Publications by authors named "Rene Leen"

20Publications

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in .

N Engl J Med 2019 04;380(15):1433-1441

From Amsterdam University Medical Centers, University of Amsterdam, Departments of Clinical Chemistry, Pediatrics, and Clinical Genetics, Emma Children's Hospital, Amsterdam Gastroenterology and Metabolism (A.B.P.K., R.L., J.K., J. Meijer, L.A.T., M.T., M.W., R.J.A.W., H.R.W., C.D.M.K.), and United for Metabolic Diseases (A.B.P.K., R.J.A.W., H.R.W., C.D.M.K.), Amsterdam, and the Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht (J.J.F.A.V., J.H.V.), and the Project MinE ALS Sequencing Consortium (J.J.F.A.V., J.H.V.), Utrecht - all in the Netherlands; the Departments of Biochemistry and Molecular Biology and Medical Genetics, Cumming School of Medicine, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary (M.T.-G.), Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute (P.A.R., M.J.J., M.S.K., J. MacIsaac, W.W.W., C.D.M.K.), the Faculty of Pharmaceutical Sciences (B.I.D., G.E.B.W., C.J.R.), and the Departments of Medical Genetics (C.M., I.-S.R.-B., W.W.W.) and Pediatrics (C.D.M.K.), University of British Columbia, Vancouver, the Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital and University of Toronto (K.B.-A., F.K., M.L., Y.W., X.-Y.W.), the Centre for Applied Genomics, Genetics and Genome Biology, the Hospital for Sick Children (C.N., S.W.S., B.T., R.K.C.Y.), and the Department of Molecular Genetics (C.N., S.W.S., R.K.C.Y.), the McLaughlin Centre (S.W.S.), and the Departments of Medicine, Physiology, and Laboratory Medicine and Pathobiology, Institute of Medical Science (X.-Y.W.), University of Toronto, Toronto, and the Division of Medical Genetics, Department of Pediatrics, Children's Hospital Eastern Ontario, University of Ottawa, Ottawa (J.S.W., M.T.G.) - all in Canada; the Departments of Medicine and Physiology, National University of Singapore (M.A.P.), and the Translational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research (M.A.P., B.S., X.X., J.Z.) - both in Singapore; Uppsala University, Department of Chemistry-Biomedical Center, Uppsala, Sweden (D.D.); Illumina, San Diego, CA (E.D., M.A.E.); Gene Structure and Disease Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (B.H., D.K., K.U.); and the Department of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom (S.S.).

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http://dx.doi.org/10.1056/NEJMoa1806627DOI Listing
April 2019

Hypothermic perfusion with retrograde outflow during right hepatectomy is safe and feasible.

Surgery 2017 07 24;162(1):48-58. Epub 2017 Mar 24.

Department of Surgery, Surgical Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2017.01.024DOI Listing
July 2017

Creatine kinase inhibition lowers systemic arterial blood pressure in spontaneously hypertensive rats: a randomized controlled trial.

J Hypertens 2016 12;34(12):2418-2426

aDepartment of Vascular Medicine bLaboratory for Genetic and Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam cDepartment of Vascular Medicine and Pharmacology, Erasmus Medical Center, Rotterdam dDepartment of Obstetrics and Gynaecology and Reproductive Biology Laboratory eDepartment of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands fThe Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1097/HJH.0000000000001090DOI Listing
December 2016

Synergistic interaction between cisplatin and gemcitabine in neuroblastoma cell lines and multicellular tumor spheroids.

Cancer Lett 2012 Jun 17;319(1):23-30. Epub 2011 Dec 17.

Academic Medical Center, University of Amsterdam, Laboratory Genetic Metabolic Diseases, PO Box 22700, 1100 DE Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835110076
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http://dx.doi.org/10.1016/j.canlet.2011.12.016DOI Listing
June 2012

Promising effects of the 4HPR-BSO combination in neuroblastoma monolayers and spheroids.

Free Radic Biol Med 2011 Sep 23;51(6):1213-20. Epub 2011 Jun 23.

Laboratory of Genetic Metabolic Diseases and Department of Pediatrics/Emma Children's Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.06.019DOI Listing
September 2011

Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma.

Cell Mol Life Sci 2010 Mar 26;67(5):807-16. Epub 2009 Nov 26.

Laboratory Genetic Metabolic Diseases, Department of Pediatrics/Emma Children's Hospital, Academic Medical Centre, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s00018-009-0212-2
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http://dx.doi.org/10.1007/s00018-009-0212-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824117PMC
March 2010

Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour models.

Int J Oncol 2009 Mar;34(3):813-9

Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology, Academic Medical Centre-University of Amsterdam, 1100 DE Amsterdam, The Netherlands.

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http://dx.doi.org/10.3892/ijo_00000207DOI Listing
March 2009

Quantitative analysis of the experimental cytotoxic drug cyclopentenyl cytosine and its metabolite in plasma with HPLC tandem mass spectrometry.

Biomed Chromatogr 2008 Dec;22(12):1368-73

Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/bmc.1067DOI Listing
December 2008

Pleiotropic effects of fenretinide in neuroblastoma cell lines and multicellular tumor spheroids.

Int J Oncol 2008 May;32(5):1011-9

Laboratory Genetic Metabolic Diseases and Department of Pediatrics/Emma Children's Hospital, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands.

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May 2008

Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity.

Biochem J 2006 Jan;393(Pt 2):537-43

Department of Clinical Chemistry, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1042/BJ20050893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360704PMC
January 2006

Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma.

Cancer Chemother Pharmacol 2006 Jan 5;57(1):105-13. Epub 2005 Nov 5.

Academic Medical Center, Department of Clinical Chemistry and Emma Children's Hospital, University of Amsterdam, 1100 Amsterdam, DE, The Netherlands.

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http://link.springer.com/10.1007/s00280-005-0005-8
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http://dx.doi.org/10.1007/s00280-005-0005-8DOI Listing
January 2006

Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells.

Cancer Lett 2006 Feb;233(2):240-6

Laboratory Genetic Metabolic Diseases, Department of Paediatrics/Emma Children's Hospital and Clinical Chemistry, Academic Medical Centre, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.canlet.2005.03.016DOI Listing
February 2006

Absence of cardiotoxicity of the experimental cytotoxic drug cyclopentenyl cytosine (CPEC) in rats.

Arch Toxicol 2005 May 2;79(5):268-76. Epub 2005 Feb 2.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Albinusdreef 2, Postbox 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-004-0633-5DOI Listing
May 2005

Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicity.

Int J Cancer 2003 Jan;103(3):387-92

Department of Clinical Chemistry, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/ijc.10858DOI Listing
January 2003

Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.

FEBS Lett 2002 Sep;527(1-3):229-33

Academic Medical Center, University of Amsterdam, Department of Clinical Chemistry and Emma Children's Hospital, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s0014-5793(02)03234-9DOI Listing
September 2002

Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line.

Int J Cancer 2002 Apr;98(4):616-23

Laboratory of Genetic Metabolic Diseases, Division of Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Emma Kinderziekenhuis AMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.10211DOI Listing
April 2002