Reuben S Harris

Reuben S Harris

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Reuben S Harris

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MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets.

Life Sci Alliance 2020 Apr 24;3(4). Epub 2020 Feb 24.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA

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http://dx.doi.org/10.26508/lsa.201900606DOI Listing
April 2020

The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H.

J Mol Biol 2019 Dec 16;431(24):5019-5031. Epub 2019 Oct 16.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948013PMC
December 2019

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase.

Proc Natl Acad Sci U S A 2019 Oct 14;116(44):22158-22163. Epub 2019 Oct 14.

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455;

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http://dx.doi.org/10.1073/pnas.1904024116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825264PMC
October 2019

HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators.

Cell Rep 2019 Oct;29(5):1057-1065.e4

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903395PMC
October 2019

A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B.

Antibodies (Basel) 2019 Sep 10;8(3). Epub 2019 Sep 10.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.3390/antib8030047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783943PMC
September 2019

The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1.

J Biol Chem 2019 08 19;294(32):12099-12111. Epub 2019 Jun 19.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455

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http://dx.doi.org/10.1074/jbc.RA119.008443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690700PMC
August 2019

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1.

J Gen Virol 2019 Jul 30;100(7):1140-1152. Epub 2019 May 30.

3 Center for Genome Engineering, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1099/jgv.0.001276DOI Listing
July 2019

Determinants of Oligonucleotide Selectivity of APOBEC3B.

J Chem Inf Model 2019 May 10;59(5):2264-2273. Epub 2018 Sep 10.

Department of Chemistry and Biochemistry , University of California, San Diego , La Jolla , California 92093-0340 , United States.

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http://dx.doi.org/10.1021/acs.jcim.8b00427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644697PMC
May 2019

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1.

J Gen Virol 2019 Jul 30;100(7):1140-1152. Epub 2019 May 30.

3 Center for Genome Engineering, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1099/jgv.0.001276DOI Listing
July 2019

Evolved Proteins Inhibit Entry of Enfuvirtide-Resistant HIV-1.

ACS Infect Dis 2019 04 12;5(4):634-640. Epub 2019 Mar 12.

Department of Chemistry , Colorado State University , 200 W. Lake Street , Fort Collins , Colorado 80523 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00362DOI Listing
April 2019

A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination.

Methods 2019 03 19;156:79-84. Epub 2018 Dec 19.

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397784PMC
March 2019

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction.

Mol Cell Biol 2018 12 13;38(23). Epub 2018 Nov 13.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA

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http://dx.doi.org/10.1128/MCB.00356-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234287PMC
December 2018

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.

Retrovirology 2018 12 17;15(1):78. Epub 2018 Dec 17.

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, MN, USA.

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https://retrovirology.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12977-018-0459-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297987PMC
December 2018

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease.

Nat Commun 2018 10 8;9(1):4137. Epub 2018 Oct 8.

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1038/s41467-018-06594-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175962PMC
October 2018

A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells.

Nucleic Acids Res 2018 08;46(14):e84

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, MN 55455, USA.

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http://dx.doi.org/10.1093/nar/gky332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101615PMC
August 2018

APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.

J Mol Biol 2018 08 19;430(17):2695-2708. Epub 2018 May 19.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.04.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456046PMC
August 2018

Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G.

J Virol 2018 06 29;92(12). Epub 2018 May 29.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA

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http://dx.doi.org/10.1128/JVI.00447-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974497PMC
June 2018

Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template.

Commun Biol 2018 31;1:54. Epub 2018 May 31.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1038/s42003-018-0054-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123678PMC
May 2018

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G.

PLoS Pathog 2018 04 20;14(4):e1007010. Epub 2018 Apr 20.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931688PMC
April 2018

Evaluation of sequence variability in HIV-1 gp41 C-peptide helix-grafted proteins.

Bioorg Med Chem 2018 03 1;26(6):1220-1224. Epub 2017 Aug 1.

Department of Chemistry, Colorado State University, Fort Collins, CO, USA; Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.07.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013034PMC
March 2018

APOBEC Enzymes as Targets for Virus and Cancer Therapy.

Cell Chem Biol 2018 01 16;25(1):36-49. Epub 2017 Nov 16.

Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775913PMC
January 2018

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.

Mol Cell 2018 01 28;69(1):75-86.e9. Epub 2017 Dec 28.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991973PMC
January 2018

Mutation Signatures Including APOBEC in Cancer Cell Lines.

JNCI Cancer Spectr 2018 Jan 17;2(1). Epub 2018 Mar 17.

