Publications

Lipid Management After First Diagnosis of Coronary Artery Disease: Contemporary Results From an Observational Cohort Study.
Clin Ther 2017 Nov 2;39(11):2311-2320.e2. Epub 2017 Nov 2.
Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Germany.

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
Hypertension 2017 Oct 7;70(4):743-750. Epub 2017 Aug 7.
From the General and Interventional Cardiology, University Heart Center Hamburg, Germany (T.Z., C.M., A.J., M.K., J.T.N., R.B.S., F.O., S.B.); DZHK (German Centre for Cardiovascular Research), Germany (T.Z., C.S., C.M., P.S.W., A.T., A.S., A.K., A.J., M.K., J.T.N., T.K., R.B.S., M.D., T.M., K.J.L., S.B.F., U.L., A.Z., U.V., S.B.); Institute of Human Genetics (K.S., T.M., H.P.), Molecular Epidemiology (C.G., S.W.), and Institute of Epidemiology II (C.G., S.W.), Helmholtz Zentrum München, Germany; Institut für Medizinische Biometrie und Statistik, Universitätsklinikum Schleswig-Holstein, Germany (C.M., A.S., A.Z.); Institute for Translational Genomics and Population Sciences, UCLA Medical Center (S.K., J.I.R., X.G.); Preventive Cardiology and Preventive Medicine (P.S.W.), Institute of Clinical Chemistry and Laboratory Medicine (K.J.L.), and Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Institute for Community Medicine (A.T.) and Department of Internal Medicine B (M.D., S.B.F.), University Medicine Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Greifswald, Germany (C.S., T.K., U.V., G.H.); Department of Internal Medicine (D.H., J.D.) and Department of Epidemiology and Prevention (Y.L.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli IS, Italy (L.I., S.C.); Department of Cardiology and Pneumology, Charite, Universitätsmedizin Berlin, Germany (A.K., U.L.); National Institute for Health and Welfare, Helsinki, Finland (K.K.); Institute for Clinical Diabetology, German Diabetes Center, Duesseldorf, Germany (M.R., M.C.-K., C.H.); Department of Endocrinology and Diabetology, Medical Faculty Düsseldorf, Germany (M.R.); German Center for Diabetes Research (DZD), Munich, Germany (M.R., S.W., M.C.-K., C.H.); Sorbonne Universités, UPMC, INSERM, UMR_S 1166, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (D.-A.T.); Institute of Human Genetics, Technische Universität München, Germany (T.M., P.W., H.P.); ZIK_FunGene, Universität Greifswald, Germany (U.V., G.H.); and Columbia University Medical Center, New York, NY (W.P.).

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe).
Circulation 2017 Oct 16;136(17):1588-1597. Epub 2017 Oct 16.
From Department of General and Interventional Cardiology, University Heart Center Hamburg, Germany (C.M., F.M.O., S.B., T.Z., R.B.S.); DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Germany (C.M., S.B., T.Z., R.B.S.); National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, MA (T.J.N.); Department of Community Medicine, University of Tromso The Arctic University of Norway, Tromsø (I.N.); Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy (F.G., S.C., M.B.D., G.d.G., L.I.); EPIMED Research Center, Department of Medicine and Surgery, University of Insubria, Varese, Italy (F.G.); National Institute for Health and Welfare, Helsinki, Finland (T.J.N., E.V., P.J., T.P., K.K., V.S.); Catalan Department of Health, Barcelona, Spain (S. Sans); Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Netherlands (G.P.); Center of Excellence for Public Health, Institute of Clinical Sciences, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland (M.H.); Research Center for Prevention and Health, the Capital Region of Denmark, Copenhagen (A.L.); Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark (A.L.); Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (A.L., T.J.); Department of Epidemiology and Public Health, University College London, UK (M.B.); Laboratory of Experimental Cardiology, University Medical Center Utrecht, Netherlands (H.M.d.R.); Department of Clinical Medicine, Brain and Circulation Research Group, UiT The Arctic University of Norway, Tromsø (E.M.); Research Center for Prevention and Health, Glostrup University Hospital, Denmark (T.J.); Faculty of Medicine, Aalborg University, Denmark (T.J.); Department of Public Health and Clinical Medicine, and Heart Centre, Umeå University, Sweden (S. Söderberg); and Department of Medicine and Surgery, University of Insubria, Varese, Italy (L.I.).



