Ren-Hua Chung

Ren-Hua Chung

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Ren-Hua Chung

Ren-Hua Chung

Publications by authors named "Ren-Hua Chung"

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pWGBSSimla: a profile-based whole-genome bisulfite sequencing data simulator incorporating methylation QTLs, allele-specific methylations and differentially methylated regions.

Bioinformatics 2019 Aug 9. Epub 2019 Aug 9.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.1093/bioinformatics/btz635DOI Listing
August 2019

A multi-omics data simulator for complex disease studies and its application to evaluate multi-omics data analysis methods for disease classification.

Gigascience 2019 05;8(5)

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, No. 35, Keyan Road, Zhunan, 350, Taiwan.

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http://dx.doi.org/10.1093/gigascience/giz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486474PMC
May 2019

Genetic loci determining total immunoglobulin E levels from birth through adulthood.

Allergy 2019 Mar 28;74(3):621-625. Epub 2018 Nov 28.

Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

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http://doi.wiley.com/10.1111/all.13654
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http://dx.doi.org/10.1111/all.13654DOI Listing
March 2019

Gene Is Associated With Triglyceride Levels In Subjects With Family History Of Hypertension From The SAPPHIRe And TWB Projects.

Int J Med Sci 2018 14;15(10):1035-1042. Epub 2018 Jun 14.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan.

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http://dx.doi.org/10.7150/ijms.25742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036157PMC
January 2019

Single Marker Family-Based Association Analysis Conditional on Parental Information.

Methods Mol Biol 2017 ;1666:391-407

John P. Hussman Institute for Human Genomics, Leonard M. Miller School of Medicine, University of Miami, 1501 NW 10th Avenue, M860-BRB 305, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/978-1-4939-7274-6_19DOI Listing
May 2018

A Powerful Gene-Based Test Accommodating Common and Low-Frequency Variants to Detect Both Main Effects and Gene-Gene Interaction Effects in Case-Control Studies.

Front Genet 2017 8;8:228. Epub 2018 Jan 8.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.3389/fgene.2017.00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766643PMC
January 2018

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

Nat Genet 2017 Oct 4;49(10):1450-1457. Epub 2017 Sep 4.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844224PMC
October 2017

Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children.

PLoS One 2017 4;12(4):e0174691. Epub 2017 Apr 4.

Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380337PMC
August 2017

Genome-wide copy number variation analysis identified deletions in SFMBT1 associated with fasting plasma glucose in a Han Chinese population.

BMC Genomics 2017 08 8;18(1):591. Epub 2017 Aug 8.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, No 35, Keyan Road, Zhunan, Miaoli, 350, Taiwan.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/s12864
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http://dx.doi.org/10.1186/s12864-017-3975-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549306PMC
August 2017

Cost-Effectiveness Analysis of Different Genetic Testing Strategies for Lynch Syndrome in Taiwan.

PLoS One 2016 2;11(8):e0160599. Epub 2016 Aug 2.

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, 350, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160599PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970721PMC
July 2017

Pathway Analysis Incorporating Protein-Protein Interaction Networks Identified Candidate Pathways for the Seven Common Diseases.

PLoS One 2016 13;11(9):e0162910. Epub 2016 Sep 13.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021324PMC
July 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Nat Genet 2017 Jul 22;49(7):1113-1119. Epub 2017 May 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555387PMC
July 2017

GESDB: a platform of simulation resources for genetic epidemiology studies.

Database (Oxford) 2016 30;2016. Epub 2016 May 30.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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http://dx.doi.org/10.1093/database/baw082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885602PMC
January 2017

