Publications by authors named "Reisa A Sperling"

100Publications

Defining the lowest threshold for amyloid-PET to predict future cognitive decline and amyloid accumulation.

Neurology 2020 Nov 16. Epub 2020 Nov 16.

From the Michelle E. Farrell, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US Shu Jiang, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis Aaron P. Schultz, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US Michael J. Properzi, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US Julie C.Price, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA J. Alex Becker, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Heidi I.L. Jacobs, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands Bernard J. Hanseeuw, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. Dorene M. Rentz, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA Victor L Villemagne, Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Australia. Kathryn V. Papp, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA Elizabeth C. Mormino, Department of Neuroscience, Stanford University, Palo Alto, CA, USA. Rebecca A. Betensky, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Department of Biostatistics, New York University School of Global Public Health, New York, NY, USA. Keith A. Johnson, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Reisa A. Sperling, MD Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA. Rachel F. Buckley, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA, Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.

View Article and Find Full Text PDF
November 2020

The neurophysiology and seizure outcomes of late onset unexplained epilepsy.

Clin Neurophysiol 2020 Nov 19;131(11):2667-2672. Epub 2020 Sep 19.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MA, USA; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
November 2020

Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer's disease.

Neuroimage Clin 2020 2;28:102407. Epub 2020 Sep 2.

Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston 02114, MA, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

Multiple markers contribute to risk of progression from normal to mild cognitive impairment.

Neuroimage Clin 2020 28;28:102400. Epub 2020 Aug 28.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. Electronic address:

View Article and Find Full Text PDF
August 2020

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.

Neuron 2020 08 10;107(3):496-508.e6. Epub 2020 Jun 10.

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:

View Article and Find Full Text PDF
August 2020

Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study.

J Alzheimers Dis 2020 ;75(4):1437-1446

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
January 2020

The presubiculum links incipient amyloid and tau pathology to memory function in older persons.

Neurology 2020 05 9;94(18):e1916-e1928. Epub 2020 Apr 9.

From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands; Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Neurology (B.J.H.), Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.

View Article and Find Full Text PDF
May 2020

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals.

JAMA Neurol 2020 Jun;77(6):735-745

Alzheimer Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego.

View Article and Find Full Text PDF
June 2020

Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults.

Neurobiol Aging 2020 09 7;93:124-130. Epub 2020 Mar 7.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital; Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults.

JAMA Netw Open 2020 02 5;3(2):e200121. Epub 2020 Feb 5.

Division of Geriatric Psychiatry, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

View Article and Find Full Text PDF
February 2020

Word retrieval across the biomarker-confirmed Alzheimer's disease syndromic spectrum.

Neuropsychologia 2020 03 10;140:107391. Epub 2020 Feb 10.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, 02115, USA; Center for Brain/Mind Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02129, USA.

View Article and Find Full Text PDF
March 2020

Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults.

Neuroimage Clin 2019 18;24:102097. Epub 2019 Nov 18.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
September 2020

Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden.

Neuroimage Clin 2020 22;26:102052. Epub 2019 Oct 22.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

View Article and Find Full Text PDF
October 2019

Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults.

Am J Geriatr Psychiatry 2019 11 10;27(11):1247-1256. Epub 2019 May 10.

Division of Geriatric Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
November 2019

Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults.

Neurobiol Aging 2019 09 16;81:38-46. Epub 2019 May 16.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

View Article and Find Full Text PDF
September 2019

Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid.

Neurobiol Aging 2019 06 7;78:178-185. Epub 2019 Mar 7.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Gordon Center for Medical Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

View Article and Find Full Text PDF
June 2019

Regional tau pathology and loneliness in cognitively normal older adults.

Transl Psychiatry 2018 12 18;8(1):282. Epub 2018 Dec 18.

Department of Psychiatry, Division of Geriatric Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

View Article and Find Full Text PDF
December 2018

Correction: Association of anxiety with subcortical amyloidosis in cognitively normal older adults.

