Publications by authors named "Rene J M Bindels"

100Publications

Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney.

Acta Physiol (Oxf) 2020 Jun 30:e13528. Epub 2020 Jun 30.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1111/apha.13528DOI Listing
June 2020

Novel Aspects of Extracellular Vesicles in the Regulation of Renal Physiological and Pathophysiological Processes.

Front Cell Dev Biol 2020 15;8:244. Epub 2020 Apr 15.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.3389/fcell.2020.00244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174565PMC
April 2020

Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease.

FASEB J 2020 May 11;34(5):6382-6398. Epub 2020 Mar 11.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1096/fj.201902901RDOI Listing
May 2020

Sensing of tubular flow and renal electrolyte transport.

Nat Rev Nephrol 2020 06 3;16(6):337-351. Epub 2020 Mar 3.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41581-020-0259-8DOI Listing
June 2020

Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI-induced hypomagnesemia.

FASEB J 2019 10 12;33(10):11235-11246. Epub 2019 Jul 12.

Department of Physiology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center (RADBOUDUMC), Nijmegen, The Netherlands.

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http://dx.doi.org/10.1096/fj.201900839RDOI Listing
October 2019

Learning Physiology From Inherited Kidney Disorders.

Physiol Rev 2019 07;99(3):1575-1653

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands ; Institute of Physiology, University of Zurich , Zurich , Switzerland ; and Division of Nephrology, Institute of Experimental and Clinical Research (IREC), Medical School, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1152/physrev.00008.2018DOI Listing
July 2019

Renal phospholipidosis and impaired magnesium handling in high-fat-diet-fed mice.

FASEB J 2019 06 8;33(6):7192-7201. Epub 2019 Mar 8.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1096/fj.201801778RRDOI Listing
June 2019

Effect of Dapagliflozin Treatment on the Expression of Renal Sodium Transporters/Channels on High-Fat Diet Diabetic Mice.

Nephron 2019 22;142(1):51-60. Epub 2019 Feb 22.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1159/000496617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530118PMC
December 2019

Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice.

Sci Rep 2019 02 11;9(1):1770. Epub 2019 Feb 11.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-38351-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370757PMC
February 2019

Tubular flow activates magnesium transport in the distal convoluted tubule.

FASEB J 2019 04 31;33(4):5034-5044. Epub 2018 Dec 31.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; and.

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https://www.fasebj.org/doi/10.1096/fj.201802094R
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http://dx.doi.org/10.1096/fj.201802094RDOI Listing
April 2019

SLC41A1 is essential for magnesium homeostasis in vivo.

Pflugers Arch 2019 06 12;471(6):845-860. Epub 2018 Nov 12.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00424-018-2234-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533229PMC
June 2019

Magnesium deficiency prevents high-fat-diet-induced obesity in mice.

Diabetologia 2018 09 9;61(9):2030-2042. Epub 2018 Jul 9.

Department of Physiology (286), Radboud Institute for Molecular Life Sciences, Radboud university medical center, P. O. Box 9101, 6500 HB, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1007/s00125-018-4680-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096631PMC
September 2018

Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.

Am J Physiol Renal Physiol 2018 09 16;315(3):F537-F546. Epub 2018 May 16.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00622.2017DOI Listing
September 2018

Transcription factor HNF1β regulates expression of the calcium-sensing receptor in the thick ascending limb of the kidney.

Am J Physiol Renal Physiol 2018 07 21;315(1):F27-F35. Epub 2018 Mar 21.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00601.2017DOI Listing
July 2018

Dominant functional role of the novel phosphorylation site S811 in the human renal NaCl cotransporter.

FASEB J 2018 08 16;32(8):4482-4493. Epub 2018 Mar 16.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1096/fj.201701047RDOI Listing
August 2018

Primary cilia-regulated transcriptome in the renal collecting duct.

FASEB J 2018 07 8;32(7):3653-3668. Epub 2018 Feb 8.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1096/fj.201701228RDOI Listing
July 2018

The rise and fall of novel renal magnesium transporters.

