Reto Brun

Reto Brun

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Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana , Targeting Pancreatic Cancer Cells.

J Nat Prod 2019 Nov 20;82(11):3150-3164. Epub 2019 Oct 20.

Institute of Organic Chemistry , University of Würzburg , Am Hubland , D-97074 Würzburg , Germany.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00755DOI Listing
November 2019

A Near-Complete Series of Four Atropisomeric Jozimine A-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from .

J Nat Prod 2019 Nov 23;82(11):3033-3046. Epub 2019 Oct 23.

Institute of Organic Chemistry , University of Würzburg , Am Hubland , D-97074 Würzburg , Germany.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00589DOI Listing
November 2019

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.

Eur J Med Chem 2018 Aug 28;156:53-60. Epub 2018 Jun 28.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, "Sapienza" Università di Roma, p.le Aldo Moro 5, I-00185, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.06.063DOI Listing
August 2018

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

J Med Chem 2018 04 13;61(8):3350-3369. Epub 2018 Apr 13.

Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01869DOI Listing
April 2018

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

J Med Chem 2018 04 6;61(8):3370-3388. Epub 2018 Apr 6.

Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01870DOI Listing
April 2018

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.

J Nat Prod 2018 01 15;81(1):124-130. Epub 2017 Dec 15.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Muenster , PharmaCampus Corrensstrasse 48, Muenster D-48149, Germany.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.7b00747
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http://dx.doi.org/10.1021/acs.jnatprod.7b00747DOI Listing
January 2018

Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity.

Molecules 2018 Jan 27;23(2). Epub 2018 Jan 27.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany.

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http://www.mdpi.com/1420-3049/23/2/248
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http://dx.doi.org/10.3390/molecules23020248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017816PMC
January 2018

Antiprotozoal Spirombandakamines A and A, Fused Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Plant.

Org Lett 2017 12 30;19(24):6740-6743. Epub 2017 Nov 30.

Institute of Organic Chemistry, University of Würzburg , Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1021/acs.orglett.7b03473DOI Listing
December 2017

Terpenoids from the Oleo-Gum-Resin of Boswellia serrata and Their Antiplasmodial Effects In Vitro.

Planta Med 2017 Oct 24;83(14-15):1214-1226. Epub 2017 Jul 24.

Institute for Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1055/s-0043-116943DOI Listing
October 2017

Erratum: Terpenoids from the Oleo-Gum-Resin of Boswellia serrata and Their Antiplasmodial Effects In Vitro.

Planta Med 2017 10 28;83(14-15):E4. Epub 2017 Aug 28.

Institute for Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1055/s-0043-118649DOI Listing
October 2017

Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius.

Fitoterapia 2017 Sep 6;121:76-85. Epub 2017 Jul 6.

Institute of Pharmacy and Biochemistry, Department of Pharmaceutical Biology, University of Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.

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http://dx.doi.org/10.1016/j.fitote.2017.07.001DOI Listing
September 2017

Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.

Bioorg Med Chem Lett 2017 09 31;27(17):3945-3949. Epub 2017 Jul 31.

Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

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http://dx.doi.org/10.1016/j.bmcl.2017.07.081DOI Listing
September 2017

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense.

Molecules 2017 Jul 6;22(7). Epub 2017 Jul 6.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany.

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http://www.mdpi.com/1420-3049/22/7/1129
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http://dx.doi.org/10.3390/molecules22071129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152089PMC
July 2017

, , and Activities of Diamidines against Trypanosoma congolense and Trypanosoma vivax.

Antimicrob Agents Chemother 2017 05 24;61(5). Epub 2017 Apr 24.

Parasite Chemotherapy, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://aac.asm.org/lookup/doi/10.1128/AAC.02356-16
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http://dx.doi.org/10.1128/AAC.02356-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404523PMC
May 2017

Alkamides from Anacyclus pyrethrum L. and Their in Vitro Antiprotozoal Activity.

Molecules 2017 May 12;22(5). Epub 2017 May 12.

Institut für Pharmazeutische Biologie und Phytochemie (IPBP), University of Münster, PharmaCampus, Corrensstraße 48, Münster D-48149, Germany.

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http://dx.doi.org/10.3390/molecules22050796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154598PMC
May 2017

Synthesis and activity of nucleoside-based antiprotozoan compounds.

Bioorg Med Chem 2017 04 16;25(7):2091-2104. Epub 2017 Feb 16.

Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.02.016DOI Listing
April 2017

Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm.

Molecules 2017 Apr 8;22(4). Epub 2017 Apr 8.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany.