Mol Psychiatry 2020 Oct;25(10):2644

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

View Article and Find Full Text PDF
October 2020

Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.

J Neurosci 2019 01 27;39(3):548-556. Epub 2018 Nov 27.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.

View Article and Find Full Text PDF
January 2019

Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers.

Neuroimage 2019 02 17;186:446-454. Epub 2018 Nov 17.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
February 2019

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Alzheimers Dement 2019 03 9;15(3):487-496. Epub 2018 Nov 9.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, England. Electronic address:

View Article and Find Full Text PDF
March 2019

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex.

Nat Med 2018 12 29;24(12):1910-1918. Epub 2018 Oct 29.

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
December 2018

Amyloid-associated increases in longitudinal report of subjective cognitive complaints.

Alzheimers Dement (N Y) 2018 6;4:444-449. Epub 2018 Sep 6.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
September 2018

Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.

Proc Natl Acad Sci U S A 2018 10 17;115(40):10160-10165. Epub 2018 Sep 17.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129.

View Article and Find Full Text PDF
October 2018

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.

Neurology 2018 10 14;91(14):e1295-e1306. Epub 2018 Sep 14.

From the Department of Neurology (E.M., J.H., V.B., A.M.F., D.M.H., J.C.M., K.P., R.J.B.), Division of Biostatistics (G.W., C.X.), Department of Radiology (B.A.G., T.L.S.B., D.S.M.), and Department of Pathology (N.J.C.), Washington University School of Medicine, Saint Louis, MO; Department of Neuroscience (A.M.J.), Icahn School of Medicine at Mount Sinai, New York, NY; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) (R.A.), Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Argentina; University of Pittsburgh School of Medicine (S.B.B., W.K.), PA; College of Physicians and Surgeons (J.N.), Columbia University, New York, NY; Department of Neurology (J.R.), Keck School of Medicine of University of Southern California, Los Angeles; Department of Neurology (B.G., M.F.), Indiana University, Indianapolis; Massachusetts General Hospital (R.A.S., J.C.), Harvard Medical School, Boston; Butler Hospital and Brown University (S.S.), Providence, RI; Department of Neurology (N.R.G.-R.), Mayo Clinic Jacksonville, FL; Neuroscience Research Australia (P.R.S.); School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; The Florey Institute and the University of Melbourne (C.M.), Parkville, Australia; Dementia Research Centre, Institute of Neurology (M.N.R., N.C.F.), University College London, UK; German Center for Neurodegenerative Diseases (DZNE) Munich (J.L.); Department of Neurology (J.L.), Ludwig-Maximilians Universität München; German Center for Neurodegenerative Diseases (DZNE) Tübingen (M.J.); and Hertie-Institute for Clinical Brain Research (M.J.), University of Tübingen, Germany.

View Article and Find Full Text PDF
October 2018

Association of anxiety with subcortical amyloidosis in cognitively normal older adults.

Mol Psychiatry 2020 10 16;25(10):2599-2607. Epub 2018 Aug 16.

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

View Article and Find Full Text PDF
October 2020

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.

Lancet Neurol 2018 09 6;17(9):773-781. Epub 2018 Aug 6.

The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA. Electronic address:

View Article and Find Full Text PDF
September 2018

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Annu Rev Neurosci 2018 07;41:277-297

Institute of Neuroscience, Technical University of Munich, 80802 Munich, Germany; email:

View Article and Find Full Text PDF
July 2018

The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia.

Am J Geriatr Psychiatry 2018 08 3;26(8):896-904. Epub 2018 May 3.

Harvard Medical School, Boston, MA; Center for Alzheimer Research and Treatment, Department of Neurology Brigham and Women's Hospital, Boston, MA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA. Electronic address:

View Article and Find Full Text PDF
August 2018

PET staging of amyloidosis using striatum.

Alzheimers Dement 2018 10 21;14(10):1281-1292. Epub 2018 May 21.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, Charlestown, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
October 2018

Dissociable influences of ε4 and polygenic risk of AD dementia on amyloid and cognition.

