin Ther 2018 07 23;40(7):1140-1158.e4. Epub 2018 Jul 23.

David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1016/j.clinthera.2018.05.014DOI Listing
July 2018

How Important Is Adherence to Inhaled Medications Before Starting a Biologic Therapy for Asthma?

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1578-1579

Rutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, NJ.

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http://dx.doi.org/10.1016/j.jaip.2018.07.007DOI Listing
July 2018

Pepducins as a potential treatment strategy for asthma and COPD.

Curr Opin Pharmacol 2018 06 2;40:120-125. Epub 2018 May 2.

Sidney Kimmel Medical College, Center for Translational Medicine, Jane and Leonard Korman Lung Institute, Thomas Jefferson University, Philadelphia, PA 19107, United States.

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http://dx.doi.org/10.1016/j.coph.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345380PMC
June 2018

TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3.

Am J Respir Cell Mol Biol 2018 05;58(5):575-584

2 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey; and.

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http://dx.doi.org/10.1165/rcmb.2017-0247OCDOI Listing
May 2018

Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices.

J Allergy Clin Immunol 2018 05 6;141(5):1887-1890.e1. Epub 2018 Jan 6.

Department of Pediatrics, Division of Allergy and Immunology, University of Arkansas for Medical Sciences, Little Rock, Ark; Arkansas Children's Research Institute, Little Rock, Ark; Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Ark.

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http://dx.doi.org/10.1016/j.jaci.2017.11.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938135PMC
May 2018

Tralokinumab for the treatment of severe, uncontrolled asthma: the ATMOSPHERE clinical development program.

Immunotherapy 2018 03 14;10(6):473-490. Epub 2018 Mar 14.

Global Medicines Development, AstraZeneca, Gaithersburg, MD 20878, USA.

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http://dx.doi.org/10.2217/imt-2017-0191DOI Listing
March 2018

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.

FASEB J 2018 02 4;32(2):862-874. Epub 2018 Jan 4.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.201700555RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888400PMC
February 2018

RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.

Am J Respir Cell Mol Biol 2018 01;58(1):89-98

1 Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, and.

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http://dx.doi.org/10.1165/rcmb.2017-0109OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800898PMC
January 2018

Patient-reported outcomes in moderate-to-severe allergic asthmatics treated with omalizumab: a systematic literature review of randomized controlled trials.

Curr Med Res Opin 2018 01 10;34(1):65-80. Epub 2017 Nov 10.

d Rutgers, The State University of New Jersey, Rutgers Institute for Translational Medicine and Science , New Brunswick , NJ , USA.

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https://www.tandfonline.com/doi/full/10.1080/03007995.2017.1
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http://dx.doi.org/10.1080/03007995.2017.1395734DOI Listing
January 2018

Erratum.

FASEB J 2018 01;32(1):535

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.

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http://dx.doi.org/10.1096/fj.201600857RRRERRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191071PMC
January 2018

House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcεRIα.

Am J Respir Cell Mol Biol 2017 12;57(6):674-682

1 Department of Immunology, Allergy and Rheumatology, University of Cincinnati, Cincinnati, Ohio.

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http://www.atsjournals.org/doi/10.1165/rcmb.2016-0356OC
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http://dx.doi.org/10.1165/rcmb.2016-0356OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765415PMC
December 2017

Guiding principles for use of newer biologics and bronchial thermoplasty for patients with severe asthma.

Ann Allergy Asthma Immunol 2017 12 2;119(6):533-540. Epub 2017 Nov 2.

Advocate Medical Group/Advocate Healthcare, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.anai.2017.09.058DOI Listing
December 2017

Anti-IgE or Anti-IL5: That Is the Question.

J Allergy Clin Immunol Pract 2018 May - Jun;6(3):782-784. Epub 2017 Nov 14.

Rutgers Institute for Translational Medicine and Science, Rutgers Biomedical and Health Sciences, Rutgers University, New Brunswick, NJ. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2017.10.025DOI Listing
November 2017

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.

Int J Mol Sci 2017 Nov 25;18(12). Epub 2017 Nov 25.

Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Stemmler Hall, Office Suite 227, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/ijms18122525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751128PMC
November 2017

Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches.

Am J Respir Cell Mol Biol 2017 06;56(6):700-707

1 Rutgers Institute for Translational Medicine and Science, Rutgers, the State University of New Jersey, New Brunswick, New Jersey; and.

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http://dx.doi.org/10.1165/rcmb.2016-0308TRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516292PMC
June 2017

Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link?