The Changing Landscape of Atrial Fibrillation: Time to Target Heart Failure Prevention.
JACC Heart Fail 2017 Aug 14;5(8):561-564. Epub 2017 Jun 14.
Section of Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts; Section of Preventive Medicine, Department of Medicine, Boston University School of Medicine, and Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts; Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts. Electronic address:


Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.
Lancet Diabetes Endocrinol 2017 Jul 26;5(7):534-543. Epub 2017 May 26.
Department of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.

Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study.
Sci Rep 2017 Jul 24;7(1):6346. Epub 2017 Jul 24.
Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.
Cell 2017 Jul;170(3):522-533.e15
Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:




Challenging the 99th percentile: A lower troponin cutoff leads to low mortality of chest pain patients.
Int J Cardiol 2017 Apr 27;232:289-293. Epub 2016 Dec 27.
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistrasse 52, 20246 Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Martinistrasse 52, 20246 Hamburg, Germany.


Biomarkers for characterization of heart failure - Distinction of heart failure with preserved and reduced ejection fraction.
Int J Cardiol 2017 Jan 9;227:272-277. Epub 2016 Nov 9.
University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. Electronic address:


Cardiovascular Mortality in Chest Pain Patients: Comparison of Natriuretic Peptides With Novel Biomarkers of Cardiovascular Stress.
Can J Cardiol 2016 Dec 20;32(12):1470-1477. Epub 2016 May 20.
Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany. Electronic address:

Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).
Am J Cardiol 2016 Nov 24;118(10):1493-1496. Epub 2016 Aug 24.
Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands. Electronic address:

SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease.
Clin Res Cardiol 2016 Nov 30;105(11):901-911. Epub 2016 Jun 30.
Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany.

High-sensitivity troponin and novel biomarkers for the early diagnosis of non-ST-segment elevation myocardial infarction in patients with atrial fibrillation.
Eur Heart J Acute Cardiovasc Care 2016 Oct 12;5(6):419-427. Epub 2015 Oct 12.
Department of General and Interventional Cardiology, University Heart Center, Germany German Center for Cardiovascular research (DZHK), Partner Site Hamburg, Germany




Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events.
Genomics Proteomics Bioinformatics 2016 Aug 17;14(4):235-43. Epub 2016 May 17.
Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20246 Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Hamburg/Kiel/Luebeck, Germany.

Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I 1-Hour Algorithm.
JAMA Cardiol 2016 Jul;1(4):397-404
Department of General and Interventional Cardiology, University Heart Center Hamburg, University Hospital Hamburg-Eppendorf, Hamburg, Germany2German Center for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.

Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation.
Am Heart J 2016 Jun 17;176:100-6. Epub 2016 Mar 17.
NHLBI's and Boston University's Framingham Study, Framingham, MA; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA; Evans Memorial Medicine Department, Boston University School of Medicine, Boston, MA; Sections of Cardiology, Boston University School of Medicine, Boston, MA; Preventive Medicine, Boston University School of Medicine, Boston, MA; Epidemiology Department, Public Health School, Boston University, Boston, MA.

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain.
J Am Heart Assoc 2016 Apr 13;5(4):e002565. Epub 2016 Apr 13.
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, Germany.