Neurology 2018 05 28;90(18):e1605-e1612. Epub 2018 Mar 28.

From the Psychiatric and Neurodevelopmental Genetics Unit (T.G., J.W.S.), Center for Genomic Medicine, Massachusetts General Hospital; Departments of Psychiatry (T.G., J.W.S.) and Neurology (R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Athinoula A. Martinos Center for Biomedical Imaging (T.G., M.R.S.), Massachusetts General Hospital, Harvard Medical School, Charleston; School of Electrical and Computer Engineering and Nancy E. and Peter C. Meinig School of Biomedical Engineering (M.R.S.), Cornell University, Ithaca, NY; Center for Alzheimer Research and Treatment (R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Neurology and Neurological Sciences (E.C.M.), Stanford University School of Medicine, Palo Alto, CA.

View Article and Find Full Text PDF
May 2018

Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults.

Cereb Cortex 2019 03;29(3):1251-1262

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
March 2019

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.

Nat Neurosci 2018 03 5;21(3):424-431. Epub 2018 Feb 5.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
March 2018

Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults.

Am J Psychiatry 2018 06 12;175(6):530-537. Epub 2018 Jan 12.

From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston; the Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston; the Division of Geriatric Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.; the Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neurosciences, Université Catholique de Louvain, Brussels; the Department of Psychiatry, the Department of Neurology, and the Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.

View Article and Find Full Text PDF
June 2018

Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5.

Alzheimers Dement (N Y) 2017 Nov 10;3(4):668-677. Epub 2017 Nov 10.

Department of Neurology, Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
November 2017

Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals.

Neuroimage Clin 2018 31;17:388-396. Epub 2017 Oct 31.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
June 2018

Subjective memory complaints in preclinical autosomal dominant Alzheimer disease.

Neurology 2017 Oct 6;89(14):1464-1470. Epub 2017 Sep 6.

From Massachusetts General Hospital (D.J.N., R.A., B.P., R.A.S., Y.T.Q.); Harvard Medical School (D.J.N., R.A., R.A.S., Y.T.Q.); Center for Alzheimer Research and Treatment, Brigham and Women's Hospital (R.A., R.A.S.), Boston, MA; Banner Alzheimer's Institute (H.P., K.C., P.T., J.B.L., E.M.R.), Phoenix, AZ; Grupo de Neurociencias (D.C.A.-A., V.T., C.M., F.L., Y.T.Q.), Universidad de Antioquia; Instituto de Alta Tecnologia Medica (G.C.), Medellin, Colombia; and Athinoula A Martinos Center for Biomedical Imaging (Y.T.Q.), Boston, MA.

View Article and Find Full Text PDF
October 2017

Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging.

Neuroimage Clin 2017 25;15:408-414. Epub 2017 May 25.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Athinoula A. Martinos Center for Biomedical Imaging and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
March 2018

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons.

JAMA 2017 06;317(22):2305-2316

Alzheimer's Therapeutic Research Institute, Department of Neurology, University of Southern California, San Diego.

View Article and Find Full Text PDF
June 2017

Functional network integrity presages cognitive decline in preclinical Alzheimer disease.

Neurology 2017 Jul 7;89(1):29-37. Epub 2017 Jun 7.

From the Florey Institutes of Neuroscience and Mental Health (R.F.B.), Melbourne; Melbourne School of Psychological Science (R.F.B.), University of Melbourne, Australia; Department of Neurology (R.F.B., A.P.S., K.V.P., B.J.H., G.M., D.M.R., K.A.J., R.A.S., J.P.C.), Athinoula A. Martinos Center for Biomedical Imaging (A.P.S., T.H., B.J.H., J.S., K.A.J.) and Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging (J.S., K.A.J.), Department of Radiology, Massachusetts General Hospital; Harvard Medical School (R.F.B., A.P.S., T.H., K.V.P., B.J.H., G.M., D.M.R., K.A.J., R.A.S., J.P.C.); Center for Alzheimer Research and Treatment, Department of Neurology (K.V.P., G.M., D.M.R., K.A.J., R.A.S., J.P.C.), Brigham and Women's Hospital, Boston, MA: and Department of Psychiatry (E.E.S.), University of Texas Southwestern Medical Center, Dallas.