Am J Respir Cell Mol Biol 2017 04;56(4):432-442

2 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey.

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http://dx.doi.org/10.1165/rcmb.2016-0307TRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449515PMC
April 2017

Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner.

Br J Pharmacol 2016 09 3;173(18):2726-38. Epub 2016 Aug 3.

Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1111/bph.13542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995285PMC
September 2016

MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells.

PLoS One 2016 21;11(3):e0150842. Epub 2016 Mar 21.

Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801396PMC
August 2016

Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression.

Am J Physiol Lung Cell Mol Physiol 2016 08 1;311(2):L421-32. Epub 2016 Jul 1.

Department of Medicine, National Jewish Health, Denver, Colorado; Department of Medicine, University of Colorado, Denver, Colorado

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http://dx.doi.org/10.1152/ajplung.00179.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142462PMC
August 2016

Neutrophilic and Pauci-immune Phenotypes in Severe Asthma.

Immunol Allergy Clin North Am 2016 08 2;36(3):569-79. Epub 2016 Jun 2.

Clinical & Translational Science, Rutgers Institute for Translational Medicine & Science, Robert Wood Johnson Medical School, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.iac.2016.03.007DOI Listing
August 2016

Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.

Respir Res 2016 08 22;17(1):103. Epub 2016 Aug 22.

Department of Pharmacology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA.

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http://dx.doi.org/10.1186/s12931-016-0418-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994235PMC
August 2016

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

J Allergy Clin Immunol 2016 07 28;138(1):294-297.e4. Epub 2016 Feb 28.

Department of Internal Medicine and Molecular Pharmacology and Physiology, and the Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, Tampa, Fla. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.12.1315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931984PMC
July 2016

Functional capacity, health status, and inflammatory biomarker profile in a cohort of patients with chronic obstructive pulmonary disease.

J Cardiopulm Rehabil Prev 2015 Sep-Oct;35(5):348-55

Division of Pulmonary and Critical Care Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs Kohli, Pinto-Plata, Divo, and Celli); Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (Drs Kohli and Harris); Division of Pulmonary and Critical Care Medicine, Division of Sleep Medicine, University of California San Diego School of Medicine, San Diego, California (Dr Malhotra); COPD Clinical Discovery, GalaxoSmithKline, King of Prussia, Pennsylvania (Drs Lazaar, Flynn, and Tal-Singer); and Division of Pulmonary, Allergy and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (Dr Panettieri).

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HCR.0000000000000123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551136PMC
June 2016

Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma.

PLoS One 2015 24;10(7):e0134057. Epub 2015 Jul 24.

Partners Personalized Medicine, Boston, MA, United States of America; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514847PMC
May 2016

Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates.

PLoS One 2015 15;10(7):e0131093. Epub 2015 Jul 15.

Center of Excellence in Environmental Toxicology (CEET), Airways Biology Initiative, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131093PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503720PMC
April 2016

Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms.

Mol Pharmacol 2016 Jan 13;89(1):94-104. Epub 2015 Oct 13.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (R.C., J.L.B.); Department of Medicine, Pulmonary, Allergy, and Critical Care Division, Airways Biology Initiative, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (C.K.W., J.Z., R.A.P.); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (H.L., S.S.A.); and Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York (G.G.T.)

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http://molpharm.aspetjournals.org/content/89/1/94.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.115.10
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http://dx.doi.org/10.1124/mol.115.100339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702101PMC
January 2016

Bronchodilators, receptors and cross-talk: Together is better?

Postgrad Med 2015 19;127(7):771-80. Epub 2015 Aug 19.

a University of Pennsylvania, Perelman School of Medicine , Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/00325481.2015.1080589DOI Listing
November 2015

Bronchial Thermoplasty: Targeting Structural Cells in Severe Persistent Asthma.

Ann Am Thorac Soc 2015 Nov;12(11):1593-4

1 Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1513/AnnalsATS.201509-627EDDOI Listing
November 2015

RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells.

PLoS One 2014 13;9(6):e99625. Epub 2014 Jun 13.

Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099625PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057123PMC
October 2015

Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans.

PLoS Pathog 2015 Sep 3;11(9):e1005122. Epub 2015 Sep 3.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559413PMC
September 2015

MicroRNA-203 negatively regulates c-Abl, ERK1/2 phosphorylation, and proliferation in smooth muscle cells.

Physiol Rep 2015 Sep;3(9)

The Center for Cardiovascular Sciences, Albany Medical College, Albany, New York

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http://dx.doi.org/10.14814/phy2.12541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600385PMC
September 2015

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.

