Publications by authors named "Renske D M Steenbergen"

100Publications

Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1.

Proc Natl Acad Sci U S A 2021 Jan;118(3)

Tumor Virus RNA Biology Section, HIV Dynamics and Replication Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702;

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January 2021

Non-invasive detection of endometrial cancer by DNA methylation analysis in urine.

Clin Epigenetics 2020 Nov 3;12(1):165. Epub 2020 Nov 3.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.

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November 2020

DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery.

Genomics Proteomics Bioinformatics 2020 Apr 12;18(2):104-119. Epub 2020 Aug 12.

Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Westlake University, Hangzhou 310024, China; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou 310024, China. Electronic address:

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April 2020

Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities.

Biosens Bioelectron 2020 Oct 26;166:112445. Epub 2020 Jul 26.

BIOS Lab on a Chip group, Technical Medical Centre, MESA+ Institute for Nanotechnology, University of Twente, P.O. box 217, 7500, AE, Enschede, the Netherlands.

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October 2020

Vulvar intraepithelial neoplasia: Incidence and long-term risk of vulvar squamous cell carcinoma.

Int J Cancer 2021 Jan 22;148(1):90-98. Epub 2020 Jul 22.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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January 2021

A systematic review on mutation markers for bladder cancer diagnosis in urine.

BJU Int 2021 Jan 16;127(1):12-27. Epub 2020 Aug 16.

Departments of, Department of, Urology, Amsterdam University Medical Centers, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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January 2021

Circulating Tumor DNA Analysis: Clinical Implications for Colorectal Cancer Patients. A Systematic Review.

JNCI Cancer Spectr 2019 Sep 19;3(3):pkz042. Epub 2019 Jun 19.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Vrije Universiteit, Amsterdam, the Netherlands.

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September 2019

Identification of Deregulated Pathways, Key Regulators, and Novel miRNA-mRNA Interactions in HPV-Mediated Transformation.

Cancers (Basel) 2020 Mar 16;12(3). Epub 2020 Mar 16.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.

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March 2020

Methylation analysis in urine fractions for optimal CIN3 and cervical cancer detection.

Papillomavirus Res 2020 06 13;9:100193. Epub 2020 Mar 13.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam, Amsterdam, the Netherlands. Electronic address:

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June 2020

miR-9-5p Exerts a Dual Role in Cervical Cancer and Targets Transcription Factor TWIST1.

Cells 2019 Dec 26;9(1). Epub 2019 Dec 26.

Cancer Center Amsterdam, Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.

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December 2019

The use of molecular markers for cervical screening of women living with HIV in South Africa.

AIDS 2019 11;33(13):2035-2042

aDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands bDepartment of Obstetrics and Gynaecology, Steve Biko Academic Hospital, University of Pretoria cDepartment of Medical Virology, University of Pretoria and Lancet Laboratories, Pretoria, South Africa.

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November 2019

Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis.

Gynecol Oncol 2019 08 8;154(2):368-373. Epub 2019 Jun 8.

Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands. Electronic address:

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August 2019

HPV16 variant analysis in primary and recurrent CIN2/3 lesions demonstrates presence of the same consensus variant.

Papillomavirus Res 2019 06 13;7:168-172. Epub 2019 Apr 13.

Amsterdam UMC, Vrije Universiteit, Department of Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands. Electronic address:

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June 2019

Cervical cancer detection by DNA methylation analysis in urine.

Sci Rep 2019 02 28;9(1):3088. Epub 2019 Feb 28.

Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan, 1117, Amsterdam, Netherlands.

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February 2019

HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV.

Int J Mol Sci 2018 Oct 23;19(11). Epub 2018 Oct 23.

Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.

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October 2018

Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer.

Epigenetics 2018 24;13(7):769-778. Epub 2018 Aug 24.

b Department of Gynecologic Oncology , University of Groningen, University Medical Center Groningen, Cancer Research Center Groningen , Groningen , The Netherlands.

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March 2019

Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis.

Cancer Med 2018 09 20;7(9):4542-4553. Epub 2018 Jul 20.

Cancer Center Amsterdam, Department of Pathology, VU University Medical Center, VU University Medical Center, Amsterdam, The Netherlands.

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September 2018

The effect of ART on cervical cancer precursor lesions.

Lancet HIV 2018 01 26;5(1):e6-e8. Epub 2017 Oct 26.

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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January 2018

Molecular events leading to HPV-induced high grade neoplasia.

Papillomavirus Res 2016 12 12;2:85-88. Epub 2016 Apr 12.

Department of Pathology, VU University Medical Center Amsterdam, The Netherlands. Electronic address:

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December 2016

A Strategy to Find Suitable Reference Genes for miRNA Quantitative PCR Analysis and Its Application to Cervical Specimens.

J Mol Diagn 2017 09;19(5):625-637

Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands. Electronic address:

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September 2017

Selection of women at risk for cervical cancer in an HIV-infected South African population.

AIDS 2017 09;31(14):1945-1953

aCancer Centre Amsterdam, Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands bDepartment of Obstetrics and Gynaecology, Steve Biko Academic Hospital cDepartment of Medical Virology, University of Pretoria, and National Health Laboratory Service, Pretoria, South Africa dDepartment of Epidemiology and Biostatistics, VU University Medical Centre eSelf-screen B.V., Amsterdam, The Netherlands.