View Article and Find Full Text PDF
July 2017

The association between tau PET and retrospective cortical thinning in clinically normal elderly.

Neuroimage 2017 08 22;157:612-622. Epub 2017 May 22.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, 149/10.008 13th Street, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
August 2017

Neuroimaging markers associated with maintenance of optimal memory performance in late-life.

Neuropsychologia 2017 06 1;100:164-170. Epub 2017 May 1.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States; Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.

View Article and Find Full Text PDF
June 2017

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

PLoS Med 2017 04 25;14(4):e1002287. Epub 2017 Apr 25.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

View Article and Find Full Text PDF
April 2017

Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease.

Am J Geriatr Psychiatry 2017 Jul 4;25(7):683-693. Epub 2017 Jan 4.

Center of Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

View Article and Find Full Text PDF
July 2017

Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease.

Neuropsychologia 2017 05 3;99:343-349. Epub 2017 Apr 3.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
May 2017

Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden.

Neurology 2017 May 5;88(18):1759-1767. Epub 2017 Apr 5.

From the Department of Neurology (P.V., B.H., C.E.M., K.A.J., D.M.R., K.A.H., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Athinoula A. Martinos Center for Biomedical Imaging (P.V., B.H., K.A.J., R.A.S.), Department of Psychiatry (P.V., B.H., K.A.J., R.A.S.), and Department of Radiology (B.H., K.A.J.), Division of Molecular Imaging and Nuclear Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown; Center for Alzheimer Research and Treatment (P.V., R.E.A., G.A.M., K.A.J., D.M.R., R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; and Berenson-Allen Center for Noninvasive Brain Stimulation and Division for Cognitive Neurology (A.P.-L.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

View Article and Find Full Text PDF
May 2017

Cued memory decline in biomarker-defined preclinical Alzheimer disease.

Neurology 2017 Apr 10;88(15):1431-1438. Epub 2017 Mar 10.

From the Center for Alzheimer Research and Treatment (K.V.P., D.M.R., R.E.A., K.A.J., R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Department of Neurology (D.M.R., E.C.M., A.P.S., K.A.J., R.A.S.), Department of Psychiatry (Y.Q.), and Division of Nuclear Medicine and Molecular Imaging (K.A.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; and Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Massachusetts General Hospital, Charlestown.

View Article and Find Full Text PDF
April 2017

Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.

Ann Neurol 2017 Apr 6;81(4):583-596. Epub 2017 Apr 6.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, Charlestown, MA.

View Article and Find Full Text PDF
April 2017

Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β.

Alzheimers Dement 2017 Sep 28;13(9):1004-1012. Epub 2017 Feb 28.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
September 2017

Cardiorespiratory fitness is differentially associated with cortical thickness in young and older adults.

Neuroimage 2017 02 28;146:1084-1092. Epub 2016 Oct 28.

Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, USA; Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.

View Article and Find Full Text PDF
February 2017

Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults.

JAMA Psychiatry 2016 Dec;73(12):1230-1237

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts2Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts5Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.

View Article and Find Full Text PDF
December 2016

Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.

Proc Natl Acad Sci U S A 2016 10 4;113(42):E6535-E6544. Epub 2016 Oct 4.

Department of Electrical and Computer Engineering, Agency for Science, Technology and Research-National University of Singapore Clinical Imaging Research Centre, Singapore Institute for Neurotechnology and Memory Networks Program, National University of Singapore, Singapore 117599; Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129; Centre for Cognitive Neuroscience, Duke-National University of Singapore Graduate Medical School, Singapore 169857

View Article and Find Full Text PDF
October 2016