René E M Toes

René E M Toes

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René E M Toes

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Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.

Arthritis Rheumatol 2019 02 4;71(2):210-221. Epub 2019 Jan 4.

Karolinska Institutet, Stockholm, Sweden, and Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1002/art.40698DOI Listing
February 2019

Secretory form of rheumatoid arthritis-associated autoantibodies in serum are mainly of the IgM isotype, suggesting a continuous reactivation of autoantibody responses at mucosal surfaces.

Ann Rheum Dis 2019 01 14;78(1):146-148. Epub 2018 Aug 14.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2018-213724DOI Listing
January 2019

Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors.

Cancer Immunol Res 2019 01 13;7(1):6-11. Epub 2018 Nov 13.

Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0245DOI Listing
January 2019

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis.

Arthritis Res Ther 2019 01 5;21(1). Epub 2019 Jan 5.

Department of Rheumatology, Leiden University Medical Center, PO Box 9600 (Zone C1-R), Albinusdreef 2, 2233 ZA, Leiden, the Netherlands.

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http://dx.doi.org/10.1186/s13075-018-1799-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321723PMC
January 2019

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells.

Mol Pharm 2018 12 26;15(12):5565-5573. Epub 2018 Oct 26.

Department of Biomolecular Chemistry, Institute for Molecules and Materials , Radboud University Nijmegen 6525 AJ , The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00741
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282105PMC
December 2018

Effects of anticoagulants and storage conditions on clinical oxylipid levels in human plasma.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 12 9;1863(12):1511-1522. Epub 2018 Oct 9.

Leiden University Medical Center, Center for Proteomics and Metabolomics, Albinusdreef 2, 2300RC Leiden, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13881981183032
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http://dx.doi.org/10.1016/j.bbalip.2018.10.003DOI Listing
December 2018

Inflammatory features of infrapatellar fat pad in rheumatoid arthritis versus osteoarthritis reveal mostly qualitative differences.

Ann Rheum Dis 2018 07 5;77(7):1088-1090. Epub 2017 Aug 5.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2017-211673DOI Listing
July 2018

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA.

Kidney Int 2018 07 30;94(1):139-149. Epub 2018 Mar 30.

Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands; Clinic for Lupus, Vasculitis and Complement-mediated Systemic Diseases, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.01.013DOI Listing
July 2018

Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG.

J Neuroimmunol 2018 07 16;320:19-24. Epub 2018 Apr 16.

Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2018.04.010DOI Listing
July 2018

The B cell response to citrullinated antigens in the development of rheumatoid arthritis.

Nat Rev Rheumatol 2018 03 8;14(3):157-169. Epub 2018 Feb 8.

Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands.

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http://www.nature.com/doifinder/10.1038/nrrheum.2018.10
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http://dx.doi.org/10.1038/nrrheum.2018.10DOI Listing
March 2018

Variable domain glycosylation of ACPA-IgG: A missing link in the maturation of the ACPA response?

Clin Immunol 2018 01 5;186:34-37. Epub 2017 Sep 5.

Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden 2300 RC, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.09.001DOI Listing
January 2018

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.

Rheumatology (Oxford) 2017 11;56(11):2025-2030

Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam.

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http://dx.doi.org/10.1093/rheumatology/kex284DOI Listing
November 2017

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis.

Arthritis Res Ther 2017 Nov 2;19(1):246. Epub 2017 Nov 2.

Department of Rheumatology, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13075-017-1455-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667446PMC
November 2017

HLA class II and rheumatoid arthritis: the bumpy road of revelation.

Immunogenetics 2017 08 11;69(8-9):597-603. Epub 2017 Jul 11.

Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00251-017-0987-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537318PMC
August 2017

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis.

Nat Rev Rheumatol 2017 Jun 9;13(6):331-339. Epub 2017 Mar 9.

Department of Rheumatology, C1R, Leiden University Medical Center, Albinusdreef 2, Postbus 9600, 2300 RC Leiden, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2017.15DOI Listing
June 2017

The contribution of autoantibodies to post-translationally modified proteins to inflammatory arthritis.

Curr Opin Rheumatol 2017 03;29(2):195-200

Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1097/BOR.0000000000000371DOI Listing
March 2017

Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β.

J Immunol 2016 12 31;197(11):4473-4481. Epub 2016 Oct 31.

Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands

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http://dx.doi.org/10.4049/jimmunol.1502640DOI Listing
December 2016

Reply.

Arthritis Rheumatol 2016 11 9;68(11):2826-2827. Epub 2016 Oct 9.

University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1002/art.39831DOI Listing
November 2016

Rheumatoid arthritis: Autoantibody testing to predict response to therapy in RA.

Nat Rev Rheumatol 2016 10 15;12(10):566-8. Epub 2016 Sep 15.

Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, Leiden 2333 ZA, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2016.151DOI Listing
October 2016

The production and secretion of complement component C1q by human mast cells.

Mol Immunol 2016 10 17;78:164-170. Epub 2016 Sep 17.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2016.09.001DOI Listing
October 2016

Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue.

