Reisa A Sperling

Reisa A Sperling

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Reisa A Sperling

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Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults.

Am J Geriatr Psychiatry 2019 Nov 10;27(11):1247-1256. Epub 2019 May 10.

Division of Geriatric Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2019.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778491PMC
November 2019

Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden.

Neuroimage Clin 2019 Oct 22:102052. Epub 2019 Oct 22.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.102052DOI Listing
October 2019

Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults.

Neurobiol Aging 2019 09 16;81:38-46. Epub 2019 May 16.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732225PMC
September 2019

Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid.

Neurobiol Aging 2019 06 7;78:178-185. Epub 2019 Mar 7.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Gordon Center for Medical Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580193006
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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545139PMC
June 2019

Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults.

Cereb Cortex 2019 Mar;29(3):1251-1262

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/cercor/bhy031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499008PMC
March 2019

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Alzheimers Dement 2019 Mar 9;15(3):487-496. Epub 2018 Nov 9.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, England. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476313PMC
March 2019

Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers.

Neuroimage 2019 02 17;186:446-454. Epub 2018 Nov 17.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183209
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http://dx.doi.org/10.1016/j.neuroimage.2018.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338495PMC
February 2019

Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.

J Neurosci 2019 01 27;39(3):548-556. Epub 2018 Nov 27.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1523/JNEUROSCI.1397-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335746PMC
January 2019

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex.

Nat Med 2018 12 29;24(12):1910-1918. Epub 2018 Oct 29.

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41591-018-0206-4
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http://dx.doi.org/10.1038/s41591-018-0206-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518398PMC
December 2018

Correction: Association of anxiety with subcortical amyloidosis in cognitively normal older adults.

Mol Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41380-018-0323-yDOI Listing
December 2018

Regional tau pathology and loneliness in cognitively normal older adults.

Transl Psychiatry 2018 12 18;8(1):282. Epub 2018 Dec 18.

Department of Psychiatry, Division of Geriatric Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41398-018-0345-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299114PMC
December 2018

PET staging of amyloidosis using striatum.

Alzheimers Dement 2018 10 21;14(10):1281-1292. Epub 2018 May 21.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, Charlestown, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219621PMC
October 2018

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.

Neurology 2018 10 14;91(14):e1295-e1306. Epub 2018 Sep 14.

From the Department of Neurology (E.M., J.H., V.B., A.M.F., D.M.H., J.C.M., K.P., R.J.B.), Division of Biostatistics (G.W., C.X.), Department of Radiology (B.A.G., T.L.S.B., D.S.M.), and Department of Pathology (N.J.C.), Washington University School of Medicine, Saint Louis, MO; Department of Neuroscience (A.M.J.), Icahn School of Medicine at Mount Sinai, New York, NY; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) (R.A.), Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Argentina; University of Pittsburgh School of Medicine (S.B.B., W.K.), PA; College of Physicians and Surgeons (J.N.), Columbia University, New York, NY; Department of Neurology (J.R.), Keck School of Medicine of University of Southern California, Los Angeles; Department of Neurology (B.G., M.F.), Indiana University, Indianapolis; Massachusetts General Hospital (R.A.S., J.C.), Harvard Medical School, Boston; Butler Hospital and Brown University (S.S.), Providence, RI; Department of Neurology (N.R.G.-R.), Mayo Clinic Jacksonville, FL; Neuroscience Research Australia (P.R.S.); School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; The Florey Institute and the University of Melbourne (C.M.), Parkville, Australia; Dementia Research Centre, Institute of Neurology (M.N.R., N.C.F.), University College London, UK; German Center for Neurodegenerative Diseases (DZNE) Munich (J.L.); Department of Neurology (J.L.), Ludwig-Maximilians Universität München; German Center for Neurodegenerative Diseases (DZNE) Tübingen (M.J.); and Hertie-Institute for Clinical Brain Research (M.J.), University of Tübingen, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177272PMC
October 2018

Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.

Proc Natl Acad Sci U S A 2018 10 17;115(40):10160-10165. Epub 2018 Sep 17.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129.

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http://dx.doi.org/10.1073/pnas.1804641115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176586PMC
October 2018

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.