Masonic Cancer Center (MCJ, DE, NAT, RSH), Center for Genome Engineering (MCJ, DE, RSH), Department of Biochemistry, Molecular Biology, and Biophysics (MCJ, DE, RSH), Institute for Molecular Virology (MCJ, DE, RSH), Institute for Health Informatics (NAT), Howard Hughes Medical Institute (RSH), University of Minnesota, Minneapolis, MN, USA.

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https://academic.oup.com/jncics/article/doi/10.1093/jncics/p
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http://dx.doi.org/10.1093/jncics/pky002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993214PMC
January 2018

The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.

Antioxid Redox Signal 2017 Dec 18;27(16):1317-1331. Epub 2017 Apr 18.

1 Department of Biochemistry, Center for Structural Biology , Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1089/ars.2016.6888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655415PMC
December 2017

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.

Sci Rep 2017 12 12;7(1):17415. Epub 2017 Dec 12.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.

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http://dx.doi.org/10.1038/s41598-017-17694-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727031PMC
December 2017

APOBEC3B lysine residues are dispensable for DNA cytosine deamination, HIV-1 restriction, and nuclear localization.

Virology 2017 11 23;511:74-81. Epub 2017 Aug 23.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623654PMC
November 2017

Computational Model and Dynamics of Monomeric Full-Length APOBEC3G.

ACS Cent Sci 2017 Nov 20;3(11):1180-1188. Epub 2017 Oct 20.

Department of Chemistry, University of Texas at El Paso, El Paso, Texas 79968, United States.

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http://dx.doi.org/10.1021/acscentsci.7b00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704289PMC
November 2017

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.

PLoS One 2016 10;11(5):e0155391. Epub 2016 May 10.

Department of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862684PMC
July 2017

Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity.

Sci Rep 2017 04 21;7:46719. Epub 2017 Apr 21.

Laboratory of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1038/srep46719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399452PMC
April 2017

Nanoscale Characterization of Interaction of APOBEC3G with RNA.

Biochemistry 2017 03 3;56(10):1473-1481. Epub 2017 Mar 3.

Department of Pharmaceutical Sciences, College of Pharmacy, WSH, University of Nebraska Medical Center , 986025 Nebraska Medical Center, Omaha, Nebraska 68198-6025, United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.6b01189
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http://dx.doi.org/10.1021/acs.biochem.6b01189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712427PMC
March 2017

Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides.

J Mol Biol 2017 01 22;429(1):88-96. Epub 2016 Nov 22.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street S.E., Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, 515 Delaware Street S.E., Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, 2231 6th St. S.E., Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836163050
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http://dx.doi.org/10.1016/j.jmb.2016.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186364PMC
January 2017

APOBEC3B: pathological consequences of an innate immune DNA mutator.

Biomed J 2015 Mar-Apr;38(2):102-10

Masonic Cancer Center; Institute for Molecular Virology; Center for Genome Engineering; Biochemistry, Molecular Biology and Biophysics Department, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.4103/2319-4170.148904DOI Listing
December 2016

Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes.

PLoS Pathog 2016 12 1;12(12):e1005958. Epub 2016 Dec 1.

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131897PMC
December 2016

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.

Sci Adv 2016 Oct 7;2(10):e1601737. Epub 2016 Oct 7.

Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1126/sciadv.1601737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055383PMC
October 2016

Helix-Grafted Pleckstrin Homology Domains Suppress HIV-1 Infection of CD4-Positive Cells.

Chembiochem 2016 10 30;17(20):1945-1950. Epub 2016 Aug 30.

Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, USA.

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http://dx.doi.org/10.1002/cbic.201600329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013031PMC
October 2016

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma.

Clin Cancer Res 2016 Sep 25;22(18):4746-55. Epub 2016 Mar 25.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota.

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http://clincancerres.aacrjournals.org/content/early/2016/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026552PMC
September 2016

Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.

J Virol 2016 07 24;90(14):6379-6386. Epub 2016 Jun 24.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

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http://dx.doi.org/10.1128/JVI.00771-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936136PMC
July 2016

1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure.

J Mol Biol 2016 06 30;428(11):2307-2316. Epub 2016 Apr 30.

Department of Biochemistry, Molecular Biology, and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142242PMC
June 2016

Single-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes.

Biochemistry 2016 06 19;55(22):3102-6. Epub 2016 May 19.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center , Omaha, Nebraska 68198-6000, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932870PMC
June 2016

Interaction of APOBEC3A with DNA assessed by atomic force microscopy.

