Renhai Cao

Renhai Cao

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Renhai Cao

Renhai Cao

Publications by authors named "Renhai Cao"

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Pericyte-fibroblast transition promotes tumor growth and metastasis.

Proc Natl Acad Sci U S A 2016 09 7;113(38):E5618-27. Epub 2016 Sep 7.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden; Key Laboratory of International Collaborations, Second People's Hospital of Shenzhen, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China; Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE1 7RH, United Kingdom

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035870PMC
http://dx.doi.org/10.1073/pnas.1608384113DOI Listing
September 2016

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis.

Nat Commun 2016 Mar 1;7:10824. Epub 2016 Mar 1.

Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen 518057, China.

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http://dx.doi.org/10.1038/ncomms10824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773521PMC
March 2016

Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis.

Oncoimmunology 2015 Mar 22;4(3):e989777. Epub 2015 Jan 22.

Department of Microbiology; Tumor and Cell Biology; Karolinska Institute ; Stockholm, Sweden ; Department of Medicine and Health Sciences; Linköping University ; Linköping, Sweden ; Department of Cardiovascular Sciences; University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit; Glenfield Hospital ; Leicester, UK.

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http://dx.doi.org/10.4161/2162402X.2014.989777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404838PMC
March 2015

TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling.

Nat Commun 2014 Sep 17;5:4944. Epub 2014 Sep 17.

1] Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden [2] Department of Medicine and Health Sciences, Linköping University, 581 83 Linköping, Sweden [3] Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester LE3 9QP, UK.

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http://www.nature.com/articles/ncomms5944
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http://dx.doi.org/10.1038/ncomms5944DOI Listing
September 2014

Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis.

Proc Natl Acad Sci U S A 2012 Sep 11;109(39):15894-9. Epub 2012 Sep 11.

Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm, Sweden.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1208324109
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http://dx.doi.org/10.1073/pnas.1208324109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465417PMC
September 2012

When MT1-MMP meets ADAMs.

Cell Cycle 2012 Aug 1;11(15):2793-8. Epub 2012 Aug 1.

Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.

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http://dx.doi.org/10.4161/cc.20949DOI Listing
August 2012

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.

Dev Cell 2012 Jun 24;22(6):1176-90. Epub 2012 May 24.

Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.

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http://dx.doi.org/10.1016/j.devcel.2012.04.014DOI Listing
June 2012

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells.

Nat Med 2011 Dec 4;18(1):100-10. Epub 2011 Dec 4.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nm.2575DOI Listing
December 2011

Mouse corneal lymphangiogenesis model.

Nat Protoc 2011 Jun 19;6(6):817-26. Epub 2011 May 19.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nprot.2011.359DOI Listing
June 2011

Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling.

Cell Cycle 2010 May 15;9(10):1882-5. Epub 2010 May 15.

Department of Microbiology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.4161/cc.9.10.11521DOI Listing
May 2010

VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy.

Proc Natl Acad Sci U S A 2010 Jan 22;107(2):856-61. Epub 2009 Dec 22.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0911661107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818941PMC
January 2010

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature.

Proc Natl Acad Sci U S A 2009 Oct 25;106(41):17505-10. Epub 2009 Sep 25.

Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0908026106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752403PMC
October 2009

Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability.

FASEB J 2009 Jan 30;23(1):153-63. Epub 2008 Sep 30.

Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176, Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.08-113860DOI Listing
January 2009

Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.

Cell Metab 2009 Jan;9(1):99-109

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2008.11.009DOI Listing
January 2009

R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways.

J Mol Med (Berl) 2008 Jul 8;86(7):785-9. Epub 2008 Apr 8.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00109-008-0337-zDOI Listing
July 2008

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue.

Proc Natl Acad Sci U S A 2008 Jul 11;105(29):10167-72. Epub 2008 Jul 11.

Department of Microbiology, Laboratory of Angiogenesis Research, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0802486105
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http://dx.doi.org/10.1073/pnas.0802486105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481379PMC
July 2008

Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy.

PLoS One 2008 Jul 23;3(7):e2748. Epub 2008 Jul 23.

Department of Microbiology, Tumor and Cell Biology, The Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002748PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447178PMC
July 2008

IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs.

Proc Natl Acad Sci U S A 2007 Sep 18;104(39):15364-9. Epub 2007 Sep 18.

Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Copenhagen 2200N, Denmark.

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http://dx.doi.org/10.1073/pnas.0707302104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978488PMC
September 2007

Intra- and extracellular signaling by endothelial neuregulin-1.

Exp Cell Res 2007 Aug 18;313(13):2896-909. Epub 2007 Apr 18.

Department of Medical Biochemistry and Molecular Biology, and Medicity Research Laboratories, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.yexcr.2007.03.042DOI Listing
August 2007

Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs.

Proc Natl Acad Sci U S A 2007 Jul 16;104(29):12140-5. Epub 2007 Jul 16.

Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Public Health, Qi Lu Hospital, Shandong University, Jinan 250012, Shandong Province, People's Republic of China.

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http://dx.doi.org/10.1073/pnas.0704966104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920536PMC
July 2007

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.

Proc Natl Acad Sci U S A 2007 Mar 26;104(10):3919-24. Epub 2007 Feb 26.

Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Göteborg University, SE 413 45 Göteborg, Sweden.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0608360104
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http://dx.doi.org/10.1073/pnas.0608360104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820684PMC
March 2007

Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action.

Blood 2006 May 19;107(9):3531-6. Epub 2006 Jan 19.

Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1182/blood-2005-06-2538DOI Listing
May 2006

Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels.

Blood 2005 Dec 1;106(13):4184-90. Epub 2005 Sep 1.

Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsväg 16, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1182/blood-2005-01-0226DOI Listing
December 2005

Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis.

Cancer Res 2005 Oct;65(20):9261-8

Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.

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http://cancerres.aacrjournals.org/content/65/20/9261.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-04-2345DOI Listing
October 2005

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo.

Proc Natl Acad Sci U S A 2005 Oct 17;102(43):15593-8. Epub 2005 Oct 17.

Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0507865102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266150PMC
October 2005

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.

Cancer Cell 2004 Oct;6(4):333-45

Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080400274
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http://dx.doi.org/10.1016/j.ccr.2004.08.034DOI Listing
October 2004

Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.

Cancer Res 2004 Jul;64(14):4699-702

Department of Biochemistry, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong, ROC.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0810DOI Listing
July 2004

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice.

Circ Res 2004 Jun 20;94(12):1579-88. Epub 2004 May 20.

Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1161/01.RES.0000132745.76882.70DOI Listing
June 2004

Blockage of VEGF-induced angiogenesis by preventing VEGF secretion.

Circ Res 2004 Jun;94(11):1443-50

Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1161/01.RES.0000129194.61747.bfDOI Listing
June 2004

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.

Cancer Res 2004 Jun;64(12):4059-63

Department of Biochemistry, Faculty of Medicine, University of Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0291DOI Listing
June 2004

Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability.

Circ Res 2004 Mar 22;94(5):664-70. Epub 2004 Jan 22.

Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1161/01.RES.0000118600.91698.BBDOI Listing
March 2004

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.

Proc Natl Acad Sci U S A 2004 Feb;101(8):2476-81

Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356975PMC
http://dx.doi.org/10.1073/pnas.0308671100DOI Listing
February 2004

Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2.

Nat Med 2003 May 31;9(5):604-13. Epub 2003 Mar 31.

Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nm848DOI Listing
May 2003

Kringle structures and antiangiogenesis.

Curr Med Chem Anticancer Agents 2002 Nov;2(6):667-81

Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden.

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November 2002

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors.

FASEB J 2002 Oct;16(12):1575-83

Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.02-0319comDOI Listing
October 2002

Antiangiogenic mechanisms of diet-derived polyphenols.

J Nutr Biochem 2002 Jul;13(7):380-390

Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77, Stockholm, Sweden

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July 2002

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.

Proc Natl Acad Sci U S A 2002 Jun 17;99(13):8868-73. Epub 2002 Jun 17.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, POB 63, Haartmaninkatu 8, 00014, Helsinki, Finland.

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http://www.pnas.org/cgi/doi/10.1073/pnas.062040199
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http://dx.doi.org/10.1073/pnas.062040199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124390PMC
June 2002

Deletion of the laminin alpha4 chain leads to impaired microvessel maturation.

Mol Cell Biol 2002 Feb;22(4):1194-202

Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17 177 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134646PMC
http://dx.doi.org/10.1128/mcb.22.4.1194-1202.2002DOI Listing
February 2002