Lancet Neurol 2018 09 6;17(9):773-781. Epub 2018 Aug 6.

The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30251-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154505PMC
September 2018

Amyloid-associated increases in longitudinal report of subjective cognitive complaints.

Alzheimers Dement (N Y) 2018 6;4:444-449. Epub 2018 Sep 6.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.trci.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153378PMC
September 2018

The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia.

Am J Geriatr Psychiatry 2018 08 3;26(8):896-904. Epub 2018 May 3.

Harvard Medical School, Boston, MA; Center for Alzheimer Research and Treatment, Department of Neurology Brigham and Women's Hospital, Boston, MA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2018.04.008DOI Listing
August 2018

Association of anxiety with subcortical amyloidosis in cognitively normal older adults.

Mol Psychiatry 2018 Aug 16. Epub 2018 Aug 16.

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://www.nature.com/articles/s41380-018-0214-2
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http://dx.doi.org/10.1038/s41380-018-0214-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377864PMC
August 2018

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Annu Rev Neurosci 2018 07;41:277-297

Institute of Neuroscience, Technical University of Munich, 80802 Munich, Germany; email:

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http://dx.doi.org/10.1146/annurev-neuro-080317-061725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571139PMC
July 2018

Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults.

Am J Psychiatry 2018 06 12;175(6):530-537. Epub 2018 Jan 12.

From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston; the Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston; the Division of Geriatric Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.; the Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neurosciences, Université Catholique de Louvain, Brussels; the Department of Psychiatry, the Department of Neurology, and the Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1176/appi.ajp.2017.17040442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988933PMC
June 2018

Dissociable influences of ε4 and polygenic risk of AD dementia on amyloid and cognition.

Neurology 2018 05 28;90(18):e1605-e1612. Epub 2018 Mar 28.

From the Psychiatric and Neurodevelopmental Genetics Unit (T.G., J.W.S.), Center for Genomic Medicine, Massachusetts General Hospital; Departments of Psychiatry (T.G., J.W.S.) and Neurology (R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Athinoula A. Martinos Center for Biomedical Imaging (T.G., M.R.S.), Massachusetts General Hospital, Harvard Medical School, Charleston; School of Electrical and Computer Engineering and Nancy E. and Peter C. Meinig School of Biomedical Engineering (M.R.S.), Cornell University, Ithaca, NY; Center for Alzheimer Research and Treatment (R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Neurology and Neurological Sciences (E.C.M.), Stanford University School of Medicine, Palo Alto, CA.

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http://dx.doi.org/10.1212/WNL.0000000000005415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931806PMC
May 2018

Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging.

Neuroimage Clin 2017 25;15:408-414. Epub 2017 May 25.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Athinoula A. Martinos Center for Biomedical Imaging and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.nicl.2017.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458095PMC
March 2018

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.

Nat Neurosci 2018 03 5;21(3):424-431. Epub 2018 Feb 5.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41593-018-0070-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857215PMC
March 2018

Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5.

Alzheimers Dement (N Y) 2017 Nov 10;3(4):668-677. Epub 2017 Nov 10.

Department of Neurology, Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.trci.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726754PMC
November 2017

Subjective memory complaints in preclinical autosomal dominant Alzheimer disease.

Neurology 2017 Oct 6;89(14):1464-1470. Epub 2017 Sep 6.

From Massachusetts General Hospital (D.J.N., R.A., B.P., R.A.S., Y.T.Q.); Harvard Medical School (D.J.N., R.A., R.A.S., Y.T.Q.); Center for Alzheimer Research and Treatment, Brigham and Women's Hospital (R.A., R.A.S.), Boston, MA; Banner Alzheimer's Institute (H.P., K.C., P.T., J.B.L., E.M.R.), Phoenix, AZ; Grupo de Neurociencias (D.C.A.-A., V.T., C.M., F.L., Y.T.Q.), Universidad de Antioquia; Instituto de Alta Tecnologia Medica (G.C.), Medellin, Colombia; and Athinoula A Martinos Center for Biomedical Imaging (Y.T.Q.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000004533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631170PMC
October 2017

Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study.

Cereb Cortex 2017 09;27(9):4339-4349

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/cercor/bhw234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074848PMC
September 2017

Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β.

