Rene Houtman

Rene Houtman

UNVERIFIED PROFILE

Are you Rene Houtman?   Register this Author

Register author
Rene Houtman

Rene Houtman

Publications by authors named "Rene Houtman"

Are you Rene Houtman?   Register this Author

45Publications

1246Reads

20Profile Views

Cholestenoic acid analogues as inverse agonists of the liver X receptors.

J Steroid Biochem Mol Biol 2020 Jan 10;199:105585. Epub 2020 Jan 10.

Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, UMYMFOR, Buenos Aires, Argentina. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2020.105585DOI Listing
January 2020

Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation.

Neuroendocrinology 2019 19;109(3):266-276. Epub 2019 Mar 19.

Division of Endocrinology, Department Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878852PMC
March 2019

Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.

Mol Metab 2019 02 16;20:115-127. Epub 2018 Dec 16.

Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358588PMC
February 2019

The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.

Immunity 2018 10;49(4):615-626.e6

Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, Florida, USA; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; MTA-DE "Lendulet" Immunogenomics Research Group, University of Debrecen, Debrecen, Hungary. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197058PMC
October 2018

Profiling of 3696 Nuclear Receptor-Coregulator Interactions: A Resource for Biological and Clinical Discovery.

Endocrinology 2018 06;159(6):2397-2407

Molecular Cancer Research and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, CG Utrecht, Netherlands.

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/article/159/6/2397/4989896
Publisher Site
http://dx.doi.org/10.1210/en.2018-00149DOI Listing
June 2018

Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone's Antifibrotic Activity.

Hypertension 2018 04 5;71(4):599-608. Epub 2018 Feb 5.

From the Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Germany (J.G., P.S.); Institute of Pharmacology, Center for Cardiovascular Research, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (J.G., N.B., E.S., R.C., A.B., Z.B., S.B., I.R.B., M.S., A.F.-L., U.K.); DZHK (German Centre for Cardiovascular Research), partner site Berlin (J.G., N.B., E.S., A.B., S.B., I.R.B., A.F.-L., U.K.); Department of Veterinary Pathology, Freie Universität Berlin, Germany (R.K.); Pamgene International B.V., s-Hertogenbosch, The Netherlands (R.H.); and Cardiology Research, Bayer AG, Wuppertal, Germany (P.K.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10360DOI Listing
April 2018

The effects of all-trans retinoic acid on estrogen receptor signaling in the estrogen-sensitive MCF/BUS subline.

J Recept Signal Transduct Res 2018 Apr 15;38(2):112-121. Epub 2018 Feb 15.

a Division of Toxicology , Wageningen University , Wageningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10799893.2018.1436559DOI Listing
April 2018

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.

Cancer Cell 2018 02;33(2):173-186.e5

Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA 02210, USA; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02210, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02210, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813700PMC
February 2018

Differential Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand-ERα Complexes.

Environ Health Perspect 2018 01 31;126(1):017012. Epub 2018 Jan 31.

Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

View Article

Download full-text PDF

Source
https://ehp.niehs.nih.gov/doi/10.1289/EHP2505
Publisher Site
http://dx.doi.org/10.1289/EHP2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014695PMC
January 2018

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies.

Oncotarget 2017 Dec 30;8(65):109675-109691. Epub 2017 Nov 30.

Receptor Research Laboratories, Nuclear Receptor Lab (NRL) and Cytokine Receptor Lab (CRL), VIB-UGent Center for Medical Biotechnology, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.22764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752551PMC
December 2017

Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites.

Toxicol In Vitro 2017 Oct 24;44:287-302. Epub 2017 Jul 24.

Biomolecular Screening Branch, DNTP, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2017.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572750PMC
October 2017

Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action.

Biochim Biophys Acta Proteins Proteom 2017 Sep 20;1865(9):1195-1206. Epub 2017 Jun 20.

Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2017.06.011DOI Listing
September 2017

Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.

Toxicol Appl Pharmacol 2016 12 20;313:138-148. Epub 2016 Oct 20.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2016.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124510PMC
December 2016

Co-activator candidate interactions for orphan nuclear receptor NR2E1.

BMC Genomics 2016 10 26;17(1):832. Epub 2016 Oct 26.

Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-016-3173-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080790PMC
October 2016

The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide.

Mol Cancer Ther 2016 07 16;15(7):1702-12. Epub 2016 May 16.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-15-0892DOI Listing
July 2016

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.

Cancer Cell 2016 06 26;29(6):846-858. Epub 2016 May 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124371PMC
June 2016

Destabilization of the torsioned conformation of a ligand side chain inverts the LXRβ activity.