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:
Georg B Ehret Teresa Ferreira Daniel I Chasman Anne U Jackson Ellen M Schmidt Toby Johnson Gudmar Thorleifsson Jian'an Luan Lousie A Donnelly Stavroula Kanoni Ann-Kristin Petersen Vasyl Pihur Rona J Strawbridge Dmitry Shungin Maria F Hughes Osorio Meirelles Marika Kaakinen Nabila Bouatia-Naji Kati Kristiansson Sonia Shah Marcus E Kleber Xiuqing Guo Leo-Pekka Lyytikäinen Cristiano Fava Niclas Eriksson Ilja M Nolte Patrik K Magnusson Elias L Salfati Loukianos S Rallidis Elizabeth Theusch Andrew J P Smith Lasse Folkersen Kate Witkowska Tune H Pers Roby Joehanes Stuart K Kim Lazaros Lataniotis Rick Jansen Andrew D Johnson Helen Warren Young Jin Kim Wei Zhao Ying Wu Bamidele O Tayo Murielle Bochud Devin Absher Linda S Adair Najaf Amin Dan E Arking Tomas Axelsson Damiano Baldassarre Beverley Balkau Stefania Bandinelli Michael R Barnes Inês Barroso Stephen Bevan Joshua C Bis Gyda Bjornsdottir Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Morris J Brown Michel Burnier Claudia P Cabrera John C Chambers I-Shou Chang Ching-Yu Cheng Peter S Chines Ren-Hua Chung Francis S Collins John M Connell Angela Döring Jean Dallongeville John Danesh Ulf de Faire Graciela Delgado Anna F Dominiczak Alex S F Doney Fotios Drenos Sarah Edkins John D Eicher Roberto Elosua Stefan Enroth Jeanette Erdmann Per Eriksson Tonu Esko Evangelos Evangelou Alun Evans Tove Fall Martin Farrall Janine F Felix Jean Ferrières Luigi Ferrucci Myriam Fornage Terrence Forrester Nora Franceschini Oscar H Franco Duran Anders Franco-Cereceda Ross M Fraser Santhi K Ganesh He Gao Karl Gertow Francesco Gianfagna Bruna Gigante Franco Giulianini Anuj Goel Alison H Goodall Mark O Goodarzi Mathias Gorski Jürgen Gräßler Christopher Groves Vilmundur Gudnason Ulf Gyllensten Göran Hallmans Anna-Liisa Hartikainen Maija Hassinen Aki S Havulinna Caroline Hayward Serge Hercberg Karl-Heinz Herzig Andrew A Hicks Aroon D Hingorani Joel N Hirschhorn Albert Hofman Jostein Holmen Oddgeir Lingaas Holmen Jouke-Jan Hottenga Phil Howard Chao A Hsiung Steven C Hunt M Arfan Ikram Thomas Illig Carlos Iribarren Richard A Jensen Mika Kähönen Hyun Kang Sekar Kathiresan Brendan J Keating Kay-Tee Khaw Yun Kyoung Kim Eric Kim Mika Kivimaki Norman Klopp Genovefa Kolovou Pirjo Komulainen Jaspal S Kooner Gulum Kosova Ronald M Krauss Diana Kuh Zoltan Kutalik Johanna Kuusisto Kirsti Kvaløy Timo A Lakka Nanette R Lee I-Te Lee Wen-Jane Lee Daniel Levy Xiaohui Li Kae-Woei Liang Honghuang Lin Li Lin Jaana Lindström Stéphane Lobbens Satu Männistö Gabriele Müller Martina Müller-Nurasyid François Mach Hugh S Markus Eirini Marouli Mark I McCarthy Colin A McKenzie Pierre Meneton Cristina Menni Andres Metspalu Vladan Mijatovic Leena Moilanen May E Montasser Andrew D Morris Alanna C Morrison Antonella Mulas Ramaiah Nagaraja Narisu Narisu Kjell Nikus Christopher J O'Donnell Paul F O'Reilly Ken K Ong Fred Paccaud Cameron D Palmer Afshin Parsa Nancy L Pedersen Brenda W Penninx Markus Perola Annette Peters Neil Poulter Peter P Pramstaller Bruce M Psaty Thomas Quertermous Dabeeru C Rao Asif Rasheed N William N W R Rayner Frida Renström Rainer Rettig Kenneth M Rice Robert Roberts Lynda M Rose Jacques Rossouw Nilesh J Samani Serena Sanna Jouko Saramies Heribert Schunkert Sylvain Sebert Wayne H-H Sheu Young-Ah Shin Xueling Sim Johannes H Smit Albert V Smith Maria X Sosa Tim D Spector Alena Stančáková Alice Stanton Kathleen E Stirrups Heather M Stringham Johan Sundstrom Amy J Swift Ann-Christine Syvänen E-Shyong Tai Toshiko Tanaka Kirill V Tarasov Alexander Teumer Unnur Thorsteinsdottir Martin D Tobin Elena Tremoli Andre G Uitterlinden Matti Uusitupa Ahmad Vaez Dhananjay Vaidya Cornelia M van Duijn Erik P A van Iperen Ramachandran S Vasan Germaine C Verwoert Jarmo Virtamo Veronique Vitart Benjamin F Voight Peter Vollenweider Aline Wagner Louise V Wain Nicholas J Wareham Hugh Watkins Alan B Weder Harm-Jan Westra Rainford Wilks Tom Wilsgaard James F Wilson Tien Y Wong Tsun-Po Yang Jie Yao Loic Yengo Weihua Zhang Jing Hua Zhao Xiaofeng Zhu Pascal Bovet Richard S Cooper Karen L Mohlke Danish Saleheen Jong-Young Lee Paul Elliott Hinco J Gierman Cristen J Willer Lude Franke G Kees Hovingh Kent D Taylor George Dedoussis Peter Sever Andrew Wong Lars Lind Themistocles L Assimes Inger Njølstad Peter Eh Schwarz Claudia Langenberg Harold Snieder Mark J Caulfield Olle Melander Markku Laakso Juha Saltevo Rainer Rauramaa Jaakko Tuomilehto Erik Ingelsson Terho Lehtimäki Kristian Hveem Walter Palmas Winfried März Meena Kumari Veikko Salomaa Yii-Der I Chen Jerome I Rotter Philippe Froguel Marjo-Riitta Jarvelin Edward G Lakatta Kari Kuulasmaa Paul W Franks Anders Hamsten H-Erich Wichmann Colin N A Palmer Kari Stefansson Paul M Ridker Ruth J F Loos Aravinda Chakravarti Panos Deloukas Andrew P Morris Christopher Newton-Cheh Patricia B Munroe