J Allergy Clin Immunol 2016 09 28;138(3):869-880. Epub 2016 Mar 28.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.01.017DOI Listing
September 2016

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes.

Autoimmun Rev 2016 Jun 27;15(6):577-84. Epub 2016 Feb 27.

Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2016.02.018DOI Listing
June 2016

Mast cells in rheumatic disease.

Eur J Pharmacol 2016 May 2;778:116-24. Epub 2015 May 2.

Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.03.085DOI Listing
May 2016

Human mast cells costimulate T cells through a CD28-independent interaction.

Eur J Immunol 2016 05 11;46(5):1132-41. Epub 2016 Mar 11.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/eji.201545914DOI Listing
May 2016

Viral Persistence Induces Antibody Inflation without Altering Antibody Avidity.

J Virol 2016 May 14;90(9):4402-4411. Epub 2016 Apr 14.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1128/JVI.03177-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836336PMC
May 2016

The role of anticitrullinated protein antibodies in the early stages of rheumatoid arthritis.

Curr Opin Rheumatol 2016 May;28(3):275-81

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/BOR.0000000000000277DOI Listing
May 2016

Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad.

J Rheumatol 2016 Apr 15;43(4):771-8. Epub 2016 Mar 15.

From the Department of Rheumatology, Leiden University Medical Centre; Department of Radiology, Department of Orthopedics, and Department of Clinical Epidemiology, Leiden University Medical Center; TNO, Leiden; Department of Orthopedics and Otorhinolaryngology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; The Janssen Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, USA.I.R. Klein-Wieringa*, MD, PhD, Department of Rheumatology, Leiden University Medical Centre; B.J. de Lange-Brokaar*, MD, PhD, Department of Rheumatology, Leiden University Medical Centre; E. Yusuf, MD, PhD, Department of Rheumatology, Leiden University Medical Centre; S.N. Andersen, Ing, Department of Rheumatology, Leiden University Medical Centre; J.C. Kwekkeboom, Ing, Department of Rheumatology, Leiden University Medical Centre; H.M. Kroon, PhD, Department of Radiology, Leiden University Medical Center; G.J. van Osch, PhD, Professor, Department of Orthopedics and Otorhinolaryngology, Erasmus MC, University Medical Center; A.M. Zuurmond, PhD, TNO; V. Stojanovic-Susulic, PhD, Janssen Pharmaceutical Companies of Johnson & Johnson; R.G. Nelissen, MD, PhD, Professor, Department of Orthopedics, Leiden University Medical Center; R.E. Toes, PhD, Professor, Department of Rheumatology, Leiden University Medical Centre; M. Kloppenburg, MD, PhD, Professor, Department of Rheumatology, and Department of Clinical Epidemiology, Leiden University Medical Centre; A. Ioan-Facsinay, PhD, Assistant Professor, Department of Rheumatology, Leiden University Medical Centre.

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http://dx.doi.org/10.3899/jrheum.151068DOI Listing
April 2016

Reply.

Arthritis Rheumatol 2016 Mar;68(3):769-70

Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/art.39505DOI Listing
March 2016

Inducing tissue specific tolerance in autoimmune disease with tolerogenic dendritic cells.

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 92):S97-103. Epub 2015 Oct 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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December 2015

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis.

Arthritis Res Ther 2015 Nov 24;17:339. Epub 2015 Nov 24.

Department of Rheumatology, Leiden University Medical Center, C1-R, LUMC, PO Box 9600, 2300, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13075-015-0860-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657226PMC
November 2015

Anti-carbamylated protein antibodies in rheumatoid arthritis patients of Asian descent.

Rheumatology (Oxford) 2015 Oct 15;54(10):1930-2. Epub 2015 Jul 15.

Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan.

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http://dx.doi.org/10.1093/rheumatology/kev250DOI Listing
October 2015

Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.

J Rheumatol 2015 Aug 15;42(8):1383-91. Epub 2015 Jun 15.

From the Department of Rheumatology, and the Department of Medical Statistics, Leiden University Medical Center, Leiden, the Netherlands; the Section of Rheumatology at the Institution of Clinical Science, Lund University, Skåne University Hospital, Lund, Sweden, for the BARFOT study group; the Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands; Center of Experimental Rheumatology, University Hospital Zurich, Schlieren, Switzerland; the Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.D.P. de Rooy, LLM, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Tsonaka, PhD, Department of Medical Statistics, Leiden University Medical Center; M.L. Andersson, BMS, PhD; K. Forslind, Associate Professor, Senior Consultant, Section of Rheumatology at the Institution of Clinical Science, Lund University, Skåne University Hospital, for the BARFOT study group; A. Zhernakova, MD, PhD, Department of Rheumatology, Leiden University Medical Center, and Department of Genetics, University Medical Center Groningen and University of Groningen; M. Frank-Bertoncelj, MD, PhD, Center of Experimental Rheumatology, University Hospital Zurich; C.G. de Kovel, PhD; B.P. Koeleman, PhD, Department of Medical Genetics, University Medical Center Utrecht; D.M. van der Heijde, MD, PhD; T.W. Huizinga, MD, PhD; R.E. Toes, PhD, Department of Rheumatology, Leiden University Medical Center; J.J. Houwing-Duistermaat, PhD, PD, Department of Medical Statistics, Leiden University Medical Center; C. Ospelt, MD, PhD, Center of Experimental Rheumatology, University Hospital Zurich; B. Svensson, MD, PhD, Section of Rheumatology at the Institution of Clinical Science, Lund University, Skåne University Hospital, for the BARFOT study group; A.H. van der Helm-van Mil, MD, PhD, Department of Rheumatology, Leiden University Medical Center.