Am J Physiol Renal Physiol 2018 06 7;314(6):F1027-F1033. Epub 2018 Feb 7.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00634.2017DOI Listing
June 2018

Effects of a high-sodium/low-potassium diet on renal calcium, magnesium, and phosphate handling.

Am J Physiol Renal Physiol 2018 07 10;315(1):F110-F122. Epub 2018 Jan 10.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00379.2017DOI Listing
July 2018

Renal physiology: TRPC5 inhibition to treat progressive kidney disease.

Nat Rev Nephrol 2018 03 22;14(3):145-146. Epub 2018 Jan 22.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.1038/nrneph.2018.4DOI Listing
March 2018

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease.

Kidney Int 2017 11 31;92(5):1145-1156. Epub 2017 May 31.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903269PMC
November 2017

Hydrochlorothiazide treatment increases the abundance of the NaCl cotransporter in urinary extracellular vesicles of essential hypertensive patients.

Am J Physiol Renal Physiol 2017 06 8;312(6):F1063-F1072. Epub 2017 Mar 8.

Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1152/ajprenal.00644.2016DOI Listing
June 2017

Differential regulation of the Na-Ca exchanger 3 (NCX3) by protein kinase PKC and PKA.

Cell Calcium 2017 07 16;65:52-62. Epub 2017 Feb 16.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, The Netherlands; Centre for System Biology and Bioenergetics, Radboud University Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2017.02.005DOI Listing
July 2017

Fluid shear stress increases transepithelial transport of Ca in ciliated distal convoluted and connecting tubule cells.

FASEB J 2017 05 18;31(5):1796-1806. Epub 2017 Jan 18.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1096/fj.201600687RRRDOI Listing
May 2017

Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia: a case-control study.

Pharmacogenet Genomics 2017 03;27(3):83-88

Departments of aPhysiology bGastroenterology and Hepatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen cDepartment of Gastroenterology, Bernhoven Hospital, Uden dDepartment of Gastroenterology, Canisius-Wilhelmina-Hospital, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1097/FPC.0000000000000259DOI Listing
March 2017

Determinants of hypomagnesemia in patients with type 2 diabetes mellitus.

Eur J Endocrinol 2017 Jan 5;176(1):11-19. Epub 2016 Oct 5.

Departments of Physiology

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http://dx.doi.org/10.1530/EJE-16-0517DOI Listing
January 2017

Functionomics of NCC mutations in Gitelman syndrome using a novel mammalian cell-based activity assay.

Am J Physiol Renal Physiol 2016 12 31;311(6):F1159-F1167. Epub 2016 Aug 31.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00124.2016DOI Listing
December 2016

Identification of SLC41A3 as a novel player in magnesium homeostasis.

Sci Rep 2016 06 28;6:28565. Epub 2016 Jun 28.

Department of Physiology Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/srep28565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923877PMC
June 2016

P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis.

PLoS One 2016 2;11(6):e0156803. Epub 2016 Jun 2.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156803PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890750PMC
July 2017

Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?

PLoS One 2016 21;11(4):e0153483. Epub 2016 Apr 21.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153483PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839660PMC
February 2017

Urinary β-galactosidase stimulates Ca2+ transport by stabilizing TRPV5 at the plasma membrane.

Glycobiology 2016 May 7;26(5):472-81. Epub 2016 Jan 7.

Department of Physiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen 6500 HB, The Netherlands

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http://dx.doi.org/10.1093/glycob/cwv172DOI Listing
May 2016

Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?

Diabetes 2016 Jan;65(1):3-13

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K.

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http://diabetes.diabetesjournals.org/content/65/1/3.full.pdf
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-1028DOI Listing
January 2016

Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling.

Am J Physiol Renal Physiol 2016 Feb 11;310(3):F204-16. Epub 2015 Nov 11.

Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1152/ajprenal.00429.2015DOI Listing
February 2016

Calpain-3-mediated regulation of the Na⁺-Ca²⁺ exchanger isoform 3.

Pflugers Arch 2016 Feb 27;468(2):243-55. Epub 2015 Oct 27.

