Publications by authors named "Reuven Agami"

100Publications

Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels.

Mol Cell 2020 05 14;78(3):434-444.e5. Epub 2020 Apr 14.

Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.03.022DOI Listing
May 2020

More or less - the same? mRNA fluctuations are balanced during translation.

EMBO J 2019 12 22;38(23):e103651. Epub 2019 Oct 22.

Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.15252/embj.2019103651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885732PMC
December 2019

A fragment-like approach to PYCR1 inhibition.

Bioorg Med Chem Lett 2019 09 25;29(18):2626-2631. Epub 2019 Jul 25.

H5 Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands; Department of Molecular Genetics, Erasmus MC, Rotterdam University, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.07.047DOI Listing
September 2019

SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.

Cell 2019 06 16;177(7):1797-1813.e18. Epub 2019 May 16.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579486PMC
June 2019

Queuing up the ribosome: nutrition and the microbiome control protein synthesis.

EMBO J 2018 09 3;37(18). Epub 2018 Sep 3.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.15252/embj.2018100405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138431PMC
September 2018

CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells.

Cancer Lett 2018 11 23;436:87-95. Epub 2018 Aug 23.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Molecular Genetics, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.08.018DOI Listing
November 2018

Using mitoribosomal profiling to investigate human mitochondrial translation.

Wellcome Open Res 2017 11;2:116. Epub 2017 Dec 11.

The Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.13119.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771143PMC
December 2017

Long non-coding RNAs in metastasis.

Cancer Metastasis Rev 2018 03;37(1):75-81

Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10555-017-9713-xDOI Listing
March 2018

The methylated way to translation.

Oncotarget 2017 Nov 25;8(55):93313-93314. Epub 2017 Oct 25.

Reuven Agami: Division of Oncogenomics, The Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands; Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.22073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706795PMC
November 2017

Characterization of noncoding regulatory DNA in the human genome.

Nat Biotechnol 2017 Aug;35(8):732-746

Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nbt.3863DOI Listing
August 2017

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.

Cell 2017 04;169(2):326-337.e12

Division of Oncogenomics, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Department of Genetics, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388891PMC
April 2017

GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression.

Methods Mol Biol 2017 ;1543:45-55

Division of Biological Stress Response, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-6716-2_3DOI Listing
February 2018

Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers.

Nat Rev Mol Cell Biol 2016 09 6;17(9):597-604. Epub 2016 Jul 6.

Division of Biological Stress Response, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrm.2016.79DOI Listing
September 2016

Monitoring amino acid deficiencies in cancer.

Cell Cycle 2016 09 31;15(17):2229-30. Epub 2016 May 31.

a Division of Biological Stress Response, The Netherlands Cancer Institute , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1080/15384101.2016.1191256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004689PMC
September 2016

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

Nature 2016 Feb 15;530(7591):490-4. Epub 2016 Feb 15.

Division of Biological Stress Response, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature16982DOI Listing
February 2016

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Nat Biotechnol 2016 Feb 11;34(2):192-8. Epub 2016 Jan 11.

Division of Biological Stress Response, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://www.nature.com/articles/nbt.3450
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http://dx.doi.org/10.1038/nbt.3450DOI Listing
February 2016

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Circ Res 2016 Feb 15;118(3):433-8. Epub 2015 Dec 15.

From the Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands (E.E.C., A.B., H.W.M.D., I.M., N.E.G., M.E.A., C.R.B., Y.M.P.); Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands (A.P.U., R.E., R.A.); National Heart and Lung Institute, Imperial College, London, United Kingdom (S.A.C.); Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany (N.H.); and Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands (J.V.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307082DOI Listing
February 2016

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

EMBO Rep 2015 Dec 4;16(12):1723-36. Epub 2015 Nov 4.

Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands Erasmus MC, Rotterdam University, Rotterdam, The Netherlands

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http://dx.doi.org/10.15252/embr.201540717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687422PMC
December 2015

Exposure to arginine analog canavanine induces aberrant mitochondrial translation products, mitoribosome stalling, and instability of the mitochondrial proteome.

Int J Biochem Cell Biol 2015 Aug 25;65:268-74. Epub 2015 Jun 25.

Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.06.018DOI Listing
August 2015

Enhancer-associated RNAs as therapeutic targets.

Expert Opin Biol Ther 2015 May 29;15(5):723-34. Epub 2015 Mar 29.

The Netherlands Cancer Institute, Division of Biological Stress Response , Plesmanlaan 121, 1066 CX, Amsterdam , The Netherlands

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http://dx.doi.org/10.1517/14712598.2015.1029452DOI Listing
May 2015

Transcription initiation determines its end.

Mol Cell 2015 Jan;57(2):205-6

Division of Biological Stress Response, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; Erasmus MC, Rotterdam University, 3000 CA Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.006DOI Listing
January 2015

Ribosome profiling reveals features of normal and disease-associated mitochondrial translation.

Nat Commun 2013 ;4:2886

1] Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands [2].

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http://dx.doi.org/10.1038/ncomms3886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863897PMC
October 2014

Lncing protein translation to metastasis.

EMBO J 2013 Oct 24;32(20):2657-8. Epub 2013 Sep 24.

Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/emboj.2013.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801441PMC
October 2013

Identification of lethal microRNAs specific for head and neck cancer.

Clin Cancer Res 2013 Oct 13;19(20):5647-57. Epub 2013 Aug 13.

Authors' Affiliations: Departments of Otolaryngology/Head-Neck Surgery, Epidemiology and Biostatistics, and Pathology, VU University Medical Center; Department of Mathematics, VU University; Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam; and InteRNA Technologies BV, Utrecht, The Netherlands.

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http://clincancerres.aacrjournals.org/content/early/2013/09/
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http://clincancerres.aacrjournals.org/content/early/2013/08/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-2295DOI Listing
October 2013

eRNAs reach the heart of transcription.

Cell Res 2013 Oct 23;23(10):1151-2. Epub 2013 Jul 23.

1] Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands [2] Doctoral Programme in Biomedicine and Experimental Biology, Centre for Neuroscience and Cell Biology, Erasmus MC, Rotterdam University, The Netherlands.

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http://dx.doi.org/10.1038/cr.2013.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790244PMC
October 2013

A versatile microsatellite instability reporter system in human cells.

Nucleic Acids Res 2013 Sep 16;41(16):e158. Epub 2013 Jul 16.

Department of Toxicogenetics, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands and Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkt615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763563PMC
September 2013

Noncoding RNAs and cancer.

Cell 2013 Mar;153(1):9-10

Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2013.03.019DOI Listing
March 2013

Alternative cleavage and polyadenylation: extent, regulation and function.

Nat Rev Genet 2013 Jul;14(7):496-506

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrg3482DOI Listing
July 2013

Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis.

Epigenetics 2013 Feb 16;8(2):220-8. Epub 2013 Jan 16.

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/epi.23605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592908PMC
February 2013

MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5.

Autophagy 2013 Mar 15;9(3):374-85. Epub 2013 Jan 15.

Faculty of Engineering and Natural Sciences, Biological Sciences and Bioengineering Program, Sabanci University, Istanbul, Turkey.

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http://dx.doi.org/10.4161/auto.23117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590257PMC
March 2013

eRNAs are required for p53-dependent enhancer activity and gene transcription.

Mol Cell 2013 Feb 27;49(3):524-35. Epub 2012 Dec 27.

Division of Gene Regulation, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands; Doctoral Programme in Biomedicine and Experimental Biology, Centre for Neuroscience and Cell Biology, 3004-517 Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.molcel.2012.11.021DOI Listing
February 2013

Alternative cleavage and polyadenylation during colorectal cancer development.

Clin Cancer Res 2012 Oct 8;18(19):5256-66. Epub 2012 Aug 8.