Alzheimers Dement 2017 Sep 28;13(9):1004-1012. Epub 2017 Feb 28.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573651PMC
September 2017

The association between tau PET and retrospective cortical thinning in clinically normal elderly.

Neuroimage 2017 08 22;157:612-622. Epub 2017 May 22.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, 149/10.008 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2017.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772972PMC
August 2017

Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease.

Am J Geriatr Psychiatry 2017 Jul 4;25(7):683-693. Epub 2017 Jan 4.

Center of Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.jagp.2016.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906700PMC
July 2017

Functional network integrity presages cognitive decline in preclinical Alzheimer disease.

Neurology 2017 Jul 7;89(1):29-37. Epub 2017 Jun 7.

From the Florey Institutes of Neuroscience and Mental Health (R.F.B.), Melbourne; Melbourne School of Psychological Science (R.F.B.), University of Melbourne, Australia; Department of Neurology (R.F.B., A.P.S., K.V.P., B.J.H., G.M., D.M.R., K.A.J., R.A.S., J.P.C.), Athinoula A. Martinos Center for Biomedical Imaging (A.P.S., T.H., B.J.H., J.S., K.A.J.) and Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging (J.S., K.A.J.), Department of Radiology, Massachusetts General Hospital; Harvard Medical School (R.F.B., A.P.S., T.H., K.V.P., B.J.H., G.M., D.M.R., K.A.J., R.A.S., J.P.C.); Center for Alzheimer Research and Treatment, Department of Neurology (K.V.P., G.M., D.M.R., K.A.J., R.A.S., J.P.C.), Brigham and Women's Hospital, Boston, MA: and Department of Psychiatry (E.E.S.), University of Texas Southwestern Medical Center, Dallas.

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http://dx.doi.org/10.1212/WNL.0000000000004059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496516PMC
July 2017

Neuroimaging markers associated with maintenance of optimal memory performance in late-life.

Neuropsychologia 2017 06 1;100:164-170. Epub 2017 May 1.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States; Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.neuropsychologia.2017.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522601PMC
June 2017

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons.

JAMA 2017 06;317(22):2305-2316

Alzheimer's Therapeutic Research Institute, Department of Neurology, University of Southern California, San Diego.

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http://dx.doi.org/10.1001/jama.2017.6669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736301PMC
June 2017

Loneliness, depression and cognitive function in older U.S. adults.

Int J Geriatr Psychiatry 2017 05 9;32(5):564-573. Epub 2016 May 9.

Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1002/gps.4495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102822PMC
May 2017

Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden.

Neurology 2017 May 5;88(18):1759-1767. Epub 2017 Apr 5.

From the Department of Neurology (P.V., B.H., C.E.M., K.A.J., D.M.R., K.A.H., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Athinoula A. Martinos Center for Biomedical Imaging (P.V., B.H., K.A.J., R.A.S.), Department of Psychiatry (P.V., B.H., K.A.J., R.A.S.), and Department of Radiology (B.H., K.A.J.), Division of Molecular Imaging and Nuclear Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown; Center for Alzheimer Research and Treatment (P.V., R.E.A., G.A.M., K.A.J., D.M.R., R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; and Berenson-Allen Center for Noninvasive Brain Stimulation and Division for Cognitive Neurology (A.P.-L.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000003889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409840PMC
May 2017

Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease.

Neuropsychologia 2017 05 3;99:343-349. Epub 2017 Apr 3.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neuropsychologia.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473166PMC
May 2017

The influence of demographic factors on subjective cognitive concerns and beta-amyloid.

Int Psychogeriatr 2017 04 11;29(4):645-652. Epub 2016 Oct 11.

Department of Neurology,Brigham and Women's Hospital,Center for Alzheimer Research and Treatment,Boston,MA,USA.

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http://dx.doi.org/10.1017/S1041610216001502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361739PMC
April 2017

Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.

Ann Neurol 2017 Apr 6;81(4):583-596. Epub 2017 Apr 6.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, Charlestown, MA.

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http://dx.doi.org/10.1002/ana.24910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404378PMC
April 2017

Cued memory decline in biomarker-defined preclinical Alzheimer disease.