From the Department of Physiology, Centre for System Biology and Bioenergetics, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00424-015-1747-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713461PMC
February 2016

The Na+/Ca2+ Exchanger 1 (NCX1) Variant 3 as the Major Extrusion System in Renal Distal Tubular Transcellular Ca2+-Transport.

Nephron 2015 30;131(2):145-52. Epub 2015 Sep 30.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1159/000440655DOI Listing
July 2016

Dietary Inulin Fibers Prevent Proton-Pump Inhibitor (PPI)-Induced Hypocalcemia in Mice.

PLoS One 2015 23;10(9):e0138881. Epub 2015 Sep 23.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138881PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580428PMC
May 2016

Shedding of klotho by ADAMs in the kidney.

Am J Physiol Renal Physiol 2015 Aug 8;309(4):F359-68. Epub 2015 Jul 8.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1152/ajprenal.00240.2014DOI Listing
August 2015

The impact of formative testing on study behaviour and study performance of (bio)medical students: a smartphone application intervention study.

BMC Med Educ 2015 Apr 10;15:72. Epub 2015 Apr 10.

Department of Physiology, Radboud university medical center, Radboud Institute for Health Sciences, PO box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-
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http://dx.doi.org/10.1186/s12909-015-0351-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404663PMC
April 2015

Towards Understanding the Role of the Na²⁺-Ca²⁺ Exchanger Isoform 3.

Rev Physiol Biochem Pharmacol 2015 ;168:31-57

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/112_2015_23DOI Listing
January 2016

Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity.

PLoS One 2015 16;10(3):e0119028. Epub 2015 Mar 16.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119028PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361557PMC
January 2016

Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia.

Nephrol Dial Transplant 2015 Jun 11;30(6):952-7. Epub 2015 Mar 11.

Department of Medical Genetics, University Medical Centre Utrecht, Utrecht 3508 AB, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfv014DOI Listing
June 2015

Magnesium in man: implications for health and disease.

Physiol Rev 2015 Jan;95(1):1-46

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://www.physiology.org/doi/10.1152/physrev.00012.2014
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http://dx.doi.org/10.1152/physrev.00012.2014DOI Listing
January 2015

Segmental transport of Ca²⁺ and Mg²⁺ along the gastrointestinal tract.

Am J Physiol Gastrointest Liver Physiol 2015 Feb 4;308(3):G206-16. Epub 2014 Dec 4.

Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://www.physiology.org/doi/10.1152/ajpgi.00093.2014
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http://dx.doi.org/10.1152/ajpgi.00093.2014DOI Listing
February 2015

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

Bone 2015 Mar 18;72:14-22. Epub 2014 Nov 18.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.11.004DOI Listing
March 2015

Mg2+ homeostasis: the balancing act of TRPM6.

Curr Opin Nephrol Hypertens 2014 Jul;23(4):361-9

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/01.mnh.0000447023.59346.abDOI Listing
July 2014

β1-Adrenergic receptor signaling activates the epithelial calcium channel, transient receptor potential vanilloid type 5 (TRPV5), via the protein kinase A pathway.

J Biol Chem 2014 Jun 14;289(26):18489-96. Epub 2014 May 14.

From the Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands

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http://dx.doi.org/10.1074/jbc.M113.491274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140292PMC
June 2014

A novel KCNA1 mutation causing episodic ataxia type I.

Muscle Nerve 2014 Aug 14;50(2):289-91. Epub 2014 Jul 14.

Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/mus.24242DOI Listing
August 2014

Coordinated regulation of TRPV5-mediated Ca²⁺ transport in primary distal convolution cultures.

Pflugers Arch 2014 Nov 21;466(11):2077-87. Epub 2014 Feb 21.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00424-014-1470-xDOI Listing
November 2014

P2X4 receptor regulation of transient receptor potential melastatin type 6 (TRPM6) Mg2+ channels.

Pflugers Arch 2014 Oct 12;466(10):1941-52. Epub 2014 Jan 12.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00424-014-1440-3DOI Listing
October 2014

Sodium-dependent transporters in health and disease--a special issue.