PLoS One 2014 6;9(6):e99354. Epub 2014 Jun 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099354PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048275PMC
January 2016

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.

Cell Rep 2015 Dec 25;13(9):1781-8. Epub 2015 Nov 25.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247150125
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http://dx.doi.org/10.1016/j.celrep.2015.10.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684092PMC
December 2015

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.

J Biol Chem 2015 Nov 28;290(47):28120-30. Epub 2015 Sep 28.

From the Department of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, and Masonic Cancer Center,

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http://dx.doi.org/10.1074/jbc.M115.679951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653671PMC
November 2015

The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers.

Cancer Res 2015 Nov 29;75(21):4538-47. Epub 2015 Sep 29.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2171-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631676PMC
November 2015

Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif.

Oncotarget 2015 Nov;6(37):39969-79

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.18632/oncotarget.5483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741873PMC
November 2015

APOBEC3G Interacts with ssDNA by Two Modes: AFM Studies.

Sci Rep 2015 Oct 27;5:15648. Epub 2015 Oct 27.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://dx.doi.org/10.1038/srep15648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621513PMC
October 2015

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

J Med Chem 2015 Sep 11;58(18):7419-30. Epub 2015 Sep 11.

Department of Medicinal Chemistry, ‡Department of Biochemistry, Molecular Biology & Biophysics, and §Masonic Cancer Center, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610730PMC
September 2015

Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis.

Sci Adv 2015 Sep 18;1(8):e1500296. Epub 2015 Sep 18.

Department of Biochemistry, Molecular Biology Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1126/sciadv.1500296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643775PMC
September 2015

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.

Cancer Discov 2015 Jul 19;5(7):704-12. Epub 2015 Jun 19.

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497973PMC
July 2015

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G.

Nat Struct Mol Biol 2015 Jun 18;22(6):485-91. Epub 2015 May 18.

Biochemistry, Molecular Biology and Biophysics Department, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1038/nsmb.3033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456288PMC
June 2015

APOBECs and virus restriction.

Virology 2015 May 26;479-480:131-45. Epub 2015 Mar 26.

Department of Molecular Biosciences, Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, United States. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424171PMC
May 2015

Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.

Cell Rep 2015 May 14;11(8):1236-50. Epub 2015 May 14.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, QB3, University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613747PMC
May 2015

The multidimensional nature of antiviral innate immunity.

Cell Host Microbe 2015 Apr;17(4):423-5

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.chom.2015.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616157PMC
April 2015

Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.

Horm Cancer 2014 Dec 15;5(6):405-13. Epub 2014 Aug 15.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands.

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http://dx.doi.org/10.1007/s12672-014-0196-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228172PMC
December 2014

Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.

mBio 2014 Dec 23;5(6). Epub 2014 Dec 23.

Biochemistry, Molecular Biology and Biophysics Department, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA

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http://dx.doi.org/10.1128/mBio.02234-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278539PMC
December 2014

Cellular requirements for bovine immunodeficiency virus Vif-mediated inactivation of bovine APOBEC3 proteins.

J Virol 2014 Nov 20;88(21):12528-40. Epub 2014 Aug 20.

First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun, Jilin, China Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Collaborative Innovation Center of Chemical Science and Engineering, School of Life Sciences, Tianjin University, Tianjin, China

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02072-14
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248920PMC
November 2014

APOBEC3F determinants of HIV-1 Vif sensitivity.

J Virol 2014 Nov 20;88(21):12923-7. Epub 2014 Aug 20.

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA

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http://dx.doi.org/10.1128/JVI.02362-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248952PMC
November 2014

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.

PLoS Genet 2014 Nov 20;10(11):e1004761. Epub 2014 Nov 20.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238949PMC
November 2014

Small molecules that inhibit Vif-induced degradation of APOBEC3G.

Virol J 2014 Jul 1;11:122. Epub 2014 Jul 1.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaracho, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1186/1743-422X-11-122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085377PMC
July 2014

Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications.

Authors:
Reuben S Harris

Genome Med 2013 27;5(9):87. Epub 2013 Sep 27.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA ; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1186/gm490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978439PMC
May 2014

APOBEC3 multimerization correlates with HIV-1 packaging and restriction activity in living cells.

J Mol Biol 2014 Mar 17;426(6):1296-307. Epub 2013 Dec 17.

School of Physics and Astronomy, University of Minnesota, 116 Church Street Southeast, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, 515 Delaware Street Southeast, Minneapolis, MN 55455, USA; Department of Biomedical Engineering, University of Minnesota, 312 Church Street Southeast, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2013.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977201PMC
March 2014

Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus.