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http://www.mdpi.com/1420-3049/22/4/597
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http://dx.doi.org/10.3390/molecules22040597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154322PMC
April 2017

Cyclombandakamines A and A, Oxygen-Bridged Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Liana.

Org Lett 2017 03 23;19(6):1342-1345. Epub 2017 Feb 23.

Institute of Organic Chemistry, University of Würzburg , Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1021/acs.orglett.7b00209DOI Listing
March 2017

Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius.

Fitoterapia 2016 Dec 19;115:1-8. Epub 2016 Sep 19.

Institute of Pharmacy and Biochemistry, Department of Pharmaceutical Biology, University of Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.

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http://dx.doi.org/10.1016/j.fitote.2016.09.009DOI Listing
December 2016

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.

Bioorg Med Chem Lett 2016 12 3;26(24):5907-5910. Epub 2016 Nov 3.

Department of Chemistry, Georgia State University, Atlanta, GA 30303, United States.

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http://dx.doi.org/10.1016/j.bmcl.2016.11.006DOI Listing
December 2016

Directed Synthesis of All Four Pure Stereoisomers of the N,C-Coupled Naphthylisoquinoline Alkaloid Ancistrocladinium A.

Org Lett 2016 12 1;18(24):6508-6511. Epub 2016 Dec 1.

Institute of Organic Chemistry, University of Würzburg , Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1021/acs.orglett.6b03480DOI Listing
December 2016

The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes.

Arch Pharm Res 2016 Oct 1;39(10):1391-1403. Epub 2016 Sep 1.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010, Graz, Austria.

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http://dx.doi.org/10.1007/s12272-016-0826-5DOI Listing
October 2016

Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.

Bioorg Med Chem 2016 09 25;24(18):4038-4044. Epub 2016 Jun 25.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.bmc.2016.06.047DOI Listing
September 2016

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity.

Molecules 2016 Sep 15;21(9). Epub 2016 Sep 15.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, Münster D-48149, Germany.

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http://dx.doi.org/10.3390/molecules21091237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274167PMC
September 2016

Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead.

Bioorg Med Chem 2016 08 14;24(16):3781-9. Epub 2016 Jun 14.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstraße 1, A-8010 Graz, Austria.

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http://dx.doi.org/10.1016/j.bmc.2016.06.024DOI Listing
August 2016

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense.

Bioorg Med Chem 2016 06 2;24(11):2451-65. Epub 2016 Apr 2.

University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB7525, Chapel Hill, NC 27599-7525, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862372PMC
June 2016

Novel nucleoside-based antimalarial compounds.

Bioorg Med Chem Lett 2016 06 23;26(12):2861-2865. Epub 2016 Apr 23.

Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.04.053DOI Listing
June 2016

Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning.

PLoS One 2015 13;10(8):e0135556. Epub 2015 Aug 13.

Parasite Chemotherapy, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135556PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535766PMC
May 2016

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents.

Pharmaceuticals (Basel) 2016 Apr 19;9(2). Epub 2016 Apr 19.

College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA.

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http://dx.doi.org/10.3390/ph9020020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932538PMC
April 2016

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes.

Sci Rep 2016 Mar 2;6:22451. Epub 2016 Mar 2.

Medical Parasitology &Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1038/srep22451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773815PMC
March 2016

Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.

Antimicrob Agents Chemother 2015 Nov 17;59(11):6708-16. Epub 2015 Aug 17.

College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

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http://dx.doi.org/10.1128/AAC.00596-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604408PMC
November 2015

Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability.

Chemistry 2015 Oct 13;21(41):14507-18. Epub 2015 Aug 13.

Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg (Germany).

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http://dx.doi.org/10.1002/chem.201501657DOI Listing
October 2015

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.

Molecules 2015 Sep 3;20(9):16154-69. Epub 2015 Sep 3.

Institut für Pharmazeutische Biologie und Phytochemie (IPBP), University of Münster, PharmaCampus, Correnstraße 48, Münster D-48149, Germany.

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http://www.mdpi.com/1420-3049/20/9/16154
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http://dx.doi.org/10.3390/molecules200916154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332274PMC
September 2015

Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes.

Arch Pharm Res 2015 Aug 30;38(8):1455-67. Epub 2014 Nov 30.

Center for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan.

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http://dx.doi.org/10.1007/s12272-014-0523-1DOI Listing
August 2015

Antiprotozoal Effect of Artemisia indica Extracts and Essential Oil.

Planta Med 2015 Aug 17;81(12-13):1029-37. Epub 2015 Jun 17.

Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1055/s-0035-1546125DOI Listing
August 2015

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.

J Med Chem 2015 Aug 11;58(16):6422-34. Epub 2015 Aug 11.

Department of Pharmacy & Biotechnology, Alma Mater Studiorum - University of Bologna , Via Belmeloro 6/Via Irnerio 48, 40126 Bologna, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00748DOI Listing
August 2015

Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases.

Molecules 2015 Aug 4;20(8):14118-38. Epub 2015 Aug 4.

Institut für Pharmazeutische Biologie und Phytochemie (IPBP), University of Münster, PharmaCampus, Corrensstraße 48, D-48149 Münster, Germany.

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http://dx.doi.org/10.3390/molecules200814118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332118PMC
August 2015

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

Molecules 2015 May 29;20(6):10082-94. Epub 2015 May 29.

Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, PharmaCampus, Corrensstr. 48, Münster D-48149, Germany.

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http://dx.doi.org/10.3390/molecules200610082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272576PMC
May 2015

Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin.

Bioorg Med Chem 2015 Apr 13;23(7):1521-9. Epub 2015 Feb 13.

Department of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmc.2015.02.005DOI Listing
April 2015

Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.

Bioorg Med Chem Lett 2015 Apr 28;25(7):1390-3. Epub 2015 Feb 28.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University, Schubertstrasse 1, Graz A-8010, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X150016
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http://dx.doi.org/10.1016/j.bmcl.2015.02.044DOI Listing
April 2015

Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves.

BMC Complement Altern Med 2015 Mar 26;15:82. Epub 2015 Mar 26.

Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D- 40225, Dusseldorf, Germany.

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http://dx.doi.org/10.1186/s12906-015-0562-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384300PMC
March 2015

Antiprotozoal activity of (E)-cinnamic N-acylhydrazone derivatives.

Molecules 2014 Dec 5;19(12):20374-81. Epub 2014 Dec 5.

Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, P.O. Box 68023, Rio de Janeiro, RJ 21941-902, Brazil.

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http://dx.doi.org/10.3390/molecules191220374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271834PMC
December 2014

Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.

Antimicrob Agents Chemother 2014 Oct 14;58(10):5747-57. Epub 2014 Jul 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom

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http://aac.asm.org/content/58/10/5747.full.pdf
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http://aac.asm.org/cgi/doi/10.1128/AAC.01449-13
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http://dx.doi.org/10.1128/AAC.01449-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187918PMC
October 2014

In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense.

Antimicrob Agents Chemother 2014 28;58(1):325-32. Epub 2013 Oct 28.

Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1128/AAC.01263-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910805PMC
September 2014

1,2-substituted 4-(1H)-quinolones: synthesis, antimalarial and antitrypanosomal activities in vitro.

Molecules 2014 Sep 10;19(9):14204-20. Epub 2014 Sep 10.

Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Universitätsplatz 4/1, A-8010 Graz, Austria.

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http://www.mdpi.com/1420-3049/19/9/14204
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http://dx.doi.org/10.3390/molecules190914204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271202PMC
September 2014

Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase.

ChemMedChem 2014 Aug 30;9(8):1880-91. Epub 2014 Apr 30.

Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zurich (Switzerland).

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http://dx.doi.org/10.1002/cmdc.201402032DOI Listing
August 2014

In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.

Antimicrob Agents Chemother 2014 Aug 27;58(8):4452-63. Epub 2014 May 27.

Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1128/AAC.02309-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136055PMC
August 2014

HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L.

J Ethnopharmacol 2014 Aug 2;155(1):426-34. Epub 2014 Jun 2.

Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03788741140041
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http://dx.doi.org/10.1016/j.jep.2014.05.050DOI Listing
August 2014

Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modified in the terminal groups.

Eur J Med Chem 2014 Aug 12;83:167-73. Epub 2014 Jun 12.

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.06.022DOI Listing
August 2014

Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites.

Bioorg Med Chem 2014 Jul 10;22(14):3749-52. Epub 2014 May 10.

Drug Discovery Science Research Center, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.04.066DOI Listing
July 2014

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.

Angew Chem Int Ed Engl 2014 Jul 4;53(27):7079-84. Epub 2014 Jun 4.

Departement Chemie und Angewandte Biowissenschaften, ETH Zürich, Vladimir-Prelog-Weg 3-4, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/anie.201311162DOI Listing
July 2014

Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum.

Molecules 2014 May 15;19(5):6184-201. Epub 2014 May 15.

Institut für Pharmazeutische Biologie und Phytochemie (IPBP), University of Münster, Pharma Campus, Corrensstraße 48, D-48149 Münster, Germany.