Nat Genet 2016 10 12;48(10):1171-1184. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/ng.3667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042863PMC
October 2016

A combined association test for rare variants using family and case-control data.

BMC Proc 2016 18;10(Suppl 7):215-219. Epub 2016 Oct 18.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli Taiwan.

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http://dx.doi.org/10.1186/s12919-016-0033-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133518PMC
October 2016

GCORE-sib: An efficient gene-gene interaction tool for genome-wide association studies based on discordant sib pairs.

BMC Bioinformatics 2016 Jul 8;17(1):273. Epub 2016 Jul 8.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.1186/s12859-016-1145-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939061PMC
July 2016

An efficient gene-gene interaction test for genome-wide association studies in trio families.

Bioinformatics 2016 06 11;32(12):1848-55. Epub 2016 Feb 11.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.1093/bioinformatics/btw077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939888PMC
June 2016

FamPipe: An Automatic Analysis Pipeline for Analyzing Sequencing Data in Families for Disease Studies.

PLoS Comput Biol 2016 06 6;12(6):e1004980. Epub 2016 Jun 6.

Department of Psychiatry, Chang Gung Memorial Hospital-Linkou, Gueishan, Taoyuan, Taiwan.

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http://dx.doi.org/10.1371/journal.pcbi.1004980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894624PMC
June 2016

SeqSIMLA2_exact: simulate multiple disease sites in large pedigrees with given disease status for diseases with low prevalence.

Bioinformatics 2016 Feb 29;32(4):557-62. Epub 2015 Oct 29.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.

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http://bioinformatics.oxfordjournals.org/content/early/2015/
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http://bioinformatics.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/bioinformatics/btv626DOI Listing
February 2016

Family-based association test using both common and rare variants and accounting for directions of effects for sequencing data.

PLoS One 2014 22;9(9):e107800. Epub 2014 Sep 22.

Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107800PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171487PMC
December 2015

A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families.

BMC Genomics 2015 May 15;16:381. Epub 2015 May 15.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.1186/s12864-015-1620-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433014PMC
May 2015

SeqSIMLA2: simulating correlated quantitative traits accounting for shared environmental effects in user-specified pedigree structure.