The Netherlands Cancer Institute, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0543DOI Listing
October 2012

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.

Cell 2012 Apr 12;149(3):538-53. Epub 2012 Apr 12.

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2012.03.022DOI Listing
April 2012

miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.

Autophagy 2012 Feb 1;8(2):165-76. Epub 2012 Feb 1.

Faculty of Engineering and Natural Sciences, Biological Sciences and Bioengineering Program, Sabanci University, Orhanli-Tuzla, Istanbul, Turkey.

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http://dx.doi.org/10.4161/auto.8.2.18351DOI Listing
February 2012

MicroRNA regulation by RNA-binding proteins and its implications for cancer.

Nat Rev Cancer 2011 Aug 5;11(9):644-56. Epub 2011 Aug 5.

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrc3107DOI Listing
August 2011

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression.

Cell Cycle 2011 Jul 1;10(13):2172-83. Epub 2011 Jul 1.

Department of Oncology-Pathology; Cancer Center Karolinska (CCK), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4161/cc.10.13.16248DOI Listing
July 2011

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.

Nat Cell Biol 2010 Oct 5;12(10):1014-20. Epub 2010 Sep 5.

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb2105DOI Listing
October 2010

miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate.

Proc Natl Acad Sci U S A 2010 Sep 18;107(36):15804-9. Epub 2010 Aug 18.

Departments of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1073/pnas.0915022107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936650PMC
September 2010

Gene regulation and tumor suppression by the bromodomain-containing protein BRD7.

Cell Cycle 2010 Jul 7;9(14):2777-81. Epub 2010 Jul 7.

Laboratorio Nazionale CIB, Area Science Park, Trieste, Italy.

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July 2010

microRNAs, RNA binding proteins and cancer.

Authors:
Reuven Agami

Eur J Clin Invest 2010 Apr;40(4):370-4

Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1365-2362.2010.02279.xDOI Listing
April 2010

Major role for mRNA stability in shaping the kinetics of gene induction.

BMC Genomics 2010 Apr 21;11:259. Epub 2010 Apr 21.

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2164-11-259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864252PMC
April 2010

BRD7 is a candidate tumour suppressor gene required for p53 function.

Nat Cell Biol 2010 Apr 14;12(4):380-9. Epub 2010 Mar 14.

The Netherlands Cancer Institute, Division of Gene Regulation, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://www.nature.com/articles/ncb2038
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http://dx.doi.org/10.1038/ncb2038DOI Listing
April 2010

Tumorigenicity of the miR-17-92 cluster distilled.

Genes Dev 2010 Jan;24(1):1-4

Division of Gene Regulation, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1101/gad.1887110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802185PMC
January 2010

Transformation locked in a loop.

Cell 2009 Nov;139(4):654-6

Division of Gene Regulation, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2009.10.035DOI Listing
November 2009

MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells.

Stem Cells Dev 2010 Jun;19(6):877-85

Central Hematology Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1089/scd.2009.0112DOI Listing
June 2010

The miRNA-192/194 cluster regulates the Period gene family and the circadian clock.

FEBS J 2009 Oct 13;276(19):5447-55. Epub 2009 Aug 13.

Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1111/j.1742-4658.2009.07229.x
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http://dx.doi.org/10.1111/j.1742-4658.2009.07229.xDOI Listing
October 2009

Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression.

Cell Cycle 2009 May 27;8(9):1426-32. Epub 2009 May 27.

Department of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), Ernst Caspari Haus, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.4161/cc.8.9.8324DOI Listing
May 2009

Removal of AU bias from microarray mRNA expression data enhances computational identification of active microRNAs.

PLoS Comput Biol 2008 Oct 3;4(10):e1000189. Epub 2008 Oct 3.

Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pcbi.1000189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533120PMC
October 2008

A PASport to cellular proliferation.