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http://dx.doi.org/10.3899/jrheum.140741DOI Listing
August 2015

Decreased serum cell-free DNA levels in rheumatoid arthritis.

Auto Immun Highlights 2015 Aug 27;6(1-2):23-30. Epub 2015 Jun 27.

284 Department of Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s13317-015-0066-6
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http://dx.doi.org/10.1007/s13317-015-0066-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536238PMC
August 2015

Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis.

Arthritis Res Ther 2015 Aug 24;17:209. Epub 2015 Aug 24.

Department of Rheumatology, Leiden University Medical Centre, C1-R, PO Box 9600, 2300, RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1186/s13075-015-0665-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548712PMC
August 2015

Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model.

Arthritis Res Ther 2015 Aug 20;17:220. Epub 2015 Aug 20.

Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300, RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1186/s13075-015-0731-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545927PMC
August 2015

Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis".

J Immunol 2015 Jul;195(1):3-4

Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1500822DOI Listing
July 2015

Fine-mapping the human leukocyte antigen locus in rheumatoid arthritis and other rheumatic diseases: identifying causal amino acid variants?

Curr Opin Rheumatol 2015 May;27(3):256-61

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/BOR.0000000000000165DOI Listing
May 2015

Update on autoantibodies to modified proteins.

Curr Opin Rheumatol 2015 May;27(3):262-7

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/BOR.0000000000000166DOI Listing
May 2015

IL-17-producing CD4+ T cells are increased in early, active axial spondyloarthritis including patients without imaging abnormalities.

Rheumatology (Oxford) 2015 Apr 6;54(4):728-35. Epub 2014 Oct 6.

Department of Rheumatology and Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/keu382DOI Listing
April 2015

Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis.

J Rheumatol 2015 Apr 15;42(4):572-9. Epub 2015 Jan 15.

From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center.

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http://dx.doi.org/10.3899/jrheum.140767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383711PMC
April 2015

Bridging autoantibodies and arthritis: the role of Fc receptors.

Curr Top Microbiol Immunol 2014 ;382:303-19

Department of Rheumatology, Leiden University Medical Center, C1-R, Albinusdreef 2, 2333, Leiden, ZA, The Netherlands.

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http://dx.doi.org/10.1007/978-3-319-07911-0_14DOI Listing
November 2014

IgE and IL-33-mediated triggering of human basophils inhibits TLR4-induced monocyte activation.

Eur J Immunol 2014 Oct 1;44(10):3045-55. Epub 2014 Sep 1.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/eji.201444731DOI Listing
October 2014

Fatty acids, lipid mediators, and T-cell function.

Front Immunol 2014 13;5:483. Epub 2014 Oct 13.

Department of Rheumatology, Leiden University Medical Centre , Leiden , Netherlands.

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http://dx.doi.org/10.3389/fimmu.2014.00483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195378PMC
October 2014

Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity.

Exp Hematol 2014 Sep 13;42(9):753-60. Epub 2014 Apr 13.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X140014
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http://dx.doi.org/10.1016/j.exphem.2014.04.001DOI Listing
September 2014

TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells.

Eur J Immunol 2014 Jul 16;44(7):2121-9. Epub 2014 Apr 16.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/eji.201344341DOI Listing
July 2014

Are baseline high molecular weight adiponectin levels associated with radiographic progression in rheumatoid arthritis and osteoarthritis?

J Rheumatol 2014 May 1;41(5):853-7. Epub 2014 Apr 1.

From the Department of Rheumatology, and the Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.3899/jrheum.130888DOI Listing
May 2014

The pathogenic potential of autoreactive antibodies in rheumatoid arthritis.

Semin Immunopathol 2014 May 25;36(3):313-25. Epub 2014 Apr 25.

Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00281-014-0429-5DOI Listing
May 2014

Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis.

Ann Rheum Dis 2014 Apr 13;73(4):780-3. Epub 2013 Dec 13.

Department of Rheumatology, Leiden University Medical Center, , Leiden, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2013-204154DOI Listing
April 2014

Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies.

Autoimmun Rev 2014 Mar 28;13(3):225-30. Epub 2013 Oct 28.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2013.10.008DOI Listing
March 2014

HLA-B60 and the HLA-B27/HLA-B60 genotype are not risk factors for acute anterior uveitis.

Ann Rheum Dis 2014 Mar 20;73(3):633-4. Epub 2013 Nov 20.

Department of Rheumatology, Leiden University Medical Center, , Leiden, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2013-204149DOI Listing
March 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014