ADMA, subclinical changes and atrial fibrillation in the general population.
Int J Cardiol 2016 Jan 19;203:640-6. Epub 2015 May 19.
Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Germany; DZHK (Deutsches Zentrum fuer Herz-Kreislauf-Forschung e.V.), partner site Hamburg/Kiel/Luebeck, Germany. Electronic address:

ADMA and arginine derivatives in relation to non-invasive vascular function in the general population.
Atherosclerosis 2016 Jan 30;244:149-56. Epub 2015 Oct 30.
Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany. Electronic address:



Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes.
Diabetes Care 2015 Jul 15;38(7):1356-64. Epub 2015 Apr 15.
Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany

50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study.
Lancet 2015 Jul 7;386(9989):154-62. Epub 2015 May 7.
National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA, USA; Preventive Medicine Section, School of Medicine, Boston University, Boston, MA, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Long-term outcomes of secondary atrial fibrillation in the community: the Framingham Heart Study.
Circulation 2015 May 13;131(19):1648-55. Epub 2015 Mar 13.
From Cardiovascular Research Center (S.A.L., P.T.E.) and Cardiac Arrhythmia Service (S.A.L., P.T.E.), Massachusetts General Hospital, Boston; Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (X.Y., J.W.M., D.L., R.S.V., M.G.L., E.J.B.); Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands (M.R.); Department of General and Interventional Cardiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany (R.B.S.); Pulmonary Center and Section of Pulmonary and Critical Care Medicine (A.J.W.), Section of Cardiovascular Medicine (J.W.M., R.S.V., E.J.B.), and Section of Preventive Medicine (R.S.V., E.J.B.), Department of Medicine, Boston University School of Medicine, MA; Department of Medicine, Boston University Medical Center, MA (F.R.); Departments of Medicine and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester (D.D.M.); Sutter Medical Group, Sacramento, CA (T.M.T.); Population Sciences Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (D.L.); Department of Mathematics and Statistics, Boston University, MA (M.G.L.); and Departments of Biostatistics (M.G.L.) and Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA.

Kidney injury and mortality after transcatheter aortic valve implantation in a routine clinical cohort.
Catheter Cardiovasc Interv 2015 Feb 14;85(3):440-7. Epub 2014 Jul 14.
Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany.


HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Lancet 2015 Jan 24;385(9965):351-61. Epub 2014 Sep 24.
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Is it all determined at menarche?
Circulation 2015 Jan 15;131(3):227-9. Epub 2014 Dec 15.
From the University Heart Center, Department of General and Interventional Cardiology, Hamburg, Germany; and DZHK (Deutsches Zentrum fuer Herz-Kreislauf-Forschung e.V.), partner site Hamburg/Kiel/Luebeck, Germany.

A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans.
J Cardiovasc Electrophysiol 2014 Nov 25;25(11):1150-7. Epub 2014 Aug 25.
Department of Medicine, Division of Cardiology, Section of Electrophysiology, Northwestern University, Chicago, Illinois, USA.










Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.
J Am Heart Assoc 2013 Nov 15;2(6):e000307. Epub 2013 Nov 15.
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.





Sex differences in noninvasive vascular function in the community.
J Hypertens 2013 Jul;31(7):1437-46; discussion 1446
Department of General and Interventional Cardiology, University Heart Center, Hamburg Eppendorf, Hamburg, Germany.





A multiple biomarker risk score for guiding clinical decisions using a decision curve approach.
Eur J Prev Cardiol 2012 Aug 20;19(4):874-84. Epub 2011 Jul 20.
UKCRC Centre of Excellence for Public Health, School of Medicine Dentistry and Biomedical Sciences, Institute of Clinical Sciences B, Queens University Belfast, Grosvenor Road, Belfast, BT12 6BJ, UK.

Multiple endothelial biomarkers and noninvasive vascular function in the general population: the Gutenberg Health Study.
Hypertension 2012 Aug 11;60(2):288-95. Epub 2012 Jun 11.
University Heart Center, Department of General and Interventional Cardiology, Martinistr 52, 20246 Hamburg, Germany.

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Lancet 2012 Mar 14;379(9822):1214-24. Epub 2012 Mar 14.

Insulin resistance and atrial fibrillation (from the Framingham Heart Study).
Am J Cardiol 2012 Jan 12;109(1):87-90. Epub 2011 Oct 12.
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.






Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
Nat Genet 2011 Sep 11;43(10):940-7. Epub 2011 Sep 11.
Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, USA.