Cell 2008 Jul;134(2):208-10

The Netherlands Cancer Institute, Division of Gene Regulation, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2008.07.003DOI Listing
July 2008

Interplay between microRNAs and RNA-binding proteins determines developmental processes.

Cell Cycle 2008 Apr 24;7(7):899-903. Epub 2008 Jan 24.

The Netherlands Cancer Institute, Division of Tumor Biology, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/cc.7.7.5644DOI Listing
April 2008

miR-148 targets human DNMT3b protein coding region.

RNA 2008 May 26;14(5):872-7. Epub 2008 Mar 26.

Division of Tumor Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1261/rna.972008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2327368PMC
May 2008

Diverse ways to control p27Kip1 function: miRNAs come into play.

Cell Cycle 2007 Nov 16;6(22):2742-9. Epub 2007 Aug 16.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/cc.6.22.4900DOI Listing
November 2007

All roads lead to IKKepsilon.

Authors:
Reuven Agami

Cell 2007 Jun;129(6):1043-5

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2007.05.048DOI Listing
June 2007

A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.

J Exp Med 2007 Apr 2;204(4):921-8. Epub 2007 Apr 2.

Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1084/jem.20061568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118556PMC
April 2007

Classifying microRNAs in cancer: the good, the bad and the ugly.

Biochim Biophys Acta 2007 Jun 22;1775(2):274-82. Epub 2006 Nov 22.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbcan.2006.11.003DOI Listing
June 2007

Telomerase-independent regulation of ATR by human telomerase RNA.

J Biol Chem 2006 Dec 10;281(52):40503-14. Epub 2006 Nov 10.

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M607676200DOI Listing
December 2006

Immense promises for tiny molecules: uncovering miRNA functions.

Cell Cycle 2006 Jul 1;5(13):1415-21. Epub 2006 Jul 1.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/cc.5.13.2890DOI Listing
July 2006

CDK-dependent stabilization of Cdc6: linking growth and stress signals to activation of DNA replication.

Cell Cycle 2005 Dec 22;4(12):1725-8. Epub 2005 Dec 22.

The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/cc.4.12.2193DOI Listing
December 2005

p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation.

Mol Cell Biol 2005 Aug;25(16):6937-47

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam.

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http://dx.doi.org/10.1128/MCB.25.16.6937-6947.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190229PMC
August 2005

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.

Cell 2005 Jun;121(6):849-58

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2005.04.017DOI Listing
June 2005

shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts.

FEBS Lett 2005 Jan;579(1):199-202

Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel.

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http://dx.doi.org/10.1016/j.febslet.2004.11.075DOI Listing
January 2005

Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein.

EMBO J 2004 Nov 11;23(23):4627-38. Epub 2004 Nov 11.

Institute for Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Marburg, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7600470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533054PMC
November 2004

AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation.

J Biol Chem 2004 Oct 24;279(44):45676-84. Epub 2004 Aug 24.

Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M409034200
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http://dx.doi.org/10.1074/jbc.M409034200DOI Listing
October 2004

Unraveling human tumor suppressor pathways: a tale of the INK4A locus.

Cell Cycle 2004 May 15;3(5):616-20. Epub 2004 May 15.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam.

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May 2004

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

Nature 2004 Mar;428(6981):431-7

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature02371DOI Listing
March 2004

The tumor-suppressive functions of the human INK4A locus.

Cancer Cell 2003 Oct;4(4):311-9

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s1535-6108(03)00223-xDOI Listing
October 2003

Ras interference as cancer therapy.

Semin Cancer Biol 2003 Aug;13(4):267-73

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s1044-579x(03)00040-3DOI Listing
August 2003

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

EMBO J 2003 Jun;22(12):2934-47

Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/emboj/cdg307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162159PMC
June 2003

Knockdown stands up.

Trends Biotechnol 2003 Jan;21(1):2-4

Division of Tumor Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s0167-7799(02)00002-1DOI Listing
January 2003