Pflugers Arch 2014 Jan 13;466(1):1-2. Epub 2013 Dec 13.

Department of Physiology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1007/s00424-013-1416-8DOI Listing
January 2014

A molecular update on pseudohypoaldosteronism type II.

Am J Physiol Renal Physiol 2013 Dec 9;305(11):F1513-20. Epub 2013 Oct 9.

286, Dept. of Physiology, Radboud Univ. Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00440.2013DOI Listing
December 2013

Elucidation of the distal convoluted tubule transcriptome identifies new candidate genes involved in renal Mg(2+) handling.

Am J Physiol Renal Physiol 2013 Dec 2;305(11):F1563-73. Epub 2013 Oct 2.

Dept. of Physiology (286 Radboud Univ. Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, PO Box 9101, Nijmegen 6500 HB, The Netherlands.

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http://www.physiology.org/doi/10.1152/ajprenal.00322.2013
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http://dx.doi.org/10.1152/ajprenal.00322.2013DOI Listing
December 2013

Early development of hyperparathyroidism due to loss of PTH transcriptional repression in patients with HNF1β mutations?

J Clin Endocrinol Metab 2013 Oct 26;98(10):4089-96. Epub 2013 Aug 26.

MD, PhD, Radboud University Nijmegen Medical Centre, Department of Nephrology 464, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

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http://dx.doi.org/10.1210/jc.2012-3453DOI Listing
October 2013

Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling.

Kidney Int 2014 Jan 31;85(1):94-102. Epub 2013 Jul 31.

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538155614
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http://dx.doi.org/10.1038/ki.2013.280DOI Listing
January 2014

Structural analysis of calmodulin binding to ion channels demonstrates the role of its plasticity in regulation.

Pflugers Arch 2013 Nov 23;465(11):1507-19. Epub 2013 Apr 23.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 26-28, Nijmegen, 6525, GA, The Netherlands.

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http://dx.doi.org/10.1007/s00424-013-1278-0DOI Listing
November 2013

Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.

Am J Pathol 2013 Apr 4;182(4):1196-204. Epub 2013 Feb 4.

Department of Nephrology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ajpath.2012.12.011DOI Listing
April 2013

Evaluation of hypomagnesemia: lessons from disorders of tubular transport.

Am J Kidney Dis 2013 Aug 30;62(2):377-83. Epub 2012 Nov 30.

Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S02726386120134
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http://dx.doi.org/10.1053/j.ajkd.2012.07.033DOI Listing
August 2013

Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice.

Nephrol Dial Transplant 2013 Apr 7;28(4):879-89. Epub 2012 Nov 7.

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://ndt.oxfordjournals.org/content/early/2012/11/07/ndt.g
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http://ndt.oxfordjournals.org/cgi/doi/10.1093/ndt/gfs499
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http://dx.doi.org/10.1093/ndt/gfs499DOI Listing
April 2013

Urinary plasmin inhibits TRPV5 in nephrotic-range proteinuria.

J Am Soc Nephrol 2012 Nov 27;23(11):1824-34. Epub 2012 Sep 27.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2011111126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482726PMC
November 2012

Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption.

Am J Physiol Gastrointest Liver Physiol 2012 Oct 9;303(7):G879-85. Epub 2012 Aug 9.

Department of Physiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://ajpgi.physiology.org/cgi/doi/10.1152/ajpgi.00089.2012
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http://dx.doi.org/10.1152/ajpgi.00089.2012DOI Listing
October 2012

A primary culture of distal convoluted tubules expressing functional thiazide-sensitive NaCl transport.

Am J Physiol Renal Physiol 2012 Sep 3;303(6):F886-92. Epub 2012 Jul 3.

Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00114.2012DOI Listing
September 2012

Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis.

Kidney Int 2012 Dec 23;82(11):1157-66. Epub 2012 May 23.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ki.2012.179DOI Listing
December 2012

Membrane topology and intracellular processing of cyclin M2 (CNNM2).

J Biol Chem 2012 Apr 7;287(17):13644-55. Epub 2012 Mar 7.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M112.342204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340180PMC
April 2012

Regulation of magnesium balance: lessons learned from human genetic disease.