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September 2017

Gynaecological cancer: Novel molecular subtypes of cervical cancer - potential clinical consequences.

Nat Rev Clin Oncol 2017 07 11;14(7):397-398. Epub 2017 Apr 11.

Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, Netherlands.

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July 2017

Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma.

Oncotarget 2016 Dec;7(49):80735-80750

Department of Gynecologic Oncology, University of Groningen, University Medical Centre Groningen, Cancer Research Centre Groningen, Groningen, The Netherlands.

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December 2016

Management of high-risk HPV-positive women for detection of cervical (pre)cancer.

Expert Rev Mol Diagn 2016 09 5;16(9):961-74. Epub 2016 Aug 5.

a Department of Pathology , VU University Medical Center , Amsterdam , the Netherlands.

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September 2016

Prevalence of Neovaginal High-Risk Human Papillomavirus Among Transgender Women in The Netherlands.

Sex Transm Dis 2016 08;43(8):503-5

From the *Department of Plastic, Reconstructive and Hand Surgery, †EMGO + Institute for Health and Care Research, ‡Center of Expertise on Gender Dysphoria, and §Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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August 2016

Symptomatic HPV-related neovaginal lesions in transgender women: case series and review of literature.

Sex Transm Infect 2016 Nov 24;92(7):499-501. Epub 2016 Mar 24.

Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands.

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November 2016

Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression.

PLoS One 2015 6;10(7):e0132495. Epub 2015 Jul 6.

Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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April 2016

Mining for viral fragments in methylation enriched sequencing data.

Front Genet 2015 4;6:16. Epub 2015 Feb 4.

Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University Ghent, Belgium.

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February 2015

Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes.

Epigenetics 2015 23;10(1):73-81. Epub 2015 Jan 23.

a Department of Pathology; Unit of Molecular Pathology ; VU University Medical Center ; Amsterdam , The Netherlands.

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June 2016

tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities.

BMC Bioinformatics 2014 Oct 2;15:327. Epub 2014 Oct 2.

Department of Epidemiology and Biostatistics, VU University Medical Center, P,O, Box 7057, 1007 MB, Amsterdam, The Netherlands.

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October 2014

Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers.

Carcinogenesis 2014 Nov 18;35(11):2611-8. Epub 2014 Sep 18.

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands and

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November 2014

Focal chromosomal copy number aberrations in cancer-Needles in a genome haystack.

Biochim Biophys Acta 2014 Nov 7;1843(11):2698-2704. Epub 2014 Aug 7.

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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November 2014

Combined CADM1/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women.

Cancer Epidemiol Biomarkers Prev 2014 Sep 24;23(9):1933-7. Epub 2014 Jun 24.

Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands.

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September 2014

Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions.

Nat Rev Cancer 2014 Jun;14(6):395-405

Department of Pathology, VU University Medical Center, PO box 7057, 1007 Amsterdam, The Netherlands.

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June 2014

Differential in vitro immortalization capacity of eleven (probable) [corrected] high-risk human papillomavirus types.

J Virol 2014 Feb 20;88(3):1714-24. Epub 2013 Nov 20.

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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February 2014

Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma.

Mod Pathol 2012 Oct 8;25(10):1354-63. Epub 2012 Jun 8.

Unit of Molecular Pathology, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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October 2012

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia.

BMC Cancer 2012 Jan 24;12:36. Epub 2012 Jan 24.

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO box 7057, 1007 MB Amsterdam, The Netherlands.

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January 2012

The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations.

Cell Oncol (Dordr) 2012 Apr 24;35(2):77-84. Epub 2012 Jan 24.

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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April 2012

Methylation status of the E2 binding sites of HPV16 in cervical lesions determined with the Luminex® xMAP™ system.

Virology 2012 Jan 2;422(2):357-65. Epub 2011 Dec 2.

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.

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January 2012

PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro.

Mol Cancer 2011 Jun 10;10:71. Epub 2011 Jun 10.

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.

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June 2011

Comprehensive CADM1 promoter methylation analysis in NSCLC and normal lung specimens.

Lung Cancer 2011 Jun 9;72(3):316-21. Epub 2010 Nov 9.

Department of Pulmonary Diseases, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.

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June 2011

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis.

BMC Cancer 2010 Jun 9;10:271. Epub 2010 Jun 9.

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO box 7057, 1007 MB Amsterdam, the Netherlands.

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June 2010

Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.

Int J Cancer 2011 Apr 24;128(7):1596-605. Epub 2010 May 24.

Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.

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April 2011

Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation.

Proc Natl Acad Sci U S A 2010 Apr 29;107(15):7006-11. Epub 2010 Mar 29.

Deutsches Krebsforschungszentrum Heidelberg (DKFZ) Im Neuenheimer Feld 242, Research Program Infection and Cancer, Viral Transformation Mechanisms, 69120 Heidelberg, Germany.

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April 2010

Chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas.

Cancer Res 2009 Jan;69(2):647-55

Departments of Pathology and Mathematics, VU University Medical Center, Amsterdam, the Netherlands, and Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands.

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January 2009

Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesis.

Cell Oncol 2008 ;30(1):77-87

Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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March 2008

A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma.

J Immunol 2007 Oct;179(8):5317-25

Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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October 2007

HPV-mediated cervical carcinogenesis: concepts and clinical implications.

J Pathol 2006 Jan;208(2):152-64

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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January 2006