Rena Lapidus

Rena Lapidus

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Rena Lapidus

Rena Lapidus

Publications by authors named "Rena Lapidus"

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Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.

Eur J Med Chem 2019 Oct 29;180:449-456. Epub 2019 Jun 29.

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA; Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN, 47907, USA; Purdue Institute of Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN, 47907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.06.089DOI Listing
October 2019

Liquid biopsy tracking of lung tumor evolutions over time.

Expert Rev Mol Diagn 2019 Oct 16:1-10. Epub 2019 Oct 16.

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/14737159.2020.1680287DOI Listing
October 2019

Analysis of the Mechanisms of Action of Naphthoquinone-Based Anti-Acute Myeloid Leukemia Chemotherapeutics.

Molecules 2019 Aug 28;24(17). Epub 2019 Aug 28.

Department of Medicine Division of Hematology/Oncology University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.3390/molecules24173121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749238PMC
August 2019

Equipotent doses of daunorubicin and idarubicin for AML: a meta-analysis of clinical trials versus in vitro estimation.

Cancer Chemother Pharmacol 2019 Jun 9;83(6):1105-1112. Epub 2019 Apr 9.

School of Medicine, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, 22 S. Greene St., Room N9E24, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1007/s00280-019-03825-2DOI Listing
June 2019

Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway.

BMC Cancer 2019 May 22;19(1):485. Epub 2019 May 22.

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/s12885-019-5664-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532223PMC
May 2019

HER3-Targeted Affibodies with Optimized Formats Reduce Ovarian Cancer Progression in a Mouse Xenograft Model.

AAPS J 2019 Apr 4;21(3):48. Epub 2019 Apr 4.

Fischell Department of Bioengineering, University of Maryland, 3116 A. James Clark Hall, College Park, Maryland, 20742, USA.

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http://dx.doi.org/10.1208/s12248-019-0318-xDOI Listing
April 2019

Co-targeting EGFR and IKKβ/NF-κB signalling pathways in head and neck squamous cell carcinoma: a potential novel therapy for head and neck squamous cell cancer.

Br J Cancer 2019 Feb 26;120(3):306-316. Epub 2018 Dec 26.

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41416-018-0351-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353914PMC
February 2019

Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice.

EBioMedicine 2019 Feb 25;40:231-239. Epub 2019 Jan 25.

Purdue Institute for Drug Discovery, West Lafayette, IN 47907, USA; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA; Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413339PMC
February 2019

Exploiting epigenetically mediated changes: Acute myeloid leukemia, leukemia stem cells and the bone marrow microenvironment.

Adv Cancer Res 2019 21;141:213-253. Epub 2019 Jan 21.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, United States; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2018.12.005DOI Listing
January 2019

Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation.

Cell Physiol Biochem 2018 25;48(3):1259-1273. Epub 2018 Jul 25.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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https://www.karger.com/Article/FullText/492012
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http://dx.doi.org/10.1159/000492012DOI Listing
September 2018

Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local.

Front Immunol 2018 8;9:1305. Epub 2018 Jun 8.

American Gene Technologies International Inc., Rockville, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2018.01305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003257PMC
June 2018

Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines.

Future Med Chem 2018 04 13;10(7):823-835. Epub 2018 Feb 13.

Purdue Institute for Drug Discovery, Department of Chemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.4155/fmc-2017-0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367750PMC
April 2018

Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL.

Nat Commun 2018 02 26;9(1):829. Epub 2018 Feb 26.

Department of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1038/s41467-018-03028-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827760PMC
February 2018

Anticancer Properties of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity via N5 Substitution.

ChemMedChem 2018 01 18;13(2):178-185. Epub 2017 Dec 18.

Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA.

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http://doi.wiley.com/10.1002/cmdc.201700641
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http://dx.doi.org/10.1002/cmdc.201700641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912934PMC
January 2018

Comparative Analysis of Methods for Detecting Isocitrate Dehydrogenase 1 and 2 Mutations and Their Metabolic Consequence, 2-Hydroxyglutarate, in Different Neoplasms.

Appl Immunohistochem Mol Morphol 2017 May/Jun;25(5):334-337

*Marlene & Stewart Greenebaum Cancer Center, University of Maryland, School of Medicine, Baltimore, MD †Medical College of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1097/PAI.0000000000000342DOI Listing
November 2017

Breaking Mitochondrial Fasting for Cancer Treatment: Old Wine in New Bottles.

J Natl Cancer Inst 2017 11;109(11)

University of Maryland, School of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD.

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http://dx.doi.org/10.1093/jnci/djx069DOI Listing
November 2017

Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity.

Oncotarget 2017 Sep 10;8(41):70916-70940. Epub 2017 Aug 10.

Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.20200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642608PMC
September 2017

Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells.