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
Circ Cardiovasc Genet 2011 Aug 23;4(4):403-12. Epub 2011 May 23.
Department of Medicine II, University Medical Center Mainz, Germany.






Screening for Atrial Fibrillation: A Report of the AF-SCREEN International Collaboration.
Circulation 2017 05;135(19):1851-1867
From Heart Research Institute, Charles Perkins Centre, and Concord Hospital Cardiology, University of Sydney, Australia (B.F.); St Georges Hospital, London, UK (J.C.); Johns Hopkins University, Baltimore, MD (H.C.); Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (J.S.H., D.C.); Karolinska Institute, Stockholm, Sweden (M.R., J.E., L.F., E.S.); The Shanghai Institute of Hypertension, Ruijin Hospital, Jiaotong University School of Medicine, China (J.W.); Brigham and Womens Hospital, Harvard Medical School, Boston, MA (C.M.A.); The George Institute for Global Health, Sydney, Australia (C.S.A.); Barts Health NHS Trust, London, UK (S.A.); National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, MA (E.J.B.); University of Modena and Reggio Emilia, Italy (G.B.); Klinikum Coburg, Germany (J.B.); Odense University Hospital, Denmark (A.B.); Cardiovascular Research Centre, National Yang-Ming University, Taipei, Taiwan (T.- F.C.); University Hospital, Basel, Switzerland (D.C.); Université François Rabelais, Tours, France (L.F.); University of Birmingham, UK (D.A.F.); Mayo Clinic College of Medicine, Rochester, MN (B.J.G.); University of Toronto, Ontario, Canada (D.J.G., A.V.); Hackensack University Medical Centre, NJ (T.V.G.); Poche Centre, University of Sydney, Australia (K.G.); University of Western Australia, Perth (G.J.H.); Trinity College, Dublin, Ireland (J.H.); Royal Perth Hospital, University of Western Australia (G.S.H.); StopAfib.org, Dallas, TX (M.T.H.); Weill Cornell Medical College, New York (H.K.); Institute of Cardiovascular Sciences, University of Birmingham, UK (P.K.); SWBH and UHB NHS trusts, Birmingham, UK (P.K.); AFNET, Muenster, Germany (P.K.); Lankenau Institute for Medical Research, Wynnewood, OK (P.R.K.); University Hospital of Zurich, Switzerland (D.K.); Chinese University of Hong Kong (V.W.Y.L., B.P.Y.); University of Linköping, Sweden (L.-A.L.); University of Birmingham, UK; Aalborg University, Denmark (G.Y.H.L.); Arrhythmia Alliance, London, UK (T.L.); Charles Perkins Centre, University of Sydney, Australia (N.L.); Cliniques du Sud Luxembourg, Arlon, Belgium (G.H.M.); Institute for Epidemiology Statistics and Informatics, Frankfurt, Germany (C.M.); Edinburgh Napier University, UK (L.N.); Charles Perkins Centre, University of Sydney, Australia (J.O.); Duke University, Durham, NC (J.P.P.); University of Auckland, New Zealand (K.P.); University of Belgrade, Serbia (T.S.P.); KH der Elisabethinen, Ordensklinikum Linz, Austria (H.P.); University of Groningen, University Medical Centre Groningen, The Netherlands (M.R.); University of Alberta, Edmonton, Canada (R.K.S.); University Heart Centre, Hamburg, Germany (R.B.S.); The University of Hong Kong (C.-W.S.); Scripps Translational Science Institute, San Diego, CA (S.S.); Rigshospitalet, The Heart Centre, University of Copenhagen, Denmark (J.H.S.); Ospedale dell'Angelo Venice-Mestre, Venice, Italy (S.T.); Martini Hospital, Groningen, The Netherlands (R.G.T.); Stanford University, CA (M.P.T.); VA Palo Alto Health Care System, CA (M.P.T.); The Department of Medical Research, Bærum Hospital, Rud, Norway (A.T.); Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands (S.B.U.); University of Groningen, University Medical Centre Groningen, The Netherlands (I.C.V.G.); and University of Göttingen, Germany (R.W.).

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