Biochim Biophys Acta 2015 Dec 3;1851(12):1577-86. Epub 2015 Oct 3.

Dpto. Química Orgánica and UMYMFOR (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2015.09.007DOI Listing
December 2015

A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain.

Endocrinology 2015 Nov 25;156(11):4105-14. Epub 2015 Aug 25.

Department of Cognitive Neuroscience (E.A., L.T.C.M.v.W., B.R.) Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EZ Nijmegen, The Netherlands; Department of Internal Medicine (I.Z., J.K.v.d.H., L.T.C.M.v.W., I.M.M., O.C.M.), Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and Leiden Institute for Brain and Cognition, Leiden University Medical Center, 2300 RA Leiden, The Netherlands; PamGene International (D.M., R.H.), 2511 HH Den Bosch, The Netherlands; and Corcept Therapeutics (J.K.B., H.H.), Menlo Park, California 94025.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2015-1390DOI Listing
November 2015

The effect of glucuronidation on isoflavone induced estrogen receptor (ER)α and ERβ mediated coregulator interactions.

J Steroid Biochem Mol Biol 2015 Nov 7;154:245-53. Epub 2015 Sep 7.

Division of Toxicology, Wageningen University, Postbus 8000, Bode 92, 6700EA Wageningen, the Netherlands.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09600760153006
Publisher Site
http://dx.doi.org/10.1016/j.jsbmb.2015.09.002DOI Listing
November 2015

Cofactor profiling of the glucocorticoid receptor from a cellular environment.

Methods Mol Biol 2014 ;1204:83-94

Cytokine Receptor Lab, VIB Department of Medical Protein Research, Department of Biochemistry, University of Ghent, Albert Baertsoenkaai 3, 9000, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-1346-6_8DOI Listing
May 2015

Cell proliferation and modulation of interaction of estrogen receptors with coregulators induced by ERα and ERβ agonists.

J Steroid Biochem Mol Biol 2014 Sep 9;143:376-85. Epub 2014 Jun 9.

Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2014.06.002DOI Listing
September 2014

Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.

Toxicol Sci 2014 Sep 13;141(1):78-89. Epub 2014 Jun 13.

Business Unit of Toxicology & Bioassays, RIKILT - Institute of Food Safety, Wageningen University and Research Centre, Akkermaalsbos 2, 6708 WB Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfu103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833097PMC
September 2014

Identification of coregulators influenced by estrogen receptor subtype specific binding of the ER antagonists 4-hydroxytamoxifen and fulvestrant.

Chem Biol Interact 2014 Sep 8;220:222-30. Epub 2014 Jul 8.

Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2014.06.019DOI Listing
September 2014

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.

Proc Natl Acad Sci U S A 2013 May 23;110(19):7910-5. Epub 2013 Apr 23.

Department of Endocrinology and Metabolism and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1219411110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651427PMC
May 2013

Robust array-based coregulator binding assay predicting ERα-agonist potency and generating binding profiles reflecting ligand structure.

Chem Res Toxicol 2013 Mar 6;26(3):336-46. Epub 2013 Mar 6.

Business Unit of Toxicology & Bioassays, RIKILT - Institute of Food Safety, Wageningen University and Research Centre , Akkermaalsbos 2, Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx300463bDOI Listing
March 2013

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

Mol Cell Proteomics 2009 Oct 10;8(10):2212-26. Epub 2009 Jul 10.

Department of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://www.mcponline.org/lookup/doi/10.1074/mcp.M900209-MCP2
Publisher Site
http://dx.doi.org/10.1074/mcp.M900209-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758751PMC
October 2009

Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach.

Toxicol Sci 2007 Sep 8;99(1):303-14. Epub 2007 Jun 8.

RIKILT - Institute of Food Safety, Wageningen UR, 6700 AE Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
Publisher Site
http://dx.doi.org/10.1093/toxsci/kfm151DOI Listing
September 2007

Asthma, the ugly duckling of lung disease proteomics?

J Chromatogr B Analyt Technol Biomed Life Sci 2005 Feb;815(1-2):285-94

Department of Pharmaceutical Proteomics, Faculty of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S157002320400717
Publisher Site
http://dx.doi.org/10.1016/j.jchromb.2004.08.049DOI Listing
February 2005

Lung proteome alterations in a mouse model for nonallergic asthma.

Proteomics 2003 Oct;3(10):2008-18

Department of Pharmaceutical Proteomics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200300469DOI Listing
October 2003