Virology 2014 Feb 20;450-451:49-54. Epub 2013 Dec 20.

Department of Biochemistry, Molecular Biology & Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, 6-155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2013.11.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932626PMC
February 2014

Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis.

Virology 2014 Jan 26;449:82-7. Epub 2013 Nov 26.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1016/j.virol.2013.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936105PMC
January 2014

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

Cancer Res 2013 Dec 23;73(24):7222-31. Epub 2013 Oct 23.

Authors' Affiliations: Biochemistry, Molecular Biology and Biophysics Department; Masonic Cancer Center, University of Minnesota, Minneapolis; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; Medical Genome Facility and Department of Laboratory Medicine and Pathology; Department of Laboratory Medicine and Pathology; Division of Medical Oncology, Department of Oncology; Division of Epidemiology, Department of Health Sciences Research; Division of Oncology Research, Department of Oncology; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic; Women's Cancer Program, Mayo Clinic Cancer Center, Rochester, Minnesota; Department of Cancer Biology, University of Kansas, Kansas City, Kansas; Department of Obstetrics & Gynecology, University of Washington School of Medicine, Seattle, Washington; and Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867573PMC
December 2013

The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.

J Mol Biol 2013 Nov 11;425(22):4442-54. Epub 2013 Aug 11.

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.jmb.2013.07.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812309PMC
November 2013

Atomic force microscopy studies of APOBEC3G oligomerization and dynamics.

J Struct Biol 2013 Nov 18;184(2):217-25. Epub 2013 Sep 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, United States.

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http://dx.doi.org/10.1016/j.jsb.2013.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844295PMC
November 2013

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells.

Elife 2013 Oct 29;2:e01222. Epub 2013 Oct 29.

Department of Molecular and Human Genetics , Baylor College of Medicine , Houston , United States ; Department of Molecular Virology and Microbiology , Baylor College of Medicine , Houston , United States ; Dan L Duncan Cancer Center, Baylor College of Medicine , Houston , United States ; Department of Biochemistry, Molecular Biology , Baylor College of Medicine , Houston , United States.

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http://dx.doi.org/10.7554/eLife.01222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809393PMC
October 2013

Evidence for APOBEC3B mutagenesis in multiple human cancers.

Nat Genet 2013 Sep 14;45(9):977-83. Epub 2013 Jul 14.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1038/ng.2701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902892PMC
September 2013

The APOBEC3 family of retroelement restriction factors.

Curr Top Microbiol Immunol 2013 ;371:1-27

Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1007/978-3-642-37765-5_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934647PMC
August 2013

APOBEC3 inhibits DEAD-END function to regulate microRNA activity.

BMC Mol Biol 2013 Jul 26;14:16. Epub 2013 Jul 26.

Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/1471-2199-14-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729616PMC
July 2013

D316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B.

Virology 2013 Jun 29;441(1):31-9. Epub 2013 Mar 29.

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.virol.2013.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752335PMC
June 2013

Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G.

J Virol 2013 Jun 17;87(12):7008-14. Epub 2013 Apr 17.

Department of Biochemistry, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1128/JVI.03173-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676121PMC
June 2013

Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.

J Biol Chem 2013 Jun 2;288(24):17253-60. Epub 2013 May 2.

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1074/jbc.M113.458661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682529PMC
June 2013

Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F.

J Mol Biol 2013 Apr 11;425(7):1172-82. Epub 2013 Jan 11.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.jmb.2013.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602375PMC
April 2013

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.

Cell Cycle 2013 Mar 6;12(5):762-72. Epub 2013 Feb 6.

Department of Biochemistry, Molecular Biology and Biophysics, Institute of Molecular Virology, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.4161/cc.23713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610724PMC
March 2013

Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold.

ChemMedChem 2013 Jan 23;8(1):112-7. Epub 2012 Nov 23.

Department of Medicinal Chemistry, University of Minnesota - Twin Cities, 717 Delaware Street S.E., Minneapolis, MN 55414, USA.

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http://dx.doi.org/10.1002/cmdc.201200411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786134PMC
January 2013

Extensive somatic L1 retrotransposition in colorectal tumors.

Genome Res 2012 Dec 11;22(12):2328-38. Epub 2012 Sep 11.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1101/gr.145235.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514663PMC
December 2012

The restriction factors of human immunodeficiency virus.

J Biol Chem 2012 Nov 5;287(49):40875-83. Epub 2012 Oct 5.

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.R112.416925
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http://dx.doi.org/10.1074/jbc.R112.416925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510791PMC
November 2012