Clin Kidney J 2012 Feb;5(Suppl 1):i15-i24

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/ndtplus/sfr164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455826PMC
February 2012

Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia.

Magnes Res 2011 Sep;24(3):S101-8

Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1684/mrh.2011.0289DOI Listing
September 2011

Role of the transient receptor potential vanilloid 5 (TRPV5) protein N terminus in channel activity, tetramerization, and trafficking.

J Biol Chem 2011 Sep 27;286(37):32132-9. Epub 2011 Jul 27.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M111.226878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173154PMC
September 2011

Role of the calcium-sensing receptor in reducing the risk for calcium stones.

Clin J Am Soc Nephrol 2011 Aug 22;6(8):2076-82. Epub 2011 Jul 22.

Department of Physiology (286), Radboud University Nijmegen Medical Centre (RUNMC), P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.2215/CJN.00480111DOI Listing
August 2011

Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone.

Mol Cell Biol 2011 Jul 16;31(14):2845-53. Epub 2011 May 16.

Nijmegen Center for Molecular Life Sciences, 286 Physiology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, Netherlands.

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http://dx.doi.org/10.1128/MCB.01319-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133394PMC
July 2011

Insight into renal Mg2+ transporters.

Curr Opin Nephrol Hypertens 2011 Mar;20(2):169-76

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/MNH.0b013e3283435ee4DOI Listing
March 2011

γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter.

J Am Soc Nephrol 2011 Mar 16;22(3):508-17. Epub 2010 Dec 16.

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2010060606
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060444PMC
March 2011

HNF-1B specifically regulates the transcription of the γa-subunit of the Na+/K+-ATPase.

Biochem Biophys Res Commun 2011 Jan 2;404(1):284-90. Epub 2010 Dec 2.

Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X100218
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http://dx.doi.org/10.1016/j.bbrc.2010.11.108DOI Listing
January 2011

Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family.

J Physiol 2011 Apr 1;589(Pt 7):1535-42. Epub 2010 Nov 1.

Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, the Netherlands.

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http://dx.doi.org/10.1113/jphysiol.2010.199869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099013PMC
April 2011

A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation.

Cell Calcium 2010 Nov 29;48(5):275-87. Epub 2010 Oct 29.

Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1016/j.ceca.2010.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780571PMC
November 2010

Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.

Nephron Physiol 2011 1;117(2):p11-9. Epub 2010 Sep 1.

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1159/000320580DOI Listing
May 2011

The identification of Histidine 712 as a critical residue for constitutive TRPV5 internalization.

J Biol Chem 2010 Sep 13;285(37):28481-7. Epub 2010 Jul 13.

Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M110.117143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937873PMC
September 2010

2009 Homer W. Smith Award: Minerals in motion: from new ion transporters to new concepts.

J Am Soc Nephrol 2010 Aug 1;21(8):1263-9. Epub 2010 Jul 1.

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2010010001DOI Listing
August 2010

Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress.

J Biol Chem 2010 Aug 28;285(34):26081-7. Epub 2010 Jun 28.

Department of Physiology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M110.103655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924009PMC
August 2010

Involvement of claudin 3 and claudin 4 in idiopathic infantile hypercalcaemia: a novel hypothesis?

Nephrol Dial Transplant 2010 Nov 20;25(11):3504-9. Epub 2010 Apr 20.

Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfq221DOI Listing
November 2010

Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins.

Kidney Int 2010 Apr 20;77(7):601-8. Epub 2010 Jan 20.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ki.2009.522DOI Listing
April 2010

Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5.

Nephrol Dial Transplant 2010 May 4;25(5):1428-35. Epub 2009 Dec 4.

1Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfp645DOI Listing
May 2010

Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia.

J Biol Chem 2010 Jan 10;285(1):171-8. Epub 2009 Nov 10.

Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M109.041517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804162PMC
January 2010

New molecular players facilitating Mg(2+) reabsorption in the distal convoluted tubule.

Kidney Int 2010 Jan;77(1):17-22

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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January 2010