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http://www.mdpi.com/1420-3049/19/5/6184
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http://dx.doi.org/10.3390/molecules19056184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271158PMC
May 2014

Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents.

Molecules 2014 May 20;19(5):6428-38. Epub 2014 May 20.

Institut für Pharmazeutische Biologie und Phytochemie (IPBP), University of Münster, PharmaCampus, Corrensstraße 48, Münster D-48149, Germany.

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http://www.mdpi.com/1420-3049/19/5/6428
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http://dx.doi.org/10.3390/molecules19056428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271219PMC
May 2014

Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae).

Molecules 2014 Apr 25;19(5):5470-7. Epub 2014 Apr 25.

Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany.

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http://dx.doi.org/10.3390/molecules19055470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270954PMC
April 2014

Antitrypanosomal isoflavan quinones from Abrus precatorius.

Fitoterapia 2014 Mar 29;93:81-7. Epub 2013 Dec 29.

Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2013.12.015DOI Listing
March 2014

Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251.

J Nat Prod 2014 Mar 6;77(3):557-62. Epub 2014 Jan 6.

Chemical Synthesis Laboratory, SB-ISIC-LSYNC, Swiss Federal Institute of Technology (EPFL) , CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1021/np400814wDOI Listing
March 2014

Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.

Bioorg Med Chem Lett 2014 Feb 2;24(3):794-8. Epub 2014 Jan 2.

Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2013.12.099DOI Listing
February 2014

Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.

Bioorg Med Chem 2014 Jan 9;22(1):559-76. Epub 2013 Nov 9.

University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.10.050DOI Listing
January 2014

Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina.

Planta Med 2014 Jan 5;80(1):86-9. Epub 2013 Dec 5.

Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1055/s-0033-1351102DOI Listing
January 2014

A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages.

Int J Med Microbiol 2013 Dec 5;303(8):539-47. Epub 2013 Aug 5.

Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2013.07.005DOI Listing
December 2013

Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.

Antimicrob Agents Chemother 2013 Nov 19;57(11):5330-43. Epub 2013 Aug 19.

Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1128/AAC.00398-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811327PMC
November 2013

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.

Bioorg Med Chem 2013 Nov 13;21(21):6732-41. Epub 2013 Aug 13.

Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

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http://dx.doi.org/10.1016/j.bmc.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846175PMC
November 2013

Enantioselective synthesis of encecaline-derived potent antimalarial agents.

Org Biomol Chem 2013 Nov;11(42):7342-9

Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.

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http://dx.doi.org/10.1039/c3ob41583jDOI Listing
November 2013

Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.

Bioorg Med Chem 2013 Nov 5;21(22):7202-9. Epub 2013 Sep 5.

Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmc.2013.08.052DOI Listing
November 2013

Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi.

J Nat Prod 2013 Nov 6;76(11):2136-40. Epub 2013 Nov 6.

Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster , Corrensstraße 45, 48149 Münster, Germany.

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http://dx.doi.org/10.1021/np4006053DOI Listing
November 2013

Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.

Eur J Med Chem 2013 Sep 25;67:310-24. Epub 2013 Jun 25.

Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA.

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http://dx.doi.org/10.1016/j.ejmech.2013.06.033DOI Listing
September 2013

Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom.

Bioorg Med Chem 2013 Sep 2;21(17):4988-96. Epub 2013 Jul 2.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Stremayrgasse 16, A-8010 Graz, Austria.

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http://dx.doi.org/10.1016/j.bmc.2013.06.059DOI Listing
September 2013

Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.

J Med Chem 2013 Sep 9;56(18):7442-8. Epub 2013 Sep 9.

Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster , Corrensstraße 48, D-48149 Münster, Germany.

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http://dx.doi.org/10.1021/jm401007pDOI Listing
September 2013

Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR.

Nat Prod Commun 2013 Aug;8(8):1135-6

Department of Pharmacal Sciences, 4306 Walker Building, Auburn University, Auburn, AL, USA.

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August 2013

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.

J Med Chem 2013 Jul 24;56(13):5473-94. Epub 2013 Jun 24.

Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina , Chapel Hill, North Carolina 27599-7525, United States.

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http://dx.doi.org/10.1021/jm400508eDOI Listing
July 2013

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

ACS Med Chem Lett 2013 Jun 7;4(6):538-41. Epub 2013 May 7.

Dipartimento di Chimica e Tecnologie del Farmaco, "Sapienza" Università di Roma , P.le A. Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.1021/ml400039rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027138PMC
June 2013