Genet Epidemiol 2015 Jan 22;39(1):20-4. Epub 2014 Sep 22.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

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http://dx.doi.org/10.1002/gepi.21850DOI Listing
January 2015

Identification of rare variants for hypertension with incorporation of linkage information.

BMC Proc 2014 17;8(Suppl 1):S109. Epub 2014 Jun 17.

Department of Biostatistical Sciences, Division of Public Health Sciences, 1834 Wake Forest Rd., Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144469PMC
December 2014

The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance.

J Clin Psychopharmacol 2014 Apr;34(2):205-11

From the *Center for Neuropsychiatric Research, and †Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County; ‡Center for Drug Abuse and Addiction, China Medical University Hospital; §Graduate Institute of Clinical Medical Science, China Medical University; ∥Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan; ¶Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY; #Division of Clinical Trial Statistics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County; and**Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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https://insights.ovid.com/crossref?an=00004714-201404000-000
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http://dx.doi.org/10.1097/JCP.0000000000000082DOI Listing
April 2014

Pathway-PDT: a flexible pathway analysis tool for nuclear families.

BMC Bioinformatics 2013 Sep 4;14:267. Epub 2013 Sep 4.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-14-267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844459PMC
September 2013

SeqSIMLA: a sequence and phenotype simulation tool for complex disease studies.

BMC Bioinformatics 2013 Jun 20;14:199. Epub 2013 Jun 20.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

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http://dx.doi.org/10.1186/1471-2105-14-199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693898PMC
June 2013

A two-stage random forest-based pathway analysis method.

PLoS One 2012 7;7(5):e36662. Epub 2012 May 7.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036662PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346727PMC
September 2012

Single-marker family-based association analysis conditional on parental information.

Methods Mol Biol 2012 ;850:359-70

John P. Hussman Institute for Human Genomics, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1007/978-1-61779-555-8_19DOI Listing
May 2012

CAPL: an efficient association software package using family and case-control data and accounting for population stratification.

BMC Bioinformatics 2011 May 25;12:201. Epub 2011 May 25.

Center for Genetic Epidemiology and Statistical Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1186/1471-2105-12-201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123608PMC
May 2011

CAPL: a novel association test using case-control and family data and accounting for population stratification.

Genet Epidemiol 2010 Nov;34(7):747-55

Center for Genetic Epidemiology and Statistical Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA.

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http://doi.wiley.com/10.1002/gepi.20539
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http://dx.doi.org/10.1002/gepi.20539DOI Listing
November 2010

Ordered-subset analysis (OSA) for family-based association mapping of complex traits.

Genet Epidemiol 2008 Nov;32(7):627-37

Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1002/gepi.20340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582061PMC
November 2008

X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design.

Genet Epidemiol 2008 May;32(4):370-80

Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA.

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http://dx.doi.org/10.1002/gepi.20311DOI Listing
May 2008

Interpretation of simultaneous linkage and family-based association tests in genome screens.

Genet Epidemiol 2007 Feb;31(2):134-42

Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27710, USA.

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http://dx.doi.org/10.1002/gepi.20196DOI Listing
February 2007

X-APL: an improved family-based test of association in the presence of linkage for the X chromosome.

Am J Hum Genet 2007 Jan 28;80(1):59-68. Epub 2006 Nov 28.

Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.

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http://dx.doi.org/10.1086/510630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785309PMC
January 2007

The APL test: extension to general nuclear families and haplotypes and examination of its robustness.

Hum Hered 2006 27;61(4):189-99. Epub 2006 Jul 27.

Bioinformatics Research Center, North Carolina State University, Raleigh, N.C., USA.

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http://dx.doi.org/10.1159/000094774DOI Listing
December 2006

Perfect phylogeny haplotyper: haplotype inferral using a tree model.

Bioinformatics 2003 Apr;19(6):780-1

Department of Computer Science, 3051 Engineering II, University of California, One Shields Avenue, Davis, CA 95616, USA.

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http://dx.doi.org/10.1093/bioinformatics/btg078DOI Listing
April 2003