Neurology 2017 Apr 10;88(15):1431-1438. Epub 2017 Mar 10.

From the Center for Alzheimer Research and Treatment (K.V.P., D.M.R., R.E.A., K.A.J., R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Department of Neurology (D.M.R., E.C.M., A.P.S., K.A.J., R.A.S.), Department of Psychiatry (Y.Q.), and Division of Nuclear Medicine and Molecular Imaging (K.A.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; and Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Massachusetts General Hospital, Charlestown.

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http://dx.doi.org/10.1212/WNL.0000000000003812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386436PMC
April 2017

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

PLoS Med 2017 04 25;14(4):e1002287. Epub 2017 Apr 25.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404753PMC
April 2017

Cardiorespiratory fitness is differentially associated with cortical thickness in young and older adults.

Neuroimage 2017 02 28;146:1084-1092. Epub 2016 Oct 28.

Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, USA; Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2016.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321861PMC
February 2017

Decreased hippocampal metabolism in high-amyloid mild cognitive impairment.

Alzheimers Dement 2016 12 13;12(12):1288-1296. Epub 2016 Jul 13.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; The Martinos Center for Biomedical Imaging, Charlestown, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.06.2357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148703PMC
December 2016

Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults.

JAMA Psychiatry 2016 Dec;73(12):1230-1237

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts2Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts5Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.2657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5257284PMC
December 2016

Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.

J Alzheimers Dis 2016 ;50(1):249-60

Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Sagol School of Neuroscience & Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.3233/JAD-150799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712084PMC
October 2016

Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals.

JAMA Neurol 2016 Oct;73(10):1185-1191

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown2Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts4Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2016.2237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266522PMC
October 2016

Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.

Proc Natl Acad Sci U S A 2016 10 4;113(42):E6535-E6544. Epub 2016 Oct 4.

Department of Electrical and Computer Engineering, Agency for Science, Technology and Research-National University of Singapore Clinical Imaging Research Centre, Singapore Institute for Neurotechnology and Memory Networks Program, National University of Singapore, Singapore 117599; Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129; Centre for Cognitive Neuroscience, Duke-National University of Singapore Graduate Medical School, Singapore 169857

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http://dx.doi.org/10.1073/pnas.1611073113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081632PMC
October 2016

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers.

Neurology 2016 Aug 1;87(5):539-47. Epub 2016 Jul 1.

From the Departments of Radiology (C.R.J.) and Neurology (D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Clinical Neurochemistry Lab (K.B.), Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal, Sweden; Alzheimer's Association (M.C.C.), Chicago, IL; Division of Neurology (H.H.F.), UBC Hospital Clinic for Alzheimer's Disease and Related Disorders, University of British Columbia, Vancouver, Canada; Memory Clinic (G.B.F.), University Hospitals and University of Geneva, Switzerland; IRCCS Fatebenefratelli (G.B.F.), The National Centre for Alzheimer's Disease, Brescia, Italy; Sorbonne Universités (H.H.), Université Pierre et Marie Curie, Paris; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut du Cerveau et de la Moelle épinière (ICM) (H.H.), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France; Helen Wills Neuroscience Institute (W.J.J.), University of California, Berkeley; Departments of Radiology and Neurology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston; Alzheimer Center and Department of Neurology (P.S.), Vrije Universiteit Amsterdam, the Netherlands; Center for Alzheimer Research and Treatment (R.A.S.), Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School, Boston; Centre des Maladies Cognitives et Comportementales (B.D.), Institut du Cerveau et de la Moelle épinière, Paris; and Université Pierre et Marie Curie-Paris 6 (B.D.), AP-HP, Hôpital de la Salpêtrière, Paris, France.

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http://dx.doi.org/10.1212/WNL.0000000000002923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970664PMC
August 2016

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.

Neurology 2016 Aug 6;87(5):481-8. Epub 2016 Jul 6.

