Rene Wintjens

Rene Wintjens

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Rene Wintjens

Rene Wintjens

Publications by authors named "Rene Wintjens"

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Yeast filamentation signaling is connected to a specific substrate translocation mechanism of the Mep2 transceptor.

PLoS Genet 2020 Feb 18;16(2):e1008634. Epub 2020 Feb 18.

Biology of Membrane Transport Laboratory, Molecular Biology Department, Université Libre de Bruxelles, Gosselies, Belgium.

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http://dx.doi.org/10.1371/journal.pgen.1008634DOI Listing
February 2020

A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR.

Biochim Biophys Acta Proteins Proteom 2019 03 13;1867(3):248-258. Epub 2018 Dec 13.

Unité Microbiologie, Bioorganique et Macromoléculaire (CP206/04), département R3D, Faculté de Pharmacie, Université Libre de Bruxelles, B-1050 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2018.12.003DOI Listing
March 2019

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.

Biochem Biophys Res Commun 2017 05 14;487(2):403-408. Epub 2017 Apr 14.

Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculty of Pharmacy, Université Libre de Bruxelles, B-1050 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.04.074DOI Listing
May 2017

In vitro antimicrobial and anti-proliferative activities of plant extracts from Spathodea campanulata, Ficus bubu, and Carica papaya.

Pharm Biol 2016 22;54(6):1086-95. Epub 2016 Jan 22.

b Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculté De Pharmacie , Université Libre De Bruxelles (ULB) , Campus Plaine (CP 206/4), Boulevard Du Triomphe , Brussels , Belgium ;

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http://dx.doi.org/10.3109/13880209.2015.1103273DOI Listing
January 2017

Identification of compounds with anti-proliferative activity from the wood of Ficus elastica Roxb. ex Hornem. aerial roots.

Fitoterapia 2016 Jul 8;112:65-73. Epub 2016 May 8.

Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus Plaine (CP 206/4), Boulevard du Triomphe, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1016/j.fitote.2016.05.002DOI Listing
July 2016

Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32.

PLoS Genet 2015 Jul 14;11(7):e1005382. Epub 2015 Jul 14.

Biology of Membrane Transport, IBMM, Université Libre de Bruxelles, Gosselies, Belgium.

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http://dx.doi.org/10.1371/journal.pgen.1005382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501750PMC
July 2015

Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS.

PLoS Pathog 2015 Mar 4;11(3):e1004700. Epub 2015 Mar 4.

Center for Infection and Immunity (CIIL), Institut Pasteur de Lille, Lille, France; Center for Infection and Immunity (CIIL), University Lille North of France, Lille, France; UMR 8204, Centre National de la Recherche Scientifique (CNRS), Lille, France; U1019, Institut National de la Santé et de la Recherche Médicale (INSERM), Lille, France.

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http://dx.doi.org/10.1371/journal.ppat.1004700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352136PMC
March 2015

Sequence and conformation effects on ionization potential and charge distribution of homo-nucleobase stacks using M06-2X hybrid density functional theory calculations.

J Biomol Struct Dyn 2014 Apr 13;32(4):532-45. Epub 2013 Apr 13.

a BioModeling, BioInformatics and BioProcesses Department , CP 165/61 Université Libre de Bruxelles , 50 Roosevelt ave, 1050 Brussels , Belgium .

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http://dx.doi.org/10.1080/07391102.2013.783508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919198PMC
April 2014

Interplay between Halogen Bonding and Lone Pair-π Interactions: A Computational and Crystal Packing Study.

Chempluschem 2014 Apr 5;79(4):552-558. Epub 2014 Feb 5.

Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Bruxelles (Belgium).

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http://dx.doi.org/10.1002/cplu.201400005DOI Listing
April 2014

High-resolution structure of a papaya plant-defense barwin-like protein solved by in-house sulfur-SAD phasing.

Acta Crystallogr D Biol Crystallogr 2013 Oct 20;69(Pt 10):2017-26. Epub 2013 Sep 20.