J Biol Chem 2017 08 27;292(33):13890-13901. Epub 2017 Jun 27.

From the Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201,

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http://dx.doi.org/10.1074/jbc.M117.783860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566540PMC
August 2017

Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach.

ACS Med Chem Lett 2017 May 14;8(5):492-497. Epub 2017 Apr 14.

Institute for Drug Discovery, Department of Chemistry, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430396PMC
May 2017

Phase I and pharmacokinetic evaluation of the anti-telomerase agent KML-001 with cisplatin in advanced solid tumors.

Cancer Chemother Pharmacol 2016 Nov 12;78(5):959-967. Epub 2016 Sep 12.

University of Maryland School of Pharmacy, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00280-016-3148-xDOI Listing
November 2016

Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.

Cancer Cell 2016 10;30(4):637-650

Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA; University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201166PMC
October 2016

Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities.

Eur J Med Chem 2016 Aug 20;118:266-75. Epub 2016 Apr 20.

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA; Center for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.04.030DOI Listing
August 2016

Targeting IκB Kinase β/NF-κB Signaling in Human Prostate Cancer by a Novel IκB Kinase β Inhibitor CmpdA.

Mol Cancer Ther 2016 07 8;15(7):1504-14. Epub 2016 Apr 8.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland. Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936938PMC
July 2016

Synthesis, anticancer activity, and SAR analyses of compounds containing the 5:7-fused 4,6,8-triaminoimidazo[4,5-e][1,3]diazepine ring system.

Bioorg Med Chem 2016 06 9;24(12):2595-602. Epub 2016 Mar 9.

Laboratory for Drug Design & Synthesis, Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.03.015DOI Listing
June 2016

A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-kB regulates head and neck squamous cell carcinoma proliferation.

Oncotarget 2016 May;7(22):31892-906

The Marlene & Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.7441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077984PMC
May 2016

Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells.

Mol Cancer Res 2015 Dec 15;13(12):1602-14. Epub 2015 Sep 15.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland. Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690470PMC
December 2015

IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.

Am J Cancer Res 2015 15;5(10):3098-110. Epub 2015 Sep 15.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine Baltimore, MD, USA ; Department of Pathology, University of Maryland School of Medicine Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656733PMC
December 2015

Presence of isocitrate dehydrogenase mutations may predict clinical response to hypomethylating agents in patients with acute myeloid leukemia.

Am J Hematol 2015 May 27;90(5):E77-9. Epub 2015 Feb 27.

School of Medicine, Department of Internal Medicine, University of Maryland Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland.

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http://dx.doi.org/10.1002/ajh.23965DOI Listing
May 2015

In vivo screening of S100B inhibitors for melanoma therapy.

Methods Mol Biol 2013 ;963:303-17

Department of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, The University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-62703-230-8_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718549PMC
June 2013

Structure-based drug design and potent anti-cancer activity of tricyclic 5:7:5-fused diimidazo[4,5-d:4',5'-f][1,3]diazepines.

Bioorg Med Chem 2013 Feb 11;21(3):618-31. Epub 2012 Dec 11.

Laboratory for Drug Design & Synthesis, Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.

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http://dx.doi.org/10.1016/j.bmc.2012.11.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546142PMC
February 2013

Regulation of human RNase-L by the miR-29 family reveals a novel oncogenic role in chronic myelogenous leukemia.

J Interferon Cytokine Res 2013 Jan 31;33(1):34-42. Epub 2012 Oct 31.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://www.liebertpub.com/doi/10.1089/jir.2012.0062
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http://dx.doi.org/10.1089/jir.2012.0062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539258PMC
January 2013

The orally active glutamate carboxypeptidase II inhibitor E2072 exhibits sustained nerve exposure and attenuates peripheral neuropathy.

J Pharmacol Exp Ther 2012 Dec 17;343(3):746-54. Epub 2012 Sep 17.

Brain Science Institute, NeuroTranslational Drug Discovery Program, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1124/jpet.112.197665DOI Listing
December 2012

Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System.

ACS Med Chem Lett 2010 Dec;2(3):252-256

Laboratory for Drug Design & Synthesis, Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland, 21250, USA.

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http://dx.doi.org/10.1021/ml100281bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092706PMC
December 2010

A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system.

Bioorg Med Chem Lett 2010 Aug 15;20(15):4386-9. Epub 2010 Jun 15.

Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.06.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905507PMC
August 2010

Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat.

Neurotox Res 2010 May 15;17(4):380-91. Epub 2009 Sep 15.

Department of Neurosciences and Biomedical Technologies, University of Milano-Bicocca, U8, Via Cadore 48, 20052 Monza (MB), Italy.

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http://dx.doi.org/10.1007/s12640-009-9114-1DOI Listing
May 2010

Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.

Head Neck 2010 Mar;32(3):381-91

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/hed.21195DOI Listing
March 2010