From the Departments of Neurology (E.C.M., R.A.S.) and Radiology (R.A.S.), Massachusetts General Hospital, Harvard Medical School, Charlestown; Center for Alzheimer Research and Treatment, Department of Neurology (R.A.S.), and Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry (P.L.D.), Brigham and Women's Hospital, Harvard Medical School (P.L.D.), Boston, MA; Department of Psychology (A.J.H.), Yale University, New Haven, CT; Department of Psychiatry (A.J.H.), Massachusetts General Hospital, Harvard Medical School, Boston; Athinoula A. Martinos Center for Biomedical Imaging (A.J.H.) and Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research (J.W.S.), Massachusetts General Hospital, Boston; Department of Psychology and Center for Brain Science (R.L.B.), Harvard University, Cambridge; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (R.L.B., M.R.S.), Massachusetts General Hospital, Charlestown; Program in Medical and Population Genetics (P.L.D.), Broad Institute; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard (J.W.S.); and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge.

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http://dx.doi.org/10.1212/WNL.0000000000002922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970660PMC
August 2016

Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly.

Neurology 2016 Aug 29;87(9):920-6. Epub 2016 Jul 29.

From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000003050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035159PMC
August 2016

Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci.

Neurol Genet 2016 Aug 26;2(4):e90. Epub 2016 Jul 26.

Ann Romney Center for Neurologic Diseases (G.C., C.C.W., P.A.W., M.C., J.M.R., L.R.G., N.E.C., K.J.R., L.B.C., P.L.D.J., E.M.B.), Program in Translational NeuroPsychiatric Genomics (G.C., C.C.W., P.A.W., M.C., J.M.R., L.R.G., N.E.C., K.J.R., L.B.C., P.L.D.J., E.M.B.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Center for Alzheimer's Research and Treatment (K.A.J., R.A.S.), Department of Neurology, Brigham and Women's Hospital, Boston, MA; Program in Medical and Population Genetics (G.C., C.C.W., P.A.W., M.C., J.M.R., L.R.G., N.E.C., K.J.R., L.B.C., P.L.D.J., E.M.B.), Broad Institute, Cambridge, MA; Harvard Medical School (G.C., J.M.R., K.J.R., K.A.J., L.B.C., R.A.S., P.L.D.J., E.M.B.), Boston, MA; Department of Neurology (K.A.J., R.A.S.), Massachusetts General Hospital, Boston; and Rush Alzheimer's Disease Center (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1212/NXG.0000000000000090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962525PMC
August 2016

Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease.

Neuropsychology 2016 07 23;30(5):624-30. Epub 2015 Nov 23.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital.

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http://dx.doi.org/10.1037/neu0000246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877295PMC
July 2016

Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer's disease.

Neurobiol Aging 2016 06 21;42:177-88. Epub 2016 Mar 21.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857135PMC
June 2016

Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging.

Neuroimage 2016 05 23;132:334-343. Epub 2016 Feb 23.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2016.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851886PMC
May 2016

Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring.

Neurobiol Aging 2016 Apr 28;40:61-67. Epub 2015 Dec 28.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792089PMC
April 2016

The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials.

J Prev Alzheimers Dis 2016 Mar;3(1):8-12

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.14283/jpad.2015.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795477PMC
March 2016

Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity.

Hum Brain Mapp 2016 Feb 6;37(2):621-31. Epub 2015 Nov 6.

Department of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts.

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http://dx.doi.org/10.1002/hbm.23054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729206PMC
February 2016

Suspected non-Alzheimer disease pathophysiology--concept and controversy.

Nat Rev Neurol 2016 Feb 18;12(2):117-24. Epub 2016 Jan 18.

Department of Psychiatry and Neuropsychology, Institute of Mental Health and Neuroscience, Maastricht University, PO Box 616 MD Maastricht, Netherlands.

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http://dx.doi.org/10.1038/nrneurol.2015.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784257PMC
February 2016

The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease.

J Prev Alzheimers Dis 2015 Dec;2(4):242-253

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA ; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA ; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA ; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.14283/jpad.2015.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671513PMC
December 2015

Physical Activity Is Positively Associated with Episodic Memory in Aging.

J Int Neuropsychol Soc 2015 Nov;21(10):780-90

1Memory Disorders Research Center,VA Boston Healthcare System and Boston University School of Medicine,Boston,Massachusetts.

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http://dx.doi.org/10.1017/S1355617715000910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711930PMC
November 2015