Laboratoire des Biopolymères et des Nanomatériaux Supramoléculaires (CP206/04), Faculté de Pharmacie, Université Libre de Bruxelles, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1107/S0907444913018015DOI Listing
October 2013

Chemical constituents from Glyphaea brevis and Monodora myristica: chemotaxonomic significance.

Chem Biodivers 2013 Feb;10(2):224-32

Laboratoire des biopolymères et des nanomatériaux supramoléculaires, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus Plaine (CP 206/4), boulevard du Triomphe, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1002/cbdv.201100378DOI Listing
February 2013

Ceramide, cerebroside and triterpenoid saponin from the bark of aerial roots of Ficus elastica (Moraceae).

Phytochemistry 2012 Nov 7;83:95-103. Epub 2012 Sep 7.

Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculté de Pharmacie, Université Libre de Bruxelles-ULB, Campus Plaine-CP 206/4, Boulevard du Triomphe, B-1050 Brussels, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S003194221200332
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http://dx.doi.org/10.1016/j.phytochem.2012.07.010DOI Listing
November 2012

Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2012 Oct 23;56(10):5186-93. Epub 2012 Jul 23.

Tuberculosis and Mycobacteria, Communicable & Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.

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http://aac.asm.org/lookup/doi/10.1128/AAC.05385-11
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http://dx.doi.org/10.1128/AAC.05385-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457413PMC
October 2012

Evolutionary changes in antimicrobial resistance of invasive Neisseria meningitidis isolates in Belgium from 2000 to 2010: increasing prevalence of penicillin nonsusceptibility.

Antimicrob Agents Chemother 2012 May 30;56(5):2268-72. Epub 2012 Jan 30.

National Reference Centre for Neisseria Meningitidis, Bacterial Diseases Division, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium.

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http://aac.asm.org/lookup/doi/10.1128/AAC.06310-11
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http://dx.doi.org/10.1128/AAC.06310-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346653PMC
May 2012

Hypothesis/review: the structural basis of sweetness perception of sweet-tasting plant proteins can be deduced from sequence analysis.

Plant Sci 2011 Oct 23;181(4):347-54. Epub 2011 Jun 23.

Laboratoire de Chimie Générale, Faculté de Pharmacie, Université Libre de Bruxelles, Campus Plaine, boulevard du Triomphe, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.plantsci.2011.06.009DOI Listing
October 2011

Conformations consistent with charge migration observed in DNA and RNA X-ray structures.

J Biomol Struct Dyn 2011 Jun;28(6):949-53

Unite de Boinformatique génomique et structurale, Université Libre de Bruxelles CP165/61, 50 avenue Roosevelt, 1050 Brussels, Belgium.

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http://www.jbsdonline.com/mc_images/category/4310/10-rooman_
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http://www.tandfonline.com/doi/abs/10.1080/07391101101052498
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http://dx.doi.org/10.1080/073911011010524985DOI Listing
June 2011

Structural relationships in the lysozyme superfamily: significant evidence for glycoside hydrolase signature motifs.

PLoS One 2010 Nov 9;5(11):e15388. Epub 2010 Nov 9.

Structural Biology Brussels and Molecular and Cellular Interactions, VIB, Brussels, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015388PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976769PMC
November 2010

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism.

Proc Natl Acad Sci U S A 2010 Oct 20;107(40):17351-5. Epub 2010 Sep 20.

Institut National de la Santé et de la Recherche Médicale, Center for Infection and Immunity of Lille, F-59019 Lille, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1006267107
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http://dx.doi.org/10.1073/pnas.1006267107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951421PMC
October 2010

Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2009 May 23;53(5):2100-9. Epub 2009 Feb 23.

Laboratory of Molecular Pathology of Tuberculosis, Pasteur Institute, Scientific Institute of Public Health, Brussels, Belgium.

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http://dx.doi.org/10.1128/AAC.01197-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681553PMC
May 2009

Purification and characterization of a wound-inducible thaumatin-like protein from the latex of Carica papaya.