Hum Mol Genet 2015 Jun 12;24(11):3005-20. Epub 2015 Jan 12.

Center for Complex Networks Research, Department of Physics, Northeastern University, Boston, MA 02115, USA Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA Department of Theoretical Physics, Budapest University of Technology and Economics, H1111, Budapest, Hungary Center for Network Science, Central European University, Nador u. 9, 1051 Budapest, Hungary

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http://dx.doi.org/10.1093/hmg/ddv001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447811PMC
June 2015

A fungal protease allergen provokes airway hyper-responsiveness in asthma.

Nat Commun 2015 Apr 13;6:6763. Epub 2015 Apr 13.

Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID/NIH, 50 South Drive Room 4154, Bethesda, Maryland 20892-8305, USA.

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http://www.nature.com/articles/ncomms7763
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http://dx.doi.org/10.1038/ncomms7763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396684PMC
April 2015

CD38 and airway hyper-responsiveness: studies on human airway smooth muscle cells and mouse models.

Can J Physiol Pharmacol 2015 Feb 9;93(2):145-53. Epub 2014 Dec 9.

a Department of Surgical & Radiological Sciences, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1139/cjpp-2014-0410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648235PMC
February 2015

Irreversible airway obstruction in asthma: what we lose, we lose early.

Allergy Asthma Proc 2014 Mar-Apr;35(2):111-8

Translational Medicine, Respiratory, Inflammation, and Autoimmunity Group, MedImmune, LLC, Gaithersburg, Maryland, USA.

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http://www.ingentaconnect.com/content/10.2500/aap.2013.34.37
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December 2014

Development and characterization of pepducins as Gs-biased allosteric agonists.

J Biol Chem 2014 Dec 13;289(52):35668-84. Epub 2014 Nov 13.

From the Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276837PMC
December 2014

Asthma in the elderly: a study of the role of vitamin D.

Allergy Asthma Clin Immunol 2014 5;10(1):48. Epub 2014 Sep 5.

Allergy and Immunology Division, Bryn Mawr Hospital, Bryn Mawr, PA USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162927PMC
September 2014

Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation.

J Allergy Clin Immunol 2014 Aug 22;134(2):451-9. Epub 2014 Mar 22.

Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Md. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119844PMC
August 2014

β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent.

J Biol Chem 2014 Aug 27;289(33):23065-74. Epub 2014 Jun 27.

From the Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, the Department of Medicine, Division of Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132805PMC
August 2014

MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells.

Respir Res 2014 Aug 31;15:107. Epub 2014 Aug 31.

Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, 1971 Commonwealth Avenue, St, Paul 55108, MN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156970PMC
August 2014

The effect of multiple allergen immunotherapy on exhaled nitric oxide in adults with allergic rhinitis.

Allergy Asthma Clin Immunol 2013 19;9(1):31. Epub 2013 Aug 19.

Asthma, Allergy and Immunology Specialists, 875 County Line Road-Suite 107, Bryn Mawr, PA 19010, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751795PMC
May 2014

MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway.

FASEB J 2014 May 12;28(5):2347-57. Epub 2014 Feb 12.

1Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, 665 Huntington Ave., Room I-305, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986841PMC
May 2014

Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells.

Am J Respir Cell Mol Biol 2014 Apr;50(4):678-83

1 Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

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April 2014

H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel.

Biochem Biophys Res Commun 2014 Mar 12;446(1):393-8. Epub 2014 Mar 12.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003869PMC
March 2014

Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle.

FASEB J 2014 Feb 16;28(2):956-65. Epub 2013 Oct 16.

2Department of Medicine, Thomas Jefferson University, Room 317, College Bldg., 1025 Walnut St., Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898647PMC
February 2014

Asthma in the elderly: the role of exhaled nitric oxide measurements.

Respir Med 2013 May 6;107(5):785-7. Epub 2013 Mar 6.

Asthma, Allergy and Immunology Specialists, 875 County Line Road, Bryn Mawr, PA 19010, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034737PMC
May 2013

Raf-1, actin dynamics, and abelson tyrosine kinase in human airway smooth muscle cells.

Am J Respir Cell Mol Biol 2013 Feb 18;48(2):172-8. Epub 2012 Oct 18.

Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604063PMC
February 2013

Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype.

J Allergy (Cairo) 2012 20;2012:289468. Epub 2012 Nov 20.

Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508580PMC
December 2012

The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer.

Mol Biol Cell 2012 Nov 26;23(22):4456-64. Epub 2012 Sep 26.

Renal Unit, Department of Medicine, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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November 2012