Phytochemistry 2009 May 13;70(8):970-8. Epub 2009 Jun 13.

Laboratoire de Chimie Générale (CP: 206/4), Institut de Pharmacie, Université Libre de Bruxelles, Campus de la Plaine, Boulevard du Triomphe, 1050 Brussels, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S003194220900204
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http://dx.doi.org/10.1016/j.phytochem.2009.05.005DOI Listing
May 2009

X-ray structure of papaya chitinase reveals the substrate binding mode of glycosyl hydrolase family 19 chitinases.

Biochemistry 2008 Aug 18;47(32):8283-91. Epub 2008 Jul 18.

Service de Chimie Générale (CP: 206/4), Institut de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1021/bi800655uDOI Listing
August 2008

SODa: an Mn/Fe superoxide dismutase prediction and design server.

BMC Bioinformatics 2008 Jun 2;9:257. Epub 2008 Jun 2.

Unité de Bioinformatique génomique et structurale, Université Libre de Bruxelles, CP 165/61, avenue Roosevelt 50, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1186/1471-2105-9-257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442099PMC
June 2008

Crystallization and preliminary X-ray analysis of a family 19 glycosyl hydrolase from Carica papaya latex.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 May 5;64(Pt 5):371-4. Epub 2008 Apr 5.

Laboratoire de Chimie Générale (CP 206/4), Institut de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, B-1050 Bruxelles, Belgium.

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http://dx.doi.org/10.1107/S1744309108007823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376395PMC
May 2008

Mn/Fe superoxide dismutase interaction fingerprints and prediction of oligomerization and metal cofactor from sequence.

Proteins 2008 Mar;70(4):1564-77

Service de Chimie générale, Institut de Pharmacie, Université Libre de Bruxelles, 1050 Bruxelles, Belgium.

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http://dx.doi.org/10.1002/prot.21650DOI Listing
March 2008

Protonation linked equilibria and apparent affinity constants: the thermodynamic profile of the alpha-chymotrypsin-proflavin interaction.

Eur Biophys J 2007 Dec 19;37(1):11-8. Epub 2007 Apr 19.

Ingénierie Moléculaire et Biomoléculaire, CP 165/64, Université Libre de Bruxelles, 50 av. F.D. Roosevelt, 1050 Bruxelles, Belgium.

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http://dx.doi.org/10.1007/s00249-007-0148-0DOI Listing
December 2007

Structural characterization of the papaya cysteine proteinases at low pH.

Biochem Biophys Res Commun 2006 Mar 13;341(2):620-6. Epub 2006 Jan 13.

Laboratoire de Chimie Générale (CP: 206/4), Institut de Pharmacie, Université Libre de Bruxelles, Campus de la Plaine, Boulevard du Triomphe, B-1050, Bruxelles, Belgique.

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http://dx.doi.org/10.1016/j.bbrc.2005.12.210DOI Listing
March 2006

Crystal structure of papaya glutaminyl cyclase, an archetype for plant and bacterial glutaminyl cyclases.

J Mol Biol 2006 Mar 4;357(2):457-70. Epub 2006 Jan 4.

Laboratoire de Chimie Générale, Institut de Pharmacie-U.L.B. CP 206/04, Boulevard du Triomphe, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1016/j.jmb.2005.12.029DOI Listing
March 2006

Histidine-Aromatic Interactions in Proteins and Protein-Ligand Complexes:  Quantum Chemical Study of X-ray and Model Structures.

J Chem Theory Comput 2005 May;1(3):472-83

Service de Chimie quantique et Photophysique, Université Libre de Bruxelles, CP 160/09, 50 Avenue F.D. Roosevelt, B-1050 Bruxelles, Belgium, Unité de Bioinformatique génomique et structurale, Université Libre de Bruxelles, CP 165/61, 50 Avenue F.D. Roosevelt, Institut de Pharmacie, B-1050 Bruxelles, Belgium, and Service de Chimie générale, Université Libre de Bruxelles, CP 206/04, Bld du Triomphe, B-1050 Bruxelles, Belgium.

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http://dx.doi.org/10.1021/ct049875kDOI Listing
May 2005

Crystallization and preliminary X-ray diffraction studies of the glutaminyl cyclase from Carica papaya latex.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jan 23;61(Pt 1):59-61. Epub 2004 Oct 23.

Laboratoire de Chimie Générale I, Faculté de Médecine-ULB CP609, 808 Route de Lennik, B-1070 Brussels, Belgium.

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http://scripts.iucr.org/cgi-bin/paper?S1744309104025904
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http://dx.doi.org/10.1107/S1744309104025904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952388PMC
January 2005

Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum.

Mol Biochem Parasitol 2004 Sep;137(1):121-32

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, WTB/MSI Complex, DD15EH, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2004.05.005DOI Listing
September 2004

Stair motifs at protein-DNA interfaces: nonadditivity of H-bond, stacking, and cation-pi interactions.

J Am Chem Soc 2004 May;126(20):6220-1

Unité de Bioinformatique génomique et structurale, Université Libre de Bruxelles, CP 165/61, 50 avenue Roosevelt, B-1050 Bruxelles, Belgium.

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http://dx.doi.org/10.1021/ja049620gDOI Listing
May 2004

Specificity and phenetic relationships of iron- and manganese-containing superoxide dismutases on the basis of structure and sequence comparisons.

J Biol Chem 2004 Mar 12;279(10):9248-54. Epub 2003 Dec 12.

Université Libre de Bruxelles, Institut de Pharmacie, Chimie Générale, CP 206/04, Campus de la Plaine, Boulevard du Triomphe, B-1050 Bruxelles, Belgium.

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http://dx.doi.org/10.1074/jbc.M312329200DOI Listing
March 2004

Detection of three wound-induced proteins in papaya latex.

Phytochemistry 2004 Mar;65(5):525-34

Laboratoire de Chimie Générale I, Faculty of Medicine, University of Brussels, Campus Erasme (CP 609), 808 Route de Lennik, B-1070 Brussels, Belgium.

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http://dx.doi.org/10.1016/j.phytochem.2003.12.006DOI Listing
March 2004

Evidence that thermodynamic stability of papaya glutamine cyclase is only marginal.

Biopolymers 2002 Dec;65(5):325-35

Protein Chemistry Department (CP 609), Faculty of Medicine, Free University of Brussels, Campus Erasme, 808 Route de Lennik, Belgium.

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http://dx.doi.org/10.1002/bip.10234DOI Listing
December 2002

Probing the energetic and structural role of amino acid/nucleobase cation-pi interactions in protein-ligand complexes.

J Biol Chem 2002 Oct 6;277(43):40816-22. Epub 2002 Aug 6.

Ingénierie Biomoléculaire, Université Libre de Bruxelles, CP 165/64, 50 Avenue F.D. Roosevelt, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1074/jbc.M205719200DOI Listing
October 2002

Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana.

J Mol Biol 2002 Jul;320(2):321-32

UMR 8525 CNRS-Lille2, Institut de Biologie de Lille/Pasteur Institute of Lille, 59019 Lille Cedex, France.

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http://dx.doi.org/10.1016/S0022-2836(02)00429-1DOI Listing
July 2002

Cation-pi/H-bond stair motifs at protein-DNA interfaces.

J Mol Biol 2002 May;319(1):67-76

Ingénierie Biomoléculaire - CP 165/64, Université Libre de Bruxelles, 50 avenue Roosevelt, B-1050 Bruxelles, Belgium.

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http://dx.doi.org/10.1016/s0022-2836(02)00263-2DOI Listing
May 2002

Biochemical and electron paramagnetic resonance study of the iron superoxide dismutase from Plasmodium falciparum.

Mol Biochem Parasitol 2002 Apr;120(2):237-46

Laboratory of Parasitic Diseases, Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.

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http://dx.doi.org/10.1016/s0166-6851(02)00004-